Research group - Lennart Hammarström

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We focus on two main areas of immunological research - Immunogenetics and Immunotheraphy.

Genetic basis of immunodeficiency diseases

Hyper IgM syndrome (HIGM)
Common variable immunodeficiency (CVID)
IgA deficiency (IgAD)

Expression of antibody encoding genes in

Lactobacilli (Rotavirus, Clostridium difficile, HIV)
Cytokines (IL-10, IL-21)
Ligands (CD40L)

Research group leader Lennart Hammarström

Group members

Hassan AbolhassaniPhD student
Kerstin BergmanLaboratory technician
Stephan BorteAssociated
Renée EnqvistAssociated
Mingyan FangGraduate Student
Jovanka KingPhD student
Annica LindkvistLecturer
Harold MarcotteSenior researcher

Research techniques


External funding

Swedish Research Council, EU, National Institutes of Health, ALF

Teaching assignments

BMA, study programme in medicine, study programme in medicine

Selected publications

Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.
Tokuhara D, Álvarez B, Mejima M, Hiroiwa T, Takahashi Y, Kurokawa S, et al
J. Clin. Invest. 2013 Sep;123(9):3829-38

Impact of Down syndrome on the performance of neonatal screening assays for severe primary immunodeficiency diseases.
Verstegen R, Borte S, Bok L, van Zwieten P, von Döbeln U, Hammarström L, et al
J. Allergy Clin. Immunol. 2014 Apr;133(4):1208-11

The dog as a genetic model for immunoglobulin A (IgA) deficiency: identification of several breeds with low serum IgA concentrations.
Olsson M, Frankowiack M, Tengvall K, Roosje P, Fall T, Ivansson E, et al
Vet. Immunol. Immunopathol. 2014 Aug;160(3-4):255-9

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.
Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis S, et al
Science 2013 May;340(6135):976-8

Neonatal screening for severe primary immunodeficiency diseases using high-throughput triplex real-time PCR.
Borte S, von Döbeln U, Fasth A, Wang N, Janzi M, Winiarski J, et al
Blood 2012 Mar;119(11):2552-5

Selective IgA deficiency in autoimmune diseases.
Wang N, Shen N, Vyse T, Anand V, Gunnarson I, Sturfelt G, et al
Mol. Med. 2011 ;17(11-12):1383-96

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
Ferreira R, Pan-Hammarström Q, Graham R, Gateva V, Fontán G, Lee A, et al
Nat. Genet. 2010 Sep;42(9):777-80

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
, Rioux J, Goyette P, Vyse T, Hammarström L, Fernando M, et al
Proc. Natl. Acad. Sci. U.S.A. 2009 Nov;106(44):18680-5