Lectures and seminars

Seminar - Conformational features of IDPs

2016-11-2214:00 Room: Cellen, Level 4, NovumKarolinska University Hospital, Huddinge

"Conformational features of IDPs"


Professor Kyou Hoon-Han 
Expert in the area of intrinsically disordered proteins (IDPs) and has performed some ground-breaking studies of IDPs using NMR spectroscopy
Korea Research Institute of Bioscience and Biotechnology (KRIBB), South Korea

About IDP

Up to 40% of the human proteome consists of intrinsically disordered protein regions and these proteins are now the focus of a rapidly growing field of IDP research. Among other things IDPs turn out to:

- be over-represented in disease-related proteins

- be hotspots for functional adaptation of proteins

- mediate most interactions between regulatory proteins

- constitute and control the protein content of so-called membrane-less organelles (eg. nucleolus), bodies and speckles in cells as a result of liquid phase transitions and liquid phase differences

- contain most functionally important short linear motifs in proteins including most post-translation modification sites

- contain conformationally flexible protein regions whose function can be modulated in different ways - eg. by differential splicing

Contact person: Anthony Wright