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Research group André Stark

The research group's main focus is endoprotes- and trauma research.

Early migration of joint replacements can be detected using radiostereometric analysis (RSA), a high-precision method to measure three-dimensional micro-motion. Increased early micro-motion between the implant and the host bone may indicate future loosening and the need for re-operation. Using this method, loosening of implants can be detected early. It is not necessary to analyse a large number of patients over a long period of time in order to decide whether a new implant is satisfactory or not. The method mentioned above can assist in helping to prevent suffering for patients and it also cost-saving for the community.

A rigid metallic device implanted into bone alters the stress pattern and causes local bone resorption. This may lead to periprosthetic fractures and bone loss over time. Bone resorption can be studied by dual-energy X-ray absorbtiometry (DEXA) and computer tomography (CT). In our studies, different surgical options of treatment, as well as, medical treatments will be evaluated.

In addition, the evaluation of different systems in joint replacement will be investigated with the help of several Swedish registers. This will be examined in detail for patients who have suffered hip fractures.

In order to optimize the treatment of patients with hip fractures different clinical pathways for their management in hospital will be evaluated with special emphasis on patient safety and economic considerations. Joint co-operations with LIME/KI and the University of Linköping have been initiated.

Group members

Forskargruppsledare: Professor André Stark
Med dr, Överläkare Olof Sköldenberg
Med dr, Överläkare Björn Salomonsson
Med dr, Överläkare Olle Muren, e-post:olav.muren@ds.se
Med dr, Överläkare Henrik Bodén, e-post: henrik.boden@ds.se
Med dr, Överläkare Thomas Eisler, e-post: thomas.eisler@ds.se
Docent, Överläkare Torbjörn Ahl, e-post: torbjorn.ahl@ds.se
Med dr, Specialistläkare Max Gordon
Med dr, Överläkare Mats Salemyr, e-post: mats.salemyr@ds.se
Doktorand vid KI, Överläkare Ghazi Chammout
Doktorand vid KIDS, Forskningssjuksköterska Paula Kelly-Pettersson
Doktorand vid KIDS, Överläkare Agata Rysinska
Doktorand vid KIDS, Specialistläkare Magnus Ödquist
Doktorand vid KIDS, Specialistläkare Soheila Zhaeentan
Med dr, Kvalitetsutvecklare Bodil Samuelsson
Med dr, Leg ssk Maria Unbeck
Doktorand vid KIDS, Överläkare Karin Hallin e-post:karin.hallin@ds.se

Selected publications

The effect of weekly risedronate on periprosthetic bone resorption following total hip arthroplasty: a randomized, double-blind, placebo-controlled trial.
Sköldenberg O, Salemyr M, Bodén H, Ahl T, Adolphson P
J Bone Joint Surg Am 2011 Oct;93(20):1857-64

Measurement of migration of a humeral head resurfacing prosthesis using radiostereometry without implant marking: an experimental study.
Sköldenberg O, Odquist M
Acta Orthop 2011 Apr;82(2):193-7

Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.
Ahmed A, Li J, Ahmed M, Hua L, Yakovleva T, Ossipov M, et al
Arthritis Rheum. 2010 Jul;62(7):2160-9

Reduced dislocation rate after hip arthroplasty for femoral neck fractures when changing from posterolateral to anterolateral approach.
Sköldenberg O, Ekman A, Salemyr M, Bodén H
Acta Orthop 2010 Oct;81(5):583-7

A new uncemented hydroxyapatite-coated femoral component for the treatment of femoral neck fractures: two-year radiostereometric and bone densitometric evaluation in 50 hips.
Sköldenberg O, Salemyr M, Bodén H, Lundberg A, Ahl T, Adolphson P
J Bone Joint Surg Br 2011 May;93(5):665-77

Age- and health-related quality of life after total hip replacement: decreasing gains in patients above 70 years of age.
Gordon M, Greene M, Frumento P, Rolfson O, Garellick G, Stark A
Acta Orthop 2014 Jun;85(3):244-9

The influence of comorbidity scores on re-operations following primary total hip replacement: comparison and validation of three comorbidity measures.
Gordon M, Stark A, Sköldenberg O, Kärrholm J, Garellick G
Bone Joint J 2013 Sep;95-B(9):1184-91