Systematic review of nonmonotonic dose-responses of substances for human risk assessment

The project aims at evaluating the extent of evidence and the validity of the studies supporting the nonmonotonicity hypothesis for adverse effects and underlying toxic modes of action of substances (including manmade chemicals) in the area of food safety. This also includes the underlying modes of action producing a NMDR.

In particular the objectives of the review are:

1. To provide an overview on the state-of-the-science on NMDR hypothesis for substances, focusing on the food safety area.

2. To provide a critical appraisal of toxicity studies on the basis of scientific criteria for the evaluation of robustness of NMDR studies, and analysis of comparable studies.

3. To provide an inventory of data extracted from the selected toxicity studies.

This project is a collaboration with Anses (French Agency for Food, Environmental and Occupational Health & Safety), RIVM (National Institute for Public Health and the Environment) in the Netherlands and AGES (Austrian Agency for Health and Food Safety GmbH).



  • EFSA – European Food Safety Authority (2014-2015)