Randomized controlled trials (RCT) of interventions for back and neck pain
We perform clinical trials with the overall aim of evaluating the effect of commonly used treatment strategies, including manual therapy, for musculoskeletal disorders. Specific aims are to deepen the knowledge of the effect of treatments on back/neck pain regarding pain, disability, perceived recovery, cost utility and adverse reactions.
- The BJÖRN-trial (n=409). The aim of this trial was to compare naprapathic manual therapy with evidence-based advice to stay active for back or neck pain regarding pain, disability, perceived recovery, health, sick leave, etc. Naprapathy is characterized by manual manipulations with a focus on soft and connective tissues, aiming to decrease pain and disability in the musculoskeletal system. Four hundred and nine patients with pain and disability in the back or neck lasting for at least 2 weeks, were included in this randomized controlled trial. Outcomes were measured by questionnaires at baseline and after 3, 7, 12, 26 and 52 weeks.Lyssna Data from the trial is also used to identified prognostic factors for back and neck pain and to evaluate the cost effectiveness.
- The MINT-Trial (The Manual Intervention Trial) (n=1057): Our earlier trials indicate that manual therapy like naprapathy is an effective treatment for patients with unspecific back/neck pain. This trial aims to compare the effect of three different combinations of Naprapathic manual therapy (NMT) on such pain, to examine prevalence, severity and duration of adverse reactions after NMT, and to identify subgroups of patients who have greater benefit from the treatments. The method is a randomized controlled trial with three arms. Included are care seeking patients 18-65 years with non-specific neck and/or back pain. Patients got up to 6 treatments within 6 weeks and were followed with questionnaires regarding adverse reactions, pain intensity, pain related disability and perceived recovery the outcomes four times within a year. Data from the trial is also used to identified prognostic factors for back and neck pain.
- Stockholm Neck trial (The STONE-trial) (n = 620) is performed in collaboration with Associate Professor Pierre Côté, University of Ontario Institute of Technology, to explore the effect of massage therapy and physical training on sub-acute and long lasting neck pain, and to study the detailed course of neck pain. Study participants are followed by questionnaires and weekly SMS. In January 2017 are all study participants followed for one year and the main analyses will start. Data will also be used to identify prognostic factors for future secondary prevention strategies and to perform a health economic evaluation. This trial is ongoing and is funded by VR, FORTE and Karolinska Institutet.
Associate professor Eva Skillgate, +46 709 209930, Eva.Skillgate@ki.se