Laminin isoforms and their cell surface receptors in inflammation, tissue regeneration and cancer biology
In the oral cavity inflammatory diseases such as periodontitis may lead to tooth loss whereas malignant disorders such as squamous cell carcinoma may be lethal. Moreover, tissue regeneration by mesenchymal stem cells (MSCs) occurs in several entities.
The purpose of the present research is to investigate the interaction of cells with the extracellular matrix (ECM) and the relevance of this process to:
- Leukocyte recruitment during immune and inflammatory responses (Fig. 1).
- MSC biology.
- Cancer biology (cancer cell stemness/survival/migration/proliferation and tumor invasion and metastasis) (Fig. 2).
Among ECM components, laminins are studied. The contribution of laminins and their cell-surface receptors to the migration and extravasation of different leukocytes is investigated, as well as the role of laminins in MSC stemness, differentiation and homing. In addition, the contribution of these ECM to cancer cell stemness and the dissemination of several tumors, including oral squamous cell carcinoma, is studied.
Fig. 1. Recruitment of blood leukocytes
Fig. 2. Cancer cells migrating and invading
Manuel Patarroyo MD PhD
Professor of Adhesion Biology Karolinska Institutet Stockholm
Karl Tryggvason, Duke-NUS/Karolinska Institutet. Singapore/Stockholm.
Johan Hansson, Dept Oncology/Karolinska Institutet, Stockholm.
Arthur Mercurio, Univ. Massachusetts/Worcester USA.
Gerd Klein, Univ. Tubingen/Tubingen, Germany.
Sulev Ingerpuu, Univ Tartu/Tartu, Estonia.
Novo Nordisk Foundation