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Research - Anesthesia

Research projects and groups

Nutrition and metabolism

Research leaders: Professor Jan Wernerman and Professor Olav Rooijackers

Patients who undergo major surgery or critical illness are under a severe stress that has a major impact on the patient's metabolism, muscles and strength. Research have shown that good control of these metabolic and nutritional problems positively affects the outcome and recovery of the patients. We try to understand the basic pathways, mechanisms, and regulators for the breakdown of protein and muscles. We investigate how nutrition can counteract these effects. With the help of healthy volunteers, we perform proof-of-principle or mechanistic studies, and we also use research tools that include the very basic, like gene expression and enzyme activity, to more advanced clinical tools, like energy expenditure and clinical outcome.

Perioperative medicine

Research leader: Professor Sigridur Kalman

Patients presenting for surgery have become older and more ill than during earlier decades. We know that every complication after surgery has a detrimental effect on morbidity and mortality during the coming years. Preoperatively identifying patients at risk and tailoring care of the patient according to this risk is of major importance. Our research has investigated how to optimize perioperative circulation to the elderly and demonstrated that algorithms used for younger patients cannot be used. With validated risk scores, we are now able to thoroughly investigate a vulnerable group of patients in a cost effective manner. The group of patients undergoing surgery each year is large, which makes it important to maintain a health-economic perspective when evaluating both the consequences of complications and the effects of any intervention.

Simulator based training and it’s pedagogic

Research leader: Professor Li Felländer-Tsai

In a complex multi-professional environment, training and team training is mandatory. Our research focus is on multi-professional training in situ at the ICU, through the pedagogic of simulation training at the Centre for Advanced Medical Simulation and Training (CAMST), and through virtual reality training in resuscitation.

Pain medicine

Research leader: Lars Ståhle

Patients with severe and complex pain suffering are referred to the Pain unit for diagnosis, advice and treatment. One of the profile competences of the Unit of Pain medicine is Spinal Cord Stimulation (SCS). This is used if the patient has a diagnosis of peripheral neuropathic pain were pharmacological treatment are insufficient or not tolerated. Neuropathic pain emanates from nervous tissue either central or peripheral. Treatment with SCS means stimulation of the spinal cord with a low current. The success rate varies between 50–70%.

It has been estimated that more than 40.000 stimulation systems are implanted every year worldwide. This method is not well known, and we estimate that there are many patients in Sweden alone that could benefit from SCS. .

The operations which are described below are performed in Day Case Surgery.

In order to develop our SCS practice we are focusing on several research questions; how to help patients who experience a reduction in the effect of SCS over time, what is the benefits of different mode of stimulation and how to predict the which patient has the most benefit of the SCS .