Research group - Qiang Pan-Hammarström
We focus on two main areas of research: Immunogenetics and Cancer Genetics.
Regulation of immunoglobulin class switch recombination in human B cells
The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.
Induced pluripotent stems cells a platform for personalized diagnosis and therapy in patients with primary immunodeficiency
The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.
Discovery of therapeutic targets in B cell lymphoma by next generation sequencing
The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.
Research group members
DNA sequencing, including whole exome and whole genome sequencing
Gene expression analysis including realtime PCR and RNAseq/transcriptome analysis
B and T cell functional assays
Gene editing using the CRISPR/Cas9 system
The Swedish Research Council, Cancerfonden, European Research Council (ERC), Barncancerfonden (Swedish Children Cancer Fund), The Swedish Foundation for International Cooperation in Research and Higher Education (STINT), Stockholm County Council (ALF), Center for Innovative Medicine (CIMED) and Radiumhemmets research fund.
Postdoctoral fellowship available
Postdoc scholarship position on Immunology/Immunogenetics available. For details contact Prof. Pan-Hammarström
Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.
Ren W, Ye X, Su H, Li W, Liu D, Pirmoradian M, et al
Blood 2018 06;131(24):2670-2681
Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome.
Björkman A, Du L, van der Burg M, Cormier-Daire V, Borck G, Pié J, et al
J. Allergy Clin. Immunol. 2018 01;141(1):408-411.e8
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.
Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S, Buggert M, et al
J. Exp. Med. 2017 01;214(1):91-106
Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
Bronson PG, Chang D, Bhangale T, Seldin MF, Ortmann W, Ferreira RC, et al
Nat. Genet. 2016 11;48(11):1425-1429
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas.
Georgiou K, Chen L, Berglund M, Ren W, de Miranda NF, Lisboa S, et al
Blood 2016 06;127(24):3026-34
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, et al
Nat Commun 2015 Dec;6():10131
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Björkman A, Qvist P, Du L, Bartish M, Zaravinos A, Georgiou K, et al
Proc. Natl. Acad. Sci. U.S.A. 2015 Feb;112(7):2157-62
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, et al
Cell 2014 Dec;159(7):1524-37
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
de Miranda NF, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, et al
Blood 2014 Oct;124(16):2544-53
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
Enervald E, Du L, Visnes T, Björkman A, Lindgren E, Wincent J, et al
J. Exp. Med. 2013 Nov;210(12):2503-13
New facets of antibody deficiencies.
Liadaki K, Sun J, Hammarström L, Pan-Hammarström Q
Curr. Opin. Immunol. 2013 Oct;25(5):629-38
DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
de Miranda NF, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al
J. Exp. Med. 2013 Aug;210(9):1729-42
Nurture your scientific curiosity early in your research career.
Jagodic M, Stridh P, Gad AK, Paine A, Udekwu KI, Sjöholm LK, et al
Nat. Genet. 2013 Feb;45(2):116-8
Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.
Du L, Peng R, Björkman A, Filipe de Miranda N, Rosner C, Kotnis A, et al
J. Exp. Med. 2012 Feb;209(2):291-305