Cell biology of cancer - Staffan Strömblad
We aim to improve the fundamental understanding on how cancer develops and progresses. Our focus is cancer cell migration and invasion, a process critical to cancer cell dissemination by metastasis, the main lethality factor of cancer. To better understand cancer cell migration, we are using a systems microscopy approach, where live cell microscopy of migrating cancer cells is combined with mathematical analyses and modeling. With the help of transgenic mice, we are also investigating how p21-activated kinase 4 affects cancer development and progression, and we are also examining how the microenvironment's extracellular matrix influences the same processes.
We perform a large number of national and international collaborations and actively participate in different networks, including the SSF-supported pan-university network project Systems microscopy of Cancer Cell Migration and Karolinska Institutet’s Breast Cancer Theme Center (BRECT). Staffan Strömblad is the Coordinator and Vice director, respectively, for these two networks.