Epigenetic Regulation of Autophagy and Inflammation
Speaker: Prof. Sung Hee Baek, Department of Biological Sciences, Seoul National University, Seoul, South Korea
Abstract: Epigenetics encompass inheritable changes in gene expression profiles that occur without alterations to the genomic DNA sequence. Epigenetic modifications conduct important roles in diverse biological processes that range from regulation of gene expression to human diseases such as cancer. Histones and histone modifying enzymes are subject to diverse epigenetic modifications including phosphorylation, acetylation, methylation, ubiquitination, SUMOylation, ADP ribosylation, deamination, and proline isomerization.
These diverse post-translational modifications can modulate the activity of transcription factors and histone modifying enzymes by altering the chromatin state for either activation or repression. Among them, methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent pioneering studies have extended methylation to non-histone proteins in the nucleus as well, underlying molecular mechanisms such as the upstream signaling cascade that induces methylation and downstream target genes modulated by this modification have not been elucidated.
In this presentation, I will discuss our continued efforts to decipher epigenetic regulatory mechanism of chromatin modifying enzymes in autophagy and inflammation. I will introduce newly identified signaling crosstalk regulated by protein modification and address their roles in autophagy and inflammation.Contact person: Vladana Vukojevic