Vladimir Stepanov

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: SYNAPSE. 2020;74(10):e22157

Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non-human primate and human brain.

Varnäs K; Stepanov V; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2429-2439

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511.

Arakawa R; Takano A; Stenkrona P; Stepanov V; Nag S; Jahan M; Grybäck P; Bolin M; Chen L; Zhang L; He P; Villalobos A; McCarthy TJ; Halldin C; Varrone A
Article: NEUROPHARMACOLOGY. 2020;162:107809

The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans.

Varnäs K; Cselényi Z; Arakawa R; Nag S; Stepanov V; Moein MM; Johnström P; Kingston L; Elmore CS; Halldin C; Farde L
Article: NEUROPSYCHOPHARMACOLOGY. 2019;44(10):1706-1713

Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain.

Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Bundgaard C; Bang-Andersen B; Sanchez C; Halldin C; Farde L; Finnema SJ
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45(9):1605-1617

Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain.

Chiotis K; Stenkrona P; Almkvist O; Stepanov V; Ferreira D; Arakawa R; Takano A; Westman E; Varrone A; Okamura N; Shimada H; Higuchi M; Halldin C; Nordberg A
Article: NEUROPHARMACOLOGY. 2018;135:455-463

The metabotropic glutamate receptor 5 radioligand [11C]AZD9272 identifies unique binding sites in primate brain.

Varnäs K; Juréus A; Finnema SJ; Johnström P; Raboisson P; Amini N; Takano A; Stepanov V; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2018;57:12-19

Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates.

Stepanov V; Takano A; Nakao R; Amini N; Miura S; Hasui T; Kimura H; Taniguchi T; Halldin C
Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):96

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains.

Lemoine L; Gillberg P-G; Svedberg M; Stepanov V; Jia Z; Huang J; Nag S; Tian H; Ghetti B; Okamura N; Higuchi M; Halldin C; Nordberg A
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2017;20(9):683-691

Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain.

Yang K-C; Stepanov V; Martinsson S; Ettrup A; Takano A; Knudsen GM; Halldin C; Farde L; Finnema SJ
Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;46:50-53

Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.

Stepanov V; Svedberg M; Jia Z; Krasikova R; Lemoine L; Okamura N; Furumoto S; Mitsios N; Mulder J; Långström B; Nordberg A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(2):308-320

Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.

Yang K-C; Stepanov V; Amini N; Martinsson S; Takano A; Nielsen J; Bundgaard C; Bang-Andersen B; Grimwood S; Halldin C; Farde L; Finnema SJ
Article: CURRENT RADIOPHARMACEUTICALS. 2017;10(1):35-40

Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1.

Igawa H; Stepanov V; Tari L; Okuda S; Yamamoto S; Kasai S; Nagisa Y; Haggkvist J; Svedberg M; Toth M; Takano A; Halldin C
Article: NEUROIMAGE. 2016;141:10-17

A human [(11)C]T-773 PET study of PDE10A binding after oral administration of TAK-063, a PDE10A inhibitor.

Takano A; Stenkrona P; Stepanov V; Amini N; Martinsson S; Tsai M; Goldsmith P; Xie J; Wu J; Uz T; Halldin C; Macek TA
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(8):pyw023

Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.

Varnäs K; Finnema SJ; Stepanov V; Takano A; Tóth M; Svedberg M; Møller Nielsen S; Khanzhin NA; Juhl K; Bang-Andersen B; Halldin C; Farde L
Article: SYNAPSE. 2016;70(6):253-263

Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11 C]T-773 in nonhuman primates.

Takano A; Stepanov V; Nakao R; Amini N; Gulyás B; Kimura H; Halldin C
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(12):2394-2403

NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.

Aonurm-Helm A; Anier K; Zharkovsky T; Castrén E; Rantamäki T; Stepanov V; Järv J; Zharkovsky A
Article: JOURNAL OF MEMBRANE BIOLOGY. 2015;248(4):775-781

Thermal Stability of Dopamine Transporters.

Kukk S; Stepanov V; Järv J
Article: MOLECULAR IMAGING AND BIOLOGY. 2015;17(4):445-449

Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773.

Tóth M; Häggkvist J; Stepanov V; Takano A; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Gulyás B; Halldin C
Article: SYNAPSE. 2015;69(7):345-355

Evaluation of a novel PDE10A PET radioligand, [(11) C]T-773, in nonhuman primates: brain and whole body PET and brain autoradiography.

Takano A; Stepanov V; Gulyás B; Nakao R; Amini N; Miura S; Kimura H; Taniguchi T; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015;58(5):202-208

Development of a series of novel carbon-11 labeled PDE10A inhibitors.

Stepanov V; Miura S; Takano A; Amini N; Nakao R; Hasui T; Nakashima K; Taniguchi T; Kimura H; Kuroita T; Halldin C
Article: NUCLEAR MEDICINE AND BIOLOGY. 2015;42(2):146-154

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.

Harada A; Suzuki K; Miura S; Hasui T; Kamiguchi N; Ishii T; Taniguchi T; Kuroita T; Takano A; Stepanov V; Halldin C; Kimura H
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu081

Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.

Finnema SJ; Hughes ZA; Haaparanta-Solin M; Stepanov V; Nakao R; Varnäs K; Varrone A; Arponen E; Marjamäki P; Pohjanoksa K; Vuorilehto L; Babalola PA; Solin O; Grimwood S; Sallinen J; Farde L; Scheinin M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2014;55(7):1164-1170

(18)F-MCL-524, an (18)F-Labeled Dopamine D2 and D3 Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study.

Finnema SJ; Stepanov V; Nakao R; Sromek AW; Zhang T; Neumeyer JL; George SR; Seeman P; Stabin MG; Jonsson C; Farde L; Halldin C
Article: NEUROIMAGE. 2014;84:342-353

Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain.

Finnema SJ; Stepanov V; Ettrup A; Nakao R; Amini N; Svedberg M; Lehmann C; Hansen M; Knudsen GM; Halldin C
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2012;55(6):206-210

An efficient one-step radiosynthesis of [18F]FE-PE2I, a PET radioligand for imaging of dopamine transporters

Stepanov V; Krasikova R; Raus L; Loog O; Hiltunen J; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(8):1313-1321

Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates.

Varrone A; Stepanov V; Nakao R; Tóth M; Gulyás B; Emond P; Deloye JB; Vercouillie J; Stabin MG; Jonsson C; Guilloteau D; Halldin C
Article: NEUROCHEMISTRY INTERNATIONAL. 2008;53(6-8):370-373

Kinetic mechanism of dopamine transporter interaction with 1-(2-(bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909).

Stepanov V; Järv J
Article: APPLIED RADIATION AND ISOTOPES. 2007;65(3):293-300

Synthesis of 3H-labeled N-(3-iodoprop-2E-enyl)-2beta-carbomethoxy-3beta-(4-methylphenyl)nortropane (PE2I) and its interaction with mice striatal membrane fragments.

Stepanov V; Schou M; Järv J; Halldin C
Article: NEUROSCIENCE LETTERS. 2006;410(3):218-221

Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane.

Stepanov V; Järv J
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Meeting abstract: NEUROIMAGE. 2010;52:S61-S62

Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain

Finnema SJ; Varnas K; Stepanov V; Varrone A; Gulyas B; Arponen E; Helin S; Solin O; Haaparanta M; Sallinen J; Ingman K; Scheinin M; Farde L; Halldin C

Anställningar

Senior Forskningsinfrastrukturspecialist, Klinisk neurovetenskap, Karolinska Institutet, 2024-
Forskningsspecialist, Klinisk neurovetenskap, Karolinska Institutet, 2021-2023

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