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Thomas Nyström

Professor/överläkare

Besöksadress : Sjukhusbacken 10, 118 83 Stockholm
Postadress : Institutionen för klinisk forskning och utbildning, Södersjukhuset (KI SÖS), S1, Institutionen för klinisk forskning och utbildning, Södersjukhuset (KI SÖS), S1, Sjukhusbacken 10, 118 83 Stockholm
Leveransadress : Sjukhusbacken 10, 118 83 Stockholm

Publikationer

Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections: The GOLD Randomized Clinical Trial
Lind M, Polonsky W, Hirsch Ib, Heise T, Bolinder J, Dahlqvist S, et al
JAMA 2017;317(4):379-387

Estimated glucose disposal rate and long-term survival in type 2 diabetes after coronary artery bypass grafting
Nyström T, Holzmann Mj, Eliasson B, Svensson Am, Kuhl J, Sartipy U
Heart and vessels 2017;32(3):269-278

Novel oral glucose-lowering drugs are associated with lower risk of all-cause mortality, cardiovascular events and severe hypoglycaemia compared with insulin in patients with type 2 diabetes
Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson Jw
Diabetes, obesity & metabolism 2017;():-

Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia
Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson Jw
Diabetes research and clinical practice 2017;123():199-208

Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4
Larsson M, Lietzau G, Nathanson D, Östenson Cg, Mallard C, Johansson Me, et al
Bioscience reports 2016;36(6):-

Earlier intensified insulin treatment of Type 1 diabetes and its association with long-term macrovascular and renal complications
Rathsman B, Donner M, Ursing C, Nyström T
Diabetic medicine : a journal of the British Diabetic Association 2016;33(4):463-70

Exenatide infusion decreases atrial natriuretic peptide levels by reducing cardiac filling pressures in type 2 diabetes patients with decompensated congestive heart failure
Nathanson D, Frick M, Ullman B, Nyström T
Diabetology & metabolic syndrome 2016;8():5-

Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor
Darsalia V, Larsson M, Lietzau G, Nathanson D, Nyström T, Klein T, et al
Diabetes, obesity & metabolism 2016;18(5):537-41

Incidence, prevalence and mortality of type 2 diabetes requiring glucose-lowering treatment, and associated risks of cardiovascular complications: a nationwide study in Sweden, 2006-2013
Norhammar A, Bodegård J, Nyström T, Thuresson M, Eriksson Jw, Nathanson D
Diabetologia 2016;59(8):1692-701

Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu
Mansouri S, Lietzau G, Lundberg M, Nathanson D, Nyström T, Patrone C
PloS one 2016;11(6):e0156867-

Relationship between preoperative hemoglobin A1c levels and long-term mortality after coronary artery bypass grafting in patients with type 2 diabetes mellitus
Kuhl J, Sartipy U, Eliasson B, Nyström T, Holzmann Mj
International journal of cardiology 2016;202():291-6

Role of Prolactin Receptors in Lymphangioleiomyomatosis
Alkharusi A, Lesma E, Ancona S, Chiaramonte E, Nyström T, Gorio A, et al
PloS one 2016;11(1):e0146653-

Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme
Alkharusi A, Yu S, Landázuri N, Zadjali F, Davodi B, Nyström T, et al
Oncotarget 2016;7(48):79572-79583

Sulphonylurea compared to DPP-4 inhibitors in combination with metformin carries increased risk of severe hypoglycemia, cardiovascular events, and all-cause mortality
Eriksson Jw, Bodegard J, Nathanson D, Thuresson M, Nyström T, Norhammar A
Diabetes research and clinical practice 2016;117():39-47

The impact of transcutaneous oxygen pressure measurement in patients with suspected critical lower limb ischemia
Rosfors S, Kanni L, Nyström T
International angiology : a journal of the International Union of Angiology 2016;35(5):492-7

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist Exendin-4
Lietzau G, Nystrom T, Ostenson Cg, Darsalia V, Patrone C
ONCOTARGET 2016;7(5):5865-76

Antidiabetic agents and endothelial dysfunction - beyond glucose control
Eriksson L, Nyström T
Basic & clinical pharmacology & toxicology 2015;117(1):15-25

Circadian hormone profiles and insulin sensitivity in patients with Addison's disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy
Björnsdottir S, Øksnes M, Isaksson M, Methlie P, Nilsen Rm, Hustad S, et al
Clinical endocrinology 2015;83(1):28-35

Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury
Eriksson L, Saxelin R, Röhl S, Roy J, Caidahl K, Nyström T, et al
Journal of vascular research 2015;52(1):41-52

Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke
Darsalia V, Larsson M, Nathanson D, Klein T, Nyström T, Patrone C
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015;35(5):718-23

Glycemic Control in Type 1 Diabetes and Long-Term Risk of Cardiovascular Events or Death After Coronary Artery Bypass Grafting
Nyström T, Holzmann Mj, Eliasson B, Kuhl J, Sartipy U
Journal of the American College of Cardiology 2015;66(5):535-43

Long-term prognosis in patients with type 1 and 2 diabetes mellitus after coronary artery bypass grafting
Holzmann Mj, Rathsman B, Eliasson B, Kuhl J, Svensson Am, Nyström T, et al
Journal of the American College of Cardiology 2015;65(16):1644-52

Long-Term Risk of Stroke in Patients With Type 1 and Type 2 Diabetes Following Coronary Artery Bypass Grafting
Nyström T, Holzmann Mj, Sartipy U
Journal of the American Heart Association 2015;4(11):-

REPLY: Association of Glycemic Control in Type 1 Diabetes With Long-Term Risk After CABG
Nystrom T, Holzmann Mj, Sartipy U
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2015;66(24):2810-1

Accuracy and precision of commonly used methods for quantifying surgery-induced insulin resistance: Prospective observational study
Ljunggren S, Nyström T, Hahn Rg
European journal of anaesthesiology 2014;31(2):110-6

Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis
Eriksson L, Nystrom T
CARDIOVASCULAR DIABETOLOGY 2014;:152-

Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
Larsen Fj, Schiffer Ta, Ekblom B, Mattsson Mp, Checa A, Wheelock Ce, et al
The American journal of clinical nutrition 2014;99(4):843-50

Effects of high-fat diet and the anti-diabetic drug metformin on circulating GLP-1 and the relative number of intestinal L-cells
Kappe C, Zhang Q, Nyström T, Sjöholm A
Diabetology & metabolic syndrome 2014;6():70-

Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization
Darsalia V, Hua S, Larsson M, Mallard C, Nathanson D, Nyström T, et al
PloS one 2014;9(8):e103114-

GLP-1R activation for the treatment of stroke: updating and future perspectives
Darsalia V, Nathanson D, Nyström T, Klein T, Sjöholm Å, Patrone C
Reviews in endocrine & metabolic disorders 2014;15(3):233-42

Insulin sensitivity and beta-cell function after carbohydrate oral loading in hip replacement surgery: a double-blind, randomised controlled clinical trial
Ljunggren S, Hahn Rg, Nyström T
Clinical nutrition (Edinburgh, Scotland) 2014;33(3):392-8

Intensified insulin treatment is associated with improvement in skin microcirculation and ischaemic foot ulcer in patients with type 1 diabetes mellitus: a long-term follow-up study
Rathsman B, Jensen-urstad K, Nyström T
Diabetologia 2014;57(8):1703-10

Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice
Darsalia V, Olverling A, Larsson M, Mansouri S, Nathanson D, Nyström T, et al
Regulatory peptides 2014;190-191():25-31

Sex, diastolic blood pressure, and outcome after thrombolysis for ischemic stroke
Nathanson D, Patrone C, Nyström T, Von Euler M
Stroke research and treatment 2014;2014():747458-

Acute regulation of pancreatic islet microcirculation and glycaemia by telmisartan and ramipril: discordant effects between normal and type 2 diabetic rats
Olverling A, Huang Z, Nyström T, Sjöholm Å
Clinical science (London, England : 1979) 2013;125(9):433-8

Evidence for paracrine/autocrine regulation of GLP-1-producing cells
Kappe C, Zhang Q, Holst Jj, Nyström T, Sjöholm A
American journal of physiology. Cell physiology 2013;305(10):C1041-9

Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways
Erdogdu O, Eriksson L, Xu H, Sjöholm A, Zhang Q, Nyström T
Journal of molecular endocrinology 2013;50(2):229-41

Plasma volume expansion from the intravenous glucose tolerance test before and after hip replacement surgery
Hahn Rg, Nystrom T, Ljunggren S
THEORETICAL BIOLOGY AND MEDICAL MODELLING 2013;:48-

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain A Comparison With Glimepiride
Darsalia V, Ortsater H, Olverling A, Darlof E, Wolbert P, Nystrom T, et al
DIABETES 2013;62(4):1289-96

Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals
Larsen Fj, Anderson M, Ekblom B, Nystrom T
METABOLISM-CLINICAL AND EXPERIMENTAL 2012;61(1):12-6

Early signs of atherosclerosis are associated with insulin resistance in non-obese adolescent and young adults with type 1 diabetes
Rathsman B, Rosfors S, Sjöholm A, Nyström T
Cardiovascular diabetology 2012;11():145-

Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety
Nathanson D, Ullman B, Lofstrom U, Hedman A, Frick M, Sjoholm A, et al
DIABETOLOGIA 2012;55(4):926-35

Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells
Eriksson L, Erdogdu O, Nystrom T, Zhang Qm, Sjoholm A
CARDIOVASCULAR DIABETOLOGY 2012;:27-

Exendin-4 restores glucolipotoxicity-induced gene expression in human coronary artery endothelial cells
Erdogdu O, Eriksson L, Nystrom T, Sjoholm A, Zhang Qm
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2012;419(4):790-5

Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion
Nystrom T, Ortsater H, Huang Z, Zhang F, Larsen Fj, Weitzberg E, et al
FREE RADICAL BIOLOGY AND MEDICINE 2012;53(5):1017-23

A simple intravenous glucose tolerance test for assessment of insulin sensitivity
Hahn Rg, Ljunggren S, Larsen F, Nystrom T
THEORETICAL BIOLOGY AND MEDICAL MODELLING 2011;:12-

Glycerol Kinase Deficiency in Adult Hypoglycemic Acidemia
Fodor E, Hellerud C, Hulting J, Karlson-stiber C, Abrahamsson L, Nystrom T, et al
NEW ENGLAND JOURNAL OF MEDICINE 2011;364(18):1781-2

Insulin sensitivity and lipid profile in prolactinoma patients before and after normalization of prolactin by dopamine agonist therapy
Berinder K, Nystrom T, Hoybye C, Hall K, Hulting Al
PITUITARY 2011;14(3):199-207

Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men
Nathanson D, Zethelius B, Berne C, Lind L, Andren B, Ingelsson E, et al
DIABETIC MEDICINE 2011;28(3):301-5

Plasma Volume Expansion Resulting from Intravenous Glucose Tolerance Test
Hahn Rg, Nystrom T
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE 2011;:965075-

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice
Carlstrom M, Larsen Fj, Nystrom T, Hezel M, Borniquel S, Weitzberg E, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(41):17716-20

Exendin-4, GLP-1 (7-36) and GLP-1 (9-36) stimulate proliferation of human coronary artery endothelial cells through PKA- and PI3K/Akt/eNOS-dependent pathways
Erdogdu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
DIABETOLOGIA 2010;:-

Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor
Erdogdu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
MOLECULAR AND CELLULAR ENDOCRINOLOGY 2010;325(1-2):26-35

[Glycerol kinase deficiency with debut of symptoms in adult age. Unusual cause of coma, metabolic acidosis, hypoglycemia and hypothermia]
Fodor E, Hellerud C, Hulting J, Karlson-stiber C, Abrahamsson L, Nyström T, et al
Lakartidningen 2010;107(40):2408-10

Insulin sensitivity improves in patients with hyperprolactinemia after normalization of prolactin with dopamine agonists
Berinder K, Hoybye C, Nystrom T, Hulting Al
ENDOCRINE JOURNAL 2010;:S510-S510

Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease
Nathanson D, Zethelius B, Berne C, Holst Jj, Sjoholm A, Nystrom T
DIABETOLOGIA 2010;53(2):277-80

Therapeutical Role of Dietary Inorganic Nitrate in eNOS-deficient mice with Metabolic Syndrome
Carlstrom M, Larsen Fj, Nystrom T, Hezel M, Borniquel S, Weitzberg E, et al
FREE RADICAL BIOLOGY AND MEDICINE 2010;:S36-S36

Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo
Nathanson D, Erdogdu O, Pernow J, Zhang Qm, Nystrom T
REGULATORY PEPTIDES 2009;157(1-3):8-13

Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS- and PI3K/Akt-dependent pathways but independently of GLP-1 receptor
Erdogdu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
DIABETOLOGIA 2009;:S109-S109

Hypoglycemic pharmacological treatment of type 2 diabetes: Targeting the endothelium
Nathanson D, Nystrom T
MOLECULAR AND CELLULAR ENDOCRINOLOGY 2009;297(1-2):112-26

Differences in vascular activity between Exenatide and GLP-1 in rat conduit arteries ex vivo
Nystrom T, Nathanson D, Tutuncu O, Bulhak A, Pernow J, Sjoholm A
DIABETOLOGIA 2008;:S92-S92

Exendin-4 upregulates eNOS phosphorylation and promotes proliferation of human coronary artery endothelial cells through the PI3K/Akt pathway
Tutuncu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
DIABETOLOGIA 2008;:S92-S93

Nitrite in nitric oxide biology in the stomach: Impact of red wine
Laranjinha J, Gago B, Rocha B, Nystrom T, Cavaleiro C, Barbosa R, et al
FREE RADICAL RESEARCH 2008;:S25-S25

Reduced plasma levels of glucagon-like peptide-1 predict impaired glucose tolerance, but not cardiovascular disease, in elderly men
Nathanson D, Zethelius B, Sjoholm A, Berne C, Holst Jj, Nystrom T
DIABETOLOGIA 2008;:S169-S169

The potential beneficial role of glucagon-like peptide-1 in endothelial dysfunction and heart failure associated with insulin resistance
Nystrom T
HORMONE AND METABOLIC RESEARCH 2008;40(9):593-606

The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions
Gago B, Nystrom T, Cavaleiro C, Rocha Bs, Barbosa R, Lundberg Jo, et al
FREE RADICAL RESEARCH 2008;:S56-S56

The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions
Gago B, Nystrom T, Cavaleiro C, Rocha Bs, Barbosa Rm, Laranjinha J, et al
FREE RADICAL BIOLOGY AND MEDICINE 2008;45(4):404-12

C-reactive protein: A marker or a player?
Nystrom T
CLINICAL SCIENCE 2007;113(1-2):79-81

Exendin-4 rapidly increases nitric oxide production, promotes proliferation and protects against glucolipoapoptosis in human coronary artery endothelial cells
Tutuncu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
DIABETOLOGIA 2007;:S16-S16

Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock
Sunden-cullberg J, Nystrom T, Lee Ml, Mullins Ge, Tokics L, Andersson J, et al
CRITICAL CARE MEDICINE 2007;35(6):1536-42

Exendin-4 rapidly activates eNOS and protects human coronary artery endothelial cells against glucolipoapoptosis
Tutuncu O, Nathanson D, Sjoholm A, Nystrom T, Zhang Q
DIABETOLOGIA 2006;:146-146

Increased levels of tumour necrosis factor-alpha (TNF-alpha) in patients with Type II diabetes mellitus after myocardial infarction are related to endothelial dysfunction
Nystrom T, Nygren A, Sjoholm A
CLINICAL SCIENCE 2006;110(6):673-81

Inflammation and the etiology of type 2 diabetes
Sjoholm A, Nystrom T
DIABETES-METABOLISM RESEARCH AND REVIEWS 2006;22(1):4-10

Intravenous hydration with a 2.5% glucose solution in type II diabetes
Sjostrand F, Nystrom T, Hahn Rg
CLINICAL SCIENCE 2006;111(2):127-34

Endothelial inflammation in insulin resistance
Sjoholm A, Nystrom T
LANCET 2005;365(9459):610-2

Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
Nystrom T, Gonon At, Sjoholm A, Pernow J
REGULATORY PEPTIDES 2005;125(1-3):173-7

Persistent endothelial dysfunction is related to elevated C-reactive protein (CRP) levels in Type II diabetic patients after acute myocardial infarction
Nystrom T, Nygren A, Sjoholm A
CLINICAL SCIENCE 2005;108(2):121-8

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
Veitenhansl M, Stegner K, Hierl Fx, Dieterle C, Feldmeier H, Gutt B, et al
Diabetologia 2004;47(Suppl 1):A1-A464

Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
Nystrom T, Gutniak Mk, Zhang Qm, Zhang F, Holst Jj, Ahren B, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;287(6):E1209-15

Glucagon-like peptide-1 improves endothelial function in type 2 diabetic patients
Nystrom T, Gutniak M, Ahren B, Holst J, Sjoholm A
DIABETOLOGIA 2004;:A28-A28

Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease
Nystrom T, Nygren A, Sjoholm A
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;287(5):E919-25

Persistently impaired endothelial function in Type 2 diabetic patients, but not in non-diabetic patients, after acute myocardial infarction.
Nystrom T, Nygren A, Sjoholm A
DIABETOLOGIA 2003;:A413-A413

Bezafibrate-induced improvement in glucose uptake and endothelial function in protease inhibitor-associated insulin resistance
Nystrom T, Bratt G, Sjoholm A
JOURNAL OF INTERNAL MEDICINE 2002;252(6):570-4

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