Stephen Malin

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NATURE CARDIOVASCULAR RESEARCH. 2024;:356-371

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
Journal article: ATHEROSCLEROSIS. 2023;379:s23

PCSK6 ABLATION INCREASES ATHEROSCLEROTIC BURDEN, BUT PROVIDES PLAQUE STABILITY BY REGULATING TH17 AND SMOOTH MUSCLE CELL CONTENT

Matic L; Suur B; Karadimou G; Willems C; Bergman O; Lengquist M; Kronqvist M; Baumgartner R; Malin S; Gistera A; Hansson G; Malarstig A; Hedin U; Ketelhuth D
Journal article: ATHEROSCLEROSIS. 2023;379:s11

INDUCTION OF LIPID-LOWERING IMMUNE REACTIONS BY APOLIPOPROTEIN B-SPECIFIC T-HELPER CELLS IN HYPERCHOLESTEROLEMIC MICE

Lin S; Yu Y; Centa M; Malin S; Hansson G; Gistera A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2212476120

Cholinergic regulation of vascular endothelial function by human ChAT+ T cells.

Tarnawski L; Shavva VS; Kort EJ; Zhuge Z; Nilsson I; Gallina AL; Martínez-Enguita D; Heller Sahlgren B; Weiland M; Caravaca AS; Schmidt S; Chen P; Abbas K; Wang F-H; Ahmed O; Eberhardson M; Färnert A; Weitzberg E; Gustafsson M; Kehr J; Malin SG; Hult H; Carlström M; Jovinge S; Olofsson PS
Article: BIOELECTRONIC MEDICINE. 2023;9(1):6

Hepatic stellate cell activation markers are regulated by the vagus nerve in systemic inflammation.

Ahmed O; Caravaca AS; Crespo M; Dai W; Liu T; Guo Q; Leiva M; Sabio G; Shavva VS; Malin SG; Olofsson PS
Article: REDOX BIOLOGY. 2022;56:102422

NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation.

He C; Luo H; Coelho A; Liu M; Li Q; Xu J; Krämer A; Malin S; Yuan Z; Holmdahl R
Article: CIRCULATION RESEARCH. 2022;130(12):1869-1887

Animal Models of Atherosclerosis-Supportive Notes and Tricks of the Trade.

Gisterå A; Ketelhuth DFJ; Malin SG; Hansson GK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(22):e2023285119

Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit.

Caravaca AS; Gallina AL; Tarnawski L; Shavva VS; Colas RA; Dalli J; Malin SG; Hult H; Arnardottir H; Olofsson PS
Article: EMBO JOURNAL. 2022;41(7):e108397

The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.

Jurado S; Fedl AS; Jaritz M; Kostanova-Poliakova D; Malin SG; Mullighan CG; Strehl S; Fischer M; Busslinger M
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(Suppl_1)

Abstract 101: B1b Cell Homeostasis Is Maintained By Cd40 In Atherosclerosis

Reiche ME; Pattarabajinard O; Upadhye A; Poels K; van Tiel C; Malin SG; Binder CJ; Gerdes N; Weber C; Atzler D; McNamara CA; Lutgens E
Article: SCIENCE IMMUNOLOGY. 2021;6(61):eabg5003

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.

Calderón L; Schindler K; Malin SG; Schebesta A; Sun Q; Schwickert T; Alberti C; Fischer M; Jaritz M; Tagoh H; Ebert A; Minnich M; Liston A; Cochella L; Busslinger M
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gisterå A; Malin SG; Tarnawski L; Matic L; Olofsson PS
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(11):e20200147

Repression of the B cell identity factor Pax5 is not required for plasma cell development.

Liu GJ; Jaritz M; Wöhner M; Agerer B; Bergthaler A; Malin SG; Busslinger M
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(3):321-334

Treatment with a Toll-like Receptor 7 ligand evokes protective immunity against atherosclerosis in hypercholesterolaemic mice.

Karadimou G; Gisterå A; Gallina AL; Caravaca AS; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson PS; Paulsson-Berne G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(16):9054-9063

Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.

Sedimbi SK; Hägglöf T; Garimella MG; Wang S; Duhlin A; Coelho A; Ingelshed K; Mondoc E; Malin SG; Holmdahl R; Lane DP; Leadbetter EA; Karlsson MCI
Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)

Quantification of Atherosclerosis in Mice

Centa M; Ketelhuth DFJ; Malin S; Gisterå A
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)

Quantification of Atherosclerosis in Mice.

Centa M; Ketelhuth DFJ; Malin S; Gisterå A
Article: CIRCULATION. 2019;139(21):2466-2482

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.

Centa M; Jin H; Hofste L; Hellberg S; Busch A; Baumgartner R; Verzaal NJ; Lind Enoksson S; Perisic Matic L; Boddul SV; Atzler D; Li DY; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Lutgens E; Binder CJ; Maegdesfessel L; Malin SG
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gisterå A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: ARTHRITIS & RHEUMATOLOGY. 2018;70(2):193-203

Germinal Center B Cells Are Essential for Collagen-Induced Arthritis.

Dahdah A; Habir K; Nandakumar KS; Saxena A; Xu B; Holmdahl R; Malin S
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1387

A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation.

Habir K; Aeinehband S; Wermeling F; Malin S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(1):25-36

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene.

Centa M; Gruber S; Nilsson D; Polyzos KA; Johansson DK; Hansson GK; Ketelhuth DFJ; Binder CJ; Malin S
Article: ENDOCRINOLOGY. 2015;156(4):1228-1236

Androgens regulate bone marrow B lymphopoiesis in male mice by targeting osteoblast-lineage cells.

Wilhelmson AS; Stubelius A; Börjesson AE; Wu J; Stern A; Malin S; Mårtensson I-L; Ohlsson C; Carlsten H; Tivesten Å
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3753-3763

Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.

Sjöstrand M; Ambrosi A; Brauner S; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Article: NATURE IMMUNOLOGY. 2010;11(2):171-179

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.

Malin S; McManus S; Cobaleda C; Novatchkova M; Delogu A; Bouillet P; Strasser A; Busslinger M
Article: GENES & DEVELOPMENT. 2008;22(15):2048-2061

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

Schotta G; Sengupta R; Kubicek S; Malin S; Kauer M; Callén E; Celeste A; Pagani M; Opravil S; De La Rosa-Velazquez IA; Espejo A; Bedford MT; Nussenzweig A; Busslinger M; Jenuwein T
Article: IMMUNITY. 2008;28(6):751-762

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.

Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M
Article: NUCLEIC ACIDS RESEARCH. 2005;33(14):4618-4625

DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE.

Malin S; Linderson Y; Almqvist J; Ernberg I; Tallone T; Pettersson S
Article: EMBO REPORTS. 2004;5(3):291-296

Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes.

Linderson Y; Eberhard D; Malin S; Johansson A; Busslinger M; Pettersson S
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;103(6):723-729

Expression of the coxsackie and adenovirus receptor in human astrocytic tumors and xenografts.

Fuxe J; Liu L; Malin S; Philipson L; Collins VP; Pettersson RF
Article: EMBO JOURNAL. 2002;21(19):5079-5087

Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1.

Tinnikov A; Nordström K; Thorén P; Kindblom JM; Malin S; Rozell B; Adams M; Rajanayagam O; Pettersson S; Ohlsson C; Chatterjee K; Vennström B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(14):7910-7915

A mouse model for adenovirus gene delivery.

Tallone T; Malin S; Samuelsson A; Wilbertz J; Miyahara M; Okamoto K; Poellinger L; Philipson L; Pettersson S
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Preprint: BIORXIV. 2024

Adipose tissue microvascular endothelial cells form a tight vascular barrier that selectively transcytoses fatty acid tracers

Schipper R; Ioannidou A; Maestri A; Baganha F; Werngren O; Olofsson PS; Malin SG; Fisher RM; Hagberg CE
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:s756-s757

Statins regulate PNPLA3 through a mechanism that requires SREBF2 in human liver cells

Ahmed O; Shavva VS; Dai W; Tarnawski L; Malin S; Franco-Cereceda A; Eriksson P; Bjorck H; Olofsson P
Corrigendum: REDOX BIOLOGY. 2022;57:102499

Corrigendum to "NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation" [Redox Biol 56 (2022) 102422].

He C; Luo H; Coelho A; Liu M; Li Q; Xu J; Krämer A; Malin S; Yuan Z; Holmdahl R
Preprint: BIORXIV. 2022

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Björck HM; Francis R; Fagerberg L; Gisterå A; Zhang X; Metso J; Manfé V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:864602

The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease.

Smeets D; Gisterå A; Malin SG; Tsiantoulas D
Preprint: BIORXIV. 2021

Identification and Characterization of Human Activation-Induced ChAT+CD4+ T Cells

Tarnawski L; Gallina A; Kort E; Shavva V; Zhuge Z; Martínez-Enguita D; Weiland M; Caravaca A; Schmidt S; Wang F; Färnert A; Weitzberg E; Gustafsson M; Eberhardson M; Hult H; Kehr J; Malin S; Carlström M; Jovinge S; Olofsson P
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3832

Treating ApoE-/- mice with Toll-like receptor 7 ligand lead to expansion of marginal zone B cells, reduced plasma cholesterol and decreased atherosclerosis

Paulsson-Berne G; Karadimou G; Gistera A; Gallina A; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson P
Preprint: BIORXIV. 2020

Alternate models of acute dyslipidemia reveal divergent pathways upon atherosclerosis initiation

Hellberg S; Shavva VS; Metso J; Chen G; Li Q-Z; Manfè V; Olofsson PS; Jauhiainen M; Binder CJ; Malin SG
Review: CURRENT OPINION IN NEUROBIOLOGY. 2020;62:115-121

Functions of acetylcholine-producing lymphocytes in immunobiology.

Malin SG; Shavva VS; Tarnawski L; Olofsson PS
Book chapter: ENCYCLOPEDIA OF CARDIOVASCULAR RESEARCH AND MEDICINE. 2018;p. 68-76

Immune-Mediated Mechanisms of Atherosclerosis

Bäck M; Ketelhuth DFJ; Malin S; Olofsson PS; Paulsson-Berne G; Yan Z-Q; Hansson GK
Book chapter: REFERENCE MODULE IN BIOMEDICAL SCIENCES. 2018;p.

Immune-Mediated Mechanisms of Atherosclerosis

Bäck M; Ketelhuth DFJ; Malin S; Olofsson PS; Paulsson-Berne G; Yan Z-Q; Hansson GK
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):282

Antibodies promote vascular smooth muscle cell proliferation and atherosclerotic plaque stability

Centa M; Jin H; Matic LP; Baumgartner R; Li Y; Boddul SV; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Binder CJ; Maegdesfessel L; Malin S
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):271-272

Antibodies promote vascular smooth muscle cell proliferation and atherosclerotic plaque stability

Centa M; Jin H; Matic LP; Baumgartner R; Li Y; Boddul SV; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Binder CJ; Maegdesfessel L; Malin S
Conference publication: IMMUNOLOGY. 2012;137:31-32

Expression of the immune regulator TRIM21 is controlled by interferon regulatory factors

Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):210

Expression of the Immune Regulator TRIM21 is Controlled by Interferon Regulatory Factors

Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Review: CURRENT OPINION IN IMMUNOLOGY. 2010;22(2):168-176

STAT5 in B cell development and leukemia.

Malin S; McManus S; Busslinger M
Conference publication: ANTICANCER RESEARCH. 2004;24(5D):3462

AN RNAi KNOCK-OUT AND GENETIC RECONSTITUTION SYSTEM TO RESTORE wt p53 FUNCTION IN CANCER

D'Amato M; Greicius G; Malin S; Pettersson S

Forskningsbidrag

The ‘Dyslipidemic insult’ – an inflammatory response to excess lipoproteins.

Swedish Research Council

1 January 2024 - 31 December 2027
Neural control of inflammation for treatment of cardiovascular disease

Swedish Heart-Lung Foundation

1 January 2023 - 31 December 2025
The immune response to dyslipidemia - Characterization and intervention

Swedish Research Council

1 January 2021 - 31 December 2023
The interplay between dyslipidemia and inflammation in atherosclerotic plaque initiation and regression

Swedish Heart-Lung Foundation

1 January 2020 - 31 December 2021
The interplay between dyslipidemia and inflammation in atherosclerotic plaque initiation and regression

Swedish Heart-Lung Foundation

1 January 2020 - 31 December 2021
B cells in Cardiovascular Disease

Fondation Leducq

1 January 2020
Genome wide approaches to understanding lymphocyte survival

Swedish Research Council

1 January 2012 - 31 December 2014

Anställningar

Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Immunologi, Karolinska Institutet, 2020
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2004

Artiklar

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Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI