Souren Mkrtchian

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS. 2023;23(1):115-121

Calcium-Regulating Hormonal System and HMGB1 in Cardiomyopathies.

Harutyunyan KR; Abrahamyan HT; Adamyan SH; Mkrtchian S; Ter-Markosyan AS
Article: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2021;294:103746

Whole blood gene expression signature in patients with obstructive sleep apnea and effect of continuous positive airway pressure treatment.

Christensson E; Mkrtchian S; Ebberyd A; Österlund Modalen Å; Franklin KA; Eriksson LI; Jonsson Fagerlund M
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2021;65(9):1276-1284

Biomarkers for oxidative stress and organ injury during Transnasal Humidified Rapid-Insufflation Ventilatory Exchange compared to mechanical ventilation in adults undergoing microlaryngoscopy: A randomised controlled study.

Forsberg I-M; Mkrtchian S; Ebberyd A; Ullman J; Eriksson LI; Lodenius Å; Jonsson Fagerlund M
Article: SCIENCE ADVANCES. 2021;7(36):eabi6856

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Zhou Y; Arribas GH; Turku A; Jürgenson T; Mkrtchian S; Krebs K; Wang Y; Svobodova B; Milani L; Schulte G; Korabecny J; Gastaldello S; Lauschke VM
Article: BRITISH JOURNAL OF ANAESTHESIA. 2021;126(2):467-476

Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery.

Danielson M; Wiklund A; Granath F; Blennow K; Mkrtchian S; Nellgård B; Oras J; Fagerlund MJ; Granström A; Schening A; Rasmussen LS; Harris HE; Zetterberg H; Ricksten S-E; Eriksson LI
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:824696

Surgical Trauma in Mice Modifies the Content of Circulating Extracellular Vesicles.

Mkrtchian S; Ebberyd A; Veerman RE; Méndez-Lago M; Gabrielsson S; Eriksson LI; Gómez-Galán M
Article: EXPERIMENTAL PHYSIOLOGY. 2020;105(9):1634-1647

The impact of damage-associated molecular patterns on the neurotransmitter release and gene expression in the ex vivo rat carotid body.

Mkrtchian S; Kåhlin J; Gómez-Galán M; Ebberyd A; Yoshitake T; Schmidt S; Kehr J; Hildenborg M; Jonsson Fagerlund M; Erlandsson Harris H; Eriksson LI
Article: ANNALS OF NEUROLOGY. 2020;87(3):370-382

Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study.

Danielson M; Wiklund A; Granath F; Blennow K; Mkrtchian S; Nellgård B; Oras J; Jonsson Fagerlund M; Granström A; Schening A; Rasmussen LS; Erlandsson Harris H; Zetterberg H; Ricksten S-E; Eriksson LI
Article: PHARMACOGENOMICS JOURNAL. 2019;19(2):115-126

An optimized prediction framework to assess the functional impact of pharmacogenetic variants.

Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke VM
Article: BRITISH JOURNAL OF ANAESTHESIA. 2019;122(3):350-360

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Yang T; Xu G; Newton PT; Chagin AS; Mkrtchian S; Carlström M; Zhang X-M; Harris RA; Cooter M; Berger M; Maddipati KR; Akassoglou K; Terrando N
Article: HUMAN GENOMICS. 2018;12(1):26

Integrating rare genetic variants into pharmacogenetic drug response predictions.

Ingelman-Sundberg M; Mkrtchian S; Zhou Y; Lauschke VM
Article: EXPERIMENTAL CELL RESEARCH. 2017;352(2):412-419

Hypoxia regulates microRNA expression in the human carotid body.

Mkrtchian S; Lee KL; Kåhlin J; Ebberyd A; Poellinger L; Fagerlund MJ; Eriksson LI
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):399-407

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration.

Lauschke VM; Mkrtchian S; Ingelman-Sundberg M
Article: HEPATOLOGY. 2016;64(5):1743-1756

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.

Lauschke VM; Vorrink SU; Moro SML; Rezayee F; Nordling Å; Hendriks DFG; Bell CC; Sison-Young R; Park BK; Goldring CE; Ellis E; Johansson I; Mkrtchian S; Andersson TB; Ingelman-Sundberg M
Article: ANESTHESIOLOGY. 2016;125(4):700-715

Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study.

Lodenius Å; Ebberyd A; Hårdemark Cedborg A; Hagel E; Mkrtchian S; Christensson E; Ullman J; Scheinin M; Eriksson LI; Jonsson Fagerlund M
Article: SCIENTIFIC REPORTS. 2016;6:25187

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

Bell CC; Hendriks DFG; Moro SML; Ellis E; Walsh J; Renblom A; Fredriksson Puigvert L; Dankers ACA; Jacobs F; Snoeys J; Sison-Young RL; Jenkins RE; Nordling Å; Mkrtchian S; Park BK; Kitteringham NR; Goldring CEP; Lauschke VM; Ingelman-Sundberg M
Article: FEBS LETTERS. 2016;590(3):330-339

Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.

Guo J; Thiess S; Johansson I; Mkrtchian S; Ingelman-Sundberg M
Article: ENDOCRINE-RELATED CANCER. 2015;22(3):C1-C4

Targeting unfolded protein response in cancer and diabetes.

Mkrtchian S
Article: PLOS ONE. 2015;10(9):e0138487

Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran.

Neve EPA; Köfeler H; Hendriks DFG; Nordling Å; Gogvadze V; Mkrtchian S; Näslund E; Ingelman-Sundberg M
Article: PLOS ONE. 2015;10(4):e0122820

Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.

Choong E; Guo J; Persson A; Virding S; Johansson I; Mkrtchian S; Ingelman-Sundberg M
Article: PHARMACOGENOMICS JOURNAL. 2014;14(4):343-349

High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase.

Lee M-Y; Borgiani P; Johansson I; Oteri F; Mkrtchian S; Falconi M; Ingelman-Sundberg M
Article: EXPERIMENTAL PHYSIOLOGY. 2014;99(8):1089-1098

The human carotid body releases acetylcholine, ATP and cytokines during hypoxia.

Kåhlin J; Mkrtchian S; Ebberyd A; Hammarstedt-Nordenvall L; Nordlander B; Yoshitake T; Kehr J; Prabhakar N; Poellinger L; Fagerlund MJ; Eriksson LI
Article: PHARMACOGENOMICS. 2013;14(13):1615-1622

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

Stenstedt K; Travica S; Guo J; Barragan I; Pors K; Patterson L; Edler D; Mkrtchian S; Johansson I; Ingelman-Sundberg M
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(15):6273-6277

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Sheldrake HM; Travica S; Johansson I; Loadman PM; Sutherland M; Elsalem L; Illingworth N; Cresswell AJ; Reuillon T; Shnyder SD; Mkrtchian S; Searcey M; Ingelman-Sundberg M; Patterson LH; Pors K
Article: CLINICAL CANCER RESEARCH. 2013;19(11):2952-2961

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.

Travica S; Pors K; Loadman PM; Shnyder SD; Johansson I; Alandas MN; Sheldrake HM; Mkrtchian S; Patterson LH; Ingelman-Sundberg M
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2012;590(16):3807-3819

The human carotid body transcriptome with focus on oxygen sensing and inflammation--a comparative analysis.

Mkrtchian S; Kåhlin J; Ebberyd A; Gonzalez C; Sanchez D; Balbir A; Kostuk EW; Shirahata M; Fagerlund MJ; Eriksson LI
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2011;338(1):302-309

The ligands of estrogen receptor α regulate cytochrome P4502C9 (CYP2C9) expression.

Mwinyi J; Cavaco I; Yurdakok B; Mkrtchian S; Ingelman-Sundberg M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1813(6):1165-1171

ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.

Farmaki E; Mkrtchian S; Papazian I; Papavassiliou AG; Kiaris H
Article: ANESTHESIOLOGY. 2010;113(6):1270-1279

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia.

Fagerlund MJ; Kåhlin J; Ebberyd A; Schulte G; Mkrtchian S; Eriksson LI
Article: MOLECULAR PHARMACOLOGY. 2010;78(6):1004-1011

Colorectal cancer-specific cytochrome P450 2W1: intracellular localization, glycosylation, and catalytic activity.

Gomez A; Nekvindova J; Travica S; Lee M-Y; Johansson I; Edler D; Mkrtchian S; Ingelman-Sundberg M
Article: MOLECULAR PHARMACOLOGY. 2010;78(5):886-894

Regulation of CYP2C19 expression by estrogen receptor α: implications for estrogen-dependent inhibition of drug metabolism.

Mwinyi J; Cavaco I; Pedersen RS; Persson A; Burkhardt S; Mkrtchian S; Ingelman-Sundberg M
Article: LIFE SCIENCES. 2010;86(19-20):699-706

The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

Mwinyi J; Hofmann Y; Pedersen RS; Nekvindová J; Cavaco I; Mkrtchian S; Ingelman-Sundberg M
Article: JOURNAL OF CELL SCIENCE. 2010;123(Pt 5):787-794

Regulated increase in folding capacity prevents unfolded protein stress in the ER.

Christis C; Fullaondo A; Schildknegt D; Mkrtchian S; Heck AJR; Braakman I
Article: DRUG METABOLISM AND DISPOSITION. 2010;38(3):415-421

New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4.

Mwinyi J; Nekvindová J; Cavaco I; Hofmann Y; Pedersen RS; Landman E; Mkrtchian S; Ingelman-Sundberg M
Article: JOURNAL OF VIROLOGY. 2009;83(3):1483-1491

The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infection.

Rainey-Barger EK; Mkrtchian S; Tsai B
Article: MOLECULAR CARCINOGENESIS. 2008;47(11):886-892

ERp29, an endoplasmic reticulum secretion factor is involved in the growth of breast tumor xenografts.

Mkrtchian S; Baryshev M; Sargsyan E; Chatzistamou I; Volakaki A-A; Chaviaras N; Pafiti A; Triantafyllou A; Kiaris H
Article: PHARMACOGENOMICS. 2007;8(10):1315-1325

Expression of CYP2W1 in colon tumors: regulation by gene methylation.

Gomez A; Karlgren M; Edler D; Bernal ML; Mkrtchian S; Ingelman-Sundberg M
Article: REGULATORY PEPTIDES. 2007;142(3):95-100

Calcium-regulating peptide hormones and blood electrolytic balance in chronic heart failure.

Arakelyan KP; Sahakyan YA; Hayrapetyan LR; Khudaverdyan DN; Ingelman-Sundberg M; Mkrtchian S; Ter-Markosyan AS
Article: MOLECULAR BIOLOGY OF THE CELL. 2007;18(4):1253-1260

Dimerization of ERp29, a PDI-like protein, is essential for its diverse functions.

Rainey-Barger EK; Mkrtchian S; Tsai B
Article: AMERICAN JOURNAL OF DERMATOPATHOLOGY. 2006;28(5):410-412

Expression of ERp29, an endoplasmic reticulum secretion factor in basal-cell carcinoma.

Cheretis C; Dietrich F; Chatzistamou I; Politi K; Angelidou E; Kiaris H; Mkrtchian S; Koutselini H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;340(2):617-624

ERp29 is an essential endoplasmic reticulum factor regulating secretion of thyroglobulin.

Baryshev M; Sargsyan E; Mkrtchian S
Article: MOLECULAR CELL. 2005;20(2):289-300

ERp29 triggers a conformational change in polyomavirus to stimulate membrane binding.

Magnuson B; Rainey EK; Benjamin T; Baryshev M; Mkrtchian S; Tsai B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;322(2):570-576

The physiological unfolded protein response in the thyroid epithelial cells.

Sargsyan E; Baryshev M; Mkrtchian S
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2004;32(3):903-920

Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism.

Baryshev M; Sargsyan E; Wallin G; Lejnieks A; Furudate S; Hishinuma A; Mkrtchian S
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;408(1):58-68

Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly.

Gavrilovich Zgoda V; Arison B; Mkrtchian S; Ingelman-Sundberg M; Correia MA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(19):17009-17015

Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex.

Sargsyan E; Baryshev M; Szekely L; Sharipo A; Mkrtchian S
Article: GENE. 2002;285(1-2):127-139

Genomic organization and promoter characterization of the gene encoding a putative endoplasmic reticulum chaperone, ERp29.

Sargsyan E; Baryshev M; Backlund M; Sharipo A; Mkrtchian S
Article: STRUCTURE. 2001;9(6):457-471

Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.

Liepinsh E; Baryshev M; Sharipo A; Ingelman-Sundberg M; Otting G; Mkrtchian S
Article: FEBS LETTERS. 1998;431(3):322-326

Oligomerization properties of ERp29, an endoplasmic reticulum stress protein.

Mkrtchian S; Baryshev M; Matvijenko O; Sharipo A; Sandalova T; Schneider G; Ingelman-Sundberg M
Article: FEBS JOURNAL. 1998;251(1-2):304-313

A stress-inducible rat liver endoplasmic reticulum protein, ERp29.

Mkrtchian S; Fang C; Hellman U; Ingelman-Sundberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(50):31755-31763

Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells.

Backlund M; Johansson I; Mkrtchian S; Ingelman-Sundberg M
Article: BIOTECHNIQUES. 1997;23(1):52-58

Combination of direct DNA sequencing with degenerate primer-mediated PCR and 5'-/3'-RACE to screen novel cDNA sequences.

Fang C; Mkrtchian S; Ingelman-Sundberg M
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Review: JOURNAL OF INVESTIGATIVE MEDICINE. 2021;69(6):1148-1152

Can the calcium-regulating hormones counteract the detrimental impact of pro-inflammatory damage-associated molecular patterns in the development of heart failure?

Adamyan SH; Harutyunyan KR; Abrahamyan HT; Khudaverdyan DN; Mkrtchian S; Ter-Markosyan AS
Review: FRONTIERS IN PHARMACOLOGY. 2018;9:1437

Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data.

Zhou Y; Fujikura K; Mkrtchian S; Lauschke VM
Review: FRONTIERS IN MEDICINE. 2018;5:192

Calcium Signaling in Liver Injury and Regeneration.

Oliva-Vilarnau N; Hankeova S; Vorrink SU; Mkrtchian S; Andersson ER; Lauschke VM
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2018;1071:25-33

Hypoxia Regulates MicroRNA Expression in the Human Carotid Body.

Mkrtchian S; Lee KL; Kåhlin J; Ebberyd A; Poellinger L; Fagerlund MJ; Eriksson LI
Review: DRUG METABOLISM REVIEWS. 2016;48(3):369-378

The CYP2W1 enzyme: regulation, properties and activation of prodrugs.

Guo J; Johansson I; Mkrtchian S; Ingelman-Sundberg M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2015;860:371-377

The Human Carotid Body Gene Expression and Function in Signaling of Hypoxia and Inflammation.

Kåhlin J; Mkrtchian S; Ebberyd A; Eriksson LI; Fagerlund MJ
Review: ANTIOXIDANTS & REDOX SIGNALING. 2006;8(3-4):325-337

ERp29, an unusual redox-inactive member of the thioredoxin family.

Mkrtchian S; Sandalova T
Corrigendum: FEBS LETTERS. 1998;433(3):335

Oligomerization properties of ERp29, an endoplasmic reticulum stress protein (vol 431, pg 322, 1998)

Mkrtchian S; Baryshev M; Matvijenko O; Sharipo A; Sandalova T; Schneider G; Ingelman-Sundberg M

Anställningar

Senior Forskningsspecialist, Fysiologi och farmakologi, Karolinska Institutet, 2022-2024

Examina och utbildning

Docent, Cell och molekylärbiologi, Karolinska Institutet, 2007
MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 2002

Artiklar

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Anställningar

Examina och utbildning

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