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Utbildning

  • Specialist i internmedicin
  • Doktorsexamen, Karolinska Institutet, 1994
  • Godkänd av ECFMG, USA
  • Lälarexamen, Chittagong University, 1980

Forskningsbeskrivning

Diabetesforskning i cell och molekyl nivå med fokus på signal överföring, kalciumjonsignalering och jonkanaler i beta-celler

[Cellular calcium ion signalling--from basic research to benefits for patients].
Gustafsson A, Islam M
Lakartidningen ;102(44):3214-9

[6]-shogaol induces Ca²⁺ signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells.
Rebellato P, Islam M
JOP 2014 Jan;15(1):33-7

Insulin-secreting INS-1E cells express functional TRPV1 channels.
Fågelskiöld A, Kannisto K, Boström A, Hadrovic B, Farre C, Eweida M, et al
Islets ;4(1):56-63

TRP channels of islets.
Islam M
Adv. Exp. Med. Biol. 2011 ;704():811-30

CICR takes centre stage in {beta}-cells: a cute cascade connects cAMP to CICR.
Islam M
J. Physiol. (Lond.) 2010 Dec;588(Pt 24):4853

An estimated 285 million people in the world have islet failure.
Islam M
Islets ;2(4):209

ADP ribose is an endogenous ligand for the purinergic P2Y1 receptor.
Gustafsson A, Muraro L, Dahlberg C, Migaud M, Chevallier O, Khanh H, et al
Mol. Cell. Endocrinol. 2011 Feb;333(1):8-19

Transient Receptor Potential channels: What's happening? Reflections in the wake of the 2009 TRP Meeting, Karolinska Institutet, Stockholm.
Goswami C, Islam M
Channels (Austin) ;4(2):124-35

The islets of Langerhans. Preface.
Islam M
Adv. Exp. Med. Biol. 2010 ;654():vii-viii

Calcium signaling in the islets.
Islam M
Adv. Exp. Med. Biol. 2010 ;654():235-59

H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels.
Bari M, Akbar S, Eweida M, Kühn F, Gustafsson A, Lückhoff A, et al
J. Cell. Mol. Med. 2009 Sep;13(9B):3260-7

Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic beta-cells.
Woolcott O, Gustafsson A, Dzabic M, Pierro C, Tedeschi P, Sandgren J, et al
Cell Calcium 2006 Jun;39(6):529-37

[Cellular calcium ion signalling--from basic research to benefits for patients].
Gustafsson A, Islam M
Lakartidningen ;102(44):3214-9

Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets.
Quynh N, Islam M, Islam S, Florén A, Bartfai T, Langel U, et al
Biochem. Biophys. Res. Commun. 2005 Mar;328(1):213-20

Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.
Islam M, Rahman S, Mirzaei Z, Islam K
Life Sci. 2005 Jan;76(11):1239-48

Ryanodine receptor-operated activation of TRP-like channels can trigger critical Ca2+ signaling events in pancreatic beta-cells.
Gustafsson A, Ingelman-Sundberg H, Dzabic M, Awasum J, Nguyen K, Ostenson C, et al
FASEB J. 2005 Feb;19(2):301-3

Ryanodine receptors of pancreatic beta-cells mediate a distinct context-dependent signal for insulin secretion.
Bruton J, Lemmens R, Shi C, Persson-Sjögren S, Westerblad H, Ahmed M, et al
FASEB J. 2003 Feb;17(2):301-3

The ryanodine receptor calcium channel of beta-cells: molecular regulation and physiological significance.
Islam M
Diabetes 2002 May;51(5):1299-309

Ca2+-induced Ca2+ release from the endoplasmic reticulum amplifies the Ca2+ signal mediated by activation of voltage-gated L-type Ca2+ channels in pancreatic beta-cells.
Lemmens R, Larsson O, Berggren P, Islam M
J. Biol. Chem. 2001 Mar;276(13):9971-7

Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells.
Islam M, Sjöholm A, Emilsson V
Int. J. Obes. Relat. Metab. Disord. 2000 Oct;24(10):1246-53

Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle.
Westerblad H, Andrade F, Islam M
Cell Calcium 1998 Aug;24(2):105-15

Cell signaling by the type IV pili of pathogenic Neisseria.
Källström H, Islam M, Berggren P, Jonsson A
J. Biol. Chem. 1998 Aug;273(34):21777-82

In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation.
Islam M, Leibiger I, Leibiger B, Rossi D, Sorrentino V, Ekström T, et al
Proc. Natl. Acad. Sci. U.S.A. 1998 May;95(11):6145-50

Cyclic ADP-ribose and the pancreatic beta cell: where do we stand?
Islam M, Berggren P
Diabetologia 1997 Dec;40(12):1480-4

Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response.
Islam M, Morton N, Hansson A, Emilsson V
Biochem. Biophys. Res. Commun. 1997 Sep;238(3):851-5

Thiol oxidation by 2,2'-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores.
Islam M, Kindmark H, Larsson O, Berggren P
Biochem. J. 1997 Jan;321 ( Pt 2)():347-54

Insulin exocytosis and glucose-mediated increase in cytoplasmic free Ca2+ concentration in the pancreatic beta-cell are independent of cyclic ADP-ribose.
Webb D, Islam M, Efanov A, Brown G, Köhler M, Larsson O, et al
J. Biol. Chem. 1996 Aug;271(32):19074-9

Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic beta-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not the ryanodine receptor.
Islam M, Larsson O, Nilsson T, Berggren P
Biochem. J. 1995 Mar;306 ( Pt 3)():679-86

Inhibition of serine/threonine protein phosphatases promotes opening of voltage-activated L-type Ca2+ channels in insulin-secreting cells.
Haby C, Larsson O, Islam M, Aunis D, Berggren P, Zwiller J
Biochem. J. 1994 Mar;298 ( Pt 2)():341-6

Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
Islam M, Berggren P
Biochem. J. 1993 Jul;293 ( Pt 2)():423-9

Sulfhydryl oxidation induces rapid and reversible closure of the ATP-regulated K+ channel in the pancreatic beta-cell.
Islam M, Berggren P, Larsson O
FEBS Lett. 1993 Mar;319(1-2):128-32

Regulation of cytoplasmic free Ca2+ in insulin-secreting cells.
Berggren P, Arkhammar P, Islam M, Juntti-Berggren L, Khan A, Kindmark H, et al
Adv. Exp. Med. Biol. 1993 ;334():25-45

Ca(2+)-induced Ca2+ release in insulin-secreting cells.
Islam M, Rorsman P, Berggren P
FEBS Lett. 1992 Jan;296(3):287-91

Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells.
Islam M, Nilsson T, Rorsman P, Berggren P
FEBS Lett. 1991 Aug;288(1-2):27-9

Drug policy in the Third World.
Islam M
Lancet 1985 Jul;2(8445):46-7

Multiple reuse of disposable insulin syringes in hospital.
Islam M, Ali S
Bangladesh Med Res Counc Bull 1990 Dec;16(2):58-61

Stool findings in "chronic dysentery".
Azad Khan A, Islam M, Haque S
Bangladesh Med Res Counc Bull 1981 Jun;7(1):7-11

Predicting first professional M.B.B.S. examination score from the results of H.S.C. examination.
Islam M, Azad Khan A
Bangladesh Med Res Counc Bull 1980 Dec;6(2):61-72

Akademiska priser och utmärkelser

  • Career Development Award, Juvenile Diabetes Research Foundation http://jdrf.org/
  • Anders Fredrik Regnells pris, Svenska Läkaresällskapet http://www.sls.se/
  • Swedish Institute Guest Researcher Scholarship https://si.se/
  • Karolinska Institutets pris för bästa förbättringsförslag, 1998
  • Golden Jubilee Award, Chittagong Medical College http://www.cmc.edu.bd/

Dokument

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Presentationer

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 Measurement of calcium in living cells by microfluorometry

 

 

The OFF, READY and ON modes of the beta cells

 

 How does glucagon-like peptide 1 increases insulin secretion?

 

 Problem-based learning in a nutshell

Calcium Signaling in the Isletshttp://www.dropbox.com/sh/avq96whsrfcyi16/Fge7XU5wdQ#lh:null-Calcium%20signaling%20and%20diabetes.mp4