This page in English
Laddar profil information

Om mig

Richard Rosenquist Brandell was recently appointed Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery, Karolinska Institutet and Senior Physician in Clinical Genetics at Karolinska University Hospital, Sweden. He received his medical degree (1996) and PhD degree (1998) at Umeå University, Sweden, undertook a postdoctoral period at the Department of Pathology, Frankfurt am Main, Germany, and became specialist in Clinical Genetics 2004. Richard Rosenquist Brandell started his own research group at Uppsala University in 2000, focusing on molecular characterization of lymphoid malignancies, and his group rapidly became internationally renowned. He became Professor of Molecular Hematology in 2007 at the Department of Immunology, Genetics and Pathology, Uppsala University. He has initiated and led the SciLifeLab Clinical Genomics Facility in Uppsala between 2013-2017 and is currently Platform Director for the national Diagnostics Development Platform within SciLifeLab. More recently, he is coordinating the Genomics Medicine Sweden initiative that aims to build a new type of infrastructure within Swedish healthcare that implements precision medicine at a national level.

By employing a translational approach and utilizing cutting‐edge molecular tools, including next-generation sequencing technologies, Richard Rosenquist Brandell has made outstanding contributions to our understanding of the mechanisms behind the development of chronic lymphocytic leukemia (CLL), the most common adult leukemia. His studies have identified novel prognostic and predictive markers, defined new clinically relevant CLL subgroups, as well as provided significantly improved risk stratification at the individual patient level. Even more importantly, Rosenquist Brandell’s team has presented compelling evidence for a role of antigens (both autoantigens and microbial antigens) in the pathogenesis of CLL, which has generated great interest internationally. He has also built competitive networks at the national, European and international level. He is one of five founding members of an eminent European network of CLL researcher with an impressive combined cohort of more than 34,000 CLL patients from 24 academic institutions.

Richard Rosenquist Brandell has successfully supervised 23 PhD students as well as seven postdocs, and his research has resulted in more than 200 peer-reviewed papers. He was recently selected as Wallenberg Clinical Scholars 2017 by the Knut and Alice Wallenberg Foundation. 

Forskningsbeskrivning

Forskargruppsledare för gruppen Klinisk genetik

Professorspresentation

Publikationer

Antigen receptor stereotypy in chronic lymphocytic leukemia
Stamatopoulos K, Agathangelidis A, Rosenquist R, Ghia P
Leukemia 2017;31(2):282-291

Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes
Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton La, Minga E, et al
Clinical cancer research : an official journal of the American Association for Cancer Research 2017;23(17):5292-5301

EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia
Young E, Noerenberg D, Mansouri L, Ljungström V, Frick M, Sutton La, et al
Leukemia 2017;31(7):1547-1554

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia
Löf L, Arngården L, Olsson-strömberg U, Siart B, Jansson M, Dahlin Js, et al
Scientific reports 2017;7(1):623-

Genetic landscape and deregulated pathways in B-cell lymphoid malignancies
Rosenquist R, Beà S, Du Mq, Nadel B, Pan-hammarström Q
Journal of internal medicine 2017;282(5):371-394

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
Law Pj, Berndt Si, Speedy He, Camp Nj, Sava Gp, Skibola Cf, et al
Nature communications 2017;8():14175-

Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations
Rosenquist R, Ghia P, Hadzidimitriou A, Sutton La, Agathangelidis A, Baliakas P, et al
Leukemia 2017;31(7):1477-1481

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification
Sutton La, Hadzidimitriou A, Baliakas P, Agathangelidis A, Langerak Aw, Stilgenbauer S, et al
Haematologica 2017;102(6):968-971

Introduction to the symposium 'Targeted therapy in B-cell malignancies'
Smedby Ke, Rosenquist R
Journal of internal medicine 2017;282(5):358-359

Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence
Pouliou E, Xochelli A, Kanellis G, Stalika E, Sutton La, Navarro A, et al
The American journal of pathology 2017;187(7):1454-1458

Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma
Baecklund F, Foo Jn, Askling J, Eloranta S, Glimelius I, Liu Jj, et al
AMERICAN JOURNAL OF EPIDEMIOLOGY 2017;185(8):681-687

Reproducible diagnosis of Chronic Lymphocytic Leukemia by flow cytometry: an European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) harmonisation project
Rawstron Ac, Kreuzer Ka, Soosapilla A, Spacek M, Stehlikova O, Gambell P, et al
Cytometry. Part B, Clinical cytometry 2017;():-

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers
Palma M, Gentilcore G, Heimersson K, Mozaffari F, Näsman-glaser B, Young E, et al
Haematologica 2017;102(3):562-572

U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden
Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, et al
Acta oncologica (Stockholm, Sweden) 2017;():1-8

Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference
Baliakas P, Puiggros A, Xochelli A, Sutton La, Nguyen-khac F, Gardiner A, et al
HAEMATOLOGICA 2016;101(7):e299-302

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors
Bikos V, Karypidou M, Stalika E, Baliakas P, Xochelli A, Sutton La, et al
CLINICAL CANCER RESEARCH 2016;22(8):2032-40

Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia
Vardi A, Agathangelidis A, Stalika E, Karypidou M, Siorenta A, Anagnostopoulos A, et al
CLINICAL CANCER RESEARCH 2016;22(1):167-74

ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres
Navrkalova V, Young E, Baliakas P, Radova L, Sutton La, Plevova K, et al
Haematologica 2016;101(9):e369-73

B-cell malignancies: All roads lead to NF-kappa B activation
Rosenquist R, Stamatopoulos K
SEMINARS IN CANCER BIOLOGY 2016;:1-2

Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond
Rosenquist R, Rosenwald A, Du Mq, Gaidano G, Groenen P, Wotherspoon A, et al
Haematologica 2016;101(9):1002-9

Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors
Sutton La, Young E, Baliakas P, Hadzidimitriou A, Moysiadis T, Plevova K, et al
Haematologica 2016;101(8):959-67

Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression
Kopparapu Pk, Bhoi S, Mansouri L, Arabanian Ls, Plevova K, Pospisilova S, et al
Epigenetics 2016;11(5):335-43

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, et al
Blood 2016;128(23):2666-2670

Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations
Wu C, De Miranda Nf, Chen L, Wasik Am, Mansouri L, Jurczak W, et al
Oncotarget 2016;7(25):38180-38190

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
Parker H, Rose-zerilli Mjj, Larrayoz M, Clifford R, Edelmann J, Blakemore S, et al
LEUKEMIA 2016;30(11):2179-2186

Innovation In the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?
European Research Initiative Cll E, Pospisilova S, Sutton La, Malcikova J, Tausch E, Rossi D, et al
HAEMATOLOGICA 2016;101(3):263-5

Massive and parallel expression profiling using microarrayed single-cell sequencing
Vickovic S, Ståhl Pl, Salmén F, Giatrellis S, Westholm Jo, Mollbrink A, et al
Nature communications 2016;7():13182-

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions
Mansouri L, Papakonstantinou N, Ntoufa S, Stamatopoulos K, Rosenquist R
Seminars in cancer biology 2016;39():40-8

Not all subclones matter in CLL
Sutton La, Rosenquist R
BLOOD 2016;127(17):2052-4

Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2
Bhoi S, Ljungström V, Baliakas P, Mattsson M, Smedby Ke, Juliusson G, et al
Epigenetics 2016;11(6):449-55

Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed?
Baliakas P, Mattsson M, Stamatopoulos K, Rosenquist R
JOURNAL OF INTERNAL MEDICINE 2016;279(4):347-57

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
Papakonstantinou N, Ntoufa S, Chartomatsidou E, Kotta K, Agathangelidis A, Giassafaki L, et al
ONCOTARGET 2016;7(24):35946-35959

Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia
Pandzic T, Larsson J, He Lq, Kundu S, Ban K, Akhtar-ali M, et al
CLINICAL CANCER RESEARCH 2016;22(24):6217-6227

Unraveling the DNA Methylome in Mantle Cell Lymphoma: New Insights into the Cellular Origin
Mansouri L, Rosenquist R
Cancer cell 2016;30(5):665-667

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, et al
Blood 2016;127(8):1007-16

A new piece to the stereotypy "puzzle" in chronic lymphocytic leukemia
Rosenquist R
LEUKEMIA & LYMPHOMA 2015;56(11):3008-9

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Blein S, Bardel C, Danjean V, Mcguffog L, Healey S, Barrowdale D, et al
Breast cancer research : BCR 2015;17():61-

Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression
Sutton La, Rosenquist R
EXPERT REVIEW OF HEMATOLOGY 2015;8(1):71-8

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk
Sava Gp, Speedy He, Di Bernardo Mc, Dyer Mj, Holroyd A, Sunter Nj, et al
Leukemia 2015;29(3):748-51

Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution
Sutton La, Rosenquist R
HAEMATOLOGICA 2015;100(1):7-16

Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia
Mansouri L, Sutton La, Ljungström V, Bondza S, Arngården L, Bhoi S, et al
The Journal of experimental medicine 2015;212(6):833-43

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing
Parry M, Rose-zerilli Mjj, Ljungstrom V, Gibson J, Wang J, Walewska R, et al
CLINICAL CANCER RESEARCH 2015;21(18):4174-4183

Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia
Xochelli A, Agathangelidis A, Kavakiotis I, Minga E, Sutton L, Baliakas P, et al
IMMUNOGENETICS 2015;67(1):61-6

Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton La, Minga E, Tsanousa A, et al
Blood 2015;125(5):856-9

Prognostic relevance of MYD88 mutations in CLL: the jury is still out
Baliakas P, Hadzidimitriou A, Agathangelidis A, Rossi D, Sutton La, Kminkova J, et al
BLOOD 2015;126(8):1043-4

Recurrent mutations refine prognosis in chronic lymphocytic leukemia
Baliakas P, Hadzidimitriou A, Sutton La, Rossi D, Minga E, Villamor N, et al
Leukemia 2015;29(2):329-36

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
Malcovati L, Karimi M, Papaemmanuil E, Ambaglio I, Jädersten M, Jansson M, et al
Blood 2015;126(2):233-41

Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting
Sutton La, Ljungström V, Mansouri L, Young E, Cortese D, Navrkalova V, et al
Haematologica 2015;100(3):370-6

The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia
Sutton La, Rosenquist R
SEMINARS IN CANCER BIOLOGY 2015;:22-35

A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival
Baecklund F, Foo Jn, Bracci P, Darabi H, Karlsson R, Hjalgrim H, et al
BMC medical genetics 2014;15():113-

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
Speedy He, Di Bernardo Mc, Sava Gp, Dyer Mj, Holroyd A, Wang Y, et al
Nature genetics 2014;46(1):56-60

An Entity Evolving into a Community: Defining the Common Ancestor and Evolutionary Trajectory of Chronic Lymphocytic Leukemia Stereotyped Subset #4
Sutton La, Papadopoulos G, Hadzidimitriou A, Papadopoulos S, Kostareli E, Rosenquist R, et al
MOLECULAR MEDICINE 2014;:720-8

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study
Baliakas P, Hadzidimitriou A, Sutton La, Minga E, Agathangelidis A, Nichelatti M, et al
The Lancet. Haematology 2014;1(2):e74-84

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study
Baliakas P, Hadzidimitriou A, Sutton La, Minga E, Agathangelidis A, Nichelatti M, et al
LANCET HAEMATOLOGY 2014;1(2):E74-E84

Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia
Mansouri L, Sutton La, Ljungström V, Sörqvist Ef, Gunnarsson R, Smedby Ke, et al
Leukemia 2014;28(3):694-6

Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays
Pauly F, Smedby Ke, Jerkeman M, Hjalgrim H, Ohlsson M, Rosenquist R, et al
Leukemia research 2014;38(6):682-90

IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications
Vardi A, Agathangelidis A, Sutton La, Chatzouli M, Scarfò L, Mansouri L, et al
Clinical cancer research : an official journal of the American Association for Cancer Research 2014;20(2):323-30

Immunogenetic Studies of Chronic Lymphocytic Leukemia: Revelations and Speculations about Ontogeny and Clinical Evolution
Vardi A, Agathangelidis A, Sutton La, Ghia P, Rosenquist R, Stamatopoulos K
CANCER RESEARCH 2014;74(16):4211-6

Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype
Jakobsen Falk I, Fyrberg A, Paul E, Nahi H, Hermanson M, Rosenquist R, et al
British journal of haematology 2014;167(5):671-80

Lymphoma development in patients with autoimmune and inflammatory disorders--what are the driving forces?
Baecklund E, Smedby Ke, Sutton La, Askling J, Rosenquist R
Seminars in cancer biology 2014;24():61-70

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis
Benner A, Mansouri L, Rossi D, Majid A, Willander K, Parker A, et al
Haematologica 2014;99(8):1285-91

microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia
Deneberg S, Kanduri M, Ali D, Bengtzen S, Karimi M, Qu Y, et al
Epigenetics 2014;9(6):910-7

On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort
Cortese D, Sutton La, Cahill N, Smedby Ke, Geisler C, Gunnarsson R, et al
Leukemia 2014;28(3):710-3

Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia
Bergh Ac, Evaldsson C, Pedersen Lb, Geisler C, Stamatopoulos K, Rosenquist R, et al
HAEMATOLOGICA 2014;99(11):1722-30

The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors
Malcikova J, Stalika E, Davis Z, Plevova K, Trbusek M, Mansouri L, et al
BRITISH JOURNAL OF HAEMATOLOGY 2014;166(4):621-5

The microenvironment in lymphomas - Dissecting the complex crosstalk between tumor cells and 'by-stander' cells
Rosenquist R, Davi F, Ghia P
SEMINARS IN CANCER BIOLOGY 2014;:1-2

450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments
Cahill N, Bergh Ac, Kanduri M, Göransson-kultima H, Mansouri L, Isaksson A, et al
Leukemia 2013;27(1):150-8

A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma
Kanduri M, Sander B, Ntoufa S, Papakonstantinou N, Sutton La, Stamatopoulos K, et al
Epigenetics 2013;8(12):1280-8

ANGPT2 promoter methylation is strongly associated with gene expression and prognosis in chronic lymphocytic leukemia
Martinelli S, Kanduri M, Maffei R, Fiorcari S, Bulgarelli J, Marasca R, et al
EPIGENETICS 2013;8(7):720-9

Antigen selection in B-cell lymphomas-Tracing the evidence
Sutton La, Agathangelidis A, Belessi C, Darzentas N, Davi F, Ghia P, et al
SEMINARS IN CANCER BIOLOGY 2013;23(6):399-409

Antigens in lymphoma development-Current knowledge and future directions Introduction
Rosenquist R, Davi F, Stamatopoulos K
SEMINARS IN CANCER BIOLOGY 2013;23(6):397-8

Decreased survival in normal karyotype AML with single-nucleotide polymorphisms in genes encoding the AraC metabolizing enzymes cytidine deaminase and 5'-nucleotidase
Falk Ij, Fyrberg A, Paul E, Nahi H, Hermanson M, Rosenquist R, et al
American journal of hematology 2013;88(12):1001-6

Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2
Strefford Jc, Sutton La, Baliakas P, Agathangelidis A, Malcikova J, Plevova K, et al
LEUKEMIA 2013;27(11):2196-9

DNA repair genes are selectively mutated in diffuse large B cell lymphomas
De Miranda Nf, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al
The Journal of experimental medicine 2013;210(9):1729-42

Exploring the genetic landscape in chronic lymphocytic leukemia using high-resolution technologies
Gunnarsson R, Mansouri L, Rosenquist R
Leukemia & lymphoma 2013;54(8):1583-90

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
Cimba, Bcfr, Gemo Study Collaborators, Embrace, Hebon, Ontario Canc Genetics Network, et al
PLOS GENETICS 2013;9(3):e1003212-

Molecular characterization of neoplastic and normal "sister" lymphoblastoid B-cell lines from chronic lymphocytic leukemia
Lanemo Myhrinder A, Hellqvist E, Bergh Ac, Jansson M, Nilsson K, Hultman P, et al
Leukemia & lymphoma 2013;54(8):1769-79

NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia
Mansouri L, Cahill N, Gunnarsson R, Smedby Ke, Tjonnfjord E, Hjalgrim H, et al
LEUKEMIA 2013;27(2):512-4

Prognostic markers and their clinical applicability in chronic lymphocytic leukemia: where do we stand?
Rosenquist R, Cortese D, Bhoi S, Mansouri L, Gunnarsson R
Leukemia & lymphoma 2013;54(11):2351-64

rs2072135, a low-penetrance variant for chronic lymphocytic leukaemia?
Sava Gp, Speedy He, Di Bernardo Mc, Deaglio S, Karabon L, Frydecka I, et al
BRITISH JOURNAL OF HAEMATOLOGY 2013;162(2):221-8

Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients
Mansouri L, Grabowski P, Degerman S, Svenson U, Gunnarsson R, Cahill N, et al
American journal of hematology 2013;88(8):647-51

Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence
Sutton La, Kostareli E, Stalika E, Tsaftaris A, Anagnostopoulos A, Darzentas N, et al
MOLECULAR MEDICINE 2013;:230-6

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome
Chigrinova E, Rinaldi A, Kwee I, Rossi D, Rancoita Pmv, Strefford Jc, et al
BLOOD 2013;122(15):2673-82

Uncovering the DNA methylome in chronic lymphocytic leukemia
Cahill N, Rosenquist R
EPIGENETICS 2013;8(2):138-48

Whole-genome-amplified DNA as a source for mutational analysis underestimates the frequency of mutations in pediatric acute myeloid leukemia
Rosenquist R, Ehrencrona H, Hasle H, Palle J, Kanduri M
LEUKEMIA 2013;27(2):510-2

Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity
Kostareli E, Gounari M, Janus A, Murray F, Brochet X, Giudicelli V, et al
LEUKEMIA 2012;26(5):1127-31

Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype
Gréen H, Falk Ij, Lotfi K, Paul E, Hermansson M, Rosenquist R, et al
The pharmacogenomics journal 2012;12(2):111-8

Association of PHB 1630 C > T and MTHFR 677 C > T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Cimba, Kconfab, Gemo Study Collaborators, Embrace, Hebon, Swe Brca, et al
BRITISH JOURNAL OF CANCER 2012;106(12):2016-24

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis
Du L, Peng R, Björkman A, Filipe De Miranda N, Rosner C, Kotnis A, et al
The Journal of experimental medicine 2012;209(2):291-305

Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant
Ibbotson R, Athanasiadou A, Sutton La, Davis Z, Gardiner A, Baliakas P, et al
LEUKEMIA 2012;26(1):170-2

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
Kconfab Investigators, Gemo Study Collaborator, Embrace Study Collaborator, Hebon Study Collaborator, Swe-brca Study Collaborator, Cimba Study Collaborator, et al
BREAST CANCER RESEARCH 2012;14(1):R33-

Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles
Kanduri M, Marincevic M, Halldórsdóttir Am, Mansouri L, Junevik K, Ntoufa S, et al
Epigenetics 2012;7(12):1435-42

High ERG gene expression is an unfavorable prognostic marker in pediatric acute myeloid leukemia Response
Staffas A, Kanduri M, Hovland R, Rosenquist R, Ommen Hb, Abrahamsson J, et al
BLOOD 2012;119(4):1087-1088

IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia
Cahill N, Sutton La, Jansson M, Murray F, Mansouri L, Gunnarsson R, et al
Clinical lymphoma, myeloma & leukemia 2012;12(3):201-6

Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection
Rosen A, Bergh Ac, Gogolak P, Evaldsson C, Myhrinder Al, Hellqvist E, et al
ONCOIMMUNOLOGY 2012;1(1):18-27

Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia
Halldórsdóttir Am, Kanduri M, Marincevic M, Mansouri L, Isaksson A, Göransson H, et al
American journal of hematology 2012;87(4):361-7

Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia
Mansouri L, Gunnarsson R, Sutton La, Ameur A, Hooper Sd, Mayrhofer M, et al
American journal of hematology 2012;87(7):737-40

RNA-based markers as prognostic factors in chronic lymphocytic leukemia
Sevov M, Rosenquist R, Mansouri L
Expert review of hematology 2012;5(1):69-79

Screening for Cytotoxic Compounds in Poor-prognostic Chronic Lymphocytic Leukemia
Norberg M, Lindhagen E, Kanduri M, Rickardson L, Sundstrom C, Stamatopoulos K, et al
ANTICANCER RESEARCH 2012;32(8):3125-36

Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan Xj, et al
BLOOD 2012;119(19):4467-75

What information do cancer genetic counselees prioritize?
Hayat Roshanai A, Lampic C, Ingvoldstad C, Askmalm Ms, Bjorvatn C, Rosenquist R, et al
Journal of genetic counseling 2012;21(4):510-26

Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia
Gunnarsson R, Mansouri L, Isaksson A, Göransson H, Cahill N, Jansson M, et al
Haematologica 2011;96(8):1161-9

High-resolution genomic screening in mantle cell lymphoma--specific changes correlate with genomic complexity, the proliferation signature and survival
Halldórsdóttir Am, Sander B, Göransson H, Isaksson A, Kimby E, Mansouri M, et al
Genes, chromosomes & cancer 2011;50(2):113-21

Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases
European Res Initiative Cll, Langerak Aw, Davi F, Ghia P, Hadzidimitriou A, Murray F, et al
LEUKEMIA 2011;25(6):979-84

Impact of TP53 mutation and 17p deletion in mantle cell lymphoma
Halldorsdottir Am, Lundin A, Murray F, Mansouri L, Knuutila S, Sundstrom C, et al
LEUKEMIA 2011;25(12):1904-8

Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases
Hadzidimitriou A, Agathangelidis A, Darzentas N, Murray F, Delfau-larue Mh, Pedersen Lb, et al
BLOOD 2011;118(11):3088-95

LMO2 protein expression predicts survival in patients with rheumatoid arthritis and diffuse large B-cell lymphoma
Baecklund E, Backlin C, Mansouri M, Klareskog L, Askling J, Iliadou An, et al
LEUKEMIA & LYMPHOMA 2011;52(6):1146-9

LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia
Kaderi Ma, Kanduri M, Buhl Am, Sevov M, Cahill N, Gunnarsson R, et al
Haematologica 2011;96(8):1153-60

Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry
Thörn I, Forestier E, Botling J, Thuresson B, Wasslavik C, Björklund E, et al
British journal of haematology 2011;152(6):743-53

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
Staffas A, Kanduri M, Hovland R, Rosenquist R, Ommen Hb, Abrahamsson J, et al
Blood 2011;118(22):5905-13

Quantitative evaluation of p16(INK4a) promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma
Zainuddin N, Kanduri M, Berglund M, Lindell M, Amini Rm, Roos G, et al
Leukemia research 2011;35(4):438-43

The novel NF-kappa B inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia
Kanduri M, Tobin G, Aleskog A, Nilsson K, Rosenquist R
BLOOD CANCER JOURNAL 2011;:e12-

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia
Zainuddin N, Murray F, Kanduri M, Gunnarsson R, Smedby Ke, Enblad G, et al
Leukemia research 2011;35(2):272-4

Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: Implications for the origin and selection of the malignant cells
Agathangelidis A, Hadzidimitriou A, Rosenquist R, Stamatopoulos K
SEMINARS IN CANCER BIOLOGY 2011;21(5):299-307

A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence
Darzentas N, Hadzidimitriou A, Murray F, Hatzi K, Josefsson P, Laoutaris N, et al
LEUKEMIA 2010;24(1):125-32

Antigens in chronic lymphocytic leukemia-Implications for cell origin and leukemogenesis
Rosen A, Murray F, Evaldsson C, Rosenquist R
SEMINARS IN CANCER BIOLOGY 2010;20(6):400-9

Applicability of IG/TCR gene rearrangements as targets for minimal residual disease assessment in a population-based cohort of Swedish childhood acute lymphoblastic leukaemia diagnosed 2002-2006
Thörn I, Forestier E, Thuresson B, Wasslavik C, Malec M, Li A, et al
European journal of haematology 2010;84(2):117-27

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
Crowther-swanepoel D, Broderick P, Di Bernardo Mc, Dobbins Se, Torres M, Mansouri M, et al
NATURE GENETICS 2010;42(2):132-6

Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
Kanduri M, Cahill N, Goransson H, Enstrom C, Ryan F, Isaksson A, et al
BLOOD 2010;115(2):296-305

Disclosing cancer genetic information within families: perspectives of counselees and their at-risk relatives
Hayat Roshanai A, Lampic C, Rosenquist R, Nordin K
Familial cancer 2010;9(4):669-79

Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
Marincevic M, Mansouri M, Kanduri M, Isaksson A, Göransson H, Smedby Ke, et al
Haematologica 2010;95(12):2072-9

High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors
Marincevic M, Cahill N, Gunnarsson R, Isaksson A, Mansouri M, Göransson H, et al
Haematologica 2010;95(9):1519-25

Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples
Andréasson U, Edén P, Peterson C, Högerkorp Cm, Jerkeman M, Andersen N, et al
American journal of hematology 2010;85(6):418-25

IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia
Mansouri Mr, Sevov M, Aleskog A, Jondal M, Merup M, Sundström C, et al
European journal of haematology 2010;84(2):109-16

Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution
Kostareli E, Sutton La, Hadzidimitriou A, Darzentas N, Kouvatsi A, Tsaftaris A, et al
LEUKEMIA 2010;24(7):1317-24

Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukemia
Kaderi Ma, Mansouri M, Zainuddin N, Cahill N, Gunnarsson R, Jansson M, et al
Leukemia research 2010;34(3):335-9

Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients
Gunnarsson R, Isaksson A, Mansouri M, Goransson H, Jansson M, Cahill N, et al
LEUKEMIA 2010;24(1):211-5

Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity
Mansouri M, Sevov M, Fahlgren E, Tobin G, Jondal M, Osorio L, et al
Leukemia research 2010;34(3):301-6

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations
Davidsson J, Paulsson K, Lindgren D, Lilljebjörn H, Chaplin T, Forestier E, et al
Leukemia 2010;24(5):924-31

Rheumatoid arthritis, treatment with corticosteroids and risk of malignant lymphomas: results from a case-control study
Hellgren K, Iliadou A, Rosenquist R, Feltelius N, Backlin C, Enblad G, et al
Annals of the rheumatic diseases 2010;69(4):654-9

Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk
Crowther-swanepoel D, Mansouri M, Enjuanes A, Vega A, Smedby Ke, Ruiz-ponte C, et al
BRITISH JOURNAL OF HAEMATOLOGY 2010;150(4):473-9

Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1
Carvalho M, Pino Ma, Karchin R, Beddor J, Godinho-netto M, Mesquita Rd, et al
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 2009;660(1-2):1-11

Cancer genetic counselees' self-reported psychological distress, changes in life, and adherence to recommended surveillance programs 3-7 years post counseling
Hayat Roshanai A, Rosenquist R, Lampic C, Nordin K
Journal of genetic counseling 2009;18(2):185-94

Does enhanced information at cancer genetic counseling improve counselees' knowledge, risk perception, satisfaction and negotiation of information to at-risk relatives?--a randomized study
Roshanai Ah, Rosenquist R, Lampic C, Nordin K
Acta oncologica (Stockholm, Sweden) 2009;48(7):999-1009

Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia
Hadzidimitriou A, Darzentas N, Murray F, Smilevska T, Arvaniti E, Tresoldi C, et al
BLOOD 2009;113(2):403-11

Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen
Sutton La, Kostareli E, Hadzidimitriou A, Darzentas N, Tsaftaris A, Anagnostopoulos A, et al
BLOOD 2009;114(20):4460-8

Genome-wide microarray-based comparative genomic hybridization analysis of lymphoplasmacytic lymphomas reveals heterogeneous aberrations
Buckley Pg, Walsh Sh, Laurell A, Sundstrom C, Roos G, Langford Cf, et al
LEUKEMIA & LYMPHOMA 2009;50(9):1528-34

Identification of molecular targets associated with transformed diffuse large B cell lymphoma using highly purified tumor cells
Andréasson U, Dictor M, Jerkeman M, Berglund M, Sundström C, Linderoth J, et al
American journal of hematology 2009;84(12):803-8

Infrequent occurrence of PIK3CA mutations in chronic lymphocytic leukemia
Marincevic M, Tobin G, Rosenquist R
LEUKEMIA & LYMPHOMA 2009;50(5):829-30

In vitro activity of 20 agents in different prognostic subgroups of chronic lymphocytic leukemia - rolipram and prednisolone active in cells from patients with poor prognosis
Lindhagen E, Norberg M, Kanduri M, Tobin G, Saisanen L, Aberg M, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2009;83(1):22-34

Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival
Paul E, Paul E, Uggla B, Deneberg S, Bengtzen S, Hermansson M, et al
Leukemia & lymphoma 2009;50(9):1512-8

Monitoring minimal residual disease with flow cytometry, antigen-receptor gene rearrangements and fusion transcript quantification in Philadelphia-positive childhood acute lymphoblastic leukemia
Thörn I, Botling J, Hermansson M, Lönnerholm G, Sundström C, Rosenquist R, et al
Leukemia research 2009;33(8):1047-54

Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data
Göransson H, Edlund K, Rydåker M, Rasmussen M, Winquist J, Ekman S, et al
PloS one 2009;4(6):e6057-

TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
Zainuddin N, Berglund M, Wanders A, Ren Zp, Amini Rm, Lindell M, et al
Leukemia research 2009;33(1):60-6

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
Lanemo Myhrinder A, Hellqvist E, Sidorova E, Söderberg A, Baxendale H, Dahle C, et al
Blood 2008;111(7):3838-48

B cell lymphomas express CX(3)CR1 a non-B cell lineage adhesion molecule
Andreasson U, Ek S, Merz H, Rosenquist R, Andersen N, Jerkeman M, et al
CANCER LETTERS 2008;259(2):138-45

Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia
Thelander Ef, Ichimura K, Corcoran M, Barbany G, Nordgren A, Heyman M, et al
Leukemia & lymphoma 2008;49(3):477-87

Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature
Forestier E, Gauffin F, Andersen Mk, Autio K, Borgström G, Golovleva I, et al
Genes, chromosomes & cancer 2008;47(2):149-58

Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs
Davi F, Rosenquist R, Ghia P, Belessi C, Stamatopoulos K
LEUKEMIA 2008;22(1):212-4

Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
Baecklund E, Natkunam Y, Backlin C, Iliadou A, Askling J, Ekbom A, et al
British journal of haematology 2008;141(1):69-72

Introduction: the role of inflammation, autoimmune disease and infectious agents in development of leukaemia and lymphoma
Rosenquist R
JOURNAL OF INTERNAL MEDICINE 2008;264(6):512-3

Molecular genetic characterization reveals new subsets of mantle cell lymphoma
Thelander Ef, Rosenquist R
Leukemia & lymphoma 2008;49(6):1042-9

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Staaf J, Vallon-christersson J, Lindgren D, Juliusson G, Rosenquist R, Hoglund M, et al
BMC BIOINFORMATICS 2008;:409-

Or both? Response
Roos G, Rosenquist R, Stilgenbauer S
BLOOD 2008;111(12):5756-5757

Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival
Forestier E, Heyman M, Andersen Mk, Autio K, Blennow E, Borgström G, et al
British journal of haematology 2008;140(6):665-72

Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays
Ellmark P, Högerkorp Cm, Ek S, Belov L, Berglund M, Rosenquist R, et al
Cancer letters 2008;265(1):98-106

Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination
Aleskog A, Norberg M, Nygren P, Rickardson L, Kanduri M, Tobin G, et al
LEUKEMIA & LYMPHOMA 2008;49(12):2333-43

Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia--a comparative study of four differently designed, high resolution microarray platforms
Gunnarsson R, Staaf J, Jansson M, Ottesen Am, Göransson H, Liljedahl U, et al
Genes, chromosomes & cancer 2008;47(8):697-711

Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
Staaf J, Lindgren D, Vallon-christersson J, Isaksson A, Goransson H, Juliusson G, et al
GENOME BIOLOGY 2008;9(9):R136-

Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia
Roos G, Krober A, Grabowski P, Kienle D, Buhler A, Dohner H, et al
BLOOD 2008;111(4):2246-52

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C, et al
BLOOD 2008;111(3):1524-33

The BCL-2 promoter (-938C>A) polymorphism does not predict clinical outcome in chronic lymphocytic leukemia
Kaderi Ma, Norberg M, Murray F, Merup M, Sundström C, Roos G, et al
Leukemia 2008;22(2):339-43

U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner
Boström H, Leuchowius Kj, Hallböök H, Nordgren A, Thörn I, Thorselius M, et al
European journal of haematology 2008;81(3):218-25

A hypothesis-generating search for new genetic breast cancer syndromes--a national study in 803 Swedish families
Von Wachenfeldt A, Lindblom A, South Swedish Oncogenetic Study Group, Grönberg H, Einbeigi Z, Rosenquist R, et al
Hereditary cancer in clinical practice 2007;5(1):17-24

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Bomben R, Dal Bo M, Capello D, Benedetti D, Marconi D, Zucchetto A, et al
BLOOD 2007;109(7):2989-98

Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature
Forestier E, Andersen Mk, Autio K, Blennow E, Borgström G, Golovleva I, et al
Genes, chromosomes & cancer 2007;46(5):440-50

Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma
Flordal Thelander E, Ichimura K, Collins Vp, Walsh Sh, Barbany G, Hagberg A, et al
Leukemia research 2007;31(9):1219-30

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia
Raval A, Tanner Sm, Byrd Jc, Angerman Eb, Perko Jd, Chen Ss, et al
CELL 2007;129(5):879-90

ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia
European Res Initiative Cll, Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stilgenbauer S, et al
LEUKEMIA 2007;21(1):1-3

Genomic imbalances during transformation from follicular lymphoma to diffuse large B-cell lymphoma
Berglund M, Enblad G, Thunberg U, Amini Rm, Sundström C, Roos G, et al
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(1):63-75

Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma
Hedström G, Berglund M, Molin D, Fischer M, Nilsson G, Thunberg U, et al
British journal of haematology 2007;138(1):68-71

Reply to 'Male preponderance in chronic lymphocytic leukemia utilizing IGHV1-69' When size of the sample matters
Ghia P, Belessi C, Davi F, Rosenquist R, Stamatopoulos K
LEUKEMIA 2007;21(12):2539-40

Telomere length and correlation with histopathogenesis in B-cell leukemias/lymphomas
Walsh Sh, Grabowski P, Berglund M, Thunberg U, Thorsélius M, Tobin G, et al
European journal of haematology 2007;78(4):283-9

Thioredoxin, produced by stromal node microenvironment, rescues cells from apoptosis in vitro
Backman E, Bergh Ac, Lagerdahl I, Rydberg B, Sundstrom C, Tobin G, et al
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 2007;92(11):1495-504

Upregulation of bfl-1 is a potential mechanism of chemoresistance in B-cell chronic lymphocytic leukaemia
Olsson A, Norberg M, Okvist A, Derkow K, Choudhury A, Tobin G, et al
British journal of cancer 2007;97(6):769-77

Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin C, Granath F, et al
Arthritis and rheumatism 2006;54(3):692-701

Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis
Baecklund E, Backlin C, Iliadou A, Granath F, Ekbom A, Amini Rm, et al
Arthritis and rheumatism 2006;54(12):3774-81

Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status
Thorsélius M, Kröber A, Murray F, Thunberg U, Tobin G, Bühler A, et al
Blood 2006;107(7):2889-94

Subtype preference of the BCL6(397G/C) polymorphism in germinal-center and non-germinal-center subtypes of diffuse large B-cell lymphoma
Berglund M, Amini Rm, Book M, Rosenquist R, Roos G, Thunberg U
BLOOD 2006;108(10):3623-4

The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia
Skogsberg S, Tobin G, Kröber A, Kienle D, Thunberg U, Aleskog A, et al
Leukemia 2006;20(1):77-81

What is the current evidence for antigen involvement in the development of chronic lymphocytic leukemia?
Tobin G, Rosen A, Rosenquist R
HEMATOLOGICAL ONCOLOGY 2006;24(1):7-13

Absence of H2AX gene mutations in B-cell leukemias and lymphomas
Walsh Sh, Rosenquist R
LEUKEMIA 2005;19(3):464-

Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia
Fält S, Merup M, Tobin G, Thunberg U, Gahrton G, Rosenquist R, et al
Blood 2005;106(2):681-9

Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis
Berglund M, Thunberg U, Amini Rm, Book M, Roos G, Erlanson M, et al
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(8):1113-20

Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia
Thorselius M, Walsh Sh, Thunberg U, Hagberg H, Sundstrom C, Rosenquist R
LEUKEMIA RESEARCH 2005;29(2):153-8

Immunoglobulin gene analysis of mature B-cell malignancies
Walsh Sh, Rosenquist R
MEDICAL ONCOLOGY 2005;22(4):327-41

Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas
Schmitz R, Renne C, Rosenquist R, Tinguely M, Distler V, Menestrina F, et al
LEUKEMIA 2005;19(8):1452-8

Lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia derives from an extensively hypermutated B cell that lacks ongoing somatic hypermutation
Walsh Sh, Laurell A, Sundstrom G, Roos L, Sundstrom C, Rosenquist R
LEUKEMIA RESEARCH 2005;29(7):729-34

Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genes
Thelander Ef, Walsh Sh, Thorsélius M, Laurell A, Landgren O, Larsson C, et al
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(3):331-9

Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or V-H gene mutation status in chronic lymphocytic leukaemia
Tobin G, Skogsberg A, Thunberg U, Laurell A, Aleskog A, Merup M, et al
LEUKEMIA 2005;19(5):871-3

Mitogen induced activation, proliferation and surface antigen expression patterns in unmutated and hypermutated chronic lymphocytic leukemia cells
Vilpo J, Tobin G, Hulkkonen J, Hurme M, Thunberg U, Sundstrom C, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2005;75(1):34-40

Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome
Tobin G, Thunberg U, Laurell A, Karlsson K, Aleskog A, Willander K, et al
Haematologica 2005;90(4):465-9

Prognostic usage of V-H gene mutation status and its surrogate markers and the role of antigen selection in chronic lymphocytic leukemia
Tobin G, Rosenquist R
MEDICAL ONCOLOGY 2005;22(3):217-28

Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to V-H gene mutation status
Grabowski P, Hultdin M, Karlsson K, Tobin G, Aleskog A, Thunberg U, et al
BLOOD 2005;105(12):4807-12

The interleukin-10 gene promoter polymorphism (-1082) does not correlate with clinical outcome in diffuse large B-cell lymphoma
Berglund M, Thunberg U, Roos G, Rosenquist R, Enblad G
BLOOD 2005;105(12):4894-5

Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia
Dao-ung Lp, Fuller Sj, Sluyter R, Skarratt Kk, Thunberg U, Tobin G, et al
BRITISH JOURNAL OF HAEMATOLOGY 2004;125(6):815-7

Clonally related splenic marginal zone lymphoma and Hodgkin lymphoma with unmutated V gene rearrangements and a 15-yr time gap between diagnoses
Rosenquist R, Roos G, Erlanson M, Kuppers R, Brauninger A, Hansmann Ml
EUROPEAN JOURNAL OF HAEMATOLOGY 2004;73(3):210-4

Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia
Ferrer A, Ollila J, Tobin G, Nagy B, Thunberg U, Aalto Y, et al
CANCER GENETICS AND CYTOGENETICS 2004;153(1):69-72

Rheumatoid arthritis and malignant lymphomas
Baecklund E, Askling J, Rosenquist R, Ekbom A, Klareskog L
Current opinion in rheumatology 2004;16(3):254-61

Similar humoral immunity parameters in chronic lymphocytic leukemia patients independent of V-H gene mutation status
Sinisalo M, Aittoniemi J, Koski T, Tobin G, Thunberg U, Sundstrom C, et al
LEUKEMIA & LYMPHOMA 2004;45(12):2451-4

Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K, et al
Blood 2004;104(9):2879-85

V(H)3-21 gene usage in chronic lymphocytic leukemia - Characterization of a new subgroup with distinct molecular features and poor survival
Tobin G, Soderberg O, Thunberg U, Rosenquist R
LEUKEMIA & LYMPHOMA 2004;45(2):221-8

V-H gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia
Aleskog A, Tobin G, Laurell A, Thunberg U, Lindhagen E, Roos G, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2004;73(6):407-11

Analysis of a clonally related mantle cell and Hodgkin lymphoma indicates Epstein-Barr virus infection of a Hodgkin/Reed-Sternberg cell precursor in a germinal center
Tinguely M, Rosenquist R, Sundstrom C, Amini Rm, Kuppers R, Hansmann Ml, et al
AMERICAN JOURNAL OF SURGICAL PATHOLOGY 2003;27(11):1483-8

Association between telomere length and V-H gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications
Hultdin M, Rosenquist R, Thunberg U, Tobin G, Norrback Kf, Johnson A, et al
BRITISH JOURNAL OF CANCER 2003;88(4):593-8

Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope
Tobin G, Thunberg U, Johnson A, Eriksson I, Söderberg O, Karlsson K, et al
Blood 2003;101(12):4952-7

Cytogenetic abnormalities in childhood acute myeloid leukaemia: a Nordic series comprising all children enrolled in the NOPHO-93-AML trial between 1993 and 2001
Forestier E, Heim S, Blennow E, Borgström G, Holmgren G, Heinonen K, et al
British journal of haematology 2003;121(4):566-77

Ex vivo drug and irradiation sensitivities in hypermutated and unmutated forms of chronic lymphocytic leukemia cells
Kivekas I, Tobin G, Thunberg U, Vilpo L, Sundstrom C, Rosenquist R, et al
LEUKEMIA RESEARCH 2003;27(4):337-41

Genetic counselling for cancer and risk perception
Liden A, Berglund G, Hansson Mg, Rosenquist R, Sjoden Po, Nordin K
ACTA ONCOLOGICA 2003;42(7):726-34

More extensive genetic alterations in unmutated than in hypermutated cases of chronic lymphocytic leukemia
Karhu R, Tobin G, Thunberg U, Vilpo L, Sundstrom C, Knuutila S, et al
GENES CHROMOSOMES & CANCER 2003;37(4):417-20

Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma
Walsh Sh, Thorsélius M, Johnson A, Söderberg O, Jerkeman M, Björck E, et al
Blood 2003;101(10):4047-54

P2X7 polymorphism and chronic lymphocytic leukaemia - Reply
Thunberg U, Tobin G, Johnson A, Enblad G, Rosenquist R
LANCET 2003;361(9367):1478-1479

Surface antigen expression and correlation with variable heavy-chain gene mutation status in chronic lymphocytic leukemia
Vilpo J, Tobin G, Hulkkonen J, Hurme M, Thunberg U, Sundstrom C, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2003;70(1):53-9

A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma
Amini Rm, Berglund M, Rosenquist R, Von Heideman A, Lagercrantz S, Thunberg U, et al
Leukemia & lymphoma 2002;43(11):2179-89

Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization
Berglund M, Enblad G, Flordal E, Lui Wo, Backlin C, Thunberg U, et al
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2002;15(8):807-16

Clonal development of a blastoid mantle cell lymphoma studied with comparative genomic hybridization
Flordal E, Berglund M, Rosenquist R, Erlanson M, Enblad G, Roos G, et al
Cancer genetics and cytogenetics 2002;139(1):38-43

Coping style, psychological distress, risk perception, and satisfaction in subjects attending genetic counselling for hereditary cancer
Nordin K, Liden A, Hansson M, Rosenquist R, Berglund G
JOURNAL OF MEDICAL GENETICS 2002;39(9):689-94

IgV(H)3-21 gene usage in chronic lymphocytic leukemia
Tobin G, Thunberg U, Johnson A, Soderberg O, Botling J, Enblad G, et al
BLOOD 2002;100(3):1098-1099

Minimal residual disease quantification in childhood acute lymphoblastic leukemia by real-time polymerase chain reaction using the SYBR green dye
Li Ah, Forestier E, Rosenquist R, Roos G
EXPERIMENTAL HEMATOLOGY 2002;30(10):1170-7

Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia
Thunberg U, Tobin G, Johnson A, Söderberg O, Padyukov L, Hultdin M, et al
Lancet (London, England) 2002;360(9349):1935-9

Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
Tobin G, Thunberg U, Johnson A, Thorn I, Soderberg O, Hultdin M, et al
BLOOD 2002;99(6):2262-4

Somatic hypermutation and V-H gene usage in mantle cell lymphoma
Thorselius M, Walsh S, Eriksson I, Thunberg U, Johnson A, Backlin C, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2002;68(4):217-24

CD38 expression is a poor predictor for V-H gene mutational status and prognosis in chronic lymphocytic leukemia
Thunberg U, Johnson A, Roos G, Thom I, Tobin G, Sallstrom J, et al
BLOOD 2001;97(6):1892-4

Detailed clonality analysis of relapsing precursor B acute lymphoblastic leukemia: implications for minimal residual disease detection
Li Ah, Rosenquist R, Forestier E, Lindh J, Roos G
LEUKEMIA RESEARCH 2001;25(12):1033-45

Telomere length and telomerase activity in malignant lymphomas at diagnosis and relapse
Remes K, Norrback Kf, Rosenquist R, Mehle C, Lindh J, Roos G
BRITISH JOURNAL OF CANCER 2000;82(3):601-7

Clonal evolution as judged by immunoglobulin heavy chain gene rearrangements in relapsing precursor-B acute lymphoblastic leukemia
Rosenquist R, Thunberg U, Li Ah, Forestier E, Lonnerholm G, Lindh J, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 1999;63(3):171-9

Clonal rearrangements in childhood and adult precursor B acute lymphoblastic leukemia: a comparative polymerase chain reaction study using multiple sets of primers
Li Ah, Rosenquist R, Forestier E, Holmberg D, Lindh J, Lofvenberg E, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 1999;63(4):211-8

V-H gene family utilization in different B-cell lymphoma subgroups
Rosenquist R, Lindstrom A, Holmberg D, Lindh J, Roos G
EUROPEAN JOURNAL OF HAEMATOLOGY 1999;62(2):123-8

Alterations of the immunoglobulin heavy chain locus in progressive B-cell lymphomas
Rosenquist R, Linderholm B, Lindström A, Hagberg H, Sundström C, Roos G, et al
Acta oncologica (Stockholm, Sweden) 1998;37(2):193-200

Low rate of somatic hypermutations characterize progressive B-cell lymphomas
Rosenquist R, Lindstrom A, Li Ah, Roos G, Lindh J, Holmberg D
EUROPEAN JOURNAL OF HAEMATOLOGY 1998;61(3):164-72

Comparative analysis of detection systems for evaluation of PCR amplified immunoglobulin heavy-chain gene rearrangements
Thunberg U, Rosenquist R, Lindstrom A, Lindh J, Sundstrom C, Roos G, et al
DIAGNOSTIC MOLECULAR PATHOLOGY 1997;6(3):140-6

Immunoglobulin V-H gene replacements in a T-cell lymphoblastic lymphoma
Rosenquist R, Lindh J, Roos G, Holmberg D
MOLECULAR IMMUNOLOGY 1997;34(4):305-13

Visa alla publikationer