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Rachel Fisher

Professor

Besöksadress : CMM, L8:02; Karolinska Universitetessjukhuset, Solna, 171 76 Stockholm
Postadress : Institutionen för medicin, Solna (MedS), K2, Forskargrupp P Eriksson, Cmm, L8:03, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm
Leveransadress : Cmm, L8:02, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm

Publikationer

Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue
Cheung L, Fisher Rm, Kuzmina N, Li D, Li X, Werngren O, et al
The Journal of investigative dermatology 2016;136(3):640-8

Ceramides are associated with inflammatory processes in human mediastinal adipose tissue
Gertow J, Kjellqvist S, Ståhlman M, Cheung L, Gottfries J, Werngren O, et al
Nutrition, metabolism, and cardiovascular diseases : NMCD 2014;24(2):124-31

Stand up for health--avoiding sedentary behaviour might lengthen your telomeres: secondary outcomes from a physical activity RCT in older people
Sjögren P, Fisher R, Kallings L, Svenson U, Roos G, Hellénius Ml
British journal of sports medicine 2014;48(19):1407-9

Human mediastinal adipose tissue displays certain characteristics of brown fat
Cheung L, Gertow J, Werngren O, Folkersen L, Petrovic N, Nedergaard J, et al
Nutrition & diabetes 2013;3():e66-

MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response
Thulin P, Wei T, Werngren O, Cheung L, Fisher Rm, Grandér D, et al
International journal of molecular medicine 2013;31(5):1003-10

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
Kolak M, Gertow J, Westerbacka J, Summers Sa, Liska J, Franco-cereceda A, et al
Lipids in health and disease 2012;11():115-

Functional changes in adipose tissue in a randomised controlled trial of physical activity
Sjögren P, Sierra-johnson J, Kallings Lv, Cederholm T, Kolak M, Halldin M, et al
Lipids in health and disease 2012;11():80-

Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity
Zadravec D, Brolinson A, Fisher Rm, Carneheim C, Csikasz Ri, Bertrand-michel J, et al
FASEB JOURNAL 2010;24(11):4366-77

Systemic inflammation activates the nuclear factor-kappa B regulatory pathway in adipose tissue
Ekstrom M, Halle M, Bjessmo S, Liska J, Kolak M, Fisher R, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2010;299(2):E234-40

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
Kotronen A, Johansson Le, Johansson Lm, Roos C, Westerbacka J, Hamsten A, et al
DIABETOLOGIA 2009;52(6):1056-60

Beneficial effects of individualized physical activity on prescription on body composition and cardiometabolic risk factors: results from a randomized controlled trial
Kallings Lv, Johnson Js, Fisher Rm, De Faire U, Stahle A, Hemmingsson E, et al
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION 2009;16(1):80-4

Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population
Sierra-johnson J, Fisher Rm, Romero-corral A, Somers Vk, Lopez-jimenez F, Ohrvik J, et al
EUROPEAN HEART JOURNAL 2009;30(6):710-7

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
Kotronen A, Yki-jarvinen H, Aminoff A, Bergholm R, Pietilainen Kh, Westerbacka J, et al
EUROPEAN JOURNAL OF ENDOCRINOLOGY 2009;160(4):593-602

IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome
Sierra-johnson J, Romero-corral A, Somers Vk, Lopez-jimenez F, Malarstig A, Brismar K, et al
CLINICAL SCIENCE 2009;116(5-6):507-12

Autoantibodies against modified apolipoprotein B-100 in relation to low-density lipoprotein size and the metabolic syndrome in otherwise healthy men
Sjogren P, Fredrikson Gn, Rosell M, De Faire U, Hamsten A, Nilsson J, et al
METABOLISM-CLINICAL AND EXPERIMENTAL 2008;57(3):362-6

Eating meals irregularly: A novel environmental risk factor for the metabolic syndrome
Sierra-johnson J, Unden Al, Linestrand M, Rosell M, Sjogren P, Kolak M, et al
OBESITY 2008;16(6):1302-7

Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance
Sjogren P, Sierra-johnson J, Gertow K, Rosell M, Vessby B, De Faire U, et al
DIABETOLOGIA 2008;51(2):328-35

Gene expression in human NAFLD
Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, et al
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2008;294(5):G1281-7

High plasma concentrations of autoantibodies against native peptide 210 of apoB-100 are related to less coronary atherosclerosis and lower risk of myocardial infarction
Sjogren P, Fredrikson Gn, Samnegard A, Ericsson Cg, Ohrvik J, Fisher Rm, et al
EUROPEAN HEART JOURNAL 2008;29(18):2218-26

Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation
Krapivner S, Popov S, Chernogubova E, Hellenius Ml, Fisher Rm, Hamsten A, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2008;93(5):1995-2001

Insulin regulation of MCP-1 in human adipose tissue of obese and lean women
Westerbacka J, Corner A, Kolak M, Makkonen J, Turpeinen U, Hamsten A, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2008;294(5):E841-5

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity
Kolak M, Westerbacka J, Velagapudi Vr, Wagsater D, Yetukuri L, Makkonen J, et al
DIABETES 2007;56(8):1960-8

ApoB/apoA-1 ratio: an independent predictor of insulin resistance in US non-diabetic subjects
Sierra-johnson J, Romero-corral A, Somers Vk, Lopez-jimenez F, Walldius G, Hamsten A, et al
EUROPEAN HEART JOURNAL 2007;28(21):2637-43

Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes
Kolak M, Yki-jarvinen H, Kannisto K, Tiikkainen M, Hamsten A, Eriksson P, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2007;92(2):720-4

Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Siren J, Hamsten A, et al
DIABETES 2007;56(11):2759-65

Increased expression of the macrophage markers and of 11 beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity
Makkonen J, Westerbacka J, Kolak M, Sutinen J, Corner A, Hamsten A, et al
INTERNATIONAL JOURNAL OF OBESITY 2007;31(10):1617-25

Markers of endothelial activity are related to components of the metabolic syndrome, but not to circulating concentrations of the advanced glycation end-product N epsilon-carboxymethyl-lysine in healthy Swedish men
Sjogren P, Basta G, De Caterina R, Rosell M, Basu S, Silveira A, et al
ATHEROSCLEROSIS 2007;195(2):E168-E175

Markers of endothelial activity are related to components of the metabolic syndrome, but not to circulating concentrations of the advanced glycation end-product N epsilon-carboxymethyl-lysine in healthy Swedish men
Sjögren P, Basta G, De Caterina R, Rosell M, Basu S, Silveira A, et al
Atherosclerosis 2007;195(2):e168-75

Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects
Westerbacka J, Corner A, Kannisto K, Kolak M, Makkonen J, Korsheninnikova E, et al
DIABETOLOGIA 2006;49(1):132-40

Fatty acid handling protein expression in adipose tissue, fatty acid composition of adipose tissue and serum, and markers of insulin resistance
Gertow K, Rosell M, Sjogren P, Eriksson P, Vessby B, De Faire U, et al
EUROPEAN JOURNAL OF CLINICAL NUTRITION 2006;60(12):1406-13

Oxidized LDL and the metabolic syndrome - In response
Sjogren P, Hamsten A, Hellenius Ml, Fisher Rm
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2006;26(4):E31-E32

Fatty acid transport proteins and insulin resistance
Fisher Rm, Gertow K
CURRENT OPINION IN LIPIDOLOGY 2005;16(2):173-8

Measures of oxidized low-density lipoprotein and oxidative stress are not related and not elevated in otherwise healthy men with the metabolic syndrome
Sjogren P, Basu S, Rosell M, Silveira A, De Faire U, Vessby B, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(12):2580-6

Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
Sutinen J, Kannisto K, Korsheninnikova E, Fisher Rm, Ehrenborg E, Nyman T, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;286(6):E941-9

Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance
Gertow K, Pietilainen Kh, Yki-jarvinen H, Kaprio J, Rissanen A, Eriksson P, et al
DIABETOLOGIA 2004;47(6):1118-25

Female-predominant expression of fatty acid translocase/CD36 in rat and human liver
Stahlberg N, Rico-bautista E, Fisher Rm, Wu Xx, Cheung L, Flores-morales A, et al
ENDOCRINOLOGY 2004;145(4):1972-9

Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome
Gertow K, Bellanda M, Eriksson P, Boquist S, Hamsten A, Sunnerhagen M, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2004;89(1):392-9

Milk-derived fatty acids are associated with a more favorable LDL particle size distribution in healthy men
Sjogren P, Rosell M, Skoglund-andersson C, Zdravkovic S, Vessby B, De Faire U, et al
JOURNAL OF NUTRITION 2004;134(7):1729-35

A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution
Gertow K, Skoglund-andersson C, Eriksson P, Boquist S, Orth-gomer K, Schenck-gustafsson K, et al
ATHEROSCLEROSIS 2003;167(2):265-73

Enhanced bridging function and augmented monocyte adhesion by lipoprotein lipase N9: insights into increased risk of coronary artery disease in N9 carriers
Fisher Rm, Benhizia F, Schreiber R, Makoveichuk E, Putt W, Al-haideri M, et al
ATHEROSCLEROSIS 2003;166(2):243-51

Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy
Kannisto K, Sutinen J, Korsheninnikova E, Fisher Rm, Ehrenborg E, Gertow K, et al
AIDS 2003;17(12):1753-62

Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
Skoglund-andersson C, Ehrenborg E, Fisher Rm, Olivercrona G, Hamsten A, Karpe F
ATHEROSCLEROSIS 2003;167(2):311-7

Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy
Yki-jarvinen H, Sutinen J, Silveira A, Korsheninnikova E, Fisher Rm, Kannisto K, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(4):688-94

Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue
Fisher Rm, Hoffstedt J, Hotamisligil Gs, Thorne A, Ryden M
INTERNATIONAL JOURNAL OF OBESITY 2002;26(10):1379-85

Fatty acid binding protein expression in different human adipose tissue depots in relation to rates of lipolysis and insulin concentration in obese individuals
Fisher Rm, Thorne A, Hamsten A, Arner P
MOLECULAR AND CELLULAR BIOCHEMISTRY 2002;239(1-2):95-100

Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals
Fisher Rm, Eriksson P, Hoffstedt J, Hotamisligil Gs, Thorne A, Ryden M, et al
DIABETOLOGIA 2001;44(10):1268-73

Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men
Waterworth Dm, Talmud Pj, Bujac Sr, Fisher Rm, Miller Gj, Humphries Se
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2000;20(12):2663-9

Genetic factors associated with response of LDL subfractions to change in the nature of dietary fat
Wallace Aj, Humphries Se, Fisher Rm, Mann Ji, Chisholm A, Sutherland Whf
ATHEROSCLEROSIS 2000;149(2):387-94

Effect of variation in the apo A-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II
Ears Grp, Fisher Rm, Burke H, Nicaud V, Ehnholm C, Humphries Se
JOURNAL OF LIPID RESEARCH 1999;40(2):287-94

Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis
Fisher Rm, Humphries Se, Talmud Pj
ATHEROSCLEROSIS 1997;135(2):145-59

Determinants of postprandial lipemia in men with coronary artery disease and low levels of HDL cholesterol
Syvanne M, Talmud Pj, Humphries Se, Fisher Rm, Rosseneu M, Hilden H, et al
JOURNAL OF LIPID RESEARCH 1997;38(7):1463-72

Lipoprotein lipase variants D9N and N291S, are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations - Studies in the fasting and postprandial states: The European atherosclerosis research studies
Gerdes C, Fisher Rm, Nicaud V, Boer J, Humphries Se, Talmud Pj, et al
CIRCULATION 1997;96(3):733-40

Very-low-density lipoprotein subfraction composition and metabolism by adipose tissue
Fisher Rm, Miles Jm, Kottke Ba, Frayn Kn, Coppack Sw
METABOLISM-CLINICAL AND EXPERIMENTAL 1997;46(6):605-10

Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM study
Mailly F, Fisher Rm, Nicaud V, Luong La, Evans Ae, Marquesvidal P, et al
ATHEROSCLEROSIS 1996;122(1):21-8

Carbohydrate metabolism in insulin resistance: Glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal
Coppack Sw, Fisher Rm, Humphreys Sm, Clark Ml, Pointon Jj, Frayn Kn
CLINICAL SCIENCE 1996;90(5):409-15

Lipoprotein lipase gene mutations D9N and N291S in four pedigrees with familial combined hyperlipidaemia
Debruin Twa, Mailly F, Vanbarlingen Hhjj, Fisher R, Cabezas Mc, Talmud P, et al
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 1996;26(8):631-9

Periprandial systemic and regional lipase activity in normal humans
Coppack Sw, Yost Tj, Fisher Rm, Eckel Rh, Miles Jm
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1996;270(4):E718-22

HUMAN TRIACYLGLYCEROL-RICH LIPOPROTEIN SUBFRACTIONS AS SUBSTRATES FOR LIPOPROTEIN-LIPASE
Fisher Rm, Coppack Sw, Humphreys Sm, Gibbons Gf, Frayn Kn
CLINICA CHIMICA ACTA 1995;236(1):7-17

IMPAIRED POSTPRANDIAL CLEARANCE OF TRIACYLGLYCEROL-RICH LIPOPROTEINS IN ADIPOSE-TISSUE IN OBESE SUBJECTS
Potts Jl, Coppack Sw, Fisher Rm, Humphreys Sm, Gibbons Gf, Frayn Kn
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1995;268(4):E588-94

INTERACTION OF THE LIPOPROTEIN-LIPASE ASPARAGINE-291-]SERINE MUTATION WITH BODY-MASS INDEX DETERMINES ELEVATED PLASMA TRIACYLGLYCEROL CONCENTRATIONS - A STUDY IN HYPERLIPIDEMIC SUBJECTS, MYOCARDIAL-INFARCTION SURVIVORS, AND HEALTHY-ADULTS
Fisher Rm, Mailly F, Peacock Re, Hamsten A, Seed M, Yudkin Js, et al
JOURNAL OF LIPID RESEARCH 1995;36(10):2104-12

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