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Pontus Aspenström

Professor

Besöksadress : Nobels Väg 16 171 77 Stockholm
Postadress : Institutionen för mikrobiologi, tumör- och cellbiologi (MTC), C1, Pontus Aspenström grupp, Box 280 171 77 Stockholm

Publikationer

Resolution, target density and labeling effects in colocalization studies - suppression of false positives by nanoscopy and modified algorithms
Xu L, Rönnlund D, Aspenström P, Braun Lj, Gad Ak, Widengren J
The FEBS journal 2016;283(5):882-98

Mitotic redistribution of the mitochondrial network by Miro and Cenp-F
Kanfer G, Courthéoux T, Peterka M, Meier S, Soste M, Melnik A, et al
Nature communications 2015;6():8015-

RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane
Blom M, Reis K, Nehru V, Blom H, Gad Ak, Aspenström P
Experimental cell research 2015;333(2):208-19

Analysis of Rho GTPase-induced localization of nanoscale adhesions using fluorescence nanoscopy
Gad Ak, Rönnlund D, Widengren J, Aspenström P
Methods in molecular biology (Clifton, N.J.) 2014;1120():339-57

Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking
Aspenstrom P
BIOLOGICAL CHEMISTRY 2014;395(5):477-84

BAR domain proteins regulate Rho GTPase signaling
Aspenström P
Small GTPases 2014;5(2):7-

Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness
Rathje Ls, Nordgren N, Pettersson T, Rönnlund D, Widengren J, Aspenström P, et al
Proceedings of the National Academy of Sciences of the United States of America 2014;111(4):1515-20

Estrogen supports urothelial defense mechanisms
Lüthje P, Brauner H, Ramos Nl, Ovregaard A, Gläser R, Hirschberg Al, et al
Science translational medicine 2013;5(190):190ra80-

Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics
Nehru V, Almeida Fn, Aspenström P
Biochemical and biophysical research communications 2013;433(2):163-9

Passaging techniques and ROCK inhibitor exert reversible effects on morphology and pluripotency marker gene expression of human embryonic stem cell lines
Holm F, Nikdin H, Kjartansdóttir Kr, Gaudenzi G, Fried K, Aspenström P, et al
Stem cells and development 2013;22(13):1883-92

RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor
Nehru V, Voytyuk O, Lennartsson J, Aspenström P
Traffic (Copenhagen, Denmark) 2013;14(12):1242-54

RhoD Binds the Rab5 Effector Rabankyrin-5 and has a Role in Trafficking of the Platelet-derived Growth Factor Receptor
Nehru V, Voytyuk O, Lennartsson J, Aspenstrom P
TRAFFIC 2013;14(12):1242-1254

SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins
Risse Sl, Vaz B, Burton Mf, Aspenstrom P, Piekorz Rp, Brunsveld L, et al
BIOLOGICAL CHEMISTRY 2013;394(3):421-32

Spatial organization of proteins in metastasizing cells
Rönnlund D, Gad Ak, Blom H, Aspenström P, Widengren J
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2013;83(9):855-65

RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules
Gad Ak, Nehru V, Ruusala A, Aspenström P
Molecular biology of the cell 2012;23(24):4807-19

Rho GTPases link cellular contractile force to the density and distribution of nanoscale adhesions
Gad Akb, Ronnlund D, Spaar A, Savchenko Aa, Petranyi G, Blom H, et al
FASEB JOURNAL 2012;26(6):2374-82

ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion
Naji L, Pacholsky D, Aspenstrom P
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2011;409(1):96-102

Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases
Sandin A, Dagnell M, Gonon A, Pernow J, Stangl V, Aspenstrom P, et al
CELLULAR SIGNALLING 2011;23(5):820-6

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
Conrad M, Sandin A, Forster H, Seiler A, Frijhoff J, Dagnell M, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(36):15774-9

Characterisation of the role of Vrp1 in cell fusion during the development of visceral muscle of Drosophila melanogaster
Eriksson T, Varshney G, Aspenstrom P, Palmer Rh
BMC DEVELOPMENTAL BIOLOGY 2010;:86-

Formin-binding proteins: Modulators of formin-dependent actin polymerization
Aspenstrom P
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2010;1803(2):174-82

Members of the CIP4 family of proteins participate in the regulation of platelet-derived growth factor receptor-beta-dependent actin reorganization and migration
Toguchi M, Richnau N, Ruusala A, Aspenstrom P
BIOLOGY OF THE CELL 2010;102(4):215-30

Novel role of pleckstrin homology domain of the Bcr-Abl protein: Analysis of protein-protein and protein-lipid interactions
Miroshnychenko D, Dubrovska A, Maliuta S, Telegeev G, Aspenstrom P
EXPERIMENTAL CELL RESEARCH 2010;316(4):530-42

Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking
Gad Akb, Aspenstrom P
CELLULAR SIGNALLING 2010;22(2):183-9

Second international conference on F-BAR proteins: October 1-3, 2009 at Rånäs Slott, Sweden
Munn Al, Aspenström P
Cell adhesion & migration 2010;4(1):81-93

HUMMR, a hypoxia- and HIF-1 alpha-inducible protein, alters mitochondrial distribution and transport
Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff Hj, Rempe Da
JOURNAL OF CELL BIOLOGY 2009;185(6):1065-81

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses
Macaskill Af, Rinholm Je, Twelvetrees Ae, Arancibia-carcamo Il, Muir J, Fransson A, et al
NEURON 2009;61(4):541-55

ROLES OF F-BAR/PCH PROTEINS IN THE REGULATION OF MEMBRANE DYNAMICS AND ACTIN REORGANIZATION
Aspenstrom P
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 272 2009;:1-31

The Miro GTPases: At the heart of the mitochondrial transport machinery
Reis K, Fransson A, Aspenstrom P
FEBS LETTERS 2009;583(9):1391-8

WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics
Viklund Im, Aspenstrom P, Meas-yedid V, Zhang B, Kopec J, Agren D, et al
EXPERIMENTAL CELL RESEARCH 2009;315(6):1040-52

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase
Saotome M, Safiulina D, Szabadkai G, Das S, Fransson A, Aspenstrom P, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(52):20728-33

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes - Evidence for an autoregulatory mechanism
Berthold J, Schenkova K, Ramos S, Miura Y, Furukawa M, Aspenstrom P, et al
EXPERIMENTAL CELL RESEARCH 2008;314(19):3453-65

Nck Adapters Are Involved in the Formation of Dorsal Ruffles, Cell Migration, and Rho Signaling Downstream of the Platelet-derived Growth Factor beta Receptor
Ruusala A, Pawson T, Heldin Ch, Aspenstrom P
JOURNAL OF BIOLOGICAL CHEMISTRY 2008;283(44):30034-44

The atypical rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics
Ruusala A, Aspenstrom P
MOLECULAR AND CELLULAR BIOLOGY 2008;28(5):1802-14

Angiomotin regulates endothelial cell migration during embryonic angiogenesis
Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, et al
GENES & DEVELOPMENT 2007;21(16):2055-68

Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes
Aspenstrom-fagerlund B, Ring L, Aspenstrom P, Tallkvist J, Ilback Ng, Glynn Aw
TOXICOLOGY 2007;237(1-3):12-23

Taking Rho GTPases to the next level: The cellular functions of atypical Rho GTPases
Aspenstrom P, Ruusala A, Pacholsky D
EXPERIMENTAL CELL RESEARCH 2007;313(17):3673-9

Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton
Aspenstrom P, Fransson A, Richnau N
TRENDS IN BIOCHEMICAL SCIENCES 2006;31(12):670-9

The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking
Fransson A, Ruusala A, Aspenstom P
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2006;344(2):500-10

The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics
Aspenstrom P, Richnau N, Johansson As
EXPERIMENTAL CELL RESEARCH 2006;312(12):2180-94

Interaction between smad7 and beta-catenin: Importance for transforming growth factor beta-induced apoptosis
Edlund S, Lee Sy, Grimsby S, Zhang Sh, Aspenstrom P, Heldin Ch, et al
MOLECULAR AND CELLULAR BIOLOGY 2005;25(4):1475-88

The verprolin family of proteins: Regulators of cell morphogenesis and endocytosis
Aspenstrom P
FEBS LETTERS 2005;579(24):5253-9

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
Chiara F, Goumans Mj, Forsberg H, Ahgren A, Rasola A, Aspenstrom P, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(41):42516-27

Human CNKI acts as a scaffold protein, linking Rho and Ras signal transduction pathways
Jaffe Ab, Aspenstrom P, Hall A
MOLECULAR AND CELLULAR BIOLOGY 2004;24(4):1736-46

Integration of signalling pathways regulated by small GTPases and calcium
Aspenstrom P
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2004;1742(1-3):51-8

Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology
Ruusala A, Aspenstrom P
FEBS LETTERS 2004;572(1-3):159-66

Rho GTPases have diverse effects on the organization of the actin filament system
Aspenstrom P, Fransson A, Saras J
BIOCHEMICAL JOURNAL 2004;:327-37

RICH-1 has a BIN/Amphiphysin/Rvsp domain responsible for binding to membrane lipids and tubulation of liposomes
Richnau N, Fransson A, Farsad K, Aspenstrom P
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2004;320(3):1034-42

Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42
Edlund S, Landstrom M, Heldin Ch, Aspenstrom P
JOURNAL OF CELL SCIENCE 2004;117(9):1835-47

The mammalian verprolin homologue WIRE participates in receptor-mediated endocytosis and regulation of the actin filament system by distinct mechanisms
Aspenstrom P
EXPERIMENTAL CELL RESEARCH 2004;298(2):485-98

Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons
Lundstrom A, Gallio M, Englund C, Steneberg P, Hemphala J, Aspenstrom P, et al
GENES & DEVELOPMENT 2004;18(17):2161-71

Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects
Saras J, Wollberg P, Aspenstrom P
EXPERIMENTAL CELL RESEARCH 2004;299(2):356-69

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis
Fransson A, Ruusala A, Aspenstrom P
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(8):6495-502

Down-regulation of Rac activity during beta(2) integrin-mediated adhesion of human neutrophils
Dib K, Melander F, Axelsson L, Dagher Mc, Aspenstrom P, Andersson T
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(26):24181-8

Effect of transforming growth factor-beta on calcium homeostasis in prostate carcinoma cells
Gizatullina Zz, Grapengiesser E, Shabalina Ig, Nedergaard J, Heldin Ch, Aspenstrom P
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;304(4):643-9

Transforming growth factor-beta 1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
Edlund S, Bu Sh, Schuster N, Aspenstrom P, Heuchel R, Heldin Ne, et al
MOLECULAR BIOLOGY OF THE CELL 2003;14(2):529-44

Analysis of the cellular function of mammalian CNK
Jaffe Ab, Aspenstrom P, Hall A
MOLECULAR BIOLOGY OF THE CELL 2002;:154A-154A

The WASP-Binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor
Aspenstrom P
EXPERIMENTAL CELL RESEARCH 2002;279(1):21-33

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
Edlund S, Landstrom M, Heldin Ch, Aspenstrom P
MOLECULAR BIOLOGY OF THE CELL 2002;13(3):902-14

Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes
Westerberg L, Greicius G, Snapper Sb, Aspenstrom P, Severinson E
BLOOD 2001;98(4):1086-94

RICH, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1
Richnau N, Aspenstrom P
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(37):35060-70

Characterization of RICH, a novel RhoGAP interacting with CIP4
Richnau Ne, Aspenstrom P
MOLECULAR BIOLOGY OF THE CELL 2000;:167A-167A

Cytoskeletal control in TGF beta signalling
Edlund Smm, Aspenstrom P
MOLECULAR BIOLOGY OF THE CELL 2000;:169A-169A

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1
Johansson As, Driessens M, Aspenstrom P
JOURNAL OF CELL SCIENCE 2000;113(18):3267-75

Effectors for the Rho GTPases
Aspenstrom P
CURRENT OPINION IN CELL BIOLOGY 1999;11(1):95-102

The Rho GTPases have multiple effects on the actin cytoskeleton
Aspenstrom P
EXPERIMENTAL CELL RESEARCH 1999;246(1):20-5

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
Nagata K, Puls A, Futter G, Aspenstrom P, Schaefer E, Nakata T, et al
EMBO JOURNAL 1998;17(1):149-58

Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42
Guinamard R, Aspenstrom P, Fougereau M, Chavrier P, Guillemot Jc
FEBS LETTERS 1998;434(3):431-6

A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
Aspenstrom P
CURRENT BIOLOGY 1997;7(7):479-87

A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1
Saras J, Franzen P, Aspenstrom P, Hellman U, Gonez Lj, Heldin Ch
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(39):24333-8

Isolation and characterisation of proteins that bind to the small GTPase cdc42.
Aspenstrom P
MOLECULAR BIOLOGY OF THE CELL 1996;:1985-1985

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65(PAK) and the JNK/SAPK MAP kinase cascade
Lamarche N, Tapon N, Stowers L, Burbelo Pd, Aspenstrom P, Bridges T, et al
CELL 1996;87(3):519-29

Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
Aspenstrom P, Lindberg U, Hall A
CURRENT BIOLOGY 1996;6(1):70-5

YEAST 2-HYBRID SYSTEM TO DETECT PROTEIN-PROTEIN INTERACTIONS WITH RHO GTPASES
Aspenstrom P, Olson Mf
SMALL GTPASES AND THEIR REGULATORS, PT B 1995;:228-41

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