Paolo Parini

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Paolo Parini är professor i klinisk kemi och forskar om kardiometabola sjukdomar på molekylär nivå. Han är också koordinator för Cardio Metabolic Unit (CMU) vid KI Campus Flemingsberg.

Artiklar

Article: EUROPEAN HEART JOURNAL OPEN. 2024;4(2):oeae010

Relation among hypertriglyceridaemia, cardiometabolic disease, and hereditary factors-design and rationale of the Stockholm hyperTRIglyceridaemia REGister study.

Andersson DP; Littmann K; Kindborg G; Eklund D; Sejersen K; Yan J; Eriksson Hogling D; Parini P; Brinck J
Article: EPMA JOURNAL. 2024;15(1):1-23

The paradigm change from reactive medical services to 3PM in ischemic stroke: a holistic approach utilising tear fluid multi-omics, mitochondria as a vital biosensor and AI-based multi-professional data interpretation.

Golubnitschaja O; Polivka J; Potuznik P; Pesta M; Stetkarova I; Mazurakova A; Lackova L; Kubatka P; Kropp M; Thumann G; Erb C; Fröhlich H; Wang W; Baban B; Kapalla M; Shapira N; Richter K; Karabatsiakis A; Smokovski I; Schmeel LC; Gkika E; Paul F; Parini P; Polivka J
Article: SCIENCE ADVANCES. 2023;9(20):eadf2982

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior.

Delbès A-S; Quiñones M; Gobet C; Castel J; Denis RGP; Berthelet J; Weger BD; Challet E; Charpagne A; Metairon S; Piccand J; Kraus M; Rohde BH; Bial J; Wilson EM; Vedin L-L; Minniti ME; Pedrelli M; Parini P; Gachon F; Luquet S
Article: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2022;23(5):919-930

Metabolic actions of the growth hormone-insulin growth factor-1 axis and its interaction with the central nervous system.

Al-Massadi O; Parini P; Fernø J; Luquet S; Quiñones M
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):296-307

Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice.

Pramfalk C; Ahmed O; Pedrelli M; Minniti ME; Luquet S; Denis RG; Olin M; Härdfeldt J; Vedin L-L; Steffensen KR; Rydén M; Hodson L; Eriksson M; Parini P
Article: JOURNAL OF LIPID RESEARCH. 2022;63(7):100232

Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.

Pavanello C; Ossoli A; Strazzella A; Risè P; Veglia F; Lhomme M; Parini P; Calabresi L
Article: ATHEROSCLEROSIS. 2022;349:175-182

Plasma Lipoprotein(a) measured in routine clinical care and the association with incident calcified aortic valve stenosis during a 14-year observational period.

Wodaje T; Littmann K; Häbel H; Bottai M; Bäck M; Parini P; Brinck J
Article: BIOFACTORS. 2022;48(3):707-717

HDL-mediated reduction of cholesterol content inhibits the proliferation of prostate cancer cells induced by LDL: Role of ABCA1 and proteasome inhibition.

Ossoli A; Giorgio E; Cetti F; Ruscica M; Rabacchi C; Tarugi P; Parini P; Pedrelli M; Gomaraschi M
Article: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY. 2022;28(18):2038-2047

Plasma lipoprotein(a) measured in the routine clinical care is associated to atherosclerotic cardiovascular disease during a 14-year follow-up.

Littmann K; Hagström E; Häbel H; Bottai M; Eriksson M; Parini P; Brinck J
Article: ATHEROSCLEROSIS. 2021;338:55-63

Lipid-lowering and anti-thrombotic therapy in patients with peripheral arterial disease: European Atherosclerosis Society/European Society of Vascular Medicine Joint Statement.

Belch JJF; Brodmann M; Baumgartner I; Binder CJ; Casula M; Heiss C; Kahan T; Parini P; Poredos P; Catapano AL; Tokgözoğlu L
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):9969

Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice.

Schiffrin M; Winkler C; Quignodon L; Naldi A; Trötzmüller M; Köfeler H; Henry H; Parini P; Desvergne B; Gilardi F
Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2021;321(4):G243-G251

Liver X receptor β regulates bile volume and the expression of aquaporins and cystic fibrosis transmembrane conductance regulator in the gallbladder.

Sweed N; Kim H-J; Hultenby K; Barros R; Parini P; Sancisi V; Strandvik B; Gabbi C
Article: SOCIAL SCIENCE & MEDICINE. 2021;282:114145

It takes two to dance the VBHC tango: A multiple case study of the adoption of value-based strategies in Sweden and Brazil.

Ramos P; Savage C; Thor J; Atun R; Carlsson KS; Makdisse M; Neto MC; Klajner S; Parini P; Mazzocato P
Article: JOURNAL OF LIPID RESEARCH. 2021;62:100065

Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos).

Pedrelli M; Parini P; Kindberg J; Arnemo JM; Bjorkhem I; Aasa U; Westerståhl M; Walentinsson A; Pavanello C; Turri M; Calabresi L; Öörni K; Camejo G; Fröbert O; Hurt-Camejo E
Article: JCI INSIGHT. 2020;5(24):140483

Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.

Cansby E; Caputo M; Gao L; Kulkarni NM; Nerstedt A; Ståhlman M; Borén J; Porosk R; Soomets U; Pedrelli M; Parini P; Marschall H-U; Nyström J; Howell BW; Mahlapuu M
Article: DIABETES CARE. 2020;43(8):1851-1858

The Association of Lipoprotein(a) Plasma Levels With Prevalence of Cardiovascular Disease and Metabolic Control Status in Patients With Type 1 Diabetes.

Littmann K; Wodaje T; Alvarsson M; Bottai M; Eriksson M; Parini P; Brinck J
Article: HEPATOLOGY. 2020;72(2):656-670

Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.

Minniti ME; Pedrelli M; Vedin L-L; Delbès A-S; Denis RGP; Öörni K; Sala C; Pirazzini C; Thiagarajan D; Nurmi HJ; Grompe M; Mills K; Garagnani P; Ellis ECS; Strom SC; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2020;1865(6):158659

Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism.

Pramfalk C; Jakobsson T; Verzijl CRC; Minniti ME; Obensa C; Ripamonti F; Olin M; Pedrelli M; Eriksson M; Parini P
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;499:110604

Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity.

Gnocchi D; Ellis ECS; Johansson H; Eriksson M; Bruscalupi G; Steffensen KR; Parini P
Article: JOURNAL OF CLINICAL LIPIDOLOGY. 2020;14(1):77-87

Impact of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab on the postprandial responses of triglyceride-rich lipoproteins in type II diabetic subjects.

Taskinen M-R; Björnson E; Andersson L; Kahri J; Porthan K; Matikainen N; Söderlund S; Pietiläinen K; Hakkarainen A; Lundbom N; Nilsson R; Ståhlman M; Adiels M; Parini P; Packard C; Borén J
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(6):660-675

Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy.

Saliba-Gustafsson P; Pedrelli M; Gertow K; Werngren O; Janas V; Pourteymour S; Baldassarre D; Tremoli E; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Pirro M; de Faire U; Humphries SE; Hamsten A; IMPROVE Study Group; Gonçalves I; Orho-Melander M; Franco-Cereceda A; Borén J; Eriksson P; Magné J; Parini P; Ehrenborg E
Article: DIGESTIVE AND LIVER DISEASE. 2019;51(7):1016-1022

Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice.

Ahmed O; Pramfalk C; Pedrelli M; Olin M; Steffensen KR; Eriksson M; Parini P
Article: NATURE COMMUNICATIONS. 2019;10(1):1684

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.

Liang N; Damdimopoulos A; Goñi S; Huang Z; Vedin L-L; Jakobsson T; Giudici M; Ahmed O; Pedrelli M; Barilla S; Alzaid F; Mendoza A; Schröder T; Kuiper R; Parini P; Hollenberg A; Lefebvre P; Francque S; Van Gaal L; Staels B; Venteclef N; Treuter E; Fan R
Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):11

Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse.

González-Granillo M; Helguero LA; Alves E; Archer A; Savva C; Pedrelli M; Ahmed O; Li X; Domingues MR; Parini P; Gustafsson J-Å; Korach-André M
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2019;479:147-158

ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis.

González-Granillo M; Savva C; Li X; Fitch M; Pedrelli M; Hellerstein M; Parini P; Korach-André M; Gustafsson J-Å
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2018;7(24):e009876

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients.

Ahmed O; Littmann K; Gustafsson U; Pramfalk C; Öörni K; Larsson L; Minniti ME; Sahlin S; Camejo G; Parini P; Eriksson M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):1723-1737

STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia.

Cansby E; Magnusson E; Nuñez-Durán E; Amrutkar M; Pedrelli M; Parini P; Hoffmann J; Ståhlman M; Howell BW; Marschall H-U; Borén J; Mahlapuu M
Article: ATHEROSCLEROSIS. 2018;275:246-255

Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption.

Parini P; Melhuish TA; Wotton D; Larsson L; Ahmed O; Eriksson M; Pramfalk C
Article: DRUGS. 2017;77(15):1613-1621

Potential Role of Thyroid Receptor β Agonists in the Treatment of Hyperlipidemia.

Jakobsson T; Vedin L-L; Parini P
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2017;47(2):137-148

Does statins promote vascular calcification in chronic kidney disease?

Chen Z; Qureshi AR; Parini P; Hurt-Camejo E; Ripsweden J; Brismar TB; Barany P; Jaminon AM; Schurgers LJ; Heimbürger O; Lindholm B; Stenvinkel P
Article: JOURNAL OF LIPID RESEARCH. 2017;58(2):420-432

The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.

Ferguson D; Zhang J; Davis MA; Helsley RN; Vedin L-L; Lee RG; Crooke RM; Graham MJ; Allende DS; Parini P; Brown JM
Article: SCIENTIFIC REPORTS. 2016;6:36937

Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.

Duszka K; Picard A; Ellero-Simatos S; Chen J; Defernez M; Paramalingam E; Pigram A; Vanoaica L; Canlet C; Parini P; Narbad A; Guillou H; Thorens B; Wahli W
Article: JOURNAL OF CONTROLLED RELEASE. 2016;241:57-67

Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells.

Moles E; Moll K; Ch'ng J-H; Parini P; Wahlgren M; Fernàndez-Busquets X
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2016;118(6):499-502

Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations.

Björkhem-Bergman L; Nylén H; Eriksson M; Parini P; Diczfalusy U
Article: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2016;310(11):G952-G961

Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo.

Li M; Ellis E; Johansson H; Nowak G; Isaksson B; Gnocchi D; Parini P; Axelsson J
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(5):787-791

Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report.

Apro J; Tietge UJF; Dikkers A; Parini P; Angelin B; Rudling M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1861(1):51-59

Culturing of HepG2 cells with human serum improve their functionality and suitability in studies of lipid metabolism.

Pramfalk C; Larsson L; Härdfeldt J; Eriksson M; Parini P
Article: JOURNAL OF LIPID RESEARCH. 2015;56(8):1633-1639

Levels of atherogenic lipoproteins are unexpectedly reduced in interstitial fluid from type 2 diabetes patients.

Apro J; Parini P; Broijersén A; Angelin B; Rudling M
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2015;82:186-193

RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form.

Rocha CSJ; Wiklander OPB; Larsson L; Moreno PMD; Parini P; Lundin KE; Smith CIE
Article: CELL REPORTS. 2015;10(3):326-338

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

Warrier M; Shih DM; Burrows AC; Ferguson D; Gromovsky AD; Brown AL; Marshall S; McDaniel A; Schugar RC; Wang Z; Sacks J; Rong X; Vallim TDA; Chou J; Ivanova PT; Myers DS; Brown HA; Lee RG; Crooke RM; Graham MJ; Liu X; Parini P; Tontonoz P; Lusis AJ; Hazen SL; Temel RE; Brown JM
Article: HEPATOLOGY. 2015;61(1):161-170

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation.

Degirolamo C; Modica S; Vacca M; Di Tullio G; Morgano A; D'Orazio A; Kannisto K; Parini P; Moschetta A
Article: ATHEROSCLEROSIS. 2014;237(2):544-554

The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice.

Kannisto K; Rehnmark S; Slätis K; Webb P; Larsson L; Gåfvels M; Eggertsen G; Parini P
Article: HEPATOLOGY. 2014;59(5):1791-1802

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice.

Han S-I; Komatsu Y; Murayama A; Steffensen KR; Nakagawa Y; Nakajima Y; Suzuki M; Oie S; Parini P; Vedin L-L; Kishimoto H; Shimano H; Gustafsson J-Å; Yanagisawa J
Article: JOURNAL OF LIPID RESEARCH. 2014;55(4):709-717

TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.

Pramfalk C; Melhuish TA; Wotton D; Jiang Z-Y; Eriksson M; Parini P
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(5):E494-E502

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis.

Archer A; Laurencikiene J; Ahmed O; Steffensen KR; Parini P; Gustafsson J-Å; Korach-André M
Article: PLOS ONE. 2014;9(4):e93552

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice.

Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Graham M; Ossoli A; Larsson L; Calabresi L; Gustafsson J-Å; Steffensen KR; Eriksson M; Parini P
Article: PLOS ONE. 2014;9(11):e113619

Cholesterol, oxysterol, triglyceride, and coenzyme Q homeostasis in ALS. Evidence against the hypothesis that elevated 27-hydroxycholesterol is a pathogenic factor.

Wuolikainen A; Acimovic J; Lövgren-Sandblom A; Parini P; Andersen PM; Björkhem I
Article: DRUG METABOLISM AND DISPOSITION. 2013;41(9):1610-1615

Atorvastatin treatment induces uptake and efflux transporters in human liver.

Björkhem-Bergman L; Bergström H; Johansson M; Parini P; Eriksson M; Rane A; Ekström L
Article: PLOS ONE. 2013;8(11):e78550

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Ellis ECS; Naugler WE; Parini P; Mörk L-M; Jorns C; Zemack H; Sandblom AL; Björkhem I; Ericzon B-G; Wilson EM; Strom SC; Grompe M
Article: PLOS ONE. 2013;8(7):e68534

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

Maioli S; Båvner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Björkhem I
Article: PLOS ONE. 2013;8(12):e78534

The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice.

Mörk L-M; Rehnmark S; Davoodpour P; Norata GD; Larsson L; Witt M-R; Malm J; Parini P
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1980-1990

Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice.

Archer A; Venteclef N; Mode A; Pedrelli M; Gabbi C; Clément K; Parini P; Gustafsson J-Å; Korach-André M
Article: JOURNAL OF INTERNAL MEDICINE. 2012;272(5):452-464

LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

Hu X; Steffensen KR; Jiang Z-Y; Parini P; Gustafsson J-Å; Gåfvels M; Eggertsen G
Article: FASEB JOURNAL. 2012;26(8):3282-3291

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.

Zadjali F; Santana-Farre R; Vesterlund M; Carow B; Mirecki-Garrido M; Hernandez-Hernandez I; Flodström-Tullberg M; Parini P; Rottenberg M; Norstedt G; Fernandez-Perez L; Flores-Morales A
Article: JOURNAL OF BONE AND MINERAL METABOLISM. 2012;30(2):202-207

Physical training increases osteoprotegerin in postmenopausal women.

Bergström I; Parini P; Gustafsson SA; Andersson G; Brinck J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;417(3):1046-1051

Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development.

Skogastierna C; Johansson M; Parini P; Eriksson M; Eriksson LC; Ekström L; Björkhem-Bergman L
Article: PLOS ONE. 2012;7(11):e48694

Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma.

Sundelin JP; Ståhlman M; Lundqvist A; Levin M; Parini P; Johansson ME; Borén J
Article: PLOS ONE. 2012;7(5):e37386

Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood.

Santana-Farré R; Mirecki-Garrido M; Bocos C; Henríquez-Hernández LA; Kahlon N; Herrera E; Norstedt G; Parini P; Flores-Morales A; Fernández-Pérez L
Article: JOURNAL OF INTERNAL MEDICINE. 2011;270(4):377-387

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.

Shafaati M; Olin M; Båvner A; Pettersson H; Rozell B; Meaney S; Parini P; Björkhem I
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2011;301(1):E210-E222

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice.

Korach-André M; Archer A; Gabbi C; Barros RP; Pedrelli M; Steffensen KR; Pettersson AT; Laurencikiene J; Parini P; Gustafsson J-Å
Article: HEART SURGERY FORUM. 2011;14(3):E195-E197

Late cardiac tamponade by chylous pericardial effusion after coronary artery bypass surgery: case report.

Albåge A; Eggertsen G; Parini P
Article: JOURNAL OF INTERNAL MEDICINE. 2011;269(3):333-339

Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism.

Pramfalk C; Parini P; Gustafsson U; Sahlin S; Eriksson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(1):403-408

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.

Korach-André M; Archer A; Barros RP; Parini P; Gustafsson J-Å
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(1):184-190

Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease.

Carrero JJ; Qureshi AR; Nakashima A; Arver S; Parini P; Lindholm B; Bárány P; Heimbürger O; Stenvinkel P
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2010;16(47):5958-5964

Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport.

Pedrelli M; Pramfalk C; Parini P
Article: JOURNAL OF LIPID RESEARCH. 2010;51(11):3289-3298

Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice.

Slätis K; Gåfvels M; Kannisto K; Ovchinnikova O; Paulsson-Berne G; Parini P; Jiang Z-Y; Eggertsen G
Article: PLOS ONE. 2010;5(9):e13087

Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4).

Aronsson L; Huang Y; Parini P; Korach-André M; Håkansson J; Gustafsson J-Å; Pettersson S; Arulampalam V; Rafter J
Article: CELL METABOLISM. 2010;12(2):187-193

Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis.

Lo Sasso G; Murzilli S; Salvatore L; D'Errico I; Petruzzelli M; Conca P; Jiang Z-Y; Calabresi L; Parini P; Moschetta A
Article: JOURNAL OF LIPID RESEARCH. 2010;51(6):1354-1362

HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.

Pramfalk C; Jiang Z-Y; Cai Q; Hu H; Zhang S-D; Han T-Q; Eriksson M; Parini P
Article: ANTICANCER RESEARCH. 2010;30(4):1105-1112

Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation.

Björkhem-Bergman L; Acimovic J; Torndal U-B; Parini P; Eriksson LC
Article: HEPATOLOGY. 2010;51(4):1334-1344

Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes.

Lo Sasso G; Celli N; Caboni M; Murzilli S; Salvatore L; Morgano A; Vacca M; Pagliani T; Parini P; Moschetta A
Article: GENES & DEVELOPMENT. 2010;24(4):381-395

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

Venteclef N; Jakobsson T; Ehrlund A; Damdimopoulos A; Mikkonen L; Ellis E; Nilsson L-M; Parini P; Jänne OA; Gustafsson J-A; Steffensen KR; Treuter E
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2010;298(2):E167-E178

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.

Korach-André M; Parini P; Larsson L; Arner A; Steffensen KR; Gustafsson J-A
Article: ATHEROSCLEROSIS. 2009;207(1):266-271

ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients.

Parini P; Jiang Z-Y; Einarsson C; Eggertsen G; Zhang S-D; Rudel LL; Han T-Q; Eriksson M
Article: LIPIDS. 2009;44(11):1011-1027

Cocoa butter and safflower oil elicit different effects on hepatic gene expression and lipid metabolism in rats.

Gustavsson C; Parini P; Ostojic J; Cheung L; Hu J; Zadjali F; Tahir F; Brismar K; Norstedt G; Tollet-Egnell P
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(8):1235-1241

Control of ACAT2 liver expression by HNF4{alpha}: lesson from MODY1 patients.

Pramfalk C; Karlsson E; Groop L; Rudel LL; Angelin B; Eriksson M; Parini P
Article: ATHEROSCLEROSIS. 2009;204(2):381-387

Hypercholesterolemia leads to elevated TGF-beta1 activity and T helper 3-dependent autoimmune responses in atherosclerotic mice.

Zhou X; Johnston TP; Johansson D; Parini P; Funa K; Svensson J; Hansson GK
Article: CIRCULATION RESEARCH. 2009;104(8):961-968

T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice.

Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Rydén M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: CARCINOGENESIS. 2009;30(4):575-579

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells.

Vedin L-L; Lewandowski SA; Parini P; Gustafsson J-A; Steffensen KR
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2009;20(3):613-620

Low serum testosterone increases mortality risk among male dialysis patients.

Carrero JJ; Qureshi AR; Parini P; Arver S; Lindholm B; Bárány P; Heimbürger O; Stenvinkel P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;379(1):49-54

Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.

Jiang Z-Y; Jiang C-Y; Wang L; Wang J-C; Zhang S-D; Einarsson C; Eriksson M; Han T-Q; Parini P; Eggertsen G
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008;28(6):1200-1206

Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2.

Parini P; Gustafsson U; Davis MA; Larsson L; Einarsson C; Wilson M; Rudling M; Tomoda H; Omura S; Sahlin S; Angelin B; Rudel LL; Eriksson M
Article: PLOS ONE. 2008;3(3):e1713

Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity.

Lång P; van Harmelen V; Rydén M; Kaaman M; Parini P; Carneheim C; Cassady AI; Hume DA; Andersson G; Arner P
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2008;471(1):63-71

Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice.

Leikin-Frenkel A; Parini P; Konikoff FM; Benthin L; Leikin-Gobbi D; Goldiner I; Einarsson C; Gilat T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(6):2094-2099

Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.

Kim H-J; Fan X; Gabbi C; Yakimchuk K; Parini P; Warner M; Gustafsson J-A
Article: JOURNAL OF LIPID RESEARCH. 2008;49(2):464-472

Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients.

Jiang Z-Y; Parini P; Eggertsen G; Davis MA; Hu H; Suo G-J; Zhang S-D; Rudel LL; Han T-Q; Einarsson C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;364(2):402-409

Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells.

Pramfalk C; Angelin B; Eriksson M; Parini P
Article: CLINICAL LIPIDOLOGY. 2007;2(6):603-607

Targeting liver X receptor β:: a new therapeutic approach to prevent atherosclerosis?

Parini P; Gustafsson J-A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(10):2191-2197

Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.

Heverin M; Meaney S; Brafman A; Shafir M; Olin M; Shafaati M; von Bahr S; Larsson L; Lövgren-Sandblom A; Diczfalusy U; Parini P; Feinstein E; Björkhem I
Article: MOLECULAR PHARMACOLOGY. 2007;72(4):947-955

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

Kotokorpi P; Ellis E; Parini P; Nilsson L-M; Strom S; Steffensen KR; Gustafsson J-A; Mode A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2007;293(3):E737-E742

Age-induced hypercholesterolemia in the rat relates to reduced elimination but not increased intestinal absorption of cholesterol.

Gälman C; Matasconi M; Persson L; Parini P; Angelin B; Rudling M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;357(3):707-711

Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression.

Nilsson L-M; Abrahamsson A; Sahlin S; Gustafsson U; Angelin B; Parini P; Einarsson C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;348(1):176-182

Improved metabolic control by depletion of Liver X Receptors in mice.

Schuster GU; Johansson L; Kietz S; Stulnig TM; Parini P; Gustafsson J-A
Article: JOURNAL OF LIPID RESEARCH. 2006;47(2):421-430

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.

Wang J; Einarsson C; Murphy C; Parini P; Björkhem I; Gåfvels M; Eggertsen G
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2006;36(2):98-104

Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system.

Parini P; Johansson L; Bröijersén A; Angelin B; Rudling M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1736(3):221-227

Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment.

Matasconi M; Parini P; Angelin B; Rudling M
Article: JOURNAL OF LIPID RESEARCH. 2005;46(9):1868-1876

Control of ACAT2 liver expression by HNF1.

Pramfalk C; Davis MA; Eriksson M; Rudel LL; Parini P
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1735(3):167-175

Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice.

Murphy C; Parini P; Wang J; Björkhem I; Eggertsen G; Gåfvels M
Article: JOURNAL OF LIPID RESEARCH. 2005;46(8):1633-1642

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.

Gnerre C; Schuster GU; Roth A; Handschin C; Johansson L; Looser R; Parini P; Podvinec M; Robertsson K; Gustafsson J-A; Meyer UA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(29):10297-10302

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice.

Johansson L; Rudling M; Scanlan TS; Lundåsen T; Webb P; Baxter J; Angelin B; Parini P
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(6):1112-1118

ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia.

Rudel LL; Lee RG; Parini P
Article: CIRCULATION RESEARCH. 2005;96(4):427-434

Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis.

Zhou X; Robertson A-KL; Rudling M; Parini P; Hansson GK
Article: CIRCULATION. 2004;110(14):2017-2023

ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.

Parini P; Davis M; Lada AT; Erickson SK; Wright TL; Gustafsson U; Sahlin S; Einarsson C; Eriksson M; Angelin B; Tomoda H; Omura S; Willingham MC; Rudel LL
Article: CIRCULATION RESEARCH. 2004;94(12):1579-1588

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.

Bråkenhielm E; Cao R; Gao B; Angelin B; Cannon B; Parini P; Cao Y
Article: PHYSIOLOGICAL GENOMICS. 2004;16(2):261-267

Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles.

Tollet-Egnell P; Parini P; Ståhlberg N; Lönnstedt I; Lee NH; Rudling M; Flores-Morales A; Norstedt G
Article: ATHEROSCLEROSIS SUPPLEMENTS. 2002;3(4):23-30

Reverse cholesterol transport in man: promotion of fecal steroid excretion by infusion of reconstituted HDL.

Angelin B; Parini P; Eriksson M
Article: CIRCULATION. 2002;106(9):1147-1153

Accumulation of foam cells in liver X receptor-deficient mice.

Schuster GU; Parini P; Wang L; Alberti S; Steffensen KR; Hansson GK; Angelin B; Gustafsson J-A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;293(5):1333-1340

Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins.

Steffensen KR; Schuster GU; Parini P; Holter E; Sadek CM; Cassel T; Eskild W; Gustafsson J-A
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2001;78(1):83-88

Estrogenic influence on the regulation of hepatic estrogen receptor-alpha and serum level of angiotensinogen in female rats.

Stavréus-Evers A; Parini P; Freyschuss B; Elger W; Reddersen G; Sahlin L; Eriksson H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;107(5):565-573

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice.

Alberti S; Schuster G; Parini P; Feltkamp D; Diczfalusy U; Rudling M; Angelin B; Björkhem I; Pettersson S; Gustafsson JA
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;278(3):640-645

Obesity and disturbed lipoprotein profile in estrogen receptor-alpha-deficient male mice.

Ohlsson C; Hellberg N; Parini P; Vidal O; Bohlooly-Y M; Rudling M; Lindberg MK; Warner M; Angelin B; Gustafsson JA
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2000;20(7):1817-1823

Biphasic effects of the natural estrogen 17beta-estradiol on hepatic cholesterol metabolism in intact female rats.

Parini P; Angelin B; Stavréus-Evers A; Freyschuss B; Eriksson H; Rudling M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1999;19(4):832-839

Cholesterol and lipoprotein metabolism in aging: reversal of hypercholesterolemia by growth hormone treatment in old rats.

Parini P; Angelin B; Rudling M
Article: AMERICAN JOURNAL OF PATHOLOGY. 1998;153(6):1923-1935

Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation.

Rudling M; Gåfvels M; Parini P; Gahrton G; Angelin B
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1997;17(9):1800-1805

Importance of estrogen receptors in hepatic LDL receptor regulation.

Parini P; Angelin B; Rudling M
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;99(9):2239-2245

Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat.

Rudling M; Parini P; Angelin B
Article: ENDOCRINOLOGY. 1995;136(9):3767-3773

Growth hormone specifically stimulates the expression of low density lipoprotein receptors in human hepatoma cells.

Parini P; Angelin B; Lobie PE; Norstedt G; Rudling M
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Review: AGEING RESEARCH REVIEWS. 2024;94:102194

Lipid droplets, autophagy, and ageing: A cell-specific tale.

Maestri A; Garagnani P; Pedrelli M; Hagberg CE; Parini P; Ehrenborg E
Review: PROGRESS IN CARDIOVASCULAR DISEASES. 2023;79:2-11

Bempedoic acid in the management of lipid disorders and cardiovascular risk. 2023 position paper of the International Lipid Expert Panel (ILEP).

Banach M; Penson PE; Farnier M; Fras Z; Latkovskis G; Laufs U; Paneni F; Parini P; Pirro M; Reiner Ž; Vrablik M; Escobar C
Review: VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2021;50(6):401-411

Lipid-lowering and anti-thrombotic therapy in patients with peripheral arterial disease.

Belch JJF; Brodmann M; Baumgartner I; Binder CJ; Casula M; Heiss C; Kahan T; Parini P; Poredos P; Catapano AL; Tokgözoğlu L
Editorial comment: ATHEROSCLEROSIS. 2021;322:77-81

Taking action: European Atherosclerosis Society targets the United Nations Sustainable Development Goals 2030 agenda to fight atherosclerotic cardiovascular disease in Europe.

Parini P; Frikke-Schmidt R; Tselepis AD; Moulin P; von Eckardstein A; Binder CJ; Catapano AL; Ray KK; Tokgözoğlu L
Review: CLINICAL EPIGENETICS. 2021;13(1):66

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside.

Sarno F; Benincasa G; List M; Barabasi A-L; Baumbach J; Ciardiello F; Filetti S; Glass K; Loscalzo J; Marchese C; Maron BA; Paci P; Parini P; Petrillo E; Silverman EK; Verrienti A; Altucci L; Napoli C; International Network Medicine Consortium
Editorial comment: AMERICAN JOURNAL OF MEDICINE. 2020;133(9):e451-e454

The Network Medicine Imperative and the Need for an International Network Medicine Consortium.

Parini P; Altucci L; Balligand J-L; Baumbach J; Ferdinandy P; Filetti S; Maron BA; Petrillo E; Silverman EK; Barabasi A-L; Loscalzo J; International Network Medicine Consortium
Editorial comment: NPJ SYSTEMS BIOLOGY AND APPLICATIONS. 2020;6(1):29

A global network for network medicine.

Maron BA; Altucci L; Balligand J-L; Baumbach J; Ferdinandy P; Filetti S; Parini P; Petrillo E; Silverman EK; Barabási A-L; Loscalzo J; International Network Medicine Consortium
Review: NATURE REVIEWS ENDOCRINOLOGY. 2018;14(10):576-590

Inflammaging: a new immune-metabolic viewpoint for age-related diseases.

Franceschi C; Garagnani P; Parini P; Giuliani C; Santoro A
Editorial comment: JOURNAL OF LIPID RESEARCH. 2018;59(9):1551-1553

Hepatic thyroid hormone receptor β1 agonism: good for lipids, good for bile?

Dawson PA; Parini P
Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553

Can LDL cholesterol be too low? Possible risks of extremely low levels.

Olsson AG; Angelin B; Assmann G; Binder CJ; Björkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Müller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
Review: ACTA PHYSIOLOGICA. 2016;217(3):184-216

Emerging role of thyroid hormone metabolites.

Gnocchi D; Steffensen KR; Bruscalupi G; Parini P
Review: BIOLOGY-BASEL. 2015;4(1):104-132

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism.

Gnocchi D; Pedrelli M; Hurt-Camejo E; Parini P
Published paper: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1851(1):9-12

Role of TG-interacting factor (Tgif) in lipid metabolism.

Pramfalk C; Eriksson M; Parini P
Published paper: TRANSPLANTATION PROCEEDINGS. 2013;45(5):1780-1786

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model.

Jorns C; Takahashi T; Callaghan E; Zemack H; Larsson L; Nowak G; Parini P; Ericzon B-G; Ellis E
Review: EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY. 2012;114(6):624-633

Cholesteryl esters and ACAT

Pramfalk C; Eriksson M; Parini P
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1812(8):929-937

Role of thyroid receptor β in lipid metabolism.

Pramfalk C; Pedrelli M; Parini P
Review: CURRENT OPINION IN LIPIDOLOGY. 2011;22(3):225-230

Hepatic Niemann-Pick C1-like 1.

Pramfalk C; Jiang Z-Y; Parini P
Editorial comment: ATHEROSCLEROSIS. 2011;215(1):249-255

Report of the 33rd annual conference of the European Lipoprotein Club, Tutzing, 6-9 September 2010.

Bernini F; Fisher R; Freeman D; Groen A; Kalopissis A; Malle E; Mulder M; Niemeier A; Parini P; Hansen AT; von Eckardstein A
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2010;11(2):64

EFFECTS OF HIGH DOSE STATIN ON THE HUMAN HEPATIC EXPRESSION OF GENES INVOLVED IN CARBOHYDRATE AND TRIGLYCERIDE METABOLISM

Pramfalk C; Parini P; Gustafsson U; Sahlin S; Eriksson M
Letter: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2009;302(3):255

Carotid atherosclerosis progression and ACAT inhibition.

Parini P; Eriksson M; Rudel LL
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2007;8(1):24

ACAT2 and human hepatic cholesterol mkiabolism: Identification of important gender-related differences

Jiang ZY; Parini P; Einarsson C; Eggertsen G; Davis MA; Wang L; Zhang SD; Rudel LL; Han TQ; Ericsson M
Corrigendum: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;348(1):326

Obesity and disturbed lipoprotein profile in estrogen receptor-α-deficient male mice (vol 278, pg 640, 2000)

Ohlsson C; Hellberg N; Parini P; Vidal O; Bohlooly-Y M; Rudling M; Lindberg MK; Warner M; Angelin B; Gustafsson J-A
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(3):374-375

Is there a need for cholesteryl ester transfer protein inhibition?

Parini P; Rudel LL
Published paper: GROWTH HORMONE & IGF RESEARCH. 1999;9 Suppl A:1-7

Effects of growth hormone on hepatic cholesterol metabolism. Lessons from studies in rats and humans.

Rudling M; Parini P; Angelin B
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Professor/Överläkare, Medicin, Huddinge, Karolinska Institutet, 2015-

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Docent, Gastroenterologi, Karolinska Institutet, 2007
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Huddinge, Karolinska Institutet, 1999

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