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Mikael Karlsson

Professor

Leveransadress : Nobels Väg 16 171 77 Stockholm

Publikationer

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Parsa R, Lund H, Georgoudaki Am, Zhang Xm, Ortlieb Guerreiro-cacais A, Grommisch D, et al
The Journal of experimental medicine 2016;213(8):1537-53

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
Prokopec Ke, Georgoudaki Am, Sohn S, Wermeling F, Grönlund H, Lindh E, et al
Journal of immunology (Baltimore, Md. : 1950) 2016;197(6):2063-8

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Baptista Ma, Keszei M, Oliveira M, Sunahara Kk, Andersson J, Dahlberg Ci, et al
Nature communications 2016;7():12175-

Exosomal cancer immunotherapy is independent of MHC molecules on exosomes
Hiltbrunner S, Larssen P, Eldh M, Martinez-bravo Mj, Wagner Ak, Karlsson Mc, et al
Oncotarget 2016;7(25):38707-38717

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses
Hägglöf T, Sedimbi Sk, Yates Jl, Parsa R, Salas Bh, Harris Ra, et al
Nature immunology 2016;17(12):1407-1414

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Georgoudaki Am, Prokopec Ke, Boura Vf, Hellqvist E, Sohn S, Östling J, et al
Cell reports 2016;15(9):2000-11

Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
Duhlin A, Chen Y, Wermeling F, Sedimbi Sk, Lindh E, Shinde R, et al
Journal of immunology (Baltimore, Md. : 1950) 2016;197(7):2618-26

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions
Smith Le, Olszewski Ma, Georgoudaki Am, Wagner Ak, Hägglöf T, Karlsson Mc, et al
Journal of leukocyte biology 2016;100(4):781-789

TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang Mf, Georgoudaki Am, Lambut L, Johansson J, Tabor V, Hagikura K, et al
Oncogene 2016;35(6):748-60

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells
Vomhof-dekrey Ee, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(40):12474-9

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
Dahlberg Ci, Torres Ml, Petersen Sh, Baptista Ma, Keszei M, Volpi S, et al
Journal of autoimmunity 2015;62():81-92

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response
Grasset Ek, Duhlin A, Agardh He, Ovchinnikova O, Hägglöf T, Forsell Mn, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(16):E2030-8

Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis
Siegmann N, Worbs D, Effinger F, Bormann T, Gebhardt M, Ulrich M, et al
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 2014;34(1):56-70

AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E, Chen Y, Georgoudaki Am, Dudziak D, Lindh E, Adams Wc, et al
Journal of autoimmunity 2013;42():62-70

Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1
Lindh E, Brännström J, Jones P, Wermeling F, Hässler S, Betterle C, et al
Journal of autoimmunity 2013;42():1-6

Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity
Näslund Ti, Gehrmann U, Qazi Kr, Karlsson Mc, Gabrielsson S
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2712-9

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization
Forsell Mn, Soldemo M, Dosenovic P, Wyatt Rt, Karlsson Mc, Karlsson Hedestam Gb
Journal of immunology (Baltimore, Md. : 1950) 2013;191(1):44-51

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes
Gehrmann U, Hiltbrunner S, Georgoudaki Am, Karlsson Mc, Näslund Ti, Gabrielsson S
Cancer research 2013;73(13):3865-76

BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses
Dosenovic P, Soldemo M, Scholz Jl, O'dell S, Grasset Ek, Pelletier N, et al
JOURNAL OF IMMUNOLOGY 2012;188(12):6018-26

Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
Swedin L, Arrighi R, Andersson-willman B, Murray A, Chen Yy, Karlsson Mci, et al
PARTICLE AND FIBRE TOXICOLOGY 2012;:16-

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
Ravishankar B, Liu Hy, Shinde R, Chandler P, Baban B, Tanaka M, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012;109(10):3909-14

Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Mattsson J, Yrlid U, Stensson A, Schon K, Karlsson Mci, Ravetch Jv, et al
JOURNAL OF IMMUNOLOGY 2011;187(7):3641-52

Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis
Carnrot C, Prokopec Ke, Rasbo K, Karlsson Mci, Kleinau S
CELLULAR & MOLECULAR IMMUNOLOGY 2011;8(4):296-304

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
Mcgaha Tl, Chen Yy, Ravishankar B, Van Rooijen N, Karlsson Mci
BLOOD 2011;117(20):5403-12

The Expression of BAFF, APRIL and TWEAK Is Altered in Eczema Skin but Not in the Circulation of Atopic and Seborrheic Eczema Patients
Chen Yy, Enoksson Sl, Johansson C, Karlsson Ma, Lundeberg L, Nilsson G, et al
PLOS ONE 2011;6(7):e22202-

The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells
Enoksson Sl, Grasset Ek, Hagglof T, Mattsson N, Kaiser Y, Gabrielsson S, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011;108(51):E1399-407

AIRE deficiency leads to impaired iNKT cell development
Lindh E, Rosmaraki E, Berg L, Brauner H, Karlsson Mci, Peltonen L, et al
JOURNAL OF AUTOIMMUNITY 2010;34(1):66-72

A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses
Chen Yy, Wermeling F, Sundqvist J, Jonsson Ab, Tryggvason K, Pikkarainen T, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2010;40(5):1451-60

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells
Wermeling F, Lind Sm, Jordo Ed, Cardell Sl, Karlsson Mci
JOURNAL OF EXPERIMENTAL MEDICINE 2010;207(5):943-52

An anatomical view on macrophages in tolerance
Wermeling F, Karlsson Mci, Mcgaha Tl
AUTOIMMUNITY REVIEWS 2009;9(1):49-52

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism
Qazi Kr, Gehrmann U, Jordo Ed, Karlsson Mci, Gabrielsson S
BLOOD 2009;113(12):2673-83

IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema
Lind Sm, Kuylenstierna C, Moll M, Jordo Ed, Winqvist O, Lundeberg L, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2009;39(8):2293-301

Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
Thunberg S, Neimert-andersson T, Cheng Q, Wermeling F, Bergstrom U, Swedin L, et al
ALLERGY 2009;64(6):919-26

AIRE regulates T-cell-independent B-cell responses through BAFF
Lindh E, Lind Sm, Lindmark E, Hassler S, Perheentupa J, Peltonen L, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(47):18466-71

A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen
Hjelm F, Karlsson Mci, Heyman B
JOURNAL OF IMMUNOLOGY 2008;180(10):6604-10

Fc gamma RIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice
Mcgaha Tl, Karlsson Mci, Ravetch Jv
JOURNAL OF IMMUNOLOGY 2008;180(8):5670-9

Identification of a receptor required for the anti-inflammatory activity of IVIG
Anthony Rm, Wermeling F, Karlsson Mci, Ravetch Jv
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008;105(50):19571-8

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
Westerberg Ls, De La Fuente Ma, Wermeling F, Ochs Hd, Karlsson Mci, Snapper Sb, et al
BLOOD 2008;112(10):4139-47

Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
Wermeling F, Chen Yy, Pikkarainen T, Scheynius A, Winqvist O, Izui S, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2007;204(10):2259-65

Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
Hassler S, Ramse C, Karlsson Mc, Larsson D, Herrmann B, Rozell B, et al
BLOOD 2006;108(6):1941-8

Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone
Karlsson Mci, Guinamard R, Bolland S, Sankala M, Steinman Rm, Ravetch Jv
JOURNAL OF EXPERIMENTAL MEDICINE 2003;198(2):333-40

Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: Implications for antibody-based therapeutics of cancer
Green Sk, Karlsson Mci, Ravetch Jv, Kerbel Rs
CANCER RESEARCH 2002;62(23):6891-900

Fc gamma RIIB in IgG-mediated suppression of antibody responses: Different impact in vivo and in vitro
Karlsson Mci, Getahun A, Heyman B
JOURNAL OF IMMUNOLOGY 2001;167(10):5558-64

IgE-mediated suppression of primary antibody responses in vivo
Karlsson Mci, De Stahl Td, Heyman B
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2001;53(4):381-5

Efficient IgG-mediated suppression of primary antibody responses in Fc gamma receptor-deficient mice
Karlsson Mci, Wernersson S, De Stahl Td, Gustavsson S, Heyman B
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999;96(5):2244-9

IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice
Wernersson S, Karlsson Mci, Dahlstrom J, Mattsson R, Verbeek Js, Heyman B
JOURNAL OF IMMUNOLOGY 1999;163(2):618-22

Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule
Vestberg M, Brunsberg U, Bergsteinsdottir K, Karlsson M, Gustafsson K, Wedekind D, et al
IMMUNOGENETICS 1998;48(5):344-9

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