This page in English
Laddar profil information

Publikationer

Disease features and outcomes in United States lupus patients of Hispanic origin and their Mestizo counterparts in Latin America: a commentary
Ugarte-gil Mf, Pons-estel Gj, Molineros J, Wojdyla D, Mcgwin G, Nath Sk, et al
Rheumatology (Oxford, England) 2016;55(3):436-40

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture
Alarcón-riquelme Me, Ziegler Jt, Molineros J, Howard Td, Moreno-estrada A, Sánchez-rodríguez E, et al
Arthritis & rheumatology (Hoboken, N.J.) 2016;68(4):932-43

Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans
Lessard Cj, Sajuthi S, Zhao J, Kim K, Ice Ja, Li H, et al
Arthritis & rheumatology (Hoboken, N.J.) 2016;68(5):1197-209

The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function
Díaz-barreiro A, Bernal-quirós M, Georg I, Marañón C, Alarcón-riquelme Me, Castillejo-lópez C
Genes and immunity 2016;17(2):128-38

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome
Liu K, Kurien Bt, Zimmerman Sl, Kaufman Km, Taft Dh, Kottyan Lc, et al
Arthritis & rheumatology (Hoboken, N.J.) 2016;68(5):1290-300

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome
Vučković F, Krištić J, Gudelj I, Teruel M, Keser T, Pezer M, et al
Arthritis & rheumatology (Hoboken, N.J.) 2015;67(11):2978-89

Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels
Wu Yy, Georg I, Díaz-barreiro A, Varela N, Lauwerys B, Kumar R, et al
Journal of immunology (Baltimore, Md. : 1950) 2015;194(12):5692-702

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Günther C, Kind B, Reijns Ma, Berndt N, Martinez-bueno M, Wolf C, et al
The Journal of clinical investigation 2015;125(1):413-24

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus
Kariuki Sn, Ghodke-puranik Y, Dorschner Jm, Chrabot Bs, Kelly Ja, Tsao Bp, et al
Genes and immunity 2015;16(1):15-23

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
Bentham J, Morris Dl, Graham Dsc, Pinder Cl, Tombleson P, Behrens Tw, et al
NATURE GENETICS 2015;47(12):1457-64

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study
Martins M, Williams Ah, Comeau M, Marion M, Ziegler Jt, Freedman Bi, et al
Genes and immunity 2015;16(2):142-50

Genomic Insights into the Ancestry and Demographic History of South America
Homburger Jr, Moreno-estrada A, Gignoux Cr, Nelson D, Sanchez E, Ortiz-tello P, et al
PLoS genetics 2015;11(12):e1005602-

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
Ombrello Mj, Remmers Ef, Tachmazidou I, Grom A, Foell D, Haas Jp, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(52):15970-5

Lupus in Latin-American patients: lessons from the GLADEL cohort
Pons-estel Gj, Catoggio Lj, Cardiel Mh, Bonfa E, Caeiro F, Sato E, et al
Lupus 2015;24(6):536-45

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression
Lu X, Zoller Ee, Weirauch Mt, Wu Z, Namjou B, Williams Ah, et al
American journal of human genetics 2015;96(5):731-9

PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6
Oparina Ny, Delgado-vega Am, Martinez-bueno M, Magro-checa C, Fernández C, Castro Ro, et al
Annals of the rheumatic diseases 2015;74(3):e14-

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share
Kottyan Lc, Zoller Ee, Bene J, Lu X, Kelly Ja, Rupert Am, et al
Human molecular genetics 2015;24(2):582-96

Towards the taxonomy of human disease
Hofmann-apitius M, Alarcón-riquelme Me, Chamberlain C, Mchale D
Nature reviews. Drug discovery 2015;14(2):75-6

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival
Wang H, Flannery Sm, Dickhöfer S, Huhn S, George J, Kubarenko Av, et al
The Journal of biological chemistry 2014;289(33):23123-31

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations
Genles, Kim-howard X, Sun C, Molineros Je, Maiti Ak, Chandru H, et al
HUMAN MOLECULAR GENETICS 2014;23(6):1656-68

Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes
Dozmorov Mg, Wren Jd, Alarcón-riquelme Me
Epigenetics 2014;9(2):276-85

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region
Armstrong Dl, Zidovetzki R, Alarcón-riquelme Me, Tsao Bp, Criswell La, Kimberly Rp, et al
Genes and immunity 2014;15(6):347-54

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis
Mayes Md, Bossini-castillo L, Gorlova O, Martin Je, Zhou X, Chen Wv, et al
American journal of human genetics 2014;94(1):47-61

Intronic variants in the NFKB1 gene may influence hearing forecast in patients with unilateral sensorineural hearing loss in Meniere's disease
Cabrera S, Sanchez E, Requena T, Martinez-bueno M, Benitez J, Perez N, et al
PloS one 2014;9(11):e112171-

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus
Chung Sa, Brown Ee, Williams Ah, Ramos Ps, Berthier Cc, Bhangale T, et al
Journal of the American Society of Nephrology : JASN 2014;25(12):2859-70

Lupus risk variants in the PXK locus alter B-cell receptor internalization
Vaughn Se, Foley C, Lu X, Patel Zh, Zoller Ee, Magnusen Af, et al
Frontiers in genetics 2014;5():450-

MHC associations with clinical and autoantibody manifestations in European SLE
Morris Dl, Fernando Mm, Taylor Ke, Chung Sa, Nititham J, Alarcón-riquelme Me, et al
Genes and immunity 2014;15(4):210-7

Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome uncovered through gene expression meta-analysis
Toro-domínguez D, Carmona-sáez P, Alarcón-riquelme Me
Arthritis research & therapy 2014;16(6):489-

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription
Guthridge Jm, Lu R, Sun H, Sun C, Wiley Gb, Dominguez N, et al
American journal of human genetics 2014;94(4):586-98

ABIN1 dysfunction as a genetic basis for lupus nephritis
Caster Dj, Korte Ea, Nanda Sk, Mcleish Kr, Oliver Rk, G'sell Rt, et al
Journal of the American Society of Nephrology : JASN 2013;24(11):1743-54

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production
Molineros Je, Maiti Ak, Sun C, Looger Ll, Han S, Kim-howard X, et al
PLoS genetics 2013;9(2):e1003222-

Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease
Requena T, Gazquez I, Moreno A, Batuecas A, Aran I, Soto-varela A, et al
Immunogenetics 2013;65(5):345-55

BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling
Bernal-quirós M, Wu Yy, Alarcón-riquelme Me, Castillejo-lópez C
PloS one 2013;8(3):e59842-

BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway
Wu Yy, Kumar R, Haque Ms, Castillejo-lópez C, Alarcón-riquelme Me
Journal of immunology (Baltimore, Md. : 1950) 2013;191(12):6110-6

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups
Kaufman Km, Zhao J, Kelly Ja, Hughes T, Adler A, Sanchez E, et al
Annals of the rheumatic diseases 2013;72(3):437-44

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes
Namjou B, Kim-howard X, Sun C, Adler A, Chung Sa, Kaufman Km, et al
PloS one 2013;8(8):e69404-

Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12, and 13, and the HLA class II region
López Herráez D, Martínez-bueno M, Riba L, García De La Torre I, Sacnún M, Goñi M, et al
Arthritis and rheumatism 2013;65(6):1457-67

Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
Manku H, Langefeld Cd, Guerra Sg, Malik Th, Alarcon-riquelme M, Anaya Jm, et al
PLOS GENETICS 2013;9(7):e1003554-

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry
Ramos Ps, Oates Jc, Kamen Dl, Williams Ah, Gaffney Pm, Kelly Ja, et al
The Journal of rheumatology 2013;40(6):842-9

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus
Wang S, Adrianto I, Wiley Gb, Lessard Cj, Kelly Ja, Adler Aj, et al
Genes and immunity 2012;13(5):380-7

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus
Hughes T, Adler A, Merrill Jt, Kelly Ja, Kaufman Km, Williams A, et al
Annals of the rheumatic diseases 2012;71(5):694-9

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus
Adrianto I, Wang S, Wiley Gb, Lessard Cj, Kelly Ja, Adler Aj, et al
Arthritis and rheumatism 2012;64(11):3695-705

Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent population
Sánchez E, García-bermúdez M, Jiménez-alonso J, De Ramón E, Sánchez-román J, Ortego-centeno N, et al
Lupus 2012;21(11):1166-71

Evaluation of TRAF6 in a large multiancestral lupus cohort
Namjou B, Choi Cb, Harley It, Alarcón-riquelme Me, Biolupus Network, Kelly Ja, et al
Arthritis and rheumatism 2012;64(6):1960-9

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus
Hughes T, Adler A, Kelly Ja, Kaufman Km, Williams Ah, Langefeld Cd, et al
Arthritis and rheumatism 2012;64(2):485-92

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
Delgado-vega Am, Dozmorov Mg, Quirós Mb, Wu Yy, Martínez-garcía B, Kozyrev Sv, et al
Annals of the rheumatic diseases 2012;71(7):1219-26

Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus
Zhou Xj, Lu Xl, Nath Sk, Lv Jc, Zhu Sn, Yang Hz, et al
Arthritis and rheumatism 2012;64(1):222-31

Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?
Costenbader Kh, Gay S, Alarcón-riquelme Me, Iaccarino L, Doria A
Autoimmunity reviews 2012;11(8):604-9

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK
Castillejo-lópez C, Delgado-vega Am, Wojcik J, Kozyrev Sv, Thavathiru E, Wu Yy, et al
Annals of the rheumatic diseases 2012;71(1):136-42

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
Löfgren Se, Frostegård J, Truedsson L, Pons-estel Ba, D'alfonso S, Witte T, et al
Genes and immunity 2012;13(3):268-74

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study
Lessard Cj, Adrianto I, Ice Ja, Wiley Gb, Kelly Ja, Glenn Sb, et al
American journal of human genetics 2012;90(4):648-60

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations
Sánchez E, Rasmussen A, Riba L, Acevedo-vasquez E, Kelly Ja, Langefeld Cd, et al
Arthritis and rheumatism 2012;64(11):3687-94

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
Niewold Tb, Kelly Ja, Kariuki Sn, Franek Bs, Kumar Aa, Kaufman Km, et al
Annals of the rheumatic diseases 2012;71(3):463-8

Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus
Teruel M, Martin Je, Ortego-centeno N, Jiménez-alonso J, Sánchez-román J, De Ramón E, et al
Human immunology 2012;73(1):107-10

Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis
Lin Cp, Adrianto I, Lessard Cj, Kelly Ja, Kaufman Km, Guthridge Jm, et al
Genes and immunity 2012;13(3):232-8

The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization
Kozyrev Sv, Bernal-quirós M, Alarcón-riquelme Me, Castillejo-lópez C
Genes and immunity 2012;13(2):129-38

Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans
Morris Dl, Taylor Ke, Fernando Mm, Nititham J, Alarcón-riquelme Me, Barcellos Lf, et al
American journal of human genetics 2012;91(5):778-93

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries
Kim K, Brown Ee, Choi Cb, Alarcón-riquelme Me, Biolupus, Kelly Ja, et al
Annals of the rheumatic diseases 2012;71(11):1809-14

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap
Ramos Ps, Criswell La, Moser Kl, Comeau Me, Williams Ah, Pajewski Nm, et al
PLoS genetics 2011;7(12):e1002406-

A putative functional variant within the UBAC2 gene is associated with increased risk of Behçet's disease
Sawalha Ah, Hughes T, Nadig A, Yılmaz V, Aksu K, Keser G, et al
Arthritis and rheumatism 2011;63(11):3607-12

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Adrianto I, Wen F, Templeton A, Wiley G, King Jb, Lessard Cj, et al
Nature genetics 2011;43(3):253-8

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility
Zhao J, Wu H, Khosravi M, Cui H, Qian X, Kelly Ja, et al
PLoS genetics 2011;7(5):e1002079-

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups
Tan W, Sunahori K, Zhao J, Deng Y, Kaufman Km, Kelly Ja, et al
Arthritis and rheumatism 2011;63(9):2755-63

Detecting epistasis with restricted response patterns in pairs of biallelic loci
Wirapati P, Forner K, Delgado-vega A, Alarcón-riquelme M, Delorenzi M, Wojcik J
Annals of human genetics 2011;75(1):133-45

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production
Chung Sa, Taylor Ke, Graham Rr, Nititham J, Lee At, Ortmann Wa, et al
PLoS genetics 2011;7(3):e1001323-

Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus
Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, et al
Arthritis and rheumatism 2011;63(12):3942-51

Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients
Webb R, Kelly Ja, Somers Ec, Hughes T, Kaufman Km, Sanchez E, et al
Annals of the rheumatic diseases 2011;70(1):151-6

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
Namjou B, Kothari Ph, Kelly Ja, Glenn Sb, Ojwang Jo, Adler A, et al
Genes and immunity 2011;12(4):270-9

Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21
Hughes T, Kim-howard X, Kelly Ja, Kaufman Km, Langefeld Cd, Ziegler J, et al
Arthritis and rheumatism 2011;63(6):1689-97

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus
Ramos Ps, Williams Ah, Ziegler Jt, Comeau Me, Guy Rt, Lessard Cj, et al
Arthritis and rheumatism 2011;63(7):2049-57

Identification of a Systemic Lupus Erythematosus Susceptibility Locus at 11p13 between PDHX and CD44 in a Multiethnic Study
Biolupus Network, Genles Network, Lessard Cj, Adrianto I, Kelly Ja, Kaufman Km, et al
AMERICAN JOURNAL OF HUMAN GENETICS 2011;88(1):83-91

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study
Sánchez E, Comeau Me, Freedman Bi, Kelly Ja, Kaufman Km, Langefeld Cd, et al
Arthritis and rheumatism 2011;63(11):3493-501

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
Sanchez E, Nadig A, Richardson Bc, Freedman Bi, Kaufman Km, Kelly Ja, et al
Annals of the rheumatic diseases 2011;70(10):1752-7

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes
Taylor Ke, Chung Sa, Graham Rr, Ortmann Wa, Lee At, Langefeld Cd, et al
PLoS genetics 2011;7(2):e1001311-

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus
Löfgren Se, Delgado-vega Am, Gallant Cj, Sánchez E, Frostegård J, Truedsson L, et al
Arthritis and rheumatism 2010;62(11):3404-14

Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus
Sanchez E, Webb Rd, Rasmussen A, Kelly Ja, Riba L, Kaufman Km, et al
Arthritis and rheumatism 2010;62(12):3722-9

Genetic associations in type I interferon related pathways with autoimmunity
Delgado-vega Am, Alarcón-riquelme Me, Kozyrev Sv
Arthritis research & therapy 2010;12 Suppl 1():S2-

IRF5 is associated with primary antiphospholipid syndrome, but is not a major risk factor
Fredi M, Tincani A, Yin H, Delgado-vega Am, Borghi Mo, Meroni Pl, et al
Arthritis and rheumatism 2010;62(4):1201-2

Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T cells and correlation with the PD-1.3A genotype in patients with systemic lupus erythematosus
Kristjansdottir H, Steinsson K, Gunnarsson I, Gröndal G, Erlendsson K, Alarcón-riquelme Me
Arthritis and rheumatism 2010;62(6):1702-11

Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells
Löfgren Se, Yin H, Delgado-vega Am, Sanchez E, Lewén S, Pons-estel Ba, et al
The Journal of rheumatology 2010;37(3):574-8

Recent findings on genetics of systemic autoimmune diseases
Delgado-vega A, Sánchez E, Löfgren S, Castillejo-lópez C, Alarcón-riquelme Me
Current opinion in immunology 2010;22(6):698-705

[Systemic lupus erythematosus. «What do we know and where are we heading?»]
Alarcón Riquelme Me
Reumatologia clinica 2010;6(1):1-2

The role of genetic variation near interferon-kappa in systemic lupus erythematosus
Harley It, Niewold Tb, Stormont Rm, Kaufman Km, Glenn Sb, Franek Bs, et al
Journal of biomedicine & biotechnology 2010;2010():-

The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases
Kurreeman Fa, Goulielmos Gn, Alizadeh Bz, Rueda B, Houwing-duistermaat J, Sanchez E, et al
Annals of the rheumatic diseases 2010;69(4):696-9

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
Orrú V, Tsai Sj, Rueda B, Fiorillo E, Stanford Sm, Dasgupta J, et al
Human molecular genetics 2009;18(3):569-79

An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels
Nassir R, Kosoy R, Tian C, White Pa, Butler Lm, Silva G, et al
BMC genetics 2009;10():39-

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
Kosoy R, Nassir R, Tian C, White Pa, Butler Lm, Silva G, et al
Human mutation 2009;30(1):69-78

A polymorphism within IL21R confers risk for systemic lupus erythematosus
Webb R, Merrill Jt, Kelly Ja, Sestak A, Kaufman Km, Langefeld Cd, et al
Arthritis and rheumatism 2009;60(8):2402-7

Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome
Yin H, Borghi Mo, Delgado-vega Am, Tincani A, Meroni Pl, Alarcón-riquelme Me
Arthritis and rheumatism 2009;60(8):2468-71

Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases
Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, et al
Genes and immunity 2009;10(6):601-5

Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing
Douglas Kb, Windels Dc, Zhao J, Gadeliya Av, Wu H, Kaufman Km, et al
Genes and immunity 2009;10(5):457-69

European Forum on Antiphospholipid Antibodies: research in progress
Meroni Pl, Tincani A, Alarcón-riquelme Me, Shoenfeld Y, Borghi Mo
Lupus 2009;18(10):924-9

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus
Chung Sa, Tian C, Taylor Ke, Lee At, Ortmann Wa, Hom G, et al
Arthritis and rheumatism 2009;60(8):2448-56

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
Han S, Kim-howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge Jm, et al
Human molecular genetics 2009;18(6):1171-80

Genetic associations of LYN with systemic lupus erythematosus
Lu R, Vidal Gs, Kelly Ja, Delgado-vega Am, Howard Xk, Macwana Sr, et al
Genes and immunity 2009;10(5):397-403

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups
Namjou B, Sestak Al, Armstrong Dl, Zidovetzki R, Kelly Ja, Jacob N, et al
Arthritis and rheumatism 2009;60(4):1085-95

Identification of a new putative functional IL18 gene variant through an association study in systemic lupus erythematosus
Sánchez E, Palomino-morales Rj, Ortego-centeno N, Jiménez-alonso J, González-gay Ma, López-nevot Ma, et al
Human molecular genetics 2009;18(19):3739-48

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans
Liu K, Li Qz, Delgado-vega Am, Abelson Ak, Sánchez E, Kelly Ja, et al
The Journal of clinical investigation 2009;119(4):911-23

Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus
Delgado-vega Am, Abelson Ak, Sánchez E, Witte T, D'alfonso S, Galeazzi M, et al
Genes and immunity 2009;10(3):248-53

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk
Abelson Ak, Delgado-vega Am, Kozyrev Sv, Sánchez E, Velázquez-cruz R, Eriksson N, et al
Annals of the rheumatic diseases 2009;68(11):1746-53

Study of functional variants of the BANK1 gene in rheumatoid arthritis
Orozco G, Abelson Ak, González-gay Ma, Balsa A, Pascual-salcedo D, García A, et al
Arthritis and rheumatism 2009;60(2):372-9

Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus
Webb R, Wren Jd, Jeffries M, Kelly Ja, Kaufman Km, Tang Y, et al
Arthritis and rheumatism 2009;60(4):1076-84

Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus
Seldin Mf, Qi L, Scherbarth Hr, Tian C, Ransom M, Silva G, et al
Genes and immunity 2008;9(4):389-93

A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
Nath Sk, Han S, Kim-howard X, Kelly Ja, Viswanathan P, Gilkeson Gs, et al
Nature genetics 2008;40(2):152-4

Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese
Siu Ho, Yang W, Lau Cs, Chan Tm, Wong Rw, Wong Wh, et al
The Journal of rheumatology 2008;35(2):360-2

Association of STAT4 with rheumatoid arthritis: a replication study in three European populations
Orozco G, Alizadeh Bz, Delgado-vega Am, González-gay Ma, Balsa A, Pascual-salcedo D, et al
Arthritis and rheumatism 2008;58(7):1974-80

Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families
Kristjansdottir H, Saevarsdottir S, Gröndal G, Alarcón-riquelme Me, Erlendsson K, Valdimarsson H, et al
Arthritis and rheumatism 2008;58(12):3865-72

Common variants within MECP2 confer risk of systemic lupus erythematosus
Sawalha Ah, Webb R, Han S, Kelly Ja, Kaufman Km, Kimberly Rp, et al
PloS one 2008;3(3):e1727-

Corrigendum: Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Kozyrev Sv, Abelson Ak, Wojcik J, Zaghlool A, Linga Reddy Mp, Sanchez E, et al
Nature genetics 2008;40(4):484-

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Kozyrev Sv, Abelson Ak, Wojcik J, Zaghlool A, Linga Reddy Mv, Sanchez E, et al
Nature genetics 2008;40(2):211-6

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
International Consortium For Systemic Lupus Erythematosus Genetics (slegen), Harley Jb, Alarcón-riquelme Me, Criswell La, Jacob Co, Kimberly Rp, et al
Nature genetics 2008;40(2):204-10

IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population
Sánchez Fo, Linga Reddy Mv, Mallbris L, Sakuraba K, Ståhle M, Alarcón-riquelme Me
The Journal of investigative dermatology 2008;128(7):1704-9

No evidence of association of the PDCD1 gene with Type 1 diabetes (vol 24, pg 1473, 2007)
Fawwaz S, Nikamo P, Torn C, Landin-olsson M, Lernmark A, Alarcon-riquelme M, et al
DIABETIC MEDICINE 2008;25(2):243-243

A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus
Linga-reddy Mv, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, et al
Tissue antigens 2007;70(5):412-4

Argentine population genetic structure: large variance in Amerindian contribution
Seldin Mf, Tian C, Shigeta R, Scherbarth Hr, Silva G, Belmont Jw, et al
American journal of physical anthropology 2007;132(3):455-62

Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus
Sánchez E, Abelson Ak, Sabio Jm, González-gay Ma, Ortego-centeno N, Jiménez-alonso J, et al
Arthritis and rheumatism 2007;56(9):3080-6

Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort
Thorburn Cm, Prokunina-olsson L, Sterba Ka, Lum Rf, Seldin Mf, Alarcon-riquelme Me, et al
Genes and immunity 2007;8(4):279-87

Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans
Reddy Mv, Velázquez-cruz R, Baca V, Lima G, Granados J, Orozco L, et al
Human genetics 2007;121(6):721-7

No evidence of association between genetic variants of the PDCD1 ligands and SLE
Abelson Ak, Johansson Cm, Kozyrev Sv, Kristjansdottir H, Gunnarsson I, Svenungsson E, et al
Genes and immunity 2007;8(1):69-74

No evidence of association of the PDCD1 gene with Type 1 diabetes
Asad S, Nikamo P, Törn C, Landin-olsson M, Lernmark A, Alarcón-riquelme M, et al
Diabetic medicine : a journal of the British Diabetic Association 2007;24(12):1473-7

Recent advances in the genetics of autoimmune diseases
Alarcón-riquelme Me
Annals of the New York Academy of Sciences 2007;1110():1-9

Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus
Kozyrev Sv, Lewén S, Reddy Pm, Pons-estel B, Argentine Collaborative Group, Witte T, et al
Arthritis and rheumatism 2007;56(4):1234-41

The genetics and biology of Irf5-mediated signaling in lupus
Kozyrev Sv, Alarcon-riquelme Me
Autoimmunity 2007;40(8):591-601

The genetics of systemic lupus erythematosus: The path ahead
Alarcon-riquelme Me
AUTOIMMUNITY 2007;40(8):549-549

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
Graham Rr, Kozyrev Sv, Baechler Ec, Reddy Mv, Plenge Rm, Bauer Jw, et al
Nature genetics 2006;38(5):550-5

Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis
Rueda B, Reddy Mv, González-gay Ma, Balsa A, Pascual-salcedo D, Petersson If, et al
Arthritis and rheumatism 2006;54(12):3815-9

Characterization of a susceptibility locus for SLE, SLEB5, on chromosome 4p14-13
Johansson Cm, Kristjánsdottir H, Gröndal G, Steinsson K, Alarcón-riquelme Me
Scandinavian journal of immunology 2006;64(3):308-13

Decreased risk for myocardial infarction and lower tumor necrosis factor-alpha levels in carriers of variants of the PDCD1 gene
Bennet Am, Alarcón-riquelme M, Wiman B, De Faire U, Prokunina-olsson L
Human immunology 2006;67(9):700-5

Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus
Forabosco P, Gorman Jd, Cleveland C, Kelly Ja, Fisher Sa, Ortmann Wa, et al
Genes and immunity 2006;7(7):609-14

Nucleic acid by-products and chronic inflammation
Alarcón-riquelme Me
Nature genetics 2006;38(8):866-7

Study of the role of a functional polymorphism of MHC2TA in rheumatoid arthritis in three ethnically different populations
Orozco G, Robledo G, Linga Reddy Mv, García A, Pascual-salcedo D, Balsa A, et al
Rheumatology (Oxford, England) 2006;45(11):1442-4

Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus
Orozco G, Sánchez E, Gómez Lm, González-gay Ma, López-nevot Ma, Torres B, et al
Annals of the rheumatic diseases 2006;65(6):791-5

The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility
Alarcón-riquelme Me
Springer seminars in immunopathology 2006;28(2):109-17

A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese
Kong Ek, Prokunina-olsson L, Wong Wh, Lau Cs, Chan Tm, Alarcón-riquelme M, et al
Arthritis and rheumatism 2005;52(4):1058-62

Examination of ancestry and ethnic affiliation using highly informative diallelic DNA markers: application to diverse and admixed populations and implications for clinical epidemiology and forensic medicine
Yang N, Li H, Criswell La, Gregersen Pk, Alarcon-riquelme Me, Kittles R, et al
Human genetics 2005;118(3-4):382-92

Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort
Alarcón-segovia D, Alarcón-riquelme Me, Cardiel Mh, Caeiro F, Massardo L, Villa Ar, et al
Arthritis and rheumatism 2005;52(4):1138-47

Genetic aspects of rheumatic diseases
Steinsson K, Alarcón-riquelme Me
Scandinavian journal of rheumatology 2005;34(3):167-77

IgG Fc receptor polymorphisms and association with autoimmune disease
Andrén M, Johanneson B, Alarcón-riquelme Me, Kleinau S
European journal of immunology 2005;35(10):3020-9

Programmed death 1 gene polymorphism and systemic lupus erythematosus in different ethnic populations: comment on the article by Lin et al
Alarcon-riquelme Me
Arthritis and rheumatism 2005;52(1):363-author

The genetics of shared autoimmunity
Alarcón-riquelme Me
Autoimmunity 2005;38(3):205-8

The genetics of systemic lupus erythematosus
Alarcón-riquelme Me
Journal of autoimmunity 2005;25 Suppl():46-8

The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1
Reddy Mv, Johansson M, Sturfelt G, Jönsen A, Gunnarsson I, Svenungsson E, et al
Genes and immunity 2005;6(8):658-62

Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
Prokunina L, Padyukov L, Bennet A, De Faire U, Wiman B, Prince J, et al
Arthritis and rheumatism 2004;50(6):1770-3

Both risk alleles for FcgammaRIIA and FcgammaRIIIA are susceptibility factors for SLE: a unifying hypothesis
Magnusson V, Johanneson B, Lima G, Odeberg J, Alarcón-segovia D, Alarcón-riquelme Me, et al
Genes and immunity 2004;5(2):130-7

Chromosome 17p12-q11 harbors susceptibility loci for systemic lupus erythematosus
Johansson Cm, Zunec R, García Ma, Scherbarth Hr, Tate Ga, Paira S, et al
Human genetics 2004;115(3):230-8

Polymorphisms of the Fc gamma receptor type IIB gene are not associated with systemic lupus erythematosus in the Swedish population
Magnusson V, Zunec R, Odeberg J, Sturfelt G, Truedsson L, Gunnarsson I, et al
Arthritis and rheumatism 2004;50(4):1348-50

Regulatory SNPs in complex diseases: their identification and functional validation
Prokunina L, Alarcón-riquelme Me
Expert reviews in molecular medicine 2004;6(10):1-15

Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus
Alarcón-riquelme Me
Arthritis research & therapy 2004;6(4):169-73

The genetic basis of systemic lupus erythematosus--knowledge of today and thoughts for tomorrow
Prokunina L, Alarcon-riquelme M
Human molecular genetics 2004;13 Spec No 1():R143-8

The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis
Prokunina L, Gunnarsson I, Sturfelt G, Truedsson L, Seligman Va, Olson Jl, et al
Arthritis and rheumatism 2004;50(1):327-8

A RUNX trio with a taste for autoimmunity
Alarcón-riquelme Me
Nature genetics 2003;35(4):299-300

Finding genes for SLE: complex interactions and complex populations
Alarcón-riquelme Me, Prokunina L
Journal of autoimmunity 2003;21(2):117-20

Functional genomics in the study of autoimmune diseases
Alarcón-riquelme Me
Autoimmunity reviews 2003;2(4):177-80

Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjögren's syndrome
Bolstad Ai, Eiken Hg, Rosenlund B, Alarcón-riquelme Me, Jonsson R
Arthritis and rheumatism 2003;48(1):174-85

A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31
Johanneson B, Lima G, Von Salomé J, Alarcón-segovia D, Alarcón-riquelme Me, Collaborative Group On The Genetics Of Sle The Biomed Ii Collaboration On The Genetics Of Sle And Sjögrens Syndrome
American journal of human genetics 2002;71(5):1060-71

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
Prokunina L, Castillejo-lópez C, Oberg F, Gunnarsson I, Berg L, Magnusson V, et al
Nature genetics 2002;32(4):666-9

Family studies in systemic lupus erythematosus
Alarcon-riquelme Me
RHEUMATOLOGY 2002;41(4):A364-366

Family studies in systemic lupus erythematosus
Alarcón-riquelme Me
Rheumatology (Oxford, England) 2002;41(4):364-6

The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross
Johansson Ac, Nakken B, Sundler M, Lindqvist Ak, Johannesson M, Alarcón-riquelme M, et al
European journal of immunology 2002;32(1):243-50

An update on the genetics of systemic lupus erythematosus
Johanneson B, Alarcón-riquelme Me
The Israel Medical Association journal : IMAJ 2001;3(2):88-93

Cytokine polymorphisms in systemic lupus erythematosus and Sjögren's syndrome
Magnusson V, Nakken B, Bolstad Ai, Alarcón-riquelme Me
Scandinavian journal of immunology 2001;54(1-2):55-61

Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes
Johansson Ac, Sundler M, Kjellén P, Johannesson M, Cook A, Lindqvist Ak, et al
European journal of immunology 2001;31(6):1847-56

Association analysis with microsatellite and SNP markers does not support the involvement of BCL-2 in systemic lupus erythematosus in Mexican and Swedish patients and their families
Johansson C, Castillejo-lópez C, Johanneson B, Svenungsson E, Gunnarsson I, Frostegård J, et al
Genes and immunity 2000;1(6):380-5

A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q
Lindqvist Ak, Steinsson K, Johanneson B, Kristjánsdóttir H, Arnasson A, Gröndal G, et al
Journal of autoimmunity 2000;14(2):169-78

Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus
Magnusson V, Lindqvist Ak, Castillejo-lópez C, Kristjánsdottir H, Steinsson K, Gröndal G, et al
Genomics 2000;70(3):307-14

A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups
Johanneson B, Steinsson K, Lindqvist Ak, Kristjánsdóttir H, Gröndal G, Sandino S, et al
Journal of autoimmunity 1999;13(1):137-41

Frontiers of SLE: review of the 5th International Congress of Systemic Lupus Erythematosus, Cancun, Mexico, April 20-25, 1998
Shoenfeld Y, Alarcon-segovia D, Buskila D, Abu-shakra M, Lorber M, Sherer Y, et al
Seminars in arthritis and rheumatism 1999;29(2):112-30

Genetic analysis of the contribution of IL10 to systemic lupus erythematosus
Alarcón-riquelme Me, Lindqvist Ak, Jonasson I, Johanneson B, Sandino S, Alcocer-varela J, et al
The Journal of rheumatology 1999;26(10):2148-52

The genetics of systemic lupus erythematosus
Lindqvist Ak, Alarcón-riquelme Me
Scandinavian journal of immunology 1999;50(6):562-71

Participation of the Bcl-2 and Fas molecules in experimental apoptosis of spleen B lymphocytes
Alvarado C, Alarcón-riquelme Me, Alcocer-varela J, Fernández C
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 1997;49(3):171-8

Polyreactive binding of antibodies generated by polyclonal B cell activation. II. Crossreactive and monospecific antibodies can be generated from an identical Ig rearrangement by differential glycosylation
Fernández C, Alarcon-riquelme Me, Sverremark E
Scandinavian journal of immunology 1997;45(3):240-7

Polyreactive binding of antibodies generated by polyclonal B cell activation. I. Polyreactivity could be caused by differential glycosylation of immunoglobulins
Fernández C, Alarcón-riquelme Me, Abedi-valugerdi M, Sverremark E, Cortes V
Scandinavian journal of immunology 1997;45(3):231-9

Chromosome-specific panels of tri- and tetranucleotide microsatellite markers for multiplex fluorescent detection and automated genotyping: evaluation of their utility in pathology and forensics
Lindqvist Ak, Magnusson Pk, Balciuniene J, Wadelius C, Lindholm E, Alarcón-riquelme Me, et al
Genome research 1996;6(12):1170-6

CDR3 regions in the preimmune VH B cell repertoire of lpr mice
Alarcón-riquelme Me, Fernández C
Clinical and experimental immunology 1995;101(1):73-7

Expression of the B cell repertoire in lpr mice; abnormal expansion of a few VHJ558 germ-line genes
Alarcón-riquelme Me, Fernández C
Clinical and experimental immunology 1995;99(2):262-8

Visa alla publikationer