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Lars-Gunnar Larsson

Professor

Besöksadress : Nobels Väg 16 171 77 Stockholm
Postadress : Institutionen för mikrobiologi, tumör- och cellbiologi (MTC), C1, Lars-Gunnar Larsson grupp, Box 280 171 77 Stockholm

Forskningsbeskrivning

Professor i tumör- och cellbiologi.

Min forskargrupp presenteras här (på engelska).

Publikationer

CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
Cepeda D, Ng Hf, Sharifi Hr, Mahmoudi S, Cerrato Vs, Fredlund E, et al
EMBO molecular medicine 2013;5(7):1067-86

Methods to study MYC-regulated cellular senescence
Tabor V, Bocci M, Larsson Lg
Methods in molecular biology (Clifton, N.J.) 2013;1012():99-116

Inhibition of the Intrinsic but Not the Extrinsic Apoptosis Pathway Accelerates and Drives Myc-Driven Tumorigenesis Towards Acute Myeloid Leukemia
Hogstrand K, Hejll E, Sander B, Rozell B, Larsson Lg, Grandien A
PLOS ONE 2012;7(2):e31366-

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, Luscher B, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012;109(4):E187-96

Cellular senescence-A barrier against tumor development?
Larsson Lg
SEMINARS IN CANCER BIOLOGY 2011;21(6):347-8

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
Larsson Lg
SEMINARS IN CANCER BIOLOGY 2011;21(6):367-76

Cdk2: a key regulator of the senescence control function of Myc
Hydbring P, Larsson Lg
AGING-US 2010;2(4):244-50

Cdk2 suppresses cellular senescence induced by the c-myc oncogene
Campaner S, Doni M, Hydbring P, Verrecchia A, Bianchi L, Sardella D, et al
NATURE CELL BIOLOGY 2010;12(1):54-9

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
Guerra L, Albihn A, Tronnersjo S, Yan Qz, Guidi R, Stenerlow B, et al
PLOS ONE 2010;5(1):e8924-

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
Hydbring P, Bahram F, Su Yt, Tronnersjo S, Hogstrand K, Von Der Lehr N, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(1):58-63

The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
Larsson Lg, Henriksson Ma
EXPERIMENTAL CELL RESEARCH 2010;316(8):1429-37

Tipping the Balance: Cdk2 Enables Myc to Suppress Senescence
Hydbring P, Larsson Lg
CANCER RESEARCH 2010;70(17):6687-91

TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity
Wu Sq, Hultquist A, Hydbring P, Cetinkaya C, Oberg F, Larsson Lg
EXPERIMENTAL CELL RESEARCH 2009;315(18):3099-111

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay
Soderberg O, Leuchowius Kj, Gullberg M, Jarvius M, Weibrecht I, Larsson Lg, et al
METHODS 2008;45(3):227-32

Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells
Cetinkaya C, Hultquist A, Su Y, Wu S, Bahram F, Pahlman S, et al
MOLECULAR CANCER THERAPEUTICS 2007;6(10):2634-41

Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70
Afanasyeva Ea, Komarova Ey, Larsson Lg, Bahram F, Margulis Ba, Guzhova Iv
INTERNATIONAL JOURNAL OF CANCER 2007;121(12):2615-21

Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleotides in plant cells
Sun Cx, Ridderstrale K, Hoglund As, Larsson Lg, Jansson C
PLANT JOURNAL 2007;52(6):1192-8

The world according to MYC
Lusher B, Larsson Lg
EMBO REPORTS 2007;8(12):1110-4

Direct observation of individual endogenous protein complexes in situ by proximity ligation
Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius Kj, Jarvius J, et al
NATURE METHODS 2006;3(12):995-1000

SNIP1: Myc's new helper in transcriptional activation
Larsson Lg
MOLECULAR CELL 2006;24(6):811-2

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
Arabi A, Wu Sq, Ridderstrale K, Bierhoff H, Shiue C, Fatyol K, et al
NATURE CELL BIOLOGY 2005;7(3):303-10

Mad 1 inhibits cell growth and proliferation but does not promote differentiation or overall survival in human U-937 monoblasts
Hultquist A, Cetinkaya C, Wu Sq, Castel A, Erlandsson A, Larsson Lg
MOLECULAR CANCER RESEARCH 2004;2(8):464-76

Implication of the ubiquitin/proteasome system in Myc-regulated transcription
Von Der Lehr N, Johansson S, Larsson Lg
Cell cycle (Georgetown, Tex.) 2003;2(5):403-7

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter
Wu Sq, Cetinkaya C, Munoz-alonso Mj, Von Der Lehr N, Bahram F, Beuger V, et al
ONCOGENE 2003;22(3):351-60

The F-Box protein Skp2 participates in c-Myc protelosornal degradation and acts as a cofactor for c-Myc-regulated transcription
Von Der Lehr N, Johansson S, Wu Sq, Bahram F, Castell A, Cetinkaya C, et al
MOLECULAR CELL 2003;11(5):1189-200

Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1
Cerni C, Skrzypek B, Popov N, Sasgary S, Schmidt G, Larsson Lg, et al
ONCOGENE 2002;21(3):447-59

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1)
Dimberg A, Bahram F, Karlberg I, Larsson Lg, Nilsson K, Oberg F
BLOOD 2002;99(6):2199-206

Cytokine-induced restoration of differentiation and cell cycle arrest in v-Myc transformed U-937 monoblasts correlates with reduced Myc activity
Oberg F, Wu S, Bahram F, Nilsson K, Larsson Lg
LEUKEMIA 2001;15(2):217-27

Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells
Guzhova I, Hultquist A, Cetinkaya C, Nilsson K, Pahlman S, Larsson Lg
INTERNATIONAL JOURNAL OF CANCER 2001;94(1):97-108

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
Bahram F, Von Der Lehr N, Cetinkaya C, Larsson Lg
BLOOD 2000;95(6):2104-10

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts
Bahram F, Wu Sq, Oberg F, Luscher B, Larsson Lg
BLOOD 1999;93(11):3900-12

The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation
Luscher B, Larsson Lg
ONCOGENE 1999;18(19):2955-66

Analysis of the DNA-binding activities of Myc/Max/Mad network complexes during induced differentiation of U-937 monoblasts and F9 teratocarcinoma cells
Larsson Lg, Bahram F, Burkhardt H, Luscher B
ONCOGENE 1997;15(6):737-48

Cytokine-induced inhibition of Myc activity in monocytic cells
Larsson Lg, Bahram F, Wu S, Oberg F, Nilsson K, Luscher B
C-MYC IN B-CELL NEOPLASIA 1997;:191-200

HEMATOPOIETIC TRANSCRIPTION FACTOR PU.1 IS DOWN-REGULATED IN HUMAN MULTIPLE-MYELOMA CELL-LINES
Pettersson M, Sundstrom C, Nilsson K, Larsson Lg
BLOOD 1995;86(7):2747-53

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