Kirsty Spalding

Om mig
Publikationer
Populärvetenskap och samverkan

Forskningsbeskrivning

Min forskning är inriktad på studier av adipocyter, en typ av fettceller,
hur de bildas och omsätts. Min forskargrupp är presenterad här [1](på
engelska).
[1] http://ki.se/en/cmb/kirsty-spaldings-group

Artiklar

Article: NATURE. 2023;613(7943):355-364

A DNA methylation atlas of normal human cell types.

Loyfer N; Magenheim J; Peretz A; Cann G; Bredno J; Klochendler A; Fox-Fisher I; Shabi-Porat S; Hecht M; Pelet T; Moss J; Drawshy Z; Amini H; Moradi P; Nagaraju S; Bauman D; Shveiky D; Porat S; Dior U; Rivkin G; Or O; Hirshoren N; Carmon E; Pikarsky A; Khalaileh A; Zamir G; Grinbaum R; Abu Gazala M; Mizrahi I; Shussman N; Korach A; Wald O; Izhar U; Erez E; Yutkin V; Samet Y; Rotnemer Golinkin D; Spalding KL; Druid H; Arner P; Shapiro AMJ; Grompe M; Aravanis A; Venn O; Jamshidi A; Shemer R; Dor Y; Glaser B; Kaplan T
Article: ELIFE. 2022;11:e76391

Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study.

Lubotzky A; Pelov I; Teplitz R; Neiman D; Smadja A; Zemmour H; Piyanzin S; Ochana B-L; Spalding KL; Glaser B; Shemer R; Dor Y; Kohn Y
Article: JCI INSIGHT. 2022;7(2):e153559

Liquid biopsy reveals collateral tissue damage in cancer.

Lubotzky A; Zemmour H; Neiman D; Gotkine M; Loyfer N; Piyanzin S; Ochana B-L; Lehmann-Werman R; Cohen D; Moss J; Magenheim J; Loftus MF; Brais L; Ng K; Mostoslavsky R; Wolpin BM; Zick A; Maoz M; Grinshpun A; Kustanovich A; Makranz C; Cohen JE; Peretz T; Hubert A; Temper M; Salah A; Avniel-Polak S; Grozinsky-Glasberg S; Spalding KL; Rokach A; Kaplan T; Glaser B; Shemer R; Dor Y
Article: NATURE MEDICINE. 2021;27(11):1941-1953

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.

Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvönen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ; Kutschke M; Arifen N; Krämer N; Aouadi M; Knibbe C; Boucher J; Thorell A; Spalding KL
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2020;97(8):800-810

Practical Guidelines for Optimization and Characterization of the Beckman Coulter CytoFLEX™ Platform.

Bhowmick D; Sheridan RTC; Bushnell TP; Spalding KL
Article: NATURE MEDICINE. 2019;25(9):1385-1389

Adipose lipid turnover and long-term changes in body weight.

Arner P; Bernard S; Appelsved L; Fu K-Y; Andersson DP; Salehpour M; Thorell A; Rydén M; Spalding KL
Article: CELL REPORTS. 2019;27(1):213-225.e5

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.

Harms MJ; Li Q; Lee S; Zhang C; Kull B; Hallen S; Thorell A; Alexandersson I; Hagberg CE; Peng X-R; Mardinoglu A; Spalding KL; Boucher J
Article: NATURE COMMUNICATIONS. 2018;9(1):5068

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease.

Moss J; Magenheim J; Neiman D; Zemmour H; Loyfer N; Korach A; Samet Y; Maoz M; Druid H; Arner P; Fu K-Y; Kiss E; Spalding KL; Landesberg G; Zick A; Grinshpun A; Shapiro AMJ; Grompe M; Wittenberg AD; Glaser B; Shemer R; Kaplan T; Dor Y
Article: CELL REPORTS. 2018;25(3):551-560.e5

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyté A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martínez-Álvarez C; Hedén P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Rydén M
Article: CELL REPORTS. 2018;24(10):2746-2756.e5

Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity.

Hagberg CE; Li Q; Kutschke M; Bhowmick D; Kiss E; Shabalina IG; Harms MJ; Shilkova O; Kozina V; Nedergaard J; Boucher J; Thorell A; Spalding KL
Article: NATURE COMMUNICATIONS. 2017;8:15253

Impact of fat mass and distribution on lipid turnover in human adipose tissue.

Spalding KL; Bernard S; Näslund E; Salehpour M; Possnert G; Appelsved L; Fu K-Y; Alkass K; Druid H; Thorell A; Rydén M; Arner P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(13):E1826-E1834

Identification of tissue-specific cell death using methylation patterns of circulating DNA.

Lehmann-Werman R; Neiman D; Zemmour H; Moss J; Magenheim J; Vaknin-Dembinsky A; Rubertsson S; Nellgård B; Blennow K; Zetterberg H; Spalding K; Haller MJ; Wasserfall CH; Schatz DA; Greenbaum CJ; Dorrell C; Grompe M; Zick A; Hubert A; Maoz M; Fendrich V; Bartsch DK; Golan T; Ben Sasson SA; Zamir G; Razin A; Cedar H; Shapiro AMJ; Glaser B; Shemer R; Dor Y
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2016;8(3):a025981

Detection and Phenotypic Characterization of Adult Neurogenesis.

Kuhn HG; Eisch AJ; Spalding K; Peterson DA
Article: CELL METABOLISM. 2015;22(3):408-417

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.

Rydén M; Uzunel M; Hård JL; Borgström E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisén J; Bernard S; Mattsson J; Arner P
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2015;7(7):a018994

Adult Neurogenesis in Humans.

Bergmann O; Spalding KL; Frisén J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015;308(9):E822-E829

Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis.

Abreu-Vieira G; Hagberg CE; Spalding KL; Cannon B; Nedergaard J
Article: JOURNAL OF LIPID RESEARCH. 2013;54(10):2909-2913

Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects.

Rydén M; Andersson DP; Bernard S; Spalding K; Arner P
Article: CELL. 2013;153(6):1219-1227

Dynamics of hippocampal neurogenesis in adult humans.

Spalding KL; Bergmann O; Alkass K; Bernard S; Salehpour M; Huttner HB; Boström E; Westerlund I; Vial C; Buchholz BA; Possnert G; Mash DC; Druid H; Frisén J
Article: PLOS ONE. 2013;8(7):e69597

Analysis of radiocarbon, stable isotopes and DNA in teeth to facilitate identification of unknown decedents.

Alkass K; Saitoh H; Buchholz BA; Bernard S; Holmlund G; Senn DR; Spalding KL; Druid H
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2012;1(6):e003467

Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia.

Frayn K; Bernard S; Spalding K; Arner P
Article: JOURNAL OF FORENSIC SCIENCES. 2012;57(5):1354-1360

Personal identification of cold case remains through combined contribution from anthropological, mtDNA, and bomb-pulse dating analyses.

Speller CF; Spalding KL; Buchholz BA; Hildebrand D; Moore J; Mathewes R; Skinner MF; Yang DY
Article: NEURON. 2012;74(4):634-639

The age of olfactory bulb neurons in humans.

Bergmann O; Liebl J; Bernard S; Alkass K; Yeung MSY; Steier P; Kutschera W; Johnson L; Landén M; Druid H; Spalding KL; Frisén J
Article: NATURE. 2011;478(7367):110-113

Dynamics of human adipose lipid turnover in health and metabolic disease.

Arner P; Bernard S; Salehpour M; Possnert G; Liebl J; Steier P; Buchholz BA; Eriksson M; Arner E; Hauner H; Skurk T; Rydén M; Frayn KN; Spalding KL
Article: FORENSIC SCIENCE INTERNATIONAL. 2011;209(1-3):34-41

Analysis of 14C and 13C in teeth provides precise birth dating and clues to geographical origin.

Alkass K; Buchholz BA; Druid H; Spalding KL
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):101-104

Fat cell turnover in humans.

Arner P; Spalding KL
Article: SURFACE AND INTERFACE ANALYSIS. 2010;42(5):398-401

Year of birth determination using radiocarbon dating of dental enamel.

Buchholz BA; Spalding KL
Article: DIABETES. 2010;59(1):105-109

Adipocyte turnover: relevance to human adipose tissue morphology.

Arner E; Westermark PO; Spalding KL; Britton T; Rydén M; Frisén J; Bernard S; Arner P
Article: NATURE. 2008;453(7196):783-787

Dynamics of fat cell turnover in humans.

Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Näslund E; Britton T; Concha H; Hassan M; Rydén M; Frisén J; Arner P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(33):12564-12568

Neocortical neurogenesis in humans is restricted to development.

Bhardwaj RD; Curtis MA; Spalding KL; Buchholz BA; Fink D; Björk-Eriksson T; Nordborg C; Gage FH; Druid H; Eriksson PS; Frisén J
Article: CELL. 2005;122(1):133-143

Retrospective birth dating of cells in humans.

Spalding KL; Bhardwaj RD; Buchholz BA; Druid H; Frisén J
Article: GENES & DEVELOPMENT. 2005;19(4):462-471

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.

Holmberg J; Armulik A; Senti K-A; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2005;21(1):33-45

Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat.

Spalding KL; Dharmarajan AM; Harvey AR
Article: NEUROSCIENCE. 2005;131(2):387-395

Retinal ganglion cell neurotrophin receptor levels and trophic requirements following target ablation in the neonatal rat.

Spalding KL; Cui Q; Harvey AR
Article: DEVELOPMENTAL NEUROBIOLOGY. 2004;60(3):319-327

Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina.

Spalding KL; Rush RA; Harvey AR
Article: EXPERIMENTAL NEUROLOGY. 2004;186(1):6-19

Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.

Mellough CB; Cui Q; Spalding KL; Symons NA; Pollett MA; Snyder EY; Macklis JD; Harvey AR
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;19(4):485-500

Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system.

Spalding KL; Tan MML; Hendry IA; Harvey AR
Article: DEVELOPMENTAL BRAIN RESEARCH. 1998;107(1):133-142

The effects of central administration of neurotrophins or transplants of fetal tectal tissue on retinal ganglion cell survival following removal of the superior colliculus in neonatal rats.

Spalding KL; Cui Q; Harvey AR
Visa fler

Alla övriga publikationer

Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):270-289

White adipocyte dysfunction and obesity-associated pathologies in humans.

Hagberg CE; Spalding KL
Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):333

Publisher Correction: White adipocyte dysfunction and obesity-associated pathologies in humans.

Hagberg CE; Spalding KL
Editorial comment: EBIOMEDICINE. 2022;81:104105

Profiling hypertrophic adipocytes in humans, from transcriptomics to diagnostics.

Li Q; Spalding KL
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1003219

The regulation of adipocyte growth in white adipose tissue.

Li Q; Spalding KL
Review: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(5):934-943

Cellular senescence and its role in white adipose tissue.

Smith U; Li Q; Rydén M; Spalding KL
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2014;56:123-132

Maintenance of white adipose tissue in man.

Hyvönen MT; Spalding KL
Published conference paper: MOLECULAR & CELLULAR PROTEOMICS. 2010;9(5):1022-1030

Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis.

Alkass K; Buchholz BA; Ohtani S; Yamamoto T; Druid H; Spalding KL
Published conference paper: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 2010;268(7-8):1295-1298

A mathematical model for the interpretation of nuclear bomb test derived ¹⁴C incorporation in biological systems

Bernard S; Frisen J; Spalding KL
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2006;572:447-451

Injury-induced retinal ganglion cell loss in the neonatal rat retina.

Spalding KL; Cui Q; Dharmarajan AM; Harvey AR
Editorial comment: NATURE. 2005;437(7057):333-334

Forensics: age written in teeth by nuclear tests.

Spalding KL; Buchholz BA; Bergman L-E; Druid H; Frisén J

Forskningsbeskrivning

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