Jonas Muhr

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Jag är professor i eukaryot molekylärbiologi vid institutionen för cell och molekylärbiologi. Min forskargrupp arbetar huvudsakligen med att försöka förstå hur hjärnstamceller regleras under kortikal utveckling och hur mitotiskt aktiva mänskliga hjärnstamceller förhindras från malign transformation.

Artiklar

Article: ISCIENCE. 2022;25(11):105317

Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer.

Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
Article: DEVELOPMENT. 2022;149(14):dev200547

SOX2 transcription factor binding and function.

Hagey DW; Bergsland M; Muhr J
Article: BIOESSAYS. 2021;43(7):e2000285

The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance.

Muhr J; Hagey DW
Article: NATURE COMMUNICATIONS. 2020;11(1):2898

CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.

Hagey DW; Topcic D; Kee N; Reynaud F; Bergsland M; Perlmann T; Muhr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.

Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nistér M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WG; Schlisio S
Article: EMBO REPORTS. 2018;19(11):e46635

Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression.

Klum S; Zaouter C; Alekseenko Z; Björklund ÅK; Hagey DW; Ericson J; Muhr J; Bergsland M
Article: PLOS GENETICS. 2018;14(2):e1007224

SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs.

Hagey DW; Klum S; Kurtsdotter I; Zaouter C; Topcic D; Andersson O; Bergsland M; Muhr J
Article: CANCER RESEARCH. 2017;77(18):4985-4997

SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.

Kurtsdotter I; Topcic D; Karlén A; Singla B; Hagey DW; Bergsland M; Siesjö P; Nistér M; Carlson JW; Lefebvre V; Persson O; Holmberg J; Muhr J
Article: CELL REPORTS. 2016;17(2):469-483

MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.

Vasconcelos FF; Sessa A; Laranjeira C; Raposo AASF; Teixeira V; Hagey DW; Tomaz DM; Muhr J; Broccoli V; Castro DS
Article: GENOME RESEARCH. 2016;26(7):908-917

Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells.

Hagey DW; Zaouter C; Combeau G; Lendahl MA; Andersson O; Huss M; Muhr J
Article: CELL REPORTS. 2014;9(5):1908-1920

Sox2 acts in a dose-dependent fashion to regulate proliferation of cortical progenitors.

Hagey DW; Muhr J
Article: CELL REPORTS. 2014;8(4):1018-1025

Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2794-2799

Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system.

Lee KE; Seo J; Shin J; Ji EH; Roh J; Kim JY; Sun W; Muhr J; Lee S; Kim J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(18):7330-7335

SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals.

Oosterveen T; Kurdija S; Ensterö M; Uhde CW; Bergsland M; Sandberg M; Sandberg R; Muhr J; Ericson J
Article: DEVELOPMENTAL CELL. 2012;23(5):1006-1019

Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.

Oosterveen T; Kurdija S; Alekseenko Z; Uhde CW; Bergsland M; Sandberg M; Andersson E; Dias JM; Muhr J; Ericson J
Article: GENES & DEVELOPMENT. 2011;25(23):2453-2464

Sequentially acting Sox transcription factors in neural lineage development.

Bergsland M; Ramsköld D; Zaouter C; Klum S; Sandberg R; Muhr J
Article: EXPERIMENTAL NEUROLOGY. 2011;229(1):65-71

Olfactory ensheathing cells promote neurite outgrowth from co-cultured brain stem slice.

Jiao Y; Novozhilova E; Karlén A; Muhr J; Olivius P
Article: PLOS ONE. 2011;6(3):e18454

Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma.

Holmberg J; He X; Peredo I; Orrego A; Hesselager G; Ericsson C; Hovatta O; Oba-Shinjo SM; Marie SKN; Nistér M; Muhr J
Article: DEVELOPMENT. 2010;137(3):437-445

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.

Marklund U; Hansson EM; Sundström E; de Angelis MH; Przemeck GKH; Lendahl U; Muhr J; Ericson J
Article: DEVELOPMENT. 2008;135(10):1843-1851

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.

Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: GENES & DEVELOPMENT. 2006;20(24):3475-3486

The establishment of neuronal properties is controlled by Sox4 and Sox11.

Bergsland M; Werme M; Malewicz M; Perlmann T; Muhr J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(16):3108-3119

A global genomic transcriptional code associated with CNS-expressed genes.

Bailey PJ; Klos JM; Andersson E; Karlén M; Källström M; Ponjavic J; Muhr J; Lenhard B; Sandelin A; Ericson J
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127

Recording Notch signaling in real time.

Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: NATURE NEUROSCIENCE. 2005;8(8):995-1001

Sox21 promotes the progression of vertebrate neurogenesis.

Sandberg M; Källström M; Muhr J
Article: NATURE NEUROSCIENCE. 2003;6(11):1162-1168

Vertebrate neurogenesis is counteracted by Sox1-3 activity.

Bylund M; Andersson E; Novitch BG; Muhr J
Article: NEURON. 2001;31(5):743-755

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.

Vallstedt A; Muhr J; Pattyn A; Pierani A; Mendelsohn M; Sander M; Jessell TM; Ericson J
Article: CELL. 2001;104(6):861-873

Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.

Muhr J; Andersson E; Persson M; Jessell TM; Ericson J
Article: NEURON. 1999;23(4):689-702

Convergent inductive signals specify midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos.

Muhr J; Graziano E; Wilson S; Jessell TM; Edlund T
Article: NEURON. 1997;19(3):487-502

Assignment of early caudal identity to neural plate cells by a signal from caudal paraxial mesoderm.

Muhr J; Jessell TM; Edlund T
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):809-816

Sonic hedgehog: a common signal for ventral patterning along the rostrocaudal axis of the neural tube.

Ericson J; Muhr J; Jessell TM; Edlund T
Article: CELL. 1995;81(5):747-756

Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.

Ericson J; Muhr J; Placzek M; Lints T; Jessell TM; Edlund T
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