Jesper Z. Haeggström

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: AMERICAN JOURNAL OF HEMATOLOGY. 2023;98(7):1000-1016

Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes.

Nshimiyimana R; Libreros S; Simard M; Chiang N; Rodriguez AR; Spur BW; Haeggström JZ; Serhan CN
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(8):7539

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase.

Teder T; König S; Singh R; Samuelsson B; Werz O; Garscha U; Haeggström JZ
Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310

Biosynthesis of prostaglandin 15dPGJ2 -glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3.

Steinmetz-Späh J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Rönnberg E; Merk D; Wermeling F; Haeggström JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
Article: ALLERGY. 2022;77(9):2677-2687

Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction.

Tang X; Rönnberg E; Säfholm J; Thulasingam M; Trauelsen M; Schwartz TW; Wheelock CE; Dahlén S-E; Nilsson G; Haeggström JZ
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:806240

The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes.

Tang X; Teder T; Samuelsson B; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2116559118

Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer.

Shay AE; Nshimiyimana R; Samuelsson B; Petasis NA; Haeggström JZ; Serhan CN
Article: NATURE COMMUNICATIONS. 2021;12(1):1728

Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis.

Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggström JZ
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(9):2420-2431

Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry.

Geib T; Thulasingam M; Haeggström JZ; Sleno L
Article: MOLECULAR ASPECTS OF MEDICINE. 2020;:100893

WITHDRAWN: The Atlas of Inflammation Resolution (AIR).

Serhan CN; Gupta SK; Perretti M; Godson C; Brennan E; Li Y; Soehnlein O; Shimizu T; Werz O; Chiurchiù V; Azzi A; Dubourdeau M; Gupta SS; Schopohl P; Hoch M; Gjorgevikj D; Khan FM; Brauer D; Tripathi A; Cesnulevicius K; Lescheid D; Schultz M; Särndahl E; Repsilber D; Kruse R; Sala A; Haeggström JZ; Levy BD; Filep JG; Wolkenhauer O
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(4):976-984

Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4.

Tang X; Fuchs D; Tan S; Trauelsen M; Schwartz TW; Wheelock CE; Li N; Haeggström JZ
Article: FASEB JOURNAL. 2019;33(12):13794-13807

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

Jouvene CC; Shay AE; Soens MA; Norris PC; Haeggström JZ; Serhan CN
Article: CELL CHEMICAL BIOLOGY. 2019;26(4):524-534.e5

Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.

König S; Pace S; Pein H; Heinekamp T; Kramer J; Romp E; Straßburger M; Troisi F; Proschak A; Dworschak J; Scherlach K; Rossi A; Sautebin L; Haeggström JZ; Hertweck C; Brakhage AA; Gerstmeier J; Proschak E; Werz O
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2018;139:24-28

Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.

Araújo AC; Tang X; Haeggström JZ
Article: FASEB JOURNAL. 2018;32(5):2827-2840

Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

Wan M; Tang X; Rekha RS; Muvva SSVJR; Brighenti S; Agerberth B; Haeggström JZ
Article: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2018;8(1):31-35

Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action.

Lisewski AM; Quiros JP; Mittal M; Putluri N; Sreekumar A; Haeggström JZ; Lichtarge O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(8):1907-1912

Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.

Di Gennaro A; Araújo AC; Busch A; Jin H; Wågsäter D; Vorkapic E; Caidahl K; Eriksson P; Samuelsson B; Maegdefessel L; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(36):9689-9694

Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.

Stsiapanava A; Samuelsson B; Haeggström JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(8):2099-2111

Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase.

Mittal M; Hasan M; Balagunaseelan N; Fauland A; Wheelock C; Rådmark O; Haeggström JZ; Rinaldo-Matthis A
Article: SCIENTIFIC REPORTS. 2016;6:38316

Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase.

Cebula M; Turan IS; Sjödin B; Thulasingam M; Brock J; Chmyrov V; Widengren J; Abe H; Mannervik B; Haeggström JZ; Rinaldo-Matthis A; Akkaya EU; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1861(11):1605-1613

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.

Liening S; Scriba GK; Rummler S; Weinigel C; Kleinschmidt TK; Haeggström JZ; Werz O; Garscha U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(35):18410-18418

Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.

Ahmad S; Ytterberg AJ; Thulasingam M; Tholander F; Bergman T; Zubarev R; Wetterholm A; Rinaldo-Matthis A; Haeggström JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016;26(15):3547-3551

Kinetic investigation of human 5-lipoxygenase with arachidonic acid.

Mittal M; Kumar RB; Balagunaseelan N; Hamberg M; Jegerschöld C; Rådmark O; Haeggström JZ; Rinaldo-Matthis A
Article: FASEB JOURNAL. 2016;30(2):884-894

Cathelicidins positively regulate pancreatic β-cell functions.

Sun J; Xu M; Ortsäter H; Lundeberg E; Juntti-Berggren L; Chen YQ; Haeggström JZ; Gudmundsson GH; Diana J; Agerberth B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977

A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase.

Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggström JZ
Article: FASEB JOURNAL. 2015;29(12):5029-5043

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.

Lehmann C; Homann J; Ball A-K; Blöcher R; Kleinschmidt TK; Basavarajappa D; Angioni C; Ferreirós N; Häfner A-K; Rådmark O; Proschak E; Haeggström JZ; Geisslinger G; Parnham MJ; Steinhilber D; Kahnt AS
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(10 Pt A):1365-1371

Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity.

Ahmad S; Thulasingam M; Palombo I; Daley DO; Johnson KA; Morgenstern R; Haeggström JZ; Rinaldo-Matthis A
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2015;355(1):108-116

Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase.

Kleinschmidt TK; Haraldsson M; Basavarajappa D; Lundeberg E; Thulasingam M; Ekoff M; Fauland A; Lehmann C; Kahnt AS; Lindbom L; Haeggström JZ
Article: MULTIPLE SCLEROSIS JOURNAL. 2015;21(10):1271-1279

Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis.

Checa A; Khademi M; Sar DG; Haeggström JZ; Lundberg JO; Piehl F; Olsson T; Wheelock CE
Article: JOURNAL OF IMMUNOLOGY. 2015;195(3):1191-1201

P2X7 Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance.

Tang X; Basavarajappa D; Haeggström JZ; Wan M
Article: SCIENTIFIC REPORTS. 2015;5:12017

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment.

Checa A; Xu N; Sar DG; Haeggström JZ; Ståhle M; Wheelock CE
Article: NATURE NEUROSCIENCE. 2015;18(1):145-153

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.

Usoskin D; Furlan A; Islam S; Abdo H; Lönnerberg P; Lou D; Hjerling-Leffler J; Haeggström J; Kharchenko O; Kharchenko PV; Linnarsson S; Ernfors P
Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2014;7(6):955-964

High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy.

Snowden SG; Grapov D; Settergren M; D'Alexandri FL; Haeggström JZ; Fiehn O; Hyötyläinen T; Pedersen TL; Newman JW; Orešič M; Pernow J; Wheelock CE
Article: ATHEROSCLEROSIS. 2014;235(2):592-598

Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5.

Wan M; Hua X; Su J; Thiagarajan D; Frostegård AG; Haeggström JZ; Frostegård J
Article: FASEB JOURNAL. 2014;28(8):3456-3467

Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.

Wan M; Soehnlein O; Tang X; van der Does AM; Smedler E; Uhlén P; Lindbom L; Agerberth B; Haeggström JZ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):971-981

Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.

Wan M; van der Does AM; Tang X; Lindbom L; Agerberth B; Haeggström JZ
Article: AMINO ACIDS. 2014;46(5):1313-1320

A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.

Byzia A; Haeggström JZ; Salvesen GS; Drag M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(11):4227-4232

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.

Stsiapanava A; Olsson U; Wan M; Kleinschmidt T; Rutishauser D; Zubarev RA; Samuelsson B; Rinaldo-Matthis A; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(8):5199-5207

Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.

Niegowski D; Kleinschmidt T; Olsson U; Ahmad S; Rinaldo-Matthis A; Haeggström JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1844(2):439-446

Product formation controlled by substrate dynamics in leukotriene A4 hydrolase.

Stsiapanava A; Tholander F; Kumar RB; Qureshi AA; Niegowski D; Hasan M; Thunnissen M; Haeggström JZ; Rinaldo-Matthis A
Article: PLOS ONE. 2014;9(5):e96763

Structure and inhibition of mouse leukotriene C4 synthase.

Niegowski D; Kleinschmidt T; Ahmad S; Qureshi AA; Mårback M; Rinaldo-Matthis A; Haeggström JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;106:72-78

Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine.

Domeij H; Hua X; Su J; Bäcklund A; Yan Z; Frostegård AG; Haeggström JZ; Modéer T; Frostegård J
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(8):1965-1972

Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin.

Salvado MD; Di Gennaro A; Lindbom L; Agerberth B; Haeggström JZ
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2013;57(8):1378-1389

Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids.

Lundström SL; Yang J; Brannan JD; Haeggström JZ; Hammock BD; Nair P; O'Byrne P; Dahlén S-E; Wheelock CE
Article: FASEB JOURNAL. 2013;27(7):2573-2583

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.

Dalli J; Zhu M; Vlasenko NA; Deng B; Haeggström JZ; Petasis NA; Serhan CN
Article: BIOCHEMISTRY. 2013;52(10):1755-1764

Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.

Ahmad S; Niegowski D; Wetterholm A; Haeggström JZ; Morgenstern R; Rinaldo-Matthis A
Article: ALLERGY. 2013;68(3):304-311

The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.

Sun J; Dahlén B; Agerberth B; Haeggström JZ
Article: JOURNAL OF LIPID RESEARCH. 2013;54(1):116-126

Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations.

Lundström SL; Saluja R; Adner M; Haeggström JZ; Nilsson G; Wheelock CE
Article: BIOCHEMISTRY. 2012;51(4):848-856

Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase.

Rinaldo-Matthis A; Ahmad S; Wetterholm A; Lachmann P; Morgenstern R; Haeggström JZ
Article: PLOS ONE. 2012;7(3):e33780

Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.

Lundström SL; Yang J; Källberg HJ; Thunberg S; Gafvelin G; Haeggström JZ; Grönneberg R; Grunewald J; van Hage M; Hammock BD; Eklund A; Wheelock ÅM; Wheelock CE
Article: PLOS ONE. 2012;7(7):e41786

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease.

Nobili E; Salvado MD; Folkersen L; Castiglioni L; Kastrup J; Wetterholm A; Tremoli E; Hansson GK; Sironi L; Haeggström JZ; Gabrielsen A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20479-20484

Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.

Haas U; Raschperger E; Hamberg M; Samuelsson B; Tryggvason K; Haeggström JZ
Article: FASEB JOURNAL. 2011;25(5):1697-1705

Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1.

Wan M; Godson C; Guiry PJ; Agerberth B; Haeggström JZ
Article: ATHEROSCLEROSIS. 2011;215(2):411-416

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.

Gertow K; Nobili E; Folkersen L; Newman JW; Pedersen TL; Ekstrand J; Swedenborg J; Kühn H; Wheelock CE; Hansson GK; Hedin U; Haeggström JZ; Gabrielsen A
Article: FASEB JOURNAL. 2011;25(4):1417-1427

Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors.

Esser J; Gehrmann U; Salvado MD; Wetterholm A; Haeggström JZ; Samuelsson B; Gabrielsson S; Scheynius A; Rådmark O
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2011;84(3-4):109-112

Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release.

Johansson A-S; Haeggström JZ; Palmblad J
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;406(1):120-134

A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding.

Helgstrand C; Hasan M; Uysal H; Haeggström JZ; Thunnissen MMGM
Article: PLOS ONE. 2011;6(8):e23864

Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure.

Lundström SL; Levänen B; Nording M; Klepczynska-Nyström A; Sköld M; Haeggström JZ; Grunewald J; Svartengren M; Hammock BD; Larsson B-M; Eklund A; Wheelock ÅM; Wheelock CE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776

Arginine 104 is a key catalytic residue in leukotriene C4 synthase.

Rinaldo-Matthis A; Wetterholm A; Martinez Molina D; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(49):21093-21097

Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.

Di Gennaro A; Wågsäter D; Mäyränpää MI; Gabrielsen A; Swedenborg J; Hamsten A; Samuelsson B; Eriksson P; Haeggström JZ
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(17):2790-2796

Subcellular localization of leukotriene receptors in human endothelial cells.

Johansson A-S; Haeggström JZ; Hultenby K; Palmblad J
Article: FEBS LETTERS. 2010;584(15):3446-3451

Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors.

Tholander F; Roques B-P; Fournié-Zaluski M-C; Thunnissen MMGM; Haeggström JZ
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2010;88(8):795-806

Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion.

Gabrielsen A; Qiu H; Bäck M; Hamberg M; Hemdahl A-L; Agardh H; Folkersen L; Swedenborg J; Hedin U; Paulsson-Berne G; Haeggström JZ; Hansson GK
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):135-139

Advances in eicosanoid research, novel therapeutic implications.

Haeggström JZ; Rinaldo-Matthis A; Wheelock CE; Wetterholm A
Article: BIOINFORMATICS. 2009;25(15):1978-1979

GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome.

Folkersen L; Diez D; Wheelock CE; Haeggström JZ; Goto S; Eriksson P; Gabrielsen A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):1131-1137

COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells.

Salvado MD; Alfranca A; Escolano A; Haeggström JZ; Redondo JM
Article: FASEB JOURNAL. 2009;23(6):1750-1757

Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).

Di Gennaro A; Kenne E; Wan M; Soehnlein O; Lindbom L; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(1):301-305

Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.

Hammarberg T; Hamberg M; Wetterholm A; Hansson H; Samuelsson B; Haeggstro M JZ
Article: METHODS IN MOLECULAR BIOLOGY. 2009;579:161-187

HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.

Lundström SL; D'Alexandri FL; Nithipatikom K; Haeggström JZ; Wheelock AM; Wheelock CE
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2008;1784(11):1865-1872

Cold adaptation of enzymes: structural, kinetic and microcalorimetric characterizations of an aminopeptidase from the Arctic psychrophile Colwellia psychrerythraea and of human leukotriene A(4) hydrolase.

Huston AL; Haeggström JZ; Feller G
Article: FASEB JOURNAL. 2008;22(10):3525-3536

Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.

Sveinbjörnsson B; Rasmuson A; Baryawno N; Wan M; Pettersen I; Ponthan F; Orrego A; Haeggström JZ; Johnsen JI; Kogner P
Article: CHEMISTRY AND BIOLOGY. 2008;15(9):920-929

Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.

Tholander F; Muroya A; Roques B-P; Fournié-Zaluski M-C; Thunnissen MMGM; Haeggström JZ
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(1):1-6

High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.

Wetterholm A; Martinez Molina D; Nordlund P; Eshaghi S; Haeggström JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2008;16(9):4963-4983

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.

Kirkland TA; Adler M; Bauman JG; Chen M; Haeggström JZ; King B; Kochanny MJ; Liang AM; Mendoza L; Phillips GB; Thunnissen M; Trinh L; Whitlow M; Ye B; Ye H; Parkinson J; Guilford WJ
Article: PROTEIN SCIENCE. 2008;17(4):673-680

Engineering membrane protein overproduction in Escherichia coli.

Martinez Molina D; Cornvik T; Eshaghi S; Haeggström JZ; Nordlund P; Sabet MI
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2008;51(1-2):101-105

Preparation of high specific activity tritium-labelled leukotriene B₄ suitable for radioligand binding assay

Schramm SI; Nagaev IY; Sabirsh A; Shevchenko VP; Arkhipova AS; Haeggstrom JZ; Myasoedov NF
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(1):19-24

Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.

Qiu H; Strååt K; Rahbar A; Wan M; Söderberg-Nauclér C; Haeggström JZ
Article: FASEB JOURNAL. 2007;21(11):2897-2905

Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses.

Wan M; Sabirsh A; Wetterholm A; Agerberth B; Haeggström JZ
Article: NATURE. 2007;448(7153):613-616

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.

Martinez Molina D; Wetterholm A; Kohl A; McCarthy AA; Niegowski D; Ohlson E; Hammarberg T; Eshaghi S; Haeggström JZ; Nordlund P
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007;67(4):1113-1118

Assay for rapid analysis of the tri-peptidase activity of LTA4 hydrolase.

Tholander F; Haeggström JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):209-212

Endothelium-dependent vascular responses induced by leukotriene B4.

Bäck M; Sakata K; Qiu H; Haeggström JZ; Dahlén S-E
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):198-202

Structure and catalytic mechanisms of leukotriene A4 hydrolase.

Haeggström JZ; Tholander F; Wetterholm A
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2006;14(21):7241-7257

Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.

Albrecht S; Defoin A; Salomon E; Tarnus C; Wetterholm A; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(21):8161-8166

Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.

Qiu H; Gabrielsen A; Agardh HE; Wan M; Wetterholm A; Wong C-H; Hedin U; Swedenborg J; Hansson GK; Samuelsson B; Paulsson-Berne G; Haeggström JZ
Article: BIOCHEMISTRY. 2006;45(18):5733-5744

Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1.

Sabirsh A; Bywater RP; Bristulf J; Owman C; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(18):6913-6918

Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.

Qiu H; Johansson A-S; Sjöström M; Wan M; Schröder O; Palmblad J; Haeggström JZ
Article: JOURNAL OF LIPID RESEARCH. 2006;47(5):1071-1080

15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells.

Schröder O; Yudina Y; Sabirsh A; Zahn N; Haeggström JZ; Stein J
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2005;73(6):431-440

Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology.

Sabirsh A; Bristulf J; Karlsson U; Owman C; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(39):33477-33486

Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae.

Tholander F; Kull F; Ohlson E; Shafqat J; Thunnissen MMGM; Haeggström JZ
Article: JOURNAL OF LIPID RESEARCH. 2005;46(6):1339-1346

Fluorescent leukotriene B4: potential applications.

Sabirsh A; Wetterholm A; Bristulf J; Leffler H; Haeggström JZ; Owman C
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(1):87-94

Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis.

Schröder O; Sjöström M; Qiu H; Jakobsson P-J; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;324(2):815-821

Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast.

Ramires R; Caiaffa MF; Tursi A; Haeggström JZ; Macchia L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(28):29023-29030

The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity.

Nigam S; Patabhiraman S; Ciccoli R; Ishdorj G; Schwarz K; Petrucev B; Kühn H; Haeggström JZ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2004;287(1):H419-H424

Leukotriene B4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor.

Bäck M; Qiu H; Haeggström JZ; Sakata K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(26):27376-27382

Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.

Rudberg PC; Tholander F; Andberg M; Thunnissen MMGM; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;312(2):271-276

Molecular and catalytic properties of three rat leukotriene C(4) synthase homologs.

Schröder O; Sjöström M; Qiu H; Stein J; Jakobsson PJ; Haeggström JZ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(8):e37-e41

Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells.

Sjöström M; Johansson A-S; Schröder O; Qiu H; Palmblad J; Haeggström JZ
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2003;59(Pt 6):1093-1095

Crystallization and X-ray diffraction data analysis of leukotriene A4 hydrolase from Saccharomyces cerevisiae.

Andersson B; Kull F; Haeggström JZ; Thunnissen MMGM
Article: FASEB JOURNAL. 2002;16(12):1648-1650

Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.

Thunnissen MMGM; Andersson B; Samuelsson B; Wong C-H; Haeggström JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2002;68-69:495-510

Leukotriene A4 hydrolase.

Haeggström JZ; Kull F; Rudberg PC; Tholander F; Thunnissen MMGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1583(1):53-62

Human mast cells express two leukotriene C(4) synthase isoenzymes and the CysLT(1) receptor.

Sjöström M; Jakobsson PJ; Juremalm M; Ahmed A; Nilsson G; Macchia L; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(7):4215-4220

Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

Rudberg PC; Tholander F; Thunnissen MMGM; Samuelsson B; Haeggstrom JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(2):1398-1404

Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.

Rudberg PC; Tholander F; Thunnissen MMGM; Haeggström JZ
Article: NEUROSCIENCE. 2002;115(3):891-897

Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system.

Fetissov SO; Schröder O; Jakobsson P-J; Samuelsson B; Haeggström JZ; Hökfelt T
Article: BIOCHEMISTRY. 2001;40(42):12695-12703

Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues.

Kull F; Ohlson E; Lind B; Haeggström JZ
Article: FEBS JOURNAL. 2001;268(9):2578-2586

Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.

Sjöström M; Jakobsson PJ; Heimburger M; Palmblad J; Haeggström JZ
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2001;8(2):131-135

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

Thunnissen MM; Nordlund P; Haeggström JZ
Article: CELL AND TISSUE RESEARCH. 2001;303(2):235-252

Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide: in situ hybridization and immunocytochemical studies.

Ichitani Y; Holmberg K; Maunsbach AB; Haeggström JZ; Samuelsson B; De Witt D; Hökfelt T
Article: BIOCHEMICAL JOURNAL. 2000;345 Pt 3(Pt 3):621-625

Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.

Andberg M; Wetterholm A; Medina JF; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(49):34683-34690

Cloning and characterization of a bifunctional leukotriene A(4) hydrolase from Saccharomyces cerevisiae.

Kull F; Ohlson E; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(3):617-624

5-Lipoxygenase upregulation by dexamethasone in human mast cells.

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Article: CHEMISTRY-A EUROPEAN JOURNAL. 1998;4(9):1698-1713

Probing the activities and mechanisms of leukotriene A₄ hydrolase with synthetic inhibitors

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Article: FEBS LETTERS. 1998;433(3):219-222

Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes.

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Analysis of the molecular mechanism of substrate-mediated inactivation of leukotriene A4 hydrolase.

Mueller MJ; Andberg M; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(37):23057-23063

Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid. Implications for the epoxide hydrolase mechanism.

Andberg MB; Hamberg M; Haeggström JZ
Article: NEUROREPORT. 1997;8(13):2949-2952

Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study.

Ichitani Y; Shi T; Haeggstrom JZ; Samuelsson B; Hökfelt T
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Effects of metal ions on the binding activity of the human leukocyte leukotriene B4 receptor.

Ng CF; Haeggström JZ; Samuelsson B
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Expression of prostaglandin endoperoxide H synthase 1 and 2 in human placenta at term.

Macchia L; Di Paola R; Guerrese MC; Chiechi LM; Tursi A; Caiaffa MF; Haeggstrom JZ
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Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4.

Mueller MJ; Andberg MB; Samuelsson B; Haeggström JZ
Article: FASEB JOURNAL. 1996;10(10):1147-1158

Lipid mediator networks in cell signaling: update and impact of cytokines.

Serhan CN; Haeggström JZ; Leslie CC
Article: FEBS JOURNAL. 1996;238(3):599-605

Formation of a novel enzymatic metabolite of leukotriene A4 in tissues of Xenopus laevis.

Strömberg F; Hamberg M; Rosenzvist U; Dahlén SE; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(12):5931-5935

Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.

Mueller MJ; Blomster M; Oppermann UC; Jörnvall H; Samuelsson B; Haeggström JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(10):1405-1415

Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase.

Hogg JH; Ollmann IR; Haeggström JZ; Wetterholm A; Samuelsson B; Wong CH
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1995;275(1):31-37

Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes.

Wetterholm A; Haeggström JZ; Samuelsson B; Yuan W; Munoz B; Wong CH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(18):8383-8387

Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

Mueller MJ; Wetterholm A; Blomster M; Jörnvall H; Samuelsson B; Haeggström JZ
Article: FEBS JOURNAL. 1995;231(3):528-534

Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase.

Blomster M; Wetterholm A; Mueller MJ; Haeggström JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(7):969-995

Investigation of the inhibition of leukotriene A4 hydrolase.

Ollmann IR; Hogg JH; Muñoz B; Haeggström JZ; Samuelsson B; Wong CH
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1257(1):58-74

Arachidonic acid metabolism in the human mast cell line HMC-1: 5-lipoxygenase gene expression and biosynthesis of thromboxane.

Macchia L; Hamberg M; Kumlin M; Butterfield JH; Haeggström JZ
Article: BIOCHEMISTRY. 1995;34(11):3536-3543

Chemical modification of leukotriene A4 hydrolase. Indications for essential tyrosyl and arginyl residues at the active site.

Mueller MJ; Samuelsson B; Haeggström JZ
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Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2014;18(1):79-93

Targeting leukotriene B4 in inflammation.

Di Gennaro A; Haeggström JZ
Editorial comment: CHEMISTRY AND BIOLOGY. 2013;20(2):138-140

Resolving resolvins.

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Review: TRENDS IN MOLECULAR MEDICINE. 2012;18(4):233-243

Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2.

Salvado MD; Alfranca A; Haeggström JZ; Redondo JM
Review: ADVANCES IN IMMUNOLOGY, VOL 150. 2012;116:51-92

The leukotrienes: immune-modulating lipid mediators of disease.

Di Gennaro A; Haeggström JZ
Review: CHEMICAL REVIEWS. 2011;111(10):5866-5898

Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease.

Haeggström JZ; Funk CD
Review: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2011;12(7):1026-1052

Lipid mediator profiling in pulmonary disease.

Lundström SL; Balgoma D; Wheelock ÅM; Haeggström JZ; Dahlén S-E; Wheelock CE
Review: BIOCHIMIE. 2010;92(6):676-681

Structures and mechanisms of enzymes in the leukotriene cascade.

Rinaldo-Matthis A; Haeggström JZ
Review: MOLECULAR BIOSYSTEMS. 2010;6(2):289-304

The use of network analyses for elucidating mechanisms in cardiovascular disease.

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Systems biology approaches and pathway tools for investigating cardiovascular disease.

Wheelock CE; Wheelock AM; Kawashima S; Diez D; Kanehisa M; van Erk M; Kleemann R; Haeggström JZ; Goto S
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Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis.

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Profiling inflammation in the ischemic human heart in vivo

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Review: THE SCIENTIFIC WORLD JOURNAL. 2002;2:1734-1749

Functional properties and molecular architecture of leukotriene A4 hydrolase, a pivotal catalyst of chemotactic leukotriene formation.

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Enzymes and receptors in the leukotriene cascade.

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Structure, function, and regulation of leukotriene A4 hydrolase.

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Leukotriene-A4 hydrolase: probing the active sites and catalytic mechanisms by site-directed mutagenesis.

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Cyclooxygenase-2 involved in stimulation of renal mechanosensitive neurons.

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Leukotriene A4 hydrolase and the committed step in leukotriene B4 biosynthesis.

Haeggström JZ
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Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4.

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Enzymatic conversion of leukotriene A4 into 5(S),12(R)-diHETE in frog tissues.

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Studies on the active site of leukotriene A4 hydrolase.

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Leukotriene A4 hydrolase activity in Xenopus laevis.

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Mutation of Tyr-383 in leukotriene A4 hydrolase: effects on enzyme activities.

Andberg M; Wetterholm A; Haeggström JZ
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Leukotriene A4 hydrolase: differential inhibition of the catalytic activities by divalent cations.

Wetterholm A; Haeggström JZ
Published paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:179-181

Metal inhibition of LTA4 hydrolase and cellular 5-lipoxygenase activity.

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