Jaakko Patrakka

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Adjungerad professor i patologi vid institutionen för laboratoriemedicin
från 1 september 2020. Primär anställning: Läkare vid Karolinska
Universitetssjukhuset. För mer information, se den engelska profilsidan.

Artiklar

Article: KIDNEY INTERNATIONAL. 2023;103(6):1120-1130

Deep learning-based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies.

Unnersjö-Jess D; Butt L; Höhne M; Sergei G; Fatehi A; Witasp A; Wernerson A; Patrakka J; Hoyer PF; Blom H; Schermer B; Bozek K; Benzing T
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):208

Soluble Klotho protects against glomerular injury through regulation of ER stress response.

Charrin E; Dabaghie D; Sen I; Unnersjö-Jess D; Möller-Hackbarth K; Burmakin M; Mencke R; Zambrano S; Patrakka J; Olauson H
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2023;38(2):311-321

The role of dendrin in IgA nephropathy.

Levin A; Schwarz A; Hulkko J; He L; Sun Y; Barany P; Bruchfeld A; Herthelius M; Wennberg L; Ebefors K; Patrakka J; Betsholtz C; Nyström J; Mölne J; Hultenby K; Witasp A; Wernerson A
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2022;33(11):2008-2025

A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2.

Hada I; Shimizu A; Takematsu H; Nishibori Y; Kimura T; Fukutomi T; Kudo A; Ito-Nitta N; Kiuchi Z; Patrakka J; Mikami N; Leclerc S; Akimoto Y; Hirayama Y; Mori S; Takano T; Yan K
Article: KIDNEY INTERNATIONAL. 2022;101(4):752-765

Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing.

Zambrano S; He L; Kano T; Sun Y; Charrin E; Lal M; Betsholtz C; Suzuki Y; Patrakka J
Article: KIDNEY INTERNATIONAL. 2021;100(4):809-823

Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway.

Möller-Hackbarth K; Dabaghie D; Charrin E; Zambrano S; Genové G; Li X; Wernerson A; Lal M; Patrakka J
Article: NATURE COMMUNICATIONS. 2021;12(1):2141

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes.

He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Möller-Hackbarth K; Unnersjö-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
Article: KIDNEY INTERNATIONAL. 2021;99(4):1010-1020

A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales.

Unnersjö-Jess D; Butt L; Höhne M; Witasp A; Kühne L; Hoyer PF; Patrakka J; Brinkkötter PT; Wernerson A; Schermer B; Benzing T; Scott L; Brismar H; Blom H
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2020;35(12):2059-2072

Novel insights into the disease transcriptome of human diabetic glomeruli and tubulointerstitium.

Levin A; Reznichenko A; Witasp A; Liu P; Greasley PJ; Sorrentino A; Blondal T; Zambrano S; Nordström J; Bruchfeld A; Barany P; Ebefors K; Erlandsson F; Patrakka J; Stenvinkel P; Nyström J; Wernerson A
Article: SCIENTIFIC REPORTS. 2020;10(1):20037

Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death.

Rodriguez PQ; Unnersjö-Jess D; Zambrano SS; Guo J; Möller-Hackbarth K; Blom H; Jahnukainen T; Ebarasi L; Patrakka J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2019;30(9):1573-1586

GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway.

Zambrano S; Möller-Hackbarth K; Li X; Rodriguez PQ; Charrin E; Schwarz A; Nyström J; Wernerson AÖ; Lal M; Patrakka J
Article: SCIENTIFIC REPORTS. 2019;9(1):8888

Coro2b, a podocyte protein downregulated in human diabetic nephropathy, is involved in the development of protamine sulphate-induced foot process effacement.

Schwarz A; Möller-Hackbarth K; Ebarasi L; Unnersjö Jess D; Zambrano S; Blom H; Wernerson A; Lal M; Patrakka J
Article: KIDNEY INTERNATIONAL. 2018;94(6):1099-1110

A CRISP(e)R view on kidney organoids allows generation of an induced pluripotent stem cell-derived kidney model for drug discovery.

Boreström C; Jonebring A; Guo J; Palmgren H; Cederblad L; Forslöw A; Svensson A; Söderberg M; Reznichenko A; Nyström J; Patrakka J; Hicks R; Maresca M; Valastro B; Collén A
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2018;29(6):1679-1689

Depletion of Gprc5a Promotes Development of Diabetic Nephropathy.

Ma X; Schwarz A; Sevilla SZ; Levin A; Hultenby K; Wernerson A; Lal M; Patrakka J
Article: KIDNEY INTERNATIONAL. 2018;93(4):1008-1013

Confocal super-resolution imaging of the glomerular filtration barrier enabled by tissue expansion.

Unnersjö-Jess D; Scott L; Sevilla SZ; Patrakka J; Blom H; Brismar H
Article: SCIENTIFIC REPORTS. 2018;8(1):4712

FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice.

Zambrano S; Rodriguez PQ; Guo J; Möller-Hackbarth K; Schwarz A; Patrakka J
Article: PLOS ONE. 2018;13(8):e0202400

Association of crumbs homolog-2 with mTORC1 in developing podocyte.

Hamano S; Nishibori Y; Hada I; Mikami N; Ito-Nitta N; Fukuhara D; Kudo A; Xiao Z; Nukui M; Patrakka J; Tryggvason K; Yan K
Article: CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017;21(4):677-684

Novel NPHS2 variant in patients with familial steroid-resistant nephrotic syndrome with early onset, slow progression and dominant inheritance pattern.

Suvanto M; Patrakka J; Jahnukainen T; Sjöström P-M; Nuutinen M; Arikoski P; Kataja J; Kestilä M; Jalanko H
Article: CELL METABOLISM. 2017;25(3):713-726

Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.

Falkevall A; Mehlem A; Palombo I; Heller Sahlgren B; Ebarasi L; He L; Ytterberg AJ; Olauson H; Axelsson J; Sundelin B; Patrakka J; Scotney P; Nash A; Eriksson U
Article: JCI INSIGHT. 2016;1(9):86177

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes.

Grahammer F; Wigge C; Schell C; Kretz O; Patrakka J; Schneider S; Klose M; Kind J; Arnold SJ; Habermann A; Bräuniger R; Rinschen MM; Völker L; Bregenzer A; Rubbenstroth D; Boerries M; Kerjaschki D; Miner JH; Walz G; Benzing T; Fornoni A; Frangakis AS; Huber TB
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2015;309(11):F955-F966

Knockdown of Tmem234 in zebrafish results in proteinuria.

Rodriguez PQ; Oddsson A; Ebarasi L; He B; Hultenby K; Wernerson A; Betsholtz C; Tryggvason K; Patrakka J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(8):2143-2157

Dendrin ablation prolongs life span by delaying kidney failure.

Weins A; Wong JS; Basgen JM; Gupta R; Daehn I; Casagrande L; Lessman D; Schwartzman M; Meliambro K; Patrakka J; Shaw A; Tryggvason K; He JC; Nicholas SB; Mundel P; Campbell KN
Article: PLOS ONE. 2015;10(3):e0122067

Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.

Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlén M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Article: NEPHRON EXTRA. 2014;4(3):146-154

Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.

Hulkko J; Patrakka J; Lal M; Tryggvason K; Hultenby K; Wernerson A
Article: PEDIATRIC NEPHROLOGY. 2013;28(2):339-343

Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy.

Rodriguez PQ; Lohkamp B; Celsi G; Mache CJ; Auer-Grumbach M; Wernerson A; Hamajima N; Tryggvason K; Patrakka J
Article: PLOS ONE. 2013;8(12):e83133

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.

Xiao Z; Rodriguez PQ; He L; Betsholtz C; Tryggvason K; Patrakka J
Article: PLOS ONE. 2013;8(8):e72750

Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes.

Mao J; Wang D; Mataleena P; He B; Niu D; Katayama K; Xu X; Ojala JR; Wang W; Shu Q; Du L; Liu A; Pikkarainen T; Patrakka J; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2013;83(1):63-71

Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.

Sistani L; Rodriguez PQ; Hultenby K; Uhlen M; Betsholtz C; Jalanko H; Tryggvason K; Wernerson A; Patrakka J
Article: KIDNEY INTERNATIONAL. 2012;82(10):1071-1083

Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics.

Perisic L; Lal M; Hulkko J; Hultenby K; Önfelt B; Sun Y; Dunér F; Patrakka J; Betsholtz C; Uhlen M; Brismar H; Tryggvason K; Wernerson A; Pikkarainen T
Article: DEVELOPMENTAL DYNAMICS. 2011;240(12):2646-2656

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainen T; Vainio S; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2011;80(10):1045-1054

Pdlim2 is a novel actin-regulating protein of podocyte foot processes.

Sistani L; Dunér F; Udumala S; Hultenby K; Uhlen M; Betsholtz C; Tryggvason K; Wernerson A; Patrakka J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(11):2037-2046

Glcci1 deficiency leads to proteinuria.

Nishibori Y; Katayama K; Parikka M; Oddsson A; Nukui M; Hultenby K; Wernerson A; He B; Ebarasi L; Raschperger E; Norlin J; Uhlén M; Patrakka J; Betsholtz C; Tryggvason K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):3965-3980

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

Yaddanapudi S; Altintas MM; Kistler AD; Fernandez I; Möller CC; Wei C; Peev V; Flesche JB; Forst A-L; Li J; Patrakka J; Xiao Z; Grahammer F; Schiffer M; Lohmüller T; Reinheckel T; Gu C; Huber TB; Ju W; Bitzer M; Rastaldi MP; Ruiz P; Tryggvason K; Shaw AS; Faul C; Sever S; Reiser J
Article: NEPHRON. 2011;117(2):e39-e46

Expression of novel podocyte-associated proteins sult1b1 and ankrd25.

Xu X; Patrakka J; Sistani L; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: NEPHRON. 2011;118(3):e39-e48

Glomerular podocytes express type 1 adenylate cyclase: inactivation results in susceptibility to proteinuria.

Xiao Z; He L; Takemoto M; Jalanko H; Chan GC; Storm DR; Betsholtz C; Tryggvason K; Patrakka J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):164-169

Molecular make-up of the glomerular filtration barrier.

Patrakka J; Tryggvason K
Article: NEPHRON. 2010;116(2):e42-e52

Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.

Dunér F; Lindström K; Hultenby K; Hulkko J; Patrakka J; Tryggvason K; Haraldsson B; Wernerson A; Pettersson E
Article: AMERICAN JOURNAL OF NEPHROLOGY. 2009;29(6):558-570

Glomerular transcriptome changes associated with lipopolysaccharide-induced proteinuria.

Sun Y; He L; Takemoto M; Patrakka J; Pikkarainen T; Genové G; Norlin J; Truvé K; Tryggvason K; Betsholtz C
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2008;23(8):2504-2511

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.

Dunér F; Patrakka J; Xiao Z; Larsson J; Vlamis-Gardikas A; Pettersson E; Tryggvason K; Hultenby K; Wernerson A
Article: TRANSPLANTATION. 2007;83(10):1316-1323

Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1).

Kuusniemi A-M; Qvist E; Sun Y; Patrakka J; Rönnholm K; Karikoski R; Jalanko H
Article: KIDNEY INTERNATIONAL. 2007;71(9):889-900

Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis.

He L; Sun Y; Patrakka J; Mostad P; Norlin J; Xiao Z; Andrae J; Tryggvason K; Samuelsson T; Betsholtz C; Takemoto M
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(3):689-697

Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.

Patrakka J; Xiao Z; Nukui M; Takemoto M; He L; Oddsson A; Perisic L; Kaukinen A; Szigyarto CA-K; Uhlén M; Jalanko H; Betsholtz C; Tryggvason K
Article: NEPHRON. 2007;106(2):e32-e36

The glomerular transcriptome and proteome.

Betsholtz C; He L; Takemoto M; Norlin J; Sun Y; Patrakka J; Tryggvason K
Article: EMBO JOURNAL. 2006;25(5):1160-1174

Large-scale identification of genes implicated in kidney glomerulus development and function.

Takemoto M; He L; Norlin J; Patrakka J; Xiao Z; Petrova T; Bondjers C; Asp J; Wallgard E; Sun Y; Samuelsson T; Mostad P; Lundin S; Miura N; Sado Y; Alitalo K; Quaggin SE; Tryggvason K; Betsholtz C
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2004;15(10):2611-2618

Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria.

Lahdenkari A-T; Lounatmaa K; Patrakka J; Holmberg C; Wartiovaara J; Kestilä M; Koskimies O; Jalanko H
Article: PEDIATRIC RESEARCH. 2004;55(5):774-781

Tissue expression of nephrin in human and pig.

Kuusniemi A-M; Kestilä M; Patrakka J; Lahdenkari A-T; Ruotsalainen V; Holmberg C; Karikoski R; Salonen R; Tryggvason K; Jalanko H
Article: PEDIATRIC RESEARCH. 2002;52(3):349-355

The number of podocyte slit diaphragms is decreased in minimal change nephrotic syndrome.

Patrakka J; Lahdenkari A-T; Koskimies O; Holmberg C; Wartiovaara J; Jalanko H
Article: LANCET. 2002;359(9317):1575-1577

Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations.

Patrakka J; Martin P; Salonen R; Kestilä M; Ruotsalainen V; Männikkö M; Ryynänen M; Rapola J; Holmberg C; Tryggvason K; Jalanko H
Article: TRANSPLANTATION. 2002;73(3):394-403

Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin.

Patrakka J; Ruotsalainen V; Reponen P; Qvist E; Laine J; Holmberg C; Tryggvason K; Jalanko H
Article: ANNALS OF MEDICINE. 2001;33(8):526-533

Genetic kidney diseases disclose the pathogenesis of proteinuria.

Jalanko H; Patrakka J; Tryggvason K; Holmberg C
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2001;12(2):289-296

Expression of nephrin in pediatric kidney diseases.

Patrakka J; Ruotsalainen V; Ketola I; Holmberg C; Heikinheimo M; Tryggvason K; Jalanko H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(6):1905-1916

Role of nephrin in cell junction formation in human nephrogenesis.

Ruotsalainen V; Patrakka J; Tissari P; Reponen P; Hess M; Kestilä M; Holmberg C; Salonen R; Heikinheimo M; Wartiovaara J; Tryggvason K; Jalanko H
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Review: FRONTIERS IN ENDOCRINOLOGY. 2018;9:409

Understanding Podocyte Biology to Develop Novel Kidney Therapeutics.

Lal MA; Patrakka J
Corrigendum: PLOS ONE. 2015;10(5):e0126079

Correction: Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin.

Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlén M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Corrigendum: DEVELOPMENTAL DYNAMICS. 2012;241(2):431

Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (vol 240, pg 2646, 2011)

Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainen T; Vainio S; Tryggvason K
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):780

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival (vol 121, pg 3965, 2011)

Yaddanapudi S; Altintas MM; Kistler AD; Fernandez I; Moeller CC; Wei C; Peev V; Flesche JB; Forst A-L; Li J; Patrakka J; Xiao Z; Grahammer F; Schiffer M; Lohmueller T; Reinheckel T; Gu C; Huber TB; Ju W; Bitzer M; Rastaldi MP; Ruiz P; Tryggvason K; Shaw AS; Faul C; Sever S; Reiser J
Review: NATURE REVIEWS NEPHROLOGY. 2009;5(8):463-468

New insights into the role of podocytes in proteinuria.

Patrakka J; Tryggvason K
Review: TRENDS IN MOLECULAR MEDICINE. 2007;13(9):396-403

Nephrin--a unique structural and signaling protein of the kidney filter.

Patrakka J; Tryggvason K
Editorial comment: CELL. 2006;125(2):221-224

Nck links nephrin to actin in kidney podocytes.

Tryggvason K; Pikkarainen T; Patrakka J
Review: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(13):1387-1401

Hereditary proteinuria syndromes and mechanisms of proteinuria.

Tryggvason K; Patrakka J; Wartiovaara J
Review: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2006;17(3):813-822

Thin basement membrane nephropathy.

Tryggvason K; Patrakka J
Published conference paper: KIDNEY INTERNATIONAL. 2000;58(3):972-980

Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients.

Patrakka J; Kestilä M; Wartiovaara J; Ruotsalainen V; Tissari P; Lenkkeri U; Männikkö M; Visapää I; Holmberg C; Rapola J; Tryggvason K; Jalanko H

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