Hanna Björck

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Teamledare vid enheten för kardiovaskulär medicin, Inst. för MedS,
Karolinska Institutet (2022- )
Postdoc vid enheten för atherosklerosforskning, Institutionen för Medicin,
Solna, Karolinska Institutet.
Doktorsexamen i Medicinsk Vetenskap – fysiologi, Linköpings universitet,
januari 2012.
Magisterexamen i Molekylärbiologi, Uppsala universitet, januari 2006
Uppsala Graduate School in Biomedical Research (UGSBR) – Uppsala
universitet, januari 2006

Forskningsbeskrivning

Thorakalt aortaaneurysm manifesterar som en sjuklig vidgning av stora
kroppspulsådern närmast hjärtat och kan leda till att blodkärlet brister.
Målsättningen med vår forskning är att klargöra de sjukdomsmekanismer
som ligger bakom aneurysm i thorakala aorta samt det kliniska förloppet som
följer. Projekten inkluderar kliniska såväl som experimentella
frågeställningar och baseras på en stor välkarakteriserad patientkohort
med tillhörande biobank.
För mer information, se den engelskspråkiga profilsidan.

Undervisning

Kursledare för 1BIO48 Molecular Medicine – Cardiometabolic and
Infectious diseases [1].
[1] https://education.ki.se/student/molecular-medicine-cardiometabolic-and-infectious-diseases-15-hp/1bi048

Artiklar

Article: BMJ OPEN. 2024;14(3):e067977

Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study.

Gaye B; Vignac M; Gådin JR; Ladouceur M; Caidahl K; Olsson C; Franco-Cereceda A; Eriksson P; Björck HM
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2023;101(10):1323-1333

SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?

Freiholtz D; Bergman O; Pradhananga S; Lång K; Poujade F-A; Granath C; Olsson C; Franco-Cereceda A; Sahlén P; Eriksson P; Björck HM
Article: CLINICAL PROTEOMICS. 2023;20(1):31

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.

Carland C; Png G; Malarstig A; Kho PF; Gustafsson S; Michaelsson K; Lind L; Tsafantakis E; Karaleftheri M; Dedoussis G; Ramisch A; Macdonald-Dunlop E; Klaric L; Joshi PK; Chen Y; Björck HM; Eriksson P; Carrasco-Zanini J; Wheeler E; Suhre K; Gilly A; Zeggini E; Viñuela A; Dermitzakis ET; Wilson JF; Langenberg C; Thareja G; Halama A; Schmidt F; SCALLOP Consortium; Zanetti D; Assimes T
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2023;101(7):801-811

Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability.

Freiholtz D; Bergman O; Lång K; Poujade F-A; Paloschi V; Granath C; Lindeman JHN; Olsson C; Franco-Cereceda A; Eriksson P; Björck HM
Article: ANNALS OF THORACIC SURGERY. 2022;114(5):1665-1670

Sex Differences in Aortopathy and Valve Diseases Among Patients Undergoing Cardiac Surgical Procedure.

Vignac M; Björck HM; Olsson C; Eriksson MJ; Jouven X; Michos ED; Franco-Cereceda A; Eriksson P; Gaye B
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2022;11(9):e024346

Acetylsalicylic Acid Is Associated With a Lower Prevalence of Ascending Aortic Aneurysm and a Decreased Aortic Expression of Cyclooxygenase 2.

Granath C; Freiholtz D; Bredin F; Olsson C; Franco-Cereceda A; Björck HM
Article: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2022;61(2):388-392

Metformin therapy is not associated with the lower prevalence of ascending aortic aneurysm in diabetic patients.

Vignac M; Ntika S; Olsson C; Franco-Cereceda A; Björck HM
Article: JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE. 2021;8(11):143

Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes.

Ntika S; Jois H; Lång K; Olsson C; Franco-Cereceda A; Björck HM; Krizhanovskii C
Article: OPEN HEART. 2021;8(2):e001857

Valve disease and aortopathy associations of bicuspid aortic valve phenotypes differ between men and women.

Granath C; Mohamed SA; Olsson C; Grattan M; Mertens L; Franco-Cereceda A; Björck HM
Article: BIOMEDICINES. 2021;9(6):697

Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1.

Ntika S; Tracy LM; Franco-Cereceda A; Björck HM; Krizhanovskii C
Article: BIORESEARCH OPEN ACCESS. 2020;9(1):269-278

Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold.

Granath C; Noren H; Björck H; Simon N; Olesen K; Rodin S; Grinnemo K-H; Österholm C
Article: CIRCULATION RESEARCH. 2020;127(10):1261-1273

Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD.

Hussain S; Khan AW; Akhmedov A; Suades R; Costantino S; Paneni F; Caidahl K; Mohammed SA; Hage C; Gkolfos C; Björck H; Pernow J; Lund LH; Lüscher TF; Cosentino F
Article: NATURE GENETICS. 2019;51(1):42-50

ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.

Gould RA; Aziz H; Woods CE; Seman-Senderos MA; Sparks E; Preuss C; Wünnemann F; Bedja D; Moats CR; McClymont SA; Rose R; Sobreira N; Ling H; MacCarrick G; Kumar AA; Luyckx I; Cannaerts E; Verstraeten A; Björk HM; Lehsau A-C; Jaskula-Ranga V; Lauridsen H; Shah AA; Bennett CL; Ellinor PT; Lin H; Isselbacher EM; Lino Cardenas CL; Butcher JT; Hughes GC; Lindsay ME; Baylor-Hopkins Center for Mendelian Genomics; MIBAVA Leducq Consortium; Mertens L; Franco-Cereceda A; Verhagen JMA; Wessels M; Mohamed SA; Eriksson P; Mital S; Van Laer L; Loeys BL; Andelfinger G; McCallion AS; Dietz HC
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(1):102-114

The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves.

Maleki S; Cottrill KA; Poujade F-A; Bhattachariya A; Bergman O; Gådin JR; Simon N; Lundströmer K; Franco-Cereceda A; Björck HM; Chan SY; Eriksson P
Article: BLOOD. 2018;132(17):1842-1850

DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis.

Ward-Caviness CK; Huffman JE; Everett K; Germain M; van Dongen J; Hill WD; Jhun MA; Brody JA; Ghanbari M; Du L; Roetker NS; de Vries PS; Waldenberger M; Gieger C; Wolf P; Prokisch H; Koenig W; O'Donnell CJ; Levy D; Liu C; Truong V; Wells PS; Trégouët D-A; Tang W; Morrison AC; Boerwinkle E; Wiggins KL; McKnight B; Guo X; Psaty BM; Sotoodenia N; Boomsma DI; Willemsen G; Ligthart L; Deary IJ; Zhao W; Ware EB; Kardia SLR; Van Meurs JBJ; Uitterlinden AG; Franco OH; Eriksson P; Franco-Cereceda A; Pankow JS; Johnson AD; Gagnon F; Morange P-E; de Geus EJC; Starr JM; Smith JA; Dehghan A; Björck HM; Smith NL; Peters A
Article: ATHEROSCLEROSIS SUPPLEMENTS. 2018;35:e6-e13

Notch, BMP and WNT/β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm.

Kostina A; Bjork H; Ignatieva E; Irtyuga O; Uspensky V; Semenova D; Maleki S; Tomilin A; Moiseeva O; Franco-Cereceda A; Gordeev M; Faggian G; Kostareva A; Eriksson P; Malashicheva A
Article: SCIENTIFIC REPORTS. 2018;8(1):2777

Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve.

Björck HM; Du L; Pulignani S; Paloschi V; Lundströmer K; Kostina AS; Österholm C; Malashicheva A; Kostareva A; Evangelista A; Teixidó-Tura G; Maleki S; Franco-Cereceda A; Eriksson P; Mechanistic Interrogation of Bicuspid Aortic Valve
Article: ATHEROSCLEROSIS. 2017;266:196-204

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.

Strawbridge RJ; Silveira A; Hoed MD; Gustafsson S; Luan J; Rybin D; Dupuis J; Li-Gao R; Kavousi M; Dehghan A; Haljas K; Lahti J; Gådin JR; Bäcklund A; de Faire U; Gertow K; Giral P; Goel A; Humphries SE; Kurl S; Langenberg C; Lannfelt LL; Lind L; Lindgren CCM; Mannarino E; Mook-Kanamori DO; Morris AP; de Mutsert R; Rauramaa R; Saliba-Gustafsson P; Sennblad B; Smit AJ; Syvänen A-C; Tremoli E; Veglia F; Zethelius B; Björck HM; Eriksson JG; Hofman A; Franco OH; Watkins H; Jukema JW; Florez JC; Wareham NJ; Meigs JB; Ingelsson E; Baldassarre D; Hamsten A; IMPROVE study group
Article: FRONTIERS IN PHYSIOLOGY. 2017;8:400

Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor.

Gillis E; Kumar AA; Luyckx I; Preuss C; Cannaerts E; van de Beek G; Wieschendorf B; Alaerts M; Bolar N; Vandeweyer G; Meester J; Wünnemann F; Gould RA; Zhurayev R; Zerbino D; Mohamed SA; Mital S; Mertens L; Björck HM; Franco-Cereceda A; McCallion AS; Van Laer L; Verhagen JMA; van de Laar IMBH; Wessels MW; Messas E; Goudot G; Nemcikova M; Krebsova A; Kempers M; Salemink S; Duijnhouwer T; Jeunemaitre X; Albuisson J; Eriksson P; Andelfinger G; Dietz HC; Verstraeten A; Loeys BL; Mibava Leducq Consortium
Article: SCIENTIFIC REPORTS. 2016;6:35712

Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves.

Maleki S; Kjellqvist S; Paloschi V; Magné J; Branca RMM; Du L; Hultenby K; Petrini J; Fuxe J; MIBAVA Leducq Consortium; Lehtiö J; Franco-Cereceda A; Eriksson P; Björck HM
Article: IJC HEART AND VASCULATURE. 2016;11:74-79

Intima-media thickness of the descending aorta in patients with bicuspid aortic valve.

Petrini J; Yousry M; Eriksson P; Björk HM; Rickenlund A; Franco-Cereceda A; Caidahl K; Eriksson MJ
Article: CYTOKINE. 2016;81:1-9

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease.

McLeod O; Silveira A; Valdes-Marquez E; Björkbacka H; Almgren P; Gertow K; Gådin JR; Bäcklund A; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Tremoli E; de Faire U; Nilsson J; Melander O; Hopewell JC; Clarke R; Björck HM; Hamsten A; Öhrvik J; Strawbridge RJ; IMPROVE Study Group
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(4):973-980

Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation.

Paloschi V; Gådin JR; Khan S; Björck HM; Du L; Maleki S; Roy J; Lindeman JHM; Mohamed SA; Tsuda T; Franco-Cereceda A; Eriksson P
Article: ANNALS OF THORACIC SURGERY. 2014;98(1):65-71

Biomechanical properties of the thoracic aneurysmal wall: differences between bicuspid aortic valve and tricuspid aortic valve patients.

Forsell C; Björck HM; Eriksson P; Franco-Cereceda A; Gasser TC
Article: AORTA. 2013;1(1):13-22

Aneurysm Development in Patients With Bicuspid Aortic Valve (BAV): Possible Connection to Repair Deficiency?

Maleki S; Björck HM; Paloschi V; Kjellqvist S; Folkersen L; Jackson V; Franco-Cereceda A; Eriksson P
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(1):129-139

Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve.

Maleki S; Björck HM; Folkersen L; Nilsson R; Renner J; Caidahl K; Franco-Cereceda A; Länne T; Eriksson P
Article: PLOS ONE. 2012;7(12):e52227

Characterization of shear-sensitive genes in the normal rat aorta identifies Hand2 as a major flow-responsive transcription factor.

Björck HM; Renner J; Maleki S; Nilsson SFE; Kihlberg J; Folkersen L; Karlsson M; Ebbers T; Eriksson P; Länne T
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2011;42(3):309-316

Impaired abdominal aortic wall integrity in elderly men carrying the angiotensin-converting enzyme D allele.

Ljungberg LU; De Basso R; Alehagen U; Björck HM; Persson K; Dahlström U; Länne T
Article: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. 2011;12(3):281-289

The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: a cross-sectional study.

Ljungberg L; Alehagen U; Länne T; Björck H; De Basso R; Dahlström U; Persson K
Article: AMERICAN JOURNAL OF HYPERTENSION. 2011;24(7):802-808

Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure.

Björck HM; Eriksson P; Alehagen U; De Basso R; Ljungberg LU; Persson K; Dahlström U; Länne T
Article: JOURNAL OF INTERNAL MEDICINE. 2009;265(3):373-381

Association of genetic variation on chromosome 9p21.3 and arterial stiffness.

Björck HM; Länne T; Alehagen U; Persson K; Rundkvist L; Hamsten A; Dahlström U; Eriksson P
Article: ATHEROSCLEROSIS. 2009;202(2):415-423

Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression.

Wågsäter D; Zhu C; Björck HM; Eriksson P
Visa fler

Alla övriga publikationer

Preprint: MEDRXIV. 2024;MEDRXIV

A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes.

Saliba-Gustafsson P; Justesen JM; Ranta A; Sharma D; Bielczyk-Maczynska E; Li J; Najmi LA; Apodaka M; Aspichueta P; Björck HM; Eriksson P; Franco-Cereceda A; Gloudemans M; Mujica E; den Hoed M; Assimes TL; Quertermous T; Carcamo-Orive I; Park CY; Knowles JW
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2019;6:182

Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve.

Maleki S; Poujade F-A; Bergman O; Gådin JR; Simon N; Lång K; Franco-Cereceda A; Body SC; Björck HM; Eriksson P
Corrigendum: FRONTIERS IN PHYSIOLOGY. 2017;8:730

Corrigendum: Candidate Gene Resequencing in a Large Bicuspid Aortic Valve-Associated Thoracic Aortic Aneurysm Cohort: SMAD6 as an Important Contributor.

Gillis E; Kumar AA; Luyckx I; Preuss C; Cannaerts E; van de Beek G; Wieschendorf B; Alaerts M; Bolar N; Vandeweyer G; Meester J; Wünnemann F; Gould RA; Zhurayev R; Zerbino D; Mohamed SA; Mital S; Mertens L; Björck HM; Franco-Cereceda A; McCallion AS; Van Laer L; Verhagen JMA; van de Laar IMBH; Wessels MW; Messas E; Goudot G; Nemcikova M; Krebsova A; Kempers M; Salemink S; Duijnhouwer T; Jeunemaitre X; Albuisson J; Eriksson P; Andelfinger G; Dietz HC; Verstraeten A; Loeys BL; Mibava Leducq Consortium

Om mig

Forskningsbeskrivning

Undervisning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI