Emma Wincent

Om mig
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Om mig

Emma Wincent är forskare inom molekylär toxikologi vid Karolinska Institutet (KI), Institutet för miljömedicin, enheten för systemtoxikologi.
Hon tog sin M.Sc. examen i Toxikologi 2002 vid KI och en doktorsexamen i Toxikologi 2009 vid Stockholms universitet. 2009 påbörjade hon en Post Doc tjänst i miljömedicin i professor Agneta Rannugs grupp vid KI, och rekryterades 2015 till "Swedish Toxicology Sciences Research Center" (SWETOX) för att leda en forskningsgren inom toxikokinetik. Hon återvände till KI, till Institutet för Miljömedicin (IMM), 2018/2019 och har sedan dess
bedrivit sin forskning där inom områden relaterade till toxikokinetik och molekylär toxikologi. Emma är också kursledare och frekvent lärare vid det globala Magisterprogrammet i Toxikologi vid Karolinska Institutet.

*/Ytterligare beskrivning av Dr. Wincents forskningsprofil finns på den engelska sidan./*

Artiklar

Journal article: PHARMACOLOGICAL RESEARCH. 2023;194:106848

Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation.

Alangari AA; Ashoori MD; Alwan W; Dawe HR; Stockinger B; Barker JN; Wincent E; Di Meglio P
Article: TOXICOLOGY IN VITRO. 2023;89:105588

PBTK modeled perfluoroalkyl acid kinetics in zebrafish eleutheroembryos suggests impacts on bioconcentrations by chorion porosity dynamics.

Billat P-A; Vogs C; Blassiau C; Brochot C; Wincent E; Brion F; Beaudouin R
Article: ENVIRONMENTAL POLLUTION. 2023;316(Pt 1):120510

Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling.

Ünlü Endirlik B; Wincent E; Dreij K
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s238

337 Multi-level dysregulation of the AHR/CYP1A1 axis in psoriasis

Ashoori M; Hardman-Smart J; Dawe H; Tosi I; vincent E; Barker J; Smith C; Di Meglio P
Article: ECOTOXICOLOGY. 2022;31(9):1382-1389

Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene.

Eriksson ANM; Rigaud C; Wincent E; Pakkanen H; Salonen P; Vehniäinen E-R
Article: AQUATIC TOXICOLOGY. 2022;252:106311

Kinetics and toxicity of an environmentally relevant mixture of halogenated organic compounds in zebrafish embryo.

Lindqvist D; Wincent E
Article: AQUATIC TOXICOLOGY. 2022;244:106083

Exposure to retene, fluoranthene, and their binary mixture causes distinct transcriptomic and apical outcomes in rainbow trout (Oncorhynchus mykiss) yolk sac alevins.

Eriksson ANM; Rigaud C; Krasnov A; Wincent E; Vehniäinen E-R
Article: DISEASE MODELS & MECHANISMS. 2021;14(12):dmm049104

Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation.

Diaz OE; Sorini C; Morales RA; Luo X; Frede A; Krais AM; Chávez MN; Wincent E; Das S; Villablanca EJ
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2020;745:141031

Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 - Transcriptomics.

Rigaud C; Eriksson A; Krasnov A; Wincent E; Pakkanen H; Lehtivuori H; Ihalainen J; Vehniäinen E-R
Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2019;53(7):3898-3907

Toxicokinetics of Perfluorinated Alkyl Acids Influences Their Toxic Potency in the Zebrafish Embryo ( Danio rerio).

Vogs C; Johanson G; Näslund M; Wulff S; Sjödin M; Hellstrandh M; Lindberg J; Wincent E
Article: BIOCHEMICAL PHARMACOLOGY. 2018;151:47-58

Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells.

Schiering C; Vonk A; Das S; Stockinger B; Wincent E
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2018;281:1-10

Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs.

Sanchez Garcia D; Sjödin M; Hellstrandh M; Norinder U; Nikiforova V; Lindberg J; Wincent E; Bergman Å; Cotgreave I; Munic Kos V
Article: NATURE. 2017;542(7640):242-245

Feedback control of AHR signalling regulates intestinal immunity.

Schiering C; Wincent E; Metidji A; Iseppon A; Li Y; Potocnik AJ; Omenetti S; Henderson CJ; Wolf CR; Nebert DW; Stockinger B
Article: BIOCHEMICAL PHARMACOLOGY. 2016;110-111:117-129

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.

Wincent E; Kubota A; Timme-Laragy A; Jönsson ME; Hahn ME; Stegeman JJ
Article: TOXICOLOGY RESEARCH. 2016;5(3):788-799

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons.

Wincent E; Le Bihanic F; Dreij K
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2016;29(1):75-86

Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ.

Smirnova A; Wincent E; Vikström Bergander L; Alsberg T; Bergman J; Rannug A; Rannug U
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;284(2):163-179

Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.

Wincent E; Stegeman JJ; Jönsson ME
Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2015;49(6):3869-3877

Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs.

Wincent E; Jönsson ME; Bottai M; Lundstedt S; Dreij K
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(9):1878-1884

Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).

Mohammadi-Bardbori A; Bengtsson J; Rannug U; Rannug A; Wincent E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(12):4479-4484

Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor.

Wincent E; Bengtsson J; Mohammadi Bardbori A; Alsberg T; Luecke S; Rannug U; Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2010;184(3):466-473

Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.

Luecke S; Wincent E; Backlund M; Rannug U; Rannug A
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2009;17(4):1648-1653

Synthesis and biological evaluation of fused thio- and selenopyrans as new indolocarbazole analogues with aryl hydrocarbon receptor affinity.

Wincent E; Shirani H; Bergman J; Rannug U; Janosik T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(5):2690-2696

The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.

Wincent E; Amini N; Luecke S; Glatt H; Bergman J; Crescenzi C; Rannug A; Rannug U
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2004;149(2-3):151-164

Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole.

Bergander L; Wincent E; Rannug A; Foroozesh M; Alworth W; Rannug U
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Alla övriga publikationer

Conference publication: TOXICOLOGY LETTERS. 2022;368:S207-S208

Estimation of chemosensory irritation potency by using a TRPV1 channel-expressing human neuroblastoma cell model

Hinojosa M; Johanson G; Vincent E; Forsby A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S238

Induced pluripotent stem cell-derived macrophages in an inflammatory skin disease model to study granuloma formation

Ashoori M; Hardman-Smart J; Dawe H; Tosi I; Vincent E; Barker J; Smith C; Di Meglio P
Review: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. 2021;18(8):559-570

AHR in the intestinal microenvironment: safeguarding barrier function.

Stockinger B; Shah K; Wincent E
Corrigendum: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;288(2):280

Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions (vol 284, pg 163, 2015)

Wincent E; Stegeman JJ; Jonsson ME
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117-S118

Ketoconazole activates the AHR by inhibiting CYP1A1 dependent metabolism of FICZ

Bengtsson J; Wincent E; Rannug A; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14

Biological effects of the proposed endogenous AHR ligand FICZ

Rannug A; Wincent E; Bardbori AM; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14

Formation and background levels of the endogenous AHR ligand FICZ in vitro and in vivo

Rannug U; Smirnova A; Alsberg T; Wincent E; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S143-S144

Metals induce cytochrome P4501A1 through inhibition of metabolic degradation of FICZ

Bardbori AM; Wincent E; Rannug U; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117

Cytochrome P4501 inhibition as a novel mechanism for activation of the Ah receptor

Wincent E; Bengtsson J; Bardbori AM; Alsberg T; Rannug U; Rannug A

Forskningsbidrag

NEMESIS: Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS

1 January 2024 - 31 December 2028
Unraveling underlying modes of action of early-life metal mixture exposure on child growth: integrating epidemiological and experimental evidence

Swedish Research Council

1 January 2023 - 31 December 2025
INQUIRE: IMPROVING INDOOR AIR QUALITY AND HEALTH: IDENTIFICATION OF CHEMICAL AND BIOLOGICAL DETERMINANTS, THEIR SOURCES, AND STRATEGIES TO PROMOTE HEALTHIER HOMES IN EUROPE

EU-HORIZON Environment and Health

1 September 2022 - 31 August 2027
The role of host microbiota in chemically induced metabolic disruption

Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

1 January 2022 - 31 December 2024
Chemical impact on tissue repair and regeneration – interrogating beneficial vs. toxicological functions of aryl hydrocarbon receptor signalling on tissue homeostasis

Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

1 January 2022 - 31 December 2024
Elucidating basis for detrimental vs.beneficial functions of the aryl hydrocarbon receptor in intestinal stem cell differentiation

Swedish Research Council

1 January 2021 - 31 December 2024
A novel mechanism-based approach for assessment of developmental toxicity of endocrine disruptors

Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

1 January 2021 - 31 December 2024
Novel in vitro approaches to quantify chemosensory irritation as basis for exposure limits

Swedish Research Council

1 December 2020 - 31 December 2023
Addressing the intestinal immunotoxic effect of environmental pollutants: perfluorinated compounds

Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

1 January 2017 - 31 December 2019
Toxicokinetic modeling of internal dose in zebrafish (Danio rerio) embryos

Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning

1 January 2015 - 31 December 2018
The consequences of a dysfunctional CYP1/AHR auto-regulatory feedback loop in AHR mediated regulation of development and immune responses

Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning

1 January 2012 - 31 December 2015
Travel contribution: Society for Toxicology's Annual Meeting in Washington, USA, 6-10 March, 2011 and participation in a mini-symposium at Woods ...

Swedish Research Council for Health Working Life and Welfare

1 February 2011 - 31 March 2011

Om mig

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