Xu Dawei

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;169:115863

Irisin protected hemopoietic stem cells and improved outcome of severe bone marrow failure.

Li H; Kong D; Zhao Y; Liu X; Xiao F; Li X; Hu J; Chen Y; Li S; Wang B; Chen Y; Jiang Y; Liu X; Feng X; Guo Y; Feng X; Ren J; Wang F; Han Y; Donelan W; Yang L; Xu D; Tang D; Zheng C
Article: BIOLOGY OF SEX DIFFERENCES. 2023;14(1):46

Dyskerin and telomerase RNA component are sex-differentially associated with outcomes and Sunitinib response in patients with clear cell renal cell carcinoma.

Yuan H; Qin X; Yang Q; Liu L; Fang Z; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;158:114193

Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer.

Qin X; Wang J; Wang X; Huang T; Fang Z; Yan L; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1126247

The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma.

Yuan H; Xiu Y; Liu T; Fan Y; Xu D
Article: FRONTIERS IN ONCOLOGY. 2023;13:1133902

The chromosomal instability 25 gene signature is identified in clear cell renal cell carcinoma and serves as a predictor for survival and Sunitinib response.

Wang C; Qin X; Guo W; Wang J; Liu L; Fang Z; Yuan H; Fan Y; Xu D
Article: MOLECULAR ONCOLOGY. 2023;17(1):150-172

Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan-cancer analysis.

Wang J; Dai M; Xing X; Wang X; Qin X; Huang T; Fang Z; Fan Y; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1208223

High DNA methylation age deceleration defines an aggressive phenotype with immunoexclusion environments in endometrial carcinoma.

Hao J; Liu T; Xiu Y; Yuan H; Xu D
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):173

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma.

Fang Z; Zhang N; Yuan X; Xing X; Li X; Qin X; Liu Z; Neo S; Liu C; Kong F; Björkholm M; Fan Y; Xu D
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;149:112796

Synergistic effects of telomerase reverse transcriptase and regulator of telomere elongation helicase 1 on aggressiveness and outcomes in adrenocortical carcinoma.

Yuan H; Wu Y; Wang J; Qin X; Huang Y; Yan L; Fana Y; Zedenius J; Juhlin CC; Larsson C; Lui W-O; Xu D
Article: CANCERS. 2022;14(6):1385

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features.

Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Strååt K; Larsson C; Neo SY; Xu D
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(2):110

The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium.

Wang L-N; Wang L; Cheng G; Dai M; Yu Y; Teng G; Zhao J; Xu D
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:971142

The cuproptosis-associated 13 gene signature as a robust predictor for outcome and response to immune- and targeted-therapies in clear cell renal cell carcinoma.

Yuan H; Qin X; Wang J; Yang Q; Fan Y; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2021;156:106575

Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.

Xia C; Sadeghi L; Strååt K; Merrien M; Wright AP; Sander B; Xu D; Österborg A; Björkholm M; Claesson H-E
Article: CANCERS. 2021;13(19):4827

DNA Methylation Age Drift Is Associated with Poor Outcomes and De-Differentiation in Papillary and Follicular Thyroid Carcinomas.

Liu T; Wang J; Xiu Y; Wu Y; Xu D
Article: JOURNAL OF CANCER. 2021;12(13):3853-3861

Regulatory region mutations of TERT, PLEKHS1 and GPR126 genes as urinary biomarkers in upper tract urothelial carcinomas.

Xing X; Yuan X; Liu T; Dai M; Fan Y; Liu C; Strååt K; Björkholm M; Xu D
Article: CANCERS. 2020;12(8):E2133-2133

PLEKHS1 Over-Expression is Associated with Metastases and Poor Outcomes in Papillary Thyroid Carcinoma.

Xing X; Mu N; Yuan X; Wang N; Juhlin CC; Strååt K; Larsson C; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020;527(2):425-431

JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L.

Dahlström J; Xia C; Xing X; Yuan X; Björkholm M; Xu D
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(6):1862-1877

GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer.

Guo Y; Yuan X; Li K; Dai M; Zhang L; Wu Y; Sun C; Chen Y; Cheng G; Liu C; Strååt K; Kong F; Zhao S; Bjorkhölm M; Xu D
Article: ONCOGENE. 2020;39(21):4286-4298

VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR.

Liu C; Liu L; Wang K; Li X-F; Ge L-Y; Ma R-Z; Fan Y-D; Li L-C; Liu Z-F; Qiu M; Hao Y-C; Shi Z-F; Xia C-Y; Strååt K; Huang Y; Ma L-L; Xu D
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2020;18(1):184

The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females.

Sun Q; Liu J; Cheng G; Dai M; Liu J; Qi Z; Zhao J; Li W; Kong F; Liu G; Björkholm M; Xu D
Article: AGING-US. 2020;12(3):2030-2048

High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer.

Wang G; Huang Y; Yang F; Tian X; Wang K; Liu L; Fan Y; Li X; Li L; Shi B; Hao Y; Xia C; Nie Q; Xin Y; Shi Z; Ma L; Xu D; Liu C
Article: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY. 2020;13(8):2123-2129

Patients with benign prostatic hyperplasia show shorter leukocyte telomere length but no association with telomerase gene polymorphisms in Han Chinese males.

Cheng G; Dai M; Xin Q; Wang L; Kong F; Xu D
Article: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES. 2020;17(14):2180-2186

Shorter Leukocyte Telomere Length coupled with lower expression of Telomerase Genes in patients with Essential Hypertension.

Cheng G; Wang L; Dai M; Wei F; Xu D
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872

Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjöholm LK; Dahlström J; Sjöberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekström TJ; Björkholm M; Strååt K
Article: EPIGENETICS. 2019;14(12):1224-1233

Telomerase activation in small intestinal neuroendocrine tumours is associated with aberrant TERT promoter methylation, but not hot-spot mutations.

Fotouhi O; Ghaderi M; Wang N; Zedenius J; Kjellman M; Xu D; Juhlin CC; Larsson C
Article: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS. 2019;37(5):301.e1-301.e10

The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA predict shorter survival in renal cell carcinoma.

Ma R; Liu C; Lu M; Yuan X; Cheng G; Kong F; Lu J; Strååt K; Björkholm M; Ma L; Xu D
Article: ONCOGENE. 2019;38(7):965-979

GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.

Yuan X; Mu N; Wang N; Strååt K; Sofiadis A; Guo Y; Stenman A; Li K; Cheng G; Zhang L; Kong F; Ekblad L; Wennerberg J; Nilsson I-L; Juhlin CC; Larsson C; Xu D
Article: CELL DEATH & DISEASE. 2019;10(2):76

ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells.

Wu Y; Li X; Yu J; Björkholm M; Xu D
Article: AGING-US. 2018;10(10):3005-3016

Longitudinal changes in leukocyte telomere length and mortality in elderly Swedish men.

Yuan X; Kronström M; Hellenius M-L; Cederholm T; Xu D; Sjögren P
Article: CANCER LETTERS. 2018;434:33-41

Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.

Yu J; Yuan X; Sjöholm L; Liu T; Kong F; Ekström TJ; Björkholm M; Xu D
Article: CELL DEATH & DISEASE. 2018;9(9):923

Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.

Wang S; Liu Z; Ye Y; Li B; Liu T; Zhang W; Liu G-H; Zhang YA; Qu J; Xu D; Chen Z
Article: CURRENT UROLOGY. 2018;11(3):131-138

Paris Polyphylla-Derived Saponins Inhibit Growth of Bladder Cancer Cells by Inducing Mutant P53 Degradation While Up-Regulating CDKN1A Expression.

Guo Y; Liu Z; Li K; Cao G; Sun C; Cheng G; Zhang D; Peng W; Liu J; Qi Y; Zhang L; Wang P; Chen Y; Lin Z; Guan Y; Zhang J; Wen J; Wang F; Kong F; Xu D; Zhao S
Article: ANNALS OF HEMATOLOGY. 2018;97(1):63-72

MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia.

Zhang X; Li B; Yu J; Dahlström J; Tran AN; Björkholm M; Xu D
Article: ONCOLOGIST. 2017;22(10):1178-1188

TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker.

Liu L; Liu C; Fotouhi O; Fan Y; Wang K; Xia C; Shi B; Zhang G; Wang K; Kong F; Larsson C; Hu S; Xu D
Article: EBIOMEDICINE. 2017;21:104-116

Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes.

Liang X; Yuan X; Yu J; Wu Y; Li K; Sun C; Li S; Shen L; Kong F; Jia J; Björkholm M; Xu D
Article: CANCER RESEARCH. 2017;77(9):2534-2547

WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells.

Zhang K; Guo Y; Wang X; Zhao H; Ji Z; Cheng C; Li L; Fang Y; Xu D; Zhu HH; Gao W-Q
Article: ONCOTARGET. 2017;8(14):23120-23129

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma.

Yuan X; Cheng G; Yu J; Zheng S; Sun C; Sun Q; Li K; Lin Z; Liu T; Li P; Xu Y; Kong F; Bjorkholm M; Xu D
Article: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. 2017;8(3):e79

Association Between the Telomerase rs2736098_TT Genotype and a Lower Risk of Chronic Hepatitis B and Cirrhosis in Chinese Males.

Cheng G; Yuan X; Wang F; Sun Q; Xin Q; Li K; Sun C; Lin Z; Luan Y; Xu Y; Li P; Kong F; Xu D
Article: FASEB JOURNAL. 2017;31(2):491-504

Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation.

Han H; Liang X; Ekberg M; Kritikou JS; Brunnström Å; Pelcman B; Matl M; Miao X; Andersson M; Yuan X; Schain F; Parvin S; Melin E; Sjöberg J; Xu D; Westerberg LS; Björkholm M; Claesson H-E
Article: ANNALS OF HEMATOLOGY. 2016;95(11):1825-1832

TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations.

Dahlström J; Liu T; Yuan X; Saft L; Ghaderi M; Wei YB; Lavebratt C; Li P; Zheng C; Björkholm M; Xu D
Article: ONCOTARGET. 2016;7(22):31972-31979

The association between the TERT rs2736100 AC genotype and reduced risk of upper tract urothelial carcinomas in a Han Chinese population.

Yuan X; Meng Y; Li P; Ge N; Kong F; Yang L; Björkholm M; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(18):25826-25835

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients.

Yuan X; Liu C; Wang K; Liu L; Liu T; Ge N; Kong F; Yang L; Björkholm M; Fan Y; Zhao S; Xu D
Article: ONCOTARGET. 2016;7(16):21332-21346

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma.

Wang N; Kjellin H; Sofiadis A; Fotouhi O; Juhlin CC; Bäckdahl M; Zedenius J; Xu D; Lehtiö J; Larsson C
Article: ONCOTARGET. 2015;6(35):38079-38092

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.

Ci X; Li B; Ma X; Kong F; Zheng C; Björkholm M; Jia J; Xu D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):122-130

Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells.

Han H; Xue-Franzén Y; Miao X; Nagy E; Li N; Xu D; Sjöberg J; Björkholm M; Claesson H-E
Article: ONCOTARGET. 2015;6(7):4888-4900

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.

Zhang X; Li B; de Jonge N; Björkholm M; Xu D
Article: ONCOLOGIST. 2015;20(3):263-269

TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer.

Wang K; Liu T; Liu C; Meng Y; Yuan X; Liu L; Ge N; Liu J; Wang C; Ren H; Yan K; Hu S; Xu Z; Fan Y; Xu D
Article: ONCOTARGET. 2014;5(23):12428-12439

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR.

Wang K; Liu T; Ge N; Liu L; Yuan X; Liu J; Kong F; Wang C; Ren H; Yan K; Hu S; Xu Z; Björkholm M; Fan Y; Zhao S; Liu C; Xu D
Article: ONCOTARGET. 2014;5(20):10048-10057

TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma.

Xie H; Liu T; Wang N; Björnhagen V; Höög A; Larsson C; Lui W-O; Xu D
Article: ONCOGENE. 2014;33(42):4978-4984

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas.

Liu T; Wang N; Cao J; Sofiadis A; Dinets A; Zedenius J; Larsson C; Xu D
Article: CANCER. 2014;120(19):2965-2979

TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA.

Wang N; Liu T; Sofiadis A; Juhlin CC; Zedenius J; Höög A; Larsson C; Xu D
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(8):E1571-E1579

Telomerase-dependent and independent telomere maintenance and its clinical implications in medullary thyroid carcinoma.

Wang N; Xu D; Sofiadis A; Höög A; Vukojević V; Bäckdahl M; Zedenius J; Larsson C
Article: ENDOCRINE-RELATED CANCER. 2014;21(3):427-434

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors.

Liu T; Brown TC; Juhlin CC; Andreasson A; Wang N; Bäckdahl M; Healy JM; Prasad ML; Korah R; Carling T; Xu D; Larsson C
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2014;12:135

Laminin 411 acts as a potent inducer of umbilical cord mesenchymal stem cell differentiation into insulin-producing cells.

Qu H; Liu X; Ni Y; Jiang Y; Feng X; Xiao J; Guo Y; Kong D; Li A; Li X; Zhuang X; Wang Z; Wang Y; Chang Y; Chen S; Kong F; Zhang X; Zhao S; Sun Y; Xu D; Wang D; Zheng C
Article: ONCOTARGET. 2014;5(7):1829-1836

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas.

Wang K; Liu T; Liu L; Liu J; Liu C; Wang C; Ge N; Ren H; Yan K; Hu S; Björkholm M; Fan Y; Xu D
Article: PLOS ONE. 2014;9(4):e94442

Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese.

Li P; Liu T; Liu J; Zhang Q; Lou F; Kong F; Cheng G; Björkholm M; Zheng C; Xu D
Article: PLOS ONE. 2014;9(1):e85085

Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.

Han H; Xu D; Liu C; Claesson H-E; Björkholm M; Sjöberg J
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;442(1-2):112-115

Differential shortening rate of telomere length in the development of human fetus.

Cheng G; Kong F; Luan Y; Sun C; Wang J; Zhang L; Jiang B; Qi T; Zhao J; Zheng C; Xu D
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2013;105(22):1719-1728

SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription.

Liu C; Wang C; Wang K; Liu L; Shen Q; Yan K; Sun X; Chen J; Liu J; Ren H; Liu H; Xu Z; Hu S; Xu D; Fan Y
Article: ONCOGENE. 2013;32(36):4203-4213

Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells.

Liu Z; Li Q; Li K; Chen L; Li W; Hou M; Liu T; Yang J; Lindvall C; Björkholm M; Jia J; Xu D
Article: BRITISH JOURNAL OF CANCER. 2013;108(11):2272-2280

Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects.

Liu T; Liang X; Li B; Björkholm M; Jia J; Xu D
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2012;44(9):1531-1540

Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells.

Li P; Hou M; Lou F; Björkholm M; Xu D
Article: GENETICS AND MOLECULAR RESEARCH. 2012;11(1):370-378

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.

Chen XF; Cai S; Chen QG; Ni ZH; Tang JH; Xu DW; Wang XB
Article: EXPERIMENTAL CELL RESEARCH. 2012;318(3):169-176

Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.

Liu C; Schain F; Han H; Xu D; Andersson-Sand H; Forsell P; Claesson H-E; Björkholm M; Sjöberg J
Article: PLOS ONE. 2012;7(12):e52703

Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.

Liu C; Xu D; Han H; Fan Y; Schain F; Xu Z; Claesson H-E; Björkholm M; Sjöberg J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;416(3-4):372-378

Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer.

Li W; Zhao L; Zang W; Liu Z; Chen L; Liu T; Xu D; Jia J
Article: JOURNAL OF PATHOLOGY. 2011;225(2):203-211

Activation of telomerase by seminal plasma in malignant and normal cervical epithelial cells.

Liu L; Liu C; Lou F; Zhang G; Wang X; Fan Y; Yan K; Wang K; Xu Z; Hu S; Björkholm M; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;407(3):599-604

Premature senescence of T cells in long-term survivors of renal transplantation.

Li P; Tian C; Ge N; Wang H; Liu L; Lou F; Björkholm M; Xu D
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(12):2604-2610

Nuclear factor {kappa}B-mediated transactivation of telomerase prevents intimal smooth muscle cell from replicative senescence during vascular repair.

Bu D-X; Johansson ME; Ren J; Xu D-W; Johnson FB; Edfeldt K; Yan Z-Q
Article: MOLECULAR CANCER. 2010;9:132

Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer.

Li W; Zeng J; Li Q; Zhao L; Liu T; Björkholm M; Jia J; Xu D
Article: GASTROENTEROLOGY. 2010;138(3):981-992

The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.

Zeng J; Ge Z; Wang L; Li Q; Wang N; Björkholm M; Jia J; Xu D
Article: FASEB JOURNAL. 2010;24(2):579-586

Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase.

Ge Z; Li W; Wang N; Liu C; Zhu Q; Björkholm M; Gruber A; Xu D
Article: JOURNAL OF PATHOLOGY. 2009;218(4):419-427

FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1.

Zeng J; Wang L; Li Q; Li W; Björkholm M; Jia J; Xu D
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2009;297(1):L196-L203

15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.

Liu C; Xu D; Liu L; Schain F; Brunnström A; Björkholm M; Claesson H-E; Sjöberg J
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(7):488-497

Activation of telomerase by human cytomegalovirus.

Strååt K; Liu C; Rahbar A; Zhu Q; Liu L; Wolmer-Solberg N; Lou F; Liu Z; Shen J; Jia J; Kyo S; Björkholm M; Sjöberg J; Söderberg-Nauclér C; Xu D
Article: CLINICAL LYMPHOMA AND MYELOMA. 2008;8(6):340-347

Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.

Schain F; Schain D; Mahshid Y; Liu C; Porwit A; Xu D; Claesson H-E; Sundström C; Björkholm M; Sjöberg J
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(10):2285-2293

Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma.

Schain F; Tryselius Y; Sjöberg J; Porwit A; Backman L; Malec M; Xu D; Vockerodt M; Baumforth KRN; Wei W; Murray PG; Björkholm M; Claesson H-E
Article: CLINICAL CANCER RESEARCH. 2008;14(12):3722-3728

CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells.

Li W; Ge Z; Liu C; Liu Z; Björkholm M; Jia J; Xu D
Article: CANCER LETTERS. 2008;260(1-2):28-36

Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.

Li W; Li L; Liu Z; Liu C; Liu Z; Strååt K; Björkholm M; Jia J; Xu D
Article: PLOS ONE. 2008;3(1):e1446

Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene.

Zhu Q; Liu C; Ge Z; Fang X; Zhang X; Strååt K; Björkholm M; Xu D
Article: MOLECULAR CANCER RESEARCH. 2007;5(8):793-800

The opposing effect of hypoxia-inducible factor-2alpha on expression of telomerase reverse transcriptase.

Lou F; Chen X; Jalink M; Zhu Q; Ge N; Zhao S; Fang X; Fan Y; Björkholm M; Liu Z; Xu D
Article: CANCER RESEARCH. 2007;67(6):2626-2631

The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.

Liu C; Fang X; Ge Z; Jalink M; Kyo S; Björkholm M; Gruber A; Sjöberg J; Xu D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;353(4):999-1003

Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA.

Jalink M; Ge Z; Liu C; Björkholm M; Gruber A; Xu D
Article: BRITISH JOURNAL OF CANCER. 2006;94(11):1658-1662

Nucleostemin mRNA is expressed in both normal and malignant renal tissues.

Fan Y; Liu Z; Zhao S; Lou F; Nilsson S; Ekman P; Xu D; Fang X
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(10):2485-2489

Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor.

Fang X; Liu Z; Fan Y; Zheng C; Nilson S; Egevad L; Ekman P; Xu D
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(1):230-237

Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation.

Ge Z; Liu C; Björkholm M; Gruber A; Xu D
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;116(3):395-400

hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer.

Palmqvist R; Zhang A; Xu D; Golovleva I; Norrback K-F; Gruber A; Oberg A; Stenling R; Roos G
Article: CLINICAL CANCER RESEARCH. 2005;11(12):4331-4337

Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissues.

Fan Y; Liu Z; Fang X; Ge Z; Ge N; Jia Y; Sun P; Lou F; Björkholm M; Gruber A; Ekman P; Xu D
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(2):284-289

Epstein-Barr virus latent membrane 2A (LMP2A) down-regulates telomerase reverse transcriptase (hTERT) in epithelial cell lines.

Chen F; Liu C; Lindvall C; Xu D; Ernberg I
Article: ONCOGENE. 2004;23(44):7441-7447

Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix.

Zhang A; Wang J; Zheng B; Fang X; Angström T; Liu C; Li X; Erlandsson F; Björkholm M; Nordenskjörd M; Gruber A; Wallin K-L; Xu D
Article: ONCOLOGY REPORTS. 2004;12(3):523-526

Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2'-deoxycytidine.

Fang X; Zheng C; Liu Z; Ekman P; Xu D
Article: EXPERIMENTAL CELL RESEARCH. 2004;297(1):61-67

Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.

Liu C; Xu D; Sjöberg J; Forsell P; Björkholm M; Claesson H-E
Journal article: METHODS IN MOLECULAR BIOLOGY. 2004;287:87-97

Inhibition of histone deacetylases.

Liu C; Xu D
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2003;72(4):940-948

Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome.

Zhang A; Zheng C; Hou M; Lindvall C; Li K-J; Erlandsson F; Björkholm M; Gruber A; Blennow E; Xu D
Article: MODERN PATHOLOGY. 2003;16(3):246-255

KI-67 AND hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma.

Elder EE; Xu D; Höög A; Enberg U; Hou M; Pisa P; Gruber A; Larsson C; Bäckdahl M
Article: LEUKEMIA RESEARCH. 2003;27(2):183-191

Different effects of metabolic inhibitors and cyclosporin A on daunorubicin transport in leukemia cells from patients with AML.

Knaust E; Porwit-MacDonald A; Gruber A; Xu D; Peterson C
Article: GENES CHROMOSOMES & CANCER. 2002;34(3):269-275

Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas.

Zhang A; Zheng C; Hou M; Lindvall C; Wallin K-L; Angström T; Yang X; Hellström A-C; Blennow E; Björkholm M; Zetterberg A; Gruber A; Xu D
Article: EXPERIMENTAL CELL RESEARCH. 2002;274(1):25-34

The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells.

Hou M; Wang X; Popov N; Zhang A; Zhao X; Zhou R; Zetterberg A; Björkholm M; Henriksson M; Gruber A; Xu D
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(1):53-60

Expression of CTLA-4 by human monocytes.

Wang X-B; Giscombe R; Yan Z; Heiden T; Xu D; Lefvert AK
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;94(3):407-413

Immature dendritic cells kill ovarian carcinoma cells by a FAS/FASL pathway, enabling them to sensitize tumor-specific CTLs.

Yang R; Xu D; Zhang A; Gruber A
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;113(2):339-346

Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide.

Lotfi K; Månsson E; Chandra J; Wang Y; Xu D; Knaust E; Spasokoukotskaja T; Liliemark E; Eriksson S; Albertioni F
Article: HAEMATOLOGICA. 2001;86(4):386-393

Telomerase activity in relation to pro- and anti-apoptotic protein expression in high grade non-Hodgkin's lymphomas.

MacNamara B; Wang W; Chen Z; Hou M; Mazur J; Gruber A; Porwit-MacDonald A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(7):3826-3831

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

Xu D; Popov N; Hou M; Wang Q; Björkholm M; Gruber A; Menkel AR; Henriksson M
Article: BRITISH JOURNAL OF CANCER. 2001;84(5):621-625

Telomerase activity in plasma cell dyscrasias.

Xu D; Zheng C; Bergenbrant S; Holm G; Björkholm M; Yi Q; Gruber A
Article: BLOOD. 2000;96(13):4313-4318

Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells.

Xu D; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Journal article: BLOOD. 2000;96(13):4313-4318

Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells

Xu D; Erickson S; Szeps M; Gruber A; Sangfelt O; Einhorn S; Pisa P; Grandér D
Article: CANCER RESEARCH. 2000;60(22):6230-6235

Frequent amplification of the telomerase reverse transcriptase gene in human tumors.

Zhang A; Zheng C; Lindvall C; Hou M; Ekedahl J; Lewensohn R; Yan Z; Yang X; Henriksson M; Blennow E; Nordenskjöld M; Zetterberg A; Björkholm M; Gruber A; Xu D
Article: ONCOGENE. 2000;19(45):5123-5133

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.

Xu D; Wang Q; Gruber A; Björkholm M; Chen Z; Zaid A; Selivanova G; Peterson C; Wiman KG; Pisa P
Article: JOURNAL OF CLINICAL ONCOLOGY. 2000;18(9):1837-1844

P-Glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positive acute myeloid leukemia.

Tidefelt U; Liliemark J; Gruber A; Liliemark E; Sundman-Engberg B; Juliusson G; Stenke L; Elmhorn-Rosenborg A; Möllgård L; Lehman S; Xu D; Covelli A; Gustavsson B; Paul C
Article: HAEMATOLOGICA. 2000;85(2):124-132

Heterogeneity of isolated mononuclear cells from patients with acute myeloid leukemia affects cellular accumulation and efflux of daunorubicin.

Knaust E; Porwit-MacDonald A; Gruber A; Xu D; Peterson C
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1999;106(3):627-633

High levels of lung resistance related protein mRNA in leukaemic cells from patients with acute myelogenous leukaemia are associated with inferior response to chemotherapy and prior treatment with mitoxantrone.

Xu D; Areström I; Virtala R; Pisa P; Peterson C; Gruber A
Article: BRITISH JOURNAL OF CANCER. 1999;80(8):1156-1161

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms.

Xu D; Gruber A; Björkholm M; Peterson C; Pisa P
Article: LEUKEMIA & LYMPHOMA. 1999;32(3-4):309-316

Intraclonal heterogeneity in the in vitro daunorubicin-induced apoptosis in acute myeloid leukemia.

Palucka KA; Knaust E; Xu D; Macnamara B; Porwit-Macdonald A; Gruber A; Peterson C; Björkholm M; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1998;102(5):1367-1375

Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia.

Xu D; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF CANCER. 1998;77(11):1732-1736

Multidrug resistance phenotype in leukaemic cells from patients with acute myelocytic leukaemia can be detected with 99Tc(m)-MIBI.

Gruber A; Areström I; Xu D; Liliemark J; Larsson SA; Jacobsson H
Article: LEUKEMIA. 1996;10(8):1354-1357

Supression of telomerase activity in HL60 cells after treatment with differentiating agents.

Xu D; Gruber A; Peterson C; Pisa P
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1996;92(4):847-854

Levels of mdr1 and mrp mRNA in leukaemic cell populations from patients with acute myelocytic leukaemia are heterogenous and inversely correlated to cellular daunorubicin accumulation.

Xu D; Knaust E; Pisa P; Palucka K; Lundeberg J; Areström I; Peterson C; Gruber A
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Review: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(11):e1111

Thyroid carcinoma-featured telomerase activation and telomere maintenance: Biology and translational/clinical significance.

Yuan X; Yuan H; Zhang N; Liu T; Xu D
Review: FRONTIERS IN IMMUNOLOGY. 2022;13:1071390

TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance.

Liu T; Li S; Xia C; Xu D
Review: CANCER LETTERS. 2020;493:1-9

TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends.

Yuan X; Dai M; Xu D
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2020;8(19):1244

Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology-a narrative review.

Yuan X; Liu T; Xu D
Review: CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2020;20(6):410-432

Telomere-related Markers for Cancer.

Yuan X; Dai M; Xu D
Review: ONCOGENE. 2019;38(34):6172-6183

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.

Yuan X; Larsson C; Xu D
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(13):E3338-3338

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics.

Yuan X; Xu D
Review: GENES. 2016;7(7):E38-38

Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications.

Liu T; Yuan X; Xu D
Letter: HAEMATOLOGICA. 2015;100(10):e402-e405

Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms.

Dahlström J; Zhang X; Ghaderi M; Hultcrantz M; Björkholm M; Xu D
Letter: ENDOCRINE-RELATED CANCER. 2015;22(3):L9-L11

TERT promoter mutations are rare in parathyroid tumors.

Haglund F; Juhlin CC; Brown T; Ghaderi M; Liu T; Stenman A; Dinets A; Prasad M; Korah R; Xu D; Carling T; Larsson C
Letter: LEUKEMIA. 2014;28(8):1751-1754

Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse.

Zhang X; Zhang Q; Dahlström J; Tran AN; Yang B; Gu Z; Ghaderi M; Porwit A; Jia J; Derolf A; Xu D; Björkholm M
Review: SCIENCE CHINA-LIFE SCIENCES. 2014;57(6):564-570

Telomerase as a "stemness" enzyme.

Kong F; Zheng C; Xu D
Letter: GENE. 2014;540(2):266-267

The absence of TERT promoter mutations in primary gastric cancer.

Liu T; Liang X; Björkholm M; Jia J; Xu D
Corrigendum: PLOS ONE. 2014;9(2):e91499

Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells (vol 9, e85085, 2014)

Han H; Xu D; Liu C; Claesson H-E; Bjoerkholm M
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):44

UNCOVERING NF-κB ACTIVATION AND FUNCTION IN INTIMAL DEVELOPMENT

Bu D; Xu D; Hansson G; Yan Z
Published paper: CANCER RESEARCH. 2003;63(8):1743-1747

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene.

Lindvall C; Hou M; Komurasaki T; Zheng C; Henriksson M; Sedivy JM; Björkholm M; Teh BT; Nordenskjöld M; Xu D
Published paper: CLINICAL CHEMISTRY. 2001;47(3):519-524

Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity.

Hou M; Xu D; Björkholm M; Gruber A
Conference publication: BLOOD. 1995;86(10):2727

Telomerase is expressed in CD34+ hematopoietic cells from normal human umbilical cord blood, adult peripheral blood and bone marrow.

Xu D; Palucka AK; Peterson C; Bjorkholm M; Gruber A; Pisa P

Anställningar

Senior Forskare, Medicin, Solna, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell medicin, Karolinska Institutet, 2006
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 1999

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Examina och utbildning

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