This page in English

Dan Grander

Professor

Besöksadress : Cancercenter Karolinska, R8:03, Karolinska Universitetssjukhuset Solna 171 76 Stockholm
Postadress : Institutionen för onkologi-patologi (OnkPat), K7, Forskargrupp Grandér, Dan, Cancercenter Karolinska, R8:03, Karolinska Universitetssjukhuset Solna 171 76 Stockholm
Leveransadress : Cancercenter Karolinska, R8:03, Karolinska Universitetssjukhuset Solna 171 76 Stockholm

Publikationer

Characterization of a novel B-CLL candidate gene - DLEU7 - located in the 13q14 tumor suppressor locus
Hammarsund M, Corcoran Mm, Wilson W, Zhu Cy, Einhorn S, Sangfelt O, et al
FEBS LETTERS 2004;556(1-3):75-80

p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines
Borgonovo Brandter L, Heyman M, Rasool O, Liu Y, Grandér D, Einhorn S
European journal of haematology 1996;56(5):313-8

An emerging role for long non-coding RNAs in cancer metastasis
Serviss Jt, Johnsson P, Grandér D
Frontiers in genetics 2014;5():234-

Pseudogenes: a novel source of trans-acting antisense RNAs
Johnsson P, Morris Kv, Grandér D
Methods in molecular biology (Clifton, N.J.) 2014;1167():213-26

The transcription map of the 13q14 region frequently deleted in B-cell chronic lymphocytic leukemia
Tyazhelova Tv, Ivanov Dv, Makeeva Nv, Kapanadze Bi, Nikitin Ea, Semov Ab, et al
RUSSIAN JOURNAL OF GENETICS 2001;37(11):1286-1292

TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity
Gatt Me, Takada K, Mani M, Lerner M, Pick M, Hideshima T, et al
BRITISH JOURNAL OF HAEMATOLOGY 2013;162(2):210-20

Interferon or down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells
Xu Dw, Erickson S, Szeps M, Gruber A, Sangfelt O, Einhorn S, et al
BLOOD 2000;96(13):4313-8

Inactivation of FBXW7/hCDC4-beta expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
Akhoondi S, Lindstrom L, Widschwendter M, Corcoran M, Bergh J, Spruck C, et al
BREAST CANCER RESEARCH 2010;12(6):R105-

How does interferon-alpha exert its antitumour activity in multiple myeloma?
Grander D
ACTA ONCOLOGICA 2000;39(7):801-5

Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells
Kharaziha P, Rodriguez P, Li Q, Rundqvist H, Bjorklund Ac, Augsten M, et al
CELL DEATH & DISEASE 2012;:e262-

SEQUENCE VARIABILITY OF A PROLONGED TETRANUCLEOTIDE REPEAT
Liu Y, Rasool O, Grander D, Lindblom A, Einhorn S
HUMAN MOLECULAR GENETICS 1995;4(4):727-9

Human papillomavirus, viral load and proliferation rate in recurrent respiratory papillomatosis in response to alpha interferon treatment
Szeps M, Dahlgren L, Aaltonen Lm, Ohd J, Kanter-lewenshon L, Dahlstrand H, et al
JOURNAL OF GENERAL VIROLOGY 2005;:1695-702

How do mutated oncogenes and tumor suppressor genes cause cancer?
Grander D
MEDICAL ONCOLOGY 1998;15(1):20-6

Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92
Moreno Tmc, Gustafsson G, Garwicz S, Grander D, Jonmundsson Gk, Frost Bm, et al
LEUKEMIA 2002;16(10):2037-45

LUMA (LUminometric Methylation Assay) - A high throughput method to the analysis of genomic DNA methylation
Karimi M, Johansson S, Stach D, Corcoran M, Grander D, Schalling M, et al
EXPERIMENTAL CELL RESEARCH 2006;312(11):1989-95

Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax
Panaretakis T, Pokrovskaja K, Shoshan Mc, Grander D
ONCOGENE 2003;22(29):4543-56

Why do so many cancer patients fail to respond to interferon therapy?
Einhorn S, Grander D
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 1996;16(4):275-81

Alternative signaling pathways regulating type I interferon-induced apoptosis
Pokrovskaja K, Panaretakis T, Grander D
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 2005;25(12):799-810

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin
Panaretakis T, Pokrovskaja K, Shoshan Mc, Grander D
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(46):44317-26

RESPONSE TO INTERFERON THERAPY IN PATIENTS WITH MULTIPLE-MYELOMA CORRELATES WITH EXPRESSION OF THE BCL-2 ONCOPROTEIN
Sangfelt O, Osterborg A, Grander D, Anderbring E, Ost A, Mellstedt H, et al
INTERNATIONAL JOURNAL OF CANCER 1995;63(2):190-2

Interferon and malignant disease - How does it work and why doesn't it always?
Grander D, Einhorn S
ACTA ONCOLOGICA 1998;37(4):331-8

Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid
Panaretakis T, Shabalina Ig, Grander D, Shoshan Mc, Depierre Jw
TOXICOLOGY AND APPLIED PHARMACOLOGY 2001;173(1):56-64

Inverse correlation between Ink4-locus deletions and ICM-DNA hyperdiploidy in childhood acute lymphoblastic leukaemia, relation to clinical characteristics and outcome
Moreno Tc, Widell S, Czader M, Grander D, Soderhall S, Gustafsson G, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2000;65(6):390-8

Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells
Buentke E, Nordstrom A, Lin H, Bjorklund Ac, Laane E, Harada M, et al
BLOOD CANCER JOURNAL 2011;:e31-

How does interferon exert its cell growth inhibitory effect?
Grander D, Sangfelt O, Erickson S
EUROPEAN JOURNAL OF HAEMATOLOGY 1997;59(3):129-35

Mechanisms of interferon-induced cell cycle arrest
Sangfelt O, Erickson S, Grander D
FRONTIERS IN BIOSCIENCE 2000;:D479-87

''Exclusive'' p15(INK4B) gene deletions in acute lymphocytic leukemia include the E1 beta exon of the p16(INK4) gene
Heyman M, Rasool O, Brandter Lb, Liu Y, Grander D, Einhorn S, et al
BLOOD 1996;87(4):1657-8

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling
Malyukova A, Dohda T, Von Der Lehr N, Akhondi S, Corcoran M, Heyman M, et al
CANCER RESEARCH 2007;67(12):5611-6

Sorafenib induces apoptosis and autophagy in prostate cancer cells in vitro
Ullen A, Farnebo M, Thyrell L, Mahmoudi S, Kharaziha P, Lennartsson L, et al
INTERNATIONAL JOURNAL OF ONCOLOGY 2010;37(1):15-20

Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia
Corcoran Mm, Rasool O, Liu Y, Iyengar A, Grander D, Ibbotson Re, et al
BLOOD 1998;91(4):1382-90

Interferon-alpha inhibits proliferation in human T lymphocytes by abrogation of interleukin 2-induced changes in cell cycle-regulatory proteins
Erickson S, Sangfelt O, Castro J, Heyman M, Einhorn S, Grander D
CELL GROWTH & DIFFERENTIATION 1999;10(8):575-82

Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?
Kuchinskaya E, Nordgren A, Heyman M, Schoumans J, Corcoran M, Staaf J, et al
LEUKEMIA 2007;21(6):1327-30

Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-alpha in hematopoietic cell lines
Sangfelt O, Erickson S, Einhorn S, Grander D
ONCOGENE 1997;14(4):415-23

In vivo induction of the interferon-stimulated protein 2 ' 5 ' oligoadenylate synthetase in tumor and peripheral blood cells during IFN-alpha treatment of metastatic melanoma
Grander D, Sangfelt O, Skoog L, Hansson J
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 1998;18(9):691-5

Effects of interferon-alpha on cell cycle regulatory proteins in leukemic cells
Szeps M, Erickson S, Gruber A, Castro J, Einhorn S, Grander D
LEUKEMIA & LYMPHOMA 2003;44(6):1019-25

Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies
Grander D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T
AUTOPHAGY 2009;5(8):1198-200

DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse
Corcoran Mm, Hammarsund M, Zhu Cy, Lerner M, Kapanadze B, Wilson B, et al
GENES CHROMOSOMES & CANCER 2004;40(4):285-97

Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity
Thyrell L, Arulampalam V, Hjortsberg L, Farnebo M, Grander D, Tamm Kp
EXPERIMENTAL CELL RESEARCH 2007;313(19):4015-24

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element
Vilborg A, Glahder Ja, Wilhelm Mt, Bersani C, Corcoran M, Mahmoudi S, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(37):15756-61

Characterisation of hairy cell leukaemia by tiling resolution array-based comparative Genome hybridisation: a series of 13 cases and review of the literature
Nordgren A, Corcoran M, Saaf A, Bremer A, Kluin-nelemans Hc, Schoumans J, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2010;84(1):17-25

Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines
Sangfelt O, Erickson S, Castro J, Heiden T, Einhorn S, Grander D
CELL GROWTH & DIFFERENTIATION 1997;8(3):343-52

Activation of STAT1 is required for interferon-alpha-mediated cell death
Arulampalam V, Kolosenko I, Hjortsbert L, Bjorklund Ac, Grander D, Tamm Kp
EXPERIMENTAL CELL RESEARCH 2011;317(1):9-19

A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16(INK4) and p15(INK4B) genes. Clinical response to interferon-alpha therapy in one of the subclones
Heyman M, Nordgren A, Jedditehrani M, Rasool O, Liu Y, Grander D, et al
LEUKEMIA 1996;10(5):909-17

Clinical significance of EGFR amplification and the aberrant EGFRVIII transcript in conventionally treated astrocytic gliomas
Liu L, Backlund Lm, Nilsson Br, Grander D, Ichimura K, Goike Hm, et al
JOURNAL OF MOLECULAR MEDICINE-JMM 2005;83(11):917-26

Parathyroid adenoma and primary CNS tumors
Backlund Lm, Grander D, Brandt L, Hall P, Ekbom A
INTERNATIONAL JOURNAL OF CANCER 2005;113(6):866-9

Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia
Liu Y, Corcoran M, Rasool O, Ivanova G, Ibbotson R, Grander D, et al
ONCOGENE 1997;15(20):2463-73

Mechanisms of Interferon-alpha induced apoptosis in malignant cells
Thyrell L, Erickson S, Zhivotovsky B, Pokrovskaja K, Sangfelt O, Castro J, et al
ONCOGENE 2002;21(8):1251-62

Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates
Wu Xs, Ivanova G, Merup M, Jansson M, Stellan B, Grander D, et al
GENOMICS 1999;60(2):161-71

Autophagy: cancer therapy's friend or foe?
Grander D, Panaretakis T
FUTURE MEDICINAL CHEMISTRY 2010;2(2):285-97

Inverse correlation between loss of heterozygosity of the short arm of chromosome 12 and p15(ink4B)/p16(ink4) gene inactivation in childhood acute lymphoblastic leukaemia
Heyman M, Moreno Tc, Liu Y, Grander D, Rasool Ol, Borgonovabrandter L, et al
BRITISH JOURNAL OF HAEMATOLOGY 1997;98(1):147-50

Factors influencing the response to interferon therapy in chronic hepatitis C - Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells
Grander D, Hultcrantz R, Weiland O, Xu B, Sangfelt O, Bjorklund Ac, et al
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 1996;31(6):604-11

Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes
Erickson S, Matikainen S, Thyrell L, Sangfelt O, Julkunen I, Einhorn S, et al
EUROPEAN JOURNAL OF BIOCHEMISTRY 2002;269(1):29-37

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression
Lerner M, Lundgren J, Akhoondi S, Jahn A, Ng Hf, Moqadam Fa, et al
CELL CYCLE 2011;10(13):2172-83

Prognostic importance of p15(INK4B) and pl6(INK4) gene inactivation in childhood acute lymphocytic leukemia
Heyman M, Rasool O, Brandter Lb, Liu Y, Grander D, Soderhall S, et al
JOURNAL OF CLINICAL ONCOLOGY 1996;14(5):1512-20

A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5
Kapanadze B, Kashuba V, Baranova A, Rasool O, Van Everdink W, Liu Y, et al
FEBS LETTERS 1998;426(2):266-70

p16(INK4)/p15(INK4B) gene inactivation is a frequent event in malignant T-cell lines
Brandter Lb, Heyman M, Rasool O, Liu Y, Grander D, Einhorn S
EUROPEAN JOURNAL OF HAEMATOLOGY 1996;56(5):313-318

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines
Dohda T, Maljukova A, Liu L, Heyman M, Grander D, Brodin D, et al
EXPERIMENTAL CELL RESEARCH 2007;313(14):3141-52

Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins
Sangfelt O, Erickson S, Castro J, Heiden T, Gustafsson A, Einhorn S, et al
ONCOGENE 1999;18(18):2798-810

Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS
Baranova A, Hammarsund M, Ivanova Dv, Skoblov M, Sangfelt O, Corcoran M, et al
GENE 2003;:103-12

P15(INK4B) AND P16(INK4) GENE INACTIVATION IN ACUTE LYMPHOCYTIC-LEUKEMIA
Rasool O, Heyman M, Brandter Lb, Liu Y, Grander D, Soderhall S, et al
BLOOD 1995;85(12):3431-6

The RBCC gene RFP2 (leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD
Lerner M, Corcoran M, Cepeda D, Nielsen Ml, Zubarev R, Ponten F, et al
MOLECULAR BIOLOGY OF THE CELL 2007;18(5):1670-82

DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1
Lerner M, Harada M, Loven J, Castro J, Davis Z, Oscier D, et al
EXPERIMENTAL CELL RESEARCH 2009;315(17):2941-52

Doxorubicin requires the sequential activation of caspase-2, protein kinase C delta, and c-Jun NH2-terminal kinase to induce apoptosis
Panaretakis T, Laane E, Pokrovskaja K, Bjorklund Ac, Moustakas A, Zhivotovsky B, et al
MOLECULAR BIOLOGY OF THE CELL 2005;16(8):3821-31

Phosphoinositide 3-kinase regulates a subset of interferon-alpha-stimulated genes
Hjortsberg L, Lindvall C, Corcoran M, Arulampalam V, Chan D, Thyrell L, et al
EXPERIMENTAL CELL RESEARCH 2007;313(2):404-14

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles
Kuchinskaya E, Heyman M, Grander D, Linderholm M, Soderhall S, Zaritskey A, et al
EUROPEAN JOURNAL OF HAEMATOLOGY 2005;74(6):466-80

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
Laane E, Tamm Kp, Buentke E, Ito K, Kharaziha P, Oscarsson J, et al
CELL DEATH AND DIFFERENTIATION 2009;16(7):1018-29

Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution
Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grander D, et al
HUMAN GENETICS 2001;109(5):542-50

Characterisation of dic(9;20)(p11-13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2
Schoumans J, Johansson B, Corcoran M, Kuchinskaya E, Golovleva I, Grander D, et al
BRITISH JOURNAL OF HAEMATOLOGY 2006;135(4):492-9

Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia
Thelander Ef, Ichimura K, Corcoran M, Barbany G, Nordgren A, Heyman M, et al
LEUKEMIA & LYMPHOMA 2008;49(3):477-87

The HPV-16 E7 oncogene sensitizes malignant cells to IFN-alpha-induced apoptosis
Thyrell L, Sangfelt O, Zhivotovsky B, Pokrovskaja K, Wang Ys, Einhorn S, et al
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 2005;25(2):63-72

Array-CGH reveals hidden gene dose changes in children with acute lymphoblastic leukaemia and a normal or failed karyotype by G-banding
Kuchinskaya E, Heyman M, Nordgren A, Schoumans J, Staaf J, Borg A, et al
BRITISH JOURNAL OF HAEMATOLOGY 2008;140(5):572-7

Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity
Weng Wh, Lerner M, Grander D, Ahlen J, Villablanca A, Pang St, et al
INTERNATIONAL JOURNAL OF ONCOLOGY 2005;26(1):5-16

Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin
Panaretakis T, Hjortsberg L, Tamm Kp, Bjorklund Ac, Joseph B, Grander D
MOLECULAR BIOLOGY OF THE CELL 2008;19(1):41-50

13Q DELETIONS IN LYMPHOID MALIGNANCIES
Liu Y, Hermanson M, Grander D, Merup M, Wu Xs, Heyman M, et al
BLOOD 1995;86(5):1911-5

Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia
Hammarsund M, Lerner M, Zhu Cy, Merup M, Jansson M, Gahrton G, et al
HUMAN MOLECULAR GENETICS 2004;13(23):2925-36

Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14
Kapanadze B, Makeeva N, Corcoran M, Jareborg N, Hammarsund M, Baranova A, et al
GENOMICS 2000;70(3):327-34

Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence
Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S, Grander D
ONCOGENE 1998;17(5):595-602

Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members
Laane E, Panaretakis T, Pokrovskaja K, Buentke E, Corcoran M, Soderhall S, et al
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 2007;92(11):1460-9

6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas
Merup M, Moreno Tc, Heyman M, Ronnberg K, Grander D, Detlofsson R, et al
BLOOD 1998;91(9):3397-400

Characterization of a hairy cell leukemia-associated 5q13.3 inversion breakpoint
Wu Xs, Merup M, Juliusson G, Jansson M, Stellan B, Grander D, et al
GENES CHROMOSOMES & CANCER 1997;20(4):337-46

Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes
Ahlen G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, et al
GUT 2009;58(4):560-9

Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell L, Hjortsberg L, Arulampalam V, Panaretakis T, Uhles S, Dagnell M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2004;279(23):24152-62

FBXW7/hCDC4 is a general tumor suppressor in human cancer
Akhoondi S, Sun D, Von Der Lehr N, Apostolidou S, Klotz K, Maljukova A, et al
CANCER RESEARCH 2007;67(19):9006-12

Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma
Xu Ld, Muller S, Thoppe Sr, Hellborg F, Kanter L, Lerner M, et al
PloS one 2014;9(11):e111125-

Evolutionary conservation of long non-coding RNAs; sequence, structure, function
Johnsson P, Lipovich L, Grandér D, Morris Kv
Biochimica et biophysica acta 2014;1840(3):1063-71

The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing
Lindqvist Cm, Nordlund J, Ekman D, Johansson A, Moghadam Bt, Raine A, et al
Human mutation 2015;36(1):118-28

Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas
Högfeldt T, Johnsson P, Grandér D, Bahnassy Aa, Porwit A, Eid S, et al
Leukemia & lymphoma 2014;55(5):1158-65

Proteomic screen reveals Fbw7 as a modulator of the NF-kappaB pathway
Arabi A, Ullah K, Branca Rm, Johansson J, Bandarra D, Haneklaus M, et al
Nature communications 2012;3():976-

MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors
Lerner M, Haneklaus M, Harada M, Grandér D
PloS one 2012;7(5):e36490-

An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma
Lin H, Kolosenko I, Björklund Ac, Protsyuk D, Österborg A, Grandér D, et al
Experimental cell research 2013;319(5):600-11

A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
Johnsson P, Ackley A, Vidarsdottir L, Lui Wo, Corcoran M, Grandér D, et al
Nature structural & molecular biology 2013;20(4):440-6

MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor delta in human monocytes during the inflammatory response
Thulin P, Wei T, Werngren O, Cheung L, Fisher Rm, Grandér D, et al
International journal of molecular medicine 2013;31(5):1003-10

IL-6 activated JAK/STAT3 pathway and sensitivity to Hsp90 inhibitors in multiple myeloma
Kolosenko I, Grander D, Tamm Kp
Current medicinal chemistry 2014;21(26):3042-7

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Mojallal M, Zheng Y, Hultin S, Audebert S, Van Harn T, Johnsson P, et al
Nature communications 2014;5():4557-

Involvement of miR17 pathway in glucocorticoid-induced cell death in pediatric acute lymphoblastic leukemia
Harada M, Pokrovskaja-tamm K, Söderhäll S, Heyman M, Grander D, Corcoran M
Leukemia & lymphoma 2012;53(10):2041-50

Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells
Ottosson-wadlund A, Ceder R, Preta G, Pokrovskaja K, Grafström Rc, Heyman M, et al
Molecular pharmacology 2013;83(1):245-55

Pseudogene-Expressed RNAs: Emerging Roles in Gene Regulation and Disease
Grandér D, Johnsson P
Current topics in microbiology and immunology 2016;394():111-26

CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer
Cepeda D, Ng Hf, Sharifi Hr, Mahmoudi S, Cerrato Vs, Fredlund E, et al
EMBO molecular medicine 2013;5(7):1067-86

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
Kolosenko I, Fryknäs M, Forsberg S, Johnsson P, Cheon H, Holvey-bates Eg, et al
International journal of cancer 2015;136(4):E51-61

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia
Holmlund T, Lindberg Mj, Grander D, Wallberg Ae
Leukemia 2013;27(3):578-85

Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies
Daneshmanesh Ah, Porwit A, Hojjat-farsangi M, Jeddi-tehrani M, Tamm Kp, Grandér D, et al
Leukemia & lymphoma 2013;54(4):843-50

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, et al
Oncogenesis 2012;1():e3-

Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, et al
Cancer research 2012;72(20):5348-62

MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion
Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, et al
The Journal of biological chemistry 2012;287(35):29899-908

Sorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha P, Chioureas D, Baltatzis G, Fonseca P, Rodriguez P, Gogvadze V, et al
Oncotarget 2015;6(35):37066-82

Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma
Sangfelt O, Einhorn S, Bjorklund Ac, Wiman Kg, Okan I, Grander D
INTERNATIONAL JOURNAL OF CANCER 1996;67(1):106-12

Visa alla publikationer