Charlotte Thålin

Om mig
Publikationer
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Om mig

My interest in the immune system developed during my Ph.D. studies when investigating the role of neutrophils and neutrophil extracellular traps (NETs) in cancer biology. My research team at the Department of Clinical Sciences, Danderyd Hospital, now includes five Ph.D. students focusing on NETs in cancer and cancer associated thrombosis and, recently, on immune responses following COVID-19 infection and vaccination.

We initiated the MEDECA study 2017, investigating immune markers as diagnostic tools in identifying patients with occult cancer. Faced with the COVID-19 pandemic, we expanded our clinical studies to also investigate longitudinal humoral and cellular immune responses following SARS-CoV-2 infection and vaccination in the COMMUNITY study. As a physician at the department of medicine, Danderyd Hospital, I divide my time between clinical work and research.
https://ki.se/en/kids/community

Utvalda publikationer

Article: THE LANCET REGIONAL HEALTH - EUROPE. 2024;38:100872

Prevalence of SARS-CoV-2 infections among Swedish healthcare workers on duty in December 2023.

Aguilera K; Bladh O; Marking U; Norin NG; Rihani A; Ujvari D; Ning FC; Klingström J; Havervall S; Åberg M; Blom K; Alm JJ; Thålin C
Letter: LANCET INFECTIOUS DISEASES. 2024;24(2):e80-e81

Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster in Sweden.

Marking U; Bladh O; Aguilera K; Yang Y; Greilert Norin N; Blom K; Hober S; Klingström J; Havervall S; Åberg M; Sheward DJ; Thålin C
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1346749

Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum.

Bladh O; Aguilera K; Marking U; Kihlgren M; Greilert Norin N; Smed-Sörensen A; Sällberg Chen M; Klingström J; Blom K; Russell MW; Havervall S; Thålin C; Åberg M
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2023;389(17):1626-1628

Mucosal and Serum Antibodies 3 Weeks after Symptomatic BA.2.86 Infection.

Bladh O; Greilert-Norin N; Havervall S; Marking U; Aguilera K; Alm JJ; Blom K; Åberg M; Klingström J; Thålin C
Letter: THE LANCET REGIONAL HEALTH - EUROPE. 2023;33:100725

Point prevalence of SARS-CoV-2 infection among healthcare workers in March and June 2023 in Sweden.

Blom K; Bladh O; Havervall S; Marking U; Greilert Norin N; Alm JJ; Klingström J; Thålin C
Letter: LANCET INFECTIOUS DISEASES. 2023;23(8):e272-e273

Mucosal IgA protects against BQ.1 and BQ.1.1 infection.

Marking U; Bladh O; Havervall S; Greilert-Norin N; Gordon M; Alm JJ; Blom K; Åberg M; Klingström J; Thålin C
Letter: LANCET MICROBE. 2023;4(7):e488

Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.

Bladh O; Marking U; Havervall S; Norin NG; Aguilera K; Hober S; Smed-Sörensen A; Gordon M; Blom K; Åberg M; Klingström J; Thålin C
Article: NATURE COMMUNICATIONS. 2023;14(1):1577

Correlates of protection and viral load trajectories in omicron breakthrough infections in triple vaccinated healthcare workers.

Marking U; Havervall S; Norin NG; Bladh O; Christ W; Gordon M; Ng H; Blom K; Phillipson M; Mangsbo S; Alm JJ; Smed-Sörensen A; Nilsson P; Hober S; Åberg M; Klingström J; Thålin C
Letter: LANCET INFECTIOUS DISEASES. 2023;23(2):150-152

7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection.

Marking U; Bladh O; Havervall S; Svensson J; Greilert-Norin N; Aguilera K; Kihlgren M; Salomonsson A-C; Månsson M; Gallini R; Kriegholm C; Bacchus P; Hober S; Gordon M; Blom K; Smed-Sörensen A; Åberg M; Klingström J; Thålin C
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(14):1333-1336

Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.

Havervall S; Marking U; Svensson J; Greilert-Norin N; Bacchus P; Nilsson P; Hober S; Gordon M; Blom K; Klingström J; Åberg M; Smed-Sörensen A; Thålin C
Letter: EMERGING INFECTIOUS DISEASES. 2022;28(10):2119-2121

Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022.

Blom K; Havervall S; Marking U; Norin NG; Bacchus P; Groenheit R; Bråve A; Thålin C; Klingström J
Letter: LANCET INFECTIOUS DISEASES. 2022;22(7):943-945

Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.

Blom K; Marking U; Havervall S; Norin NG; Gordon M; García M; Tecleab T; Christ W; Forsell M; Phillipson M; Nilsson P; Mangsbo S; Hober S; Åberg M; Klingström J; Thålin C
Article: VACCINES. 2022;10(3):359

Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.

Marking U; Havervall S; Greilert-Norin N; Ng H; Blom K; Nilsson P; Phillipson M; Hober S; Nilsson C; Mangsbo S; Christ W; Klingström J; Gordon M; Åberg M; Thålin C
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(4):e1388

Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.

Havervall S; Marking U; Greilert-Norin N; Gordon M; Ng H; Christ W; Phillipson M; Nilsson P; Hober S; Blom K; Klingström J; Mangsbo S; Åberg M; Thålin C
Article: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):72-80

Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.

Havervall S; Ng H; Jernbom Falk A; Greilert-Norin N; Månberg A; Marking U; Laurén I; Gabrielsson L; Salomonsson A-C; Aguilera K; Kihlgren M; Månsson M; Rosell A; Hellström C; Andersson E; Olofsson J; Skoglund L; Yousef J; Pin E; Lord M; Åberg M; Hedhammar M; Tegel H; Dönnes P; Phillipson M; Nilsson P; Klingström J; Mangsbo S; Hober S; Thålin C
Article: EBIOMEDICINE. 2021;70:103523

Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.

Havervall S; Marking U; Greilert-Norin N; Ng H; Gordon M; Salomonsson A-C; Hellström C; Pin E; Blom K; Mangsbo S; Phillipson M; Klingström J; Hober S; Nilsson P; Åberg M; Thålin C
Letter: LANCET HAEMATOLOGY. 2021;8(7):e475

Sustained prothrombotic changes in convalescent patients with COVID-19.

von Meijenfeldt FA; Thålin C; Lisman T
Letter: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2021;325(19):2015-2016

Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.

Havervall S; Rosell A; Phillipson M; Mangsbo SM; Nilsson P; Hober S; Thålin C
Letter: BLOOD ADVANCES. 2021;5(3):756-759

Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge.

von Meijenfeldt FA; Havervall S; Adelmeijer J; Lundström A; Magnusson M; Mackman N; Thalin C; Lisman T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(2):988-994

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19.

Ng H; Havervall S; Rosell A; Aguilera K; Parv K; von Meijenfeldt FA; Lisman T; Mackman N; Thålin C; Phillipson M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(2):878-882

Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report.

Rosell A; Havervall S; von Meijenfeldt F; Hisada Y; Aguilera K; Grover SP; Lisman T; Mackman N; Thålin C
Article: NATURE COMMUNICATIONS. 2020;11(1):5064

SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.

Rudberg A-S; Havervall S; Månberg A; Jernbom Falk A; Aguilera K; Ng H; Gabrielsson L; Salomonsson A-C; Hanke L; Murrell B; McInerney G; Olofsson J; Andersson E; Hellström C; Bayati S; Bergström S; Pin E; Sjöberg R; Tegel H; Hedhammar M; Phillipson M; Nilsson P; Hober S; Thålin C
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2732-2743

Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.

Thålin C; Aguilera K; Hall NW; Marunde MR; Burg JM; Rosell A; Daleskog M; Månsson M; Hisada Y; Meiners MJ; Sun Z-W; Whelihan MF; Cheek MA; Howard SA; Saxena-Beem S; Noubouossie DF; Key NS; Sheikh SZ; Keogh M-C; Cowles MW; Lundström S; Mackman N; Wallén H; Johnstone AL
Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(9):1724-1738

Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis.

Thålin C; Hisada Y; Lundström S; Mackman N; Wallén H
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Artiklar

Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(1):e13333

No indication of aberrant neutrophil extracellular trap release in indolent or advanced systemic mastocytosis.

Rosell A; Karlström C; Dahlin JS; Boey D; Klimkowska M; Ax K; Thålin C; Ungerstedt J
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2023;21(11):3166-3174

Neutrophil extracellular trap formation is an independent risk factor for occult cancer in patients presenting with venous thromboembolism.

Rosell A; Gautam G; Wannberg F; Ng H; Gry H; Vingbäck E; Lundström S; Mackman N; Wallén H; Westerlund E; Thålin C
Journal article: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 2023;7:101306

PB0707 Neutrophil Extracellular Traps Promote Cancer-Associated Inflammation and Myocardial Stress

Cedervall J; Herre M; Vemuri K; Dragomir A; Melo F; Svensson A; Thålin C; Rosell A; Hjalmar V; Wallén H; Lindman H; Pejler G; Hagström E; Hultström M; Larsson A; Olsson A
Journal article: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 2023;7:100824

PB1070 Small and Large Extracellular Vesicles have Different Tissue Factor Activity in Cancer, Sepsis, and COVID-19

Sachetto A; Archibald S; Hisada Y; Rosell A; Havervall S; van Es N; Nieuwland R; Campbell R; Middleton E; Rondina M; Thålin C; Mackman N
Article: THE LANCET REGIONAL HEALTH - EUROPE. 2023;30:100646

Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.

Vikström L; Fjällström P; Gwon Y-D; Sheward DJ; Wigren-Byström J; Evander M; Bladh O; Widerström M; Molnar C; Rasmussen G; Bennet L; Åberg M; Björk J; Tevell S; Thålin C; Blom K; Klingström J; Murrell B; Ahlm C; Normark J; Johansson AF; Forsell MNE
Article: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 2023;7(3):100124

Tissue factor activity of small and large extracellular vesicles in different diseases.

Sachetto ATA; Archibald SJ; Hisada Y; Rosell A; Havervall S; van Es N; Nieuwland R; Campbell RA; Middleton EA; Rondina MT; Thålin C; Mackman N
Article: ONCOIMMUNOLOGY. 2022;11(1):2049487

Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.

Cedervall J; Herre M; Dragomir A; Rabelo-Melo F; Svensson A; Thålin C; Rosell A; Hjalmar V; Wallén H; Lindman H; Pejler G; Hagström E; Hultström M; Larsson A; Olsson AK
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(5):e13215

Impact of monocyte-related modulators and kidney function on mortality in hospitalized patients with COVID-19.

Sendic S; Mansouri L; Havervall S; Thålin C; Lundahl J; Jacobson SH
Article: CYTOKINE. 2022;159:156020

IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in Sweden.

Ziegler L; Lundström A; Havervall S; Thålin C; Gigante B
Article: BMC NEPHROLOGY. 2022;23(1):299

"Role of kidney function and concentrations of BAFF, sPD-L1 and sCD25 on mortality in hospitalized patients with COVID-19".

Mansouri L; Sendic S; Havervall S; Thålin C; Jacobson SH; Lundahl J
Article: EMBO MOLECULAR MEDICINE. 2022;14(8):e15230

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.

Monteil V; Eaton B; Postnikova E; Murphy M; Braunsfeld B; Crozier I; Kricek F; Niederhöfer J; Schwarzböck A; Breid H; Devignot S; Klingström J; Thålin C; Kellner MJ; Christ W; Havervall S; Mereiter S; Knapp S; Sanchez Jimenez A; Bugajska-Schretter A; Dohnal A; Ruf C; Gugenberger R; Hagelkruys A; Montserrat N; Kozieradzki I; Hasan Ali O; Stadlmann J; Holbrook MR; Schmaljohn C; Oostenbrink C; Shoemaker RH; Mirazimi A; Wirnsberger G; Penninger JM
Article: IMMUNITY INFLAMMATION AND DISEASE. 2022;10(4):e595

Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.

Laurén I; Havervall S; Ng H; Lord M; Pettke A; Greilert-Norin N; Gabrielsson L; Chourlia A; Amoêdo-Leite C; Josyula VS; Eltahir M; Kerzeli I; Falk AJ; Hober J; Christ W; Wiberg A; Hedhammar M; Tegel H; Burman J; Xu F; Pin E; Månberg A; Klingström J; Christoffersson G; Hober S; Nilsson P; Philipson M; Dönnes P; Lindsay R; Thålin C; Mangsbo S
Article: ANTICANCER RESEARCH. 2022;42(2):965-971

Circulating Markers of Neutrophil Extracellular Traps (NETs) in Patients With Ovarian Tumors.

Dobilas A; Thalin C; Wallen H; Borgfeldt C
Article: NEW BIOTECHNOLOGY. 2022;66:46-52

A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.

Mravinacova S; Jönsson M; Christ W; Klingström J; Yousef J; Hellström C; Hedhammar M; Havervall S; Thålin C; Pin E; Tegel H; Nilsson P; Månberg A; Hober S
Article: PLOS ONE. 2022;17(1):e0262169

SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection.

Havervall S; Jernbom Falk A; Klingström J; Ng H; Greilert-Norin N; Gabrielsson L; Salomonsson A-C; Isaksson E; Rudberg A-S; Hellström C; Andersson E; Olofsson J; Skoglund L; Yousef J; Pin E; Christ W; Olausson M; Hedhammar M; Tegel H; Mangsbo S; Phillipson M; Månberg A; Hober S; Nilsson P; Thålin C
Article: PLOS ONE. 2022;17(7):e0270865

Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts.

Smith P; Rosell A; Farm M; Bruzelius M; Aguilera Gatica K; Mackman N; Odeberg J; Thålin C
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2021;47(7):775-786

Fibrin Network Porosity and Endo-/Exogenous Thrombin Cross-talk.

He S; Wallén H; Thålin C; Svensson J; Blombäck M
Article: JOURNAL OF MEDICAL VIROLOGY. 2021;93(10):5908-5916

Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.

Lundström A; Ziegler L; Havervall S; Rudberg A-S; von Meijenfeldt F; Lisman T; Mackman N; Sandén P; Thålin C
Article: SCIENTIFIC REPORTS. 2021;11(1):18025

Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.

Zenlander R; Havervall S; Magnusson M; Engstrand J; Ågren A; Thålin C; Stål P
Article: SCIENTIFIC REPORTS. 2021;11(1):14015

An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.

Razzaq M; Iglesias MJ; Ibrahim-Kosta M; Goumidi L; Soukarieh O; Proust C; Roux M; Suchon P; Boland A; Daiain D; Olaso R; Havervall S; Thalin C; Butler L; Deleuze J-F; Odeberg J; Morange P-E; Trégouët D-A
Article: NATURE COMMUNICATIONS. 2021;12(1):3695

Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.

Roxhed N; Bendes A; Dale M; Mattsson C; Hanke L; Dodig-Crnković T; Christian M; Meineke B; Elsässer S; Andréll J; Havervall S; Thålin C; Eklund C; Dillner J; Beck O; Thomas CE; McInerney G; Hong M-G; Murrell B; Fredolini C; Schwenk JM
Journal article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2021;36(Supplement_1):gfab092.0010

MO132IMPACT OF MONOCYTE CHEMOATTRACTANTS ON IN-HOSPITAL MORTALITY IN RELATION TO KIDNEY FUNCTION IN PATIENTS WITH COVID-19

Sendic S; Mansouri L; Havervall S; Thålin C; Lundahl J; Jacobson SH
Article: CIRCULATION RESEARCH. 2021;128(11):1694-1707

Perivascular Macrophages Regulate Blood Flow Following Tissue Damage.

Vågesjö E; Parv K; Ahl D; Seignez C; Herrera Hidalgo C; Giraud A; Leite C; Korsgren O; Wallén H; Juusola G; Hakovirta HH; Rundqvist H; Essand M; Holm L; Johnson RS; Thålin C; Korpisalo P; Christoffersson G; Phillipson M
Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(5):584-593

High Thrombin Generation after Acute Ischemic Stroke or Transient Ischemic Attack Is Associated with a Reduced Risk of Recurrence: An Observational Cohort Study.

Lundström A; Änggårdh-Rooth E; Mobarrez F; Thålin C; Gigante B; Laska AC; Wallén H
Journal article: THROMBOSIS RESEARCH. 2021;200:s32

PO-28 Circulating markers of neutrophil activation and nets, but not of coagulation and fibrinolysis, predict mortality in patients with terminal cancer

Rosell A; Aguilera K; Daleskog M; Hisada Y; Mackman N; Lundström S; Wallén H; Thålin C
Journal article: THROMBOSIS RESEARCH. 2021;200:s79-s80

PO-110 Identification of novel biomarkers to aid in the detection of occult cancer in high-risk patient populations: the BIT and MEDECA studies

Thålin C; Rosell A; Gabrielsson L; Månsson M; Aguilera K; Lundström S; Söderberg M; Hjalmar V; Wallén H; Group FTBAMS
Journal article: THROMBOSIS RESEARCH. 2021;200:s78

PO-107 Tumor-induced neutrophil extracellular traps contribute to organ failure in individuals with cancer

Cedervall J; Herre M; Thålin C; Wallén H; Hjalmar V; Hagström E; Larsson A; Olsson AK
Article: SCIENTIFIC REPORTS. 2021;11(1):5074

Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer.

Rosell A; Aguilera K; Hisada Y; Schmedes C; Mackman N; Wallén H; Lundström S; Thålin C
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:795026

A Model Predicting Mortality of Hospitalized Covid-19 Patients Four Days After Admission: Development, Internal and Temporal-External Validation.

Heber S; Pereyra D; Schrottmaier WC; Kammerer K; Santol J; Rumpf B; Pawelka E; Hanna M; Scholz A; Liu M; Hell A; Heiplik K; Lickefett B; Havervall S; Traugott MT; Neuböck MJ; Schörgenhofer C; Seitz T; Firbas C; Karolyi M; Weiss G; Jilma B; Thålin C; Bellmann-Weiler R; Salzer HJF; Szepannek G; Fischer MJM; Zoufaly A; Gleiss A; Assinger A
Article: PLOS ONE. 2021;16(9):e0258041

An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.

Mangsbo SM; Havervall S; Laurén I; Lindsay R; Jernbom Falk A; Marking U; Lord M; Buggert M; Dönnes P; Christoffersson G; Nilsson P; Hober S; Phillipson M; Klingström J; Thålin C
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312

Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.

Hober S; Hellström C; Olofsson J; Andersson E; Bergström S; Jernbom Falk A; Bayati S; Mravinacova S; Sjöberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingström J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Mühr LS; Eklund C; Lagheden C; Dillner J; Sivertsson Å; Havervall S; Thålin C; Tegel H; Pin E; Månberg A; Hedhammar M; Nilsson P
Article: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. 2021;5(1):132-141

Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.

von Meijenfeldt FA; Havervall S; Adelmeijer J; Lundström A; Rudberg A-S; Magnusson M; Mackman N; Thalin C; Lisman T
Article: TRANSLATIONAL STROKE RESEARCH. 2020;11(4):708-719

Prognostic Value of Circulating Microvesicle Subpopulations in Ischemic Stroke and TIA.

Lundström A; Mobarrez F; Rooth E; Thålin C; von Arbin M; Henriksson P; Gigante B; Laska A-C; Wallén H
Article: HAEMATOLOGICA. 2020;105(1):218-225

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors.

Hisada Y; Grover SP; Maqsood A; Houston R; Ay C; Noubouossie DF; Cooley BC; Wallén H; Key NS; Thålin C; Farkas ÁZ; Farkas VJ; Tenekedjiev K; Kolev K; Mackman N
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2019;48(1):111-118

A clinical practice-based evaluation of the RIETE score in predicting occult cancer in patients with venous thromboembolism.

Rosell A; Lundström S; Mackman N; Wallén H; Thålin C
Article: SCIENTIFIC REPORTS. 2018;8(1):12641

Circulating H3Cit is elevated in a human model of endotoxemia and can be detected bound to microvesicles.

Paues Göranson S; Thålin C; Lundström A; Hållström L; Lasselin J; Wallén H; Soop A; Mobarrez F
Article: THROMBOSIS RESEARCH. 2018;165:1-5

Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients.

Hisada Y; Thålin C; Lundström S; Wallén H; Mackman N
Article: PLOS ONE. 2018;13(1):e0191231

Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer.

Thålin C; Lundström S; Seignez C; Daleskog M; Lundström A; Henriksson P; Helleday T; Phillipson M; Wallén H; Demers M
Article: IMMUNOLOGIC RESEARCH. 2017;65(3):706-712

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma.

Thålin C; Daleskog M; Göransson SP; Schatzberg D; Lasselin J; Laska A-C; Kallner A; Helleday T; Wallén H; Demers M
Article: THROMBOSIS RESEARCH. 2016;139:56-64

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation.

Thålin C; Demers M; Blomgren B; Wong SL; von Arbin M; von Heijne A; Laska AC; Wallén H; Wagner DD; Aspberg S
Article: JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS. 2014;2(2):2324709614539283-232470961453928

Trousseau's Syndrome, a Previously Unrecognized Condition in Acute Ischemic Stroke Associated With Myocardial Injury.

Thalin C; Blomgren B; Mobarrez F; Lundstrom A; Laska AC; von Arbin M; von Heijne A; Rooth E; Wallen H; Aspberg S
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Alla övriga publikationer

Letter: THROMBOSIS RESEARCH. 2024;235:18-21

Analysis of NETs (neutrophil extracellular traps) in coronary thrombus and peripheral blood of patients with ST-segment elevation myocardial infarction.

Blasco A; Rosell A; Castejón R; Coronado MJ; Royuela A; Ramil E; Elorza S; Thålin C; Martín P; Angulo B; Rascón B; García-Gómez S; Zabala I; Ortega J; Silva L; Bellas C
Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(21):e55

Mucosal IgA against SARS-CoV-2 Omicron Infection. Reply.

Åberg M; Smed-Sörensen A; Thålin C
Published conference paper: THROMBOSIS RESEARCH. 2022;213 Suppl 1:S35-S41

Neutrophil extracellular traps and cancer-associated thrombosis.

Rosell A; Martinod K; Mackman N; Thålin C
Letter: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2022;20(1):267-269

Persistent endotheliopathy in the pathogenesis of long COVID syndrome: Comment from von Meijenfeldt et al.

von Meijenfeldt FA; Havervall S; Adelmeijer J; Thalin C; Lisman T
Conference publication: THROMBOSIS RESEARCH. 2022;213:S2-S3

Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress

Cedervall J; Herre M; Dragomir A; Rabelo-Melo F; Svensson A; Thalin C; Rosell A; Hjalmar V; Wallen H; Lindman H; Pejler G; Hagstrom E; Hultstrom M; Larsson A; Olsson AK
Letter: THROMBOSIS AND HAEMOSTASIS. 2021;121(12):1668-1669

COVID-19 is Associated with an Acquired Factor XIII Deficiency.

von Meijenfeldt FA; Havervall S; Adelmeijer J; Lundström A; Magnusson M; Mackman N; Thalin C; Lisman T
Letter: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(6):e381-e382

Response by Mackman et al to Letter Regarding Article, "Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report".

Mackman N; Hisada Y; Grover SP; Rosell A; Havervall S; von Meijenfeldt F; Aguilera K; Lisman T; Thålin C
Letter: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(4):E98-E100

Elevated factor V activity and antigen levels in patients with Covid-19 are related to disease severity and 30-day mortality.

von Meijenfeldt FA; Havervall S; Adelmeijer J; Lundström A; Magnusson M; Mackman N; Thalin C; Lisman T
Review: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2021;47(1):63-73

The Clotting Trigger Is an Important Determinant for the Coagulation Pathway In Vivo or In Vitro-Inference from Data Review.

He S; Cao H; Thålin C; Svensson J; Blombäck M; Wallén H
Review: LAKARTIDNINGEN. 2019;116:FI3S

[The neutrophil's multifaceted traps - the Dr Jekyll and Mr Hyde of the immune system].

Thålin C; Rosell A; Lundström S; Wallén H
Meeting abstract: THROMBOSIS RESEARCH. 2018;164:S233-S234

Performance of the RIETE score in an unselected VTE cohort

Rosell A; Lundstrom S; Wallen H; Thalin C
KI thesis / dissertation: 2017

Troponin elevation in acute stroke : clinical characteristics and the link to cancer-associated neutrophil extracellular traps

Thålin, Charlotte
Review: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES. 2015;24(10):2390-2396

Elevated Troponin Levels in Acute Stroke Patients Predict Long-term Mortality.

Thålin C; Rudberg A-S; Johansson F; Jonsson F; Laska AC; Nygren AT; von Arbin M; Wallén H; Aspberg S
Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2015;10:285-286

Elevated troponin levels in acute stroke patients predict long-term mortality

Thalin C; Rudberg AS; Laska AC; von Arbin M; Wallen H; Aspberg S
Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015;13:814

Cancer inducing netosis promotes widespread arterial thrombosis presenting as ischemic stroke with troponin elevation

Thalin C; Demers M; Blomgren B; Laska AC; von Arbin M; Wallen H; Wagner D; Aspberg S
Conference publication: CEREBROVASCULAR DISEASES. 2014;37:230

Cancer associated generalized thrombosis contributing to elevated levels of plasma troponinin A patients with acute ischemic stroke

Thalin C; Lundstrom A; Blomgren B; Mobarrez F; Laska AC; von Arbin M; Wallen H; Aspberg S

Forskningsbidrag

Towards unified quantitative assays of mucosal immunity

National Institutes of Health

1 September 2023 - 1 September 2024
Nya biomarkörer vid detektion av dold cancer i högrisk populationer

Vetenskapsrådet

1 January 2023 - 31 December 2025
The COMMUNITY study - Covid-19 Immunity

Knut och Alice Wallenbergs Stiftelse

31 March 2021 - 31 March 2023
Long-term sequele after mild SARS-CoV-2 infection

Swedish Heart-Lung Foundation

1 January 2021 - 31 December 2021

Anställningar

Anknuten till Forskning, Kliniska vetenskaper, Danderyds sjukhus, Karolinska Institutet, 2023-2026

Examina och utbildning

Docent, immunologi, Karolinska Institutet, 2022
Medicine Doktorsexamen, Institutionen för kliniska vetenskaper, Danderyds sjukhus, Karolinska Institutet, 2017
Läkarexamen, Karolinska Institutet, 2010

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