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Bruna Gigante



Adherence to a Mediterranean diet is associated with reduced risk of heart failure in men
Tektonidis Tg, Åkesson A, Gigante B, Wolk A, Larsson Sc
European journal of heart failure 2016;18(3):253-9

Cross-sectional relationships between dietary fat intake and serum cholesterol fatty acids in a Swedish cohort of 60-year-old men and women
Laguzzi F, Alsharari Z, Risérus U, Vikström M, Sjögren P, Gigante B, et al
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association 2016;29(3):325-37

Healthy Lifestyle and Risk of Heart Failure: Results From 2 Prospective Cohort Studies
Larsson Sc, Tektonidis Tg, Gigante B, Åkesson A, Wolk A
Circulation. Heart failure 2016;9(4):e002855-

A Mediterranean diet and risk of myocardial infarction, heart failure and stroke: A population-based cohort study
Tektonidis Tg, Åkesson A, Gigante B, Wolk A, Larsson Sc
Atherosclerosis 2015;243(1):93-8

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease
Gigante B, Strawbridge Rj, Velasquez Im, Golabkesh Z, Silveira A, Goel A, et al
PloS one 2015;10(3):e0119980-

Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction
Moreno Velásquez I, Golabkesh Z, Källberg H, Leander K, De Faire U, Gigante B
Atherosclerosis 2015;240(2):477-81

Clopidogrel Resistance after Minor Ischemic Stroke or Transient Ischemic Attack is Associated with Radiological Cerebral Small-Vessel Disease
Lundström A, Wallén H, Von Arbin M, Jörneskog G, Gigante B, Höeg Dembrower K, et al
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2015;24(10):2348-57

Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? A population-based case-control study
Carrasquilla Gd, Berglund A, Gigante B, Landgren Bm, De Faire U, Hallqvist J, et al
Menopause (New York, N.Y.) 2015;22(6):598-606

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels
Moreno Velásquez I, Kumar J, Björkbacka H, Nilsson J, Silveira A, Leander K, et al
Cytokine 2015;72(2):178-84

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton Kj, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen Me, et al
Nature genetics 2015;47(12):1415-25

Genetic studies of body mass index yield new insights for obesity biology
Locke Ae, Kahali B, Berndt Si, Justice Ae, Pers Th, Day Fr, et al
Nature 2015;518(7538):197-206

Interleukin-8 is associated with increased total mortality in women but not in men-findings from a community-based cohort of elderly
Moreno Velásquez I, Ärnlöv J, Leander K, Lind L, Gigante B, Carlsson Ac
Annals of medicine 2015;47(1):28-33

New genetic loci link adipose and insulin biology to body fat distribution
Shungin D, Winkler Tw, Croteau-chonka Dc, Ferreira T, Locke Ae, Mägi R, et al
Nature 2015;518(7538):187-96

Obesity, metabolic syndrome and risk of atrial fibrillation: a Swedish, prospective cohort study
Nyström Pk, Carlsson Ac, Leander K, De Faire U, Hellenius Ml, Gigante B
PloS one 2015;10(5):e0127111-

Plasma IL-5 concentration and subclinical carotid atherosclerosis
Silveira A, Mcleod O, Strawbridge Rj, Gertow K, Sennblad B, Baldassarre D, et al
Atherosclerosis 2015;239(1):125-30

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women
Marklund M, Leander K, Vikström M, Laguzzi F, Gigante B, Sjögren P, et al
Circulation 2015;132(7):586-94

Pulse pressure is not an independent predictor of incident atrial fibrillation in 60-year-old men and women
Miedel C, Leander K, De Faire U, Gigante B
Annals of medicine 2015;47(8):679-86

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
Persson J, Strawbridge Rj, Mcleod O, Gertow K, Silveira A, Baldassarre D, et al
Journal of the American Heart Association 2015;4(8):e001853-

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Tw, Justice Ae, Graff M, Barata L, Feitosa Mf, Chu S, et al
PLoS genetics 2015;11(10):e1005378-

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness)
Strawbridge Rj, Deleskog A, Mcleod O, Folkersen L, Kavousi M, Gertow K, et al
Diabetologia 2014;57(6):1159-72

Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program
Velásquez Im, Frumento P, Johansson K, Berglund A, De Faire U, Leander K, et al
International journal of cardiology 2014;172(1):173-8

Differences in anthropometric measures in immigrants and Swedish-born individuals: Results from two community-based cohort studies
Carlsson Ac, Wandell P, Riserus U, Arnlov J, Borne Y, Engstrom G, et al

Financial stress in late adulthood and diverse risks of incident cardiovascular disease and all-cause mortality in women and men
Carlsson Ac, Starrin B, Gigante B, Leander K, Hellenius Ml, De Faire U
BMC public health 2014;14():17-

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Mexican Amer Type 2 Diabet Mat2d C, Type 2 Diabet Genetic Exploration, Diabet Genetics Replication & Meta, Asian Genetic Epidemiology Network, South Asian Type Diabet Sat2d Cons, Mahajan A, et al
NATURE GENETICS 2014;46(3):234-44

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis
Shang Mm, Talukdar Ha, Hofmann Jj, Niaudet C, Asl Hf, Jain Rk, et al
Arteriosclerosis, thrombosis, and vascular biology 2014;34(9):2068-77

Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project
Stafoggia M, Cesaroni G, Peters A, Andersen Zj, Badaloni C, Beelen R, et al

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men
Gigante B, Leander K, Vikström M, Baldassarre D, Veglia F, Strawbridge Rj, et al
Atherosclerosis 2014;236(2):394-9

Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis
Mcleod O, Silveira A, Fredrikson Gn, Gertow K, Baldassarre D, Veglia F, et al
Atherosclerosis 2014;232(1):242-8

Prediction of cardiovascular disease by abdominal obesity measures is dependent on body weight and sex--results from two community based cohort studies
Carlsson Ac, Riserus U, Ärnlöv J, Borné Y, Leander K, Gigante B, et al
Nutrition, metabolism, and cardiovascular diseases : NMCD 2014;24(8):891-9

A gene-centric study of common carotid artery remodelling
Harrison Sc, Zabaneh D, Asselbergs Fw, Drenos F, Jones Gt, Shah S, et al
Atherosclerosis 2013;226(2):440-6

Causal Relevance of Blood Lipid Fractions in the Development of Carotid Atherosclerosis Mendelian Randomization Analysis
Shah S, Casas Jp, Drenos F, Whittaker J, Deanfield J, Swerdlow Di, et al

Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer Cj, Schmidt Em, Sengupta S, Gao C, Peloso Gm, et al
NATURE GENETICS 2013;45(11):1345-52

Discovery and refinement of loci associated with lipid levels
Global Lipids Genetics Consortium, Willer Cj, Schmidt Em, Sengupta S, Peloso Gm, Gustafsson S, et al
NATURE GENETICS 2013;45(11):1274-83

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia
Stitziel No, Fouchier Sw, Sjouke B, Peloso Gm, Moscoso Am, Auer Pl, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(12):2909-14

Identifying the odds ratio estimated by a two-stage instrumental variable analysis with a logistic regression model
Burgess S, Crp Chd Genetics Collaboration
Statistics in medicine 2013;32(27):4726-47

Large-scale association analysis identifies new risk loci for coronary artery disease
Wellcome Trust Case Control, Muther Consortium, Cardiogenenics Consortium, Diagram Consortium, Cardiogramplusc4d Consortium, Deloukas P, et al
NATURE GENETICS 2013;45(1):25-33

Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
Su J, Hua X, Vikström M, Leander K, Gigante B, Hellenius Ml, et al
BMC cardiovascular disorders 2013;13():1-

Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study
Carlsson Ac, Risérus U, Engström G, Ärnlöv J, Melander O, Leander K, et al
International journal of obesity (2005) 2013;37(12):1579-85

Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer
Darby Sc, Ewertz M, Mcgale P, Bennet Am, Blom-goldman U, Bronnum D, et al

Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis
Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(11):2633-8

Seven modifiable lifestyle factors predict reduced risk for ischemic cardiovascular disease and all-cause mortality regardless of body mass index: a cohort study
Carlsson Ac, Wändell Pe, Gigante B, Leander K, Hellenius Ml, De Faire U
International journal of cardiology 2013;168(2):946-52

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Magic Investigators, Diagram Consortium, Randall Jc, Winkler Tw, Kutalik Z, Berndt Si, et al
PLOS GENETICS 2013;9(6):e1003500-

The risk of type 2 diabetes in men is synergistically affected by parental history of diabetes and overweight
Wikner C, Gigante B, Hellénius Ml, De Faire U, Leander K
PloS one 2013;8(4):e61763-

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Muther Consortium, Diagram Consortium, Manning Ak, Hivert Mf, Scott Ra, Grimsby Jl, et al
NATURE GENETICS 2012;44(6):659-69

Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels
Gigante B, Leander K, Vikström M, Ye S, De Faire U
BMC cardiovascular disorders 2012;12():90-

Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 Levels
Chernogubova E, Strawbridge R, Mahdessian H, Malarstig A, Krapivner S, Gigante B, et al

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration
Angelakopoulou A, Shah T, Sofat R, Shah S, Berry Dj, Cooper J, et al
EUROPEAN HEART JOURNAL 2012;33(3):393-407

Elevated ApoB serum levels strongly predict early cardiovascular events
Gigante B, Leander K, Vikstrom M, Frumento P, Carlsson Ac, Bottai M, et al
HEART 2012;98(16):1242-5

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Gertow K, Sennblad B, Strawbridge Rj, Ohrvik J, Zabaneh D, Shah S, et al

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
Il6r Genetics Consortium Emerging Risk Factors Collaboration, Sarwar N, Butterworth As, Freitag Df, Gregson J, Willeit P, et al
Lancet (London, England) 2012;379(9822):1205-13

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Diabet Genetics Replication, Scott Ra, Lagou V, Welch Rp, Wheeler E, Montasser Me, et al
NATURE GENETICS 2012;44(9):991-1005

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Genetic Invest Anthropometric, Wellcome Trust Case Control, Meta-anal Glucose Insulin-related, Diabet Genetics Replication, Asian Genetic Epidemiology, S Asian Type 2 Diabet Sat2d, et al
NATURE GENETICS 2012;44(9):981-90

NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction
Leander K, Gigante B, Silveira A, Vikstrom M, Hamsten A, Hogberg J
CLINICA CHIMICA ACTA 2012;413(7-8):727-32

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Voight Bf, Peloso Gm, Orho-melander M, Frikke-schmidt R, Barbalic M, Jensen Mk, et al
LANCET 2012;380(9841):572-80

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Coronary Artery Dis C4d Genetics C, Muther Consortium, Peden Jf, Hopewell Jc, Saleheen D, Chambers Jc, et al
NATURE GENETICS 2011;43(4):339-44

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
Ages, Lolipop, Isis, Interheart, Hvhs, Hpfs, et al

Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden
Mcgale P, Darby Sc, Hall P, Adolfsson J, Bengtsson No, Bennet Am, et al

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogram Consortium, Schunkert H, Konig Ir, Kathiresan S, Reilly Mp, Assimes Tl, et al
NATURE GENETICS 2011;43(4):333-8

Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease
Olsson B, Gigante B, Mehlig K, Bergsten A, Leander K, De Faire U, et al

Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility
Vergeer M, Boekholdt Sm, Sandhu Ms, Ricketts Sl, Wareham Nj, Brown Mj, et al
CIRCULATION 2010;122(5):470-7

The Interaction between Coagulation Factor 2 Receptor and Interleukin 6 Haplotypes Increases the Risk of Myocardial Infarction in Men
Gigante B, Bennet Am, Leander K, Vikstrom M, De Faire U
PLOS ONE 2010;5(6):e11300-

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Procardis Consortium, Clarke R, Peden Jf, Hopewell Jc, Kyriakou T, Goel A, et al

Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study
Hagg S, Skogsberg J, Lundstrom J, Noori P, Nilsson R, Zhong H, et al
PLOS GENETICS 2009;5(12):e1000754-

The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the-129A allele in women
Zotova E, Lyrenas L, De Faire U, Morgenstern R, Gigante B, Bennet Am

Variants in the coagulation factor 2 receptor (F2R) gene influence the risk of myocardial infarction in men through an interaction with interleukin 6 serum levels
Gigante B, Vikstrom M, Meuzelaar Ls, Chernogubova E, Silveira A, Van't Hooft F, et al

Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients
Gigante B, Bellis A, Visconti R, Marino M, Morisco C, Trimarco V, et al

Plgf(-/-) eNos(-/-) mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia
Gigante B, Morlino G, Gentile Mt, Persico Mg, De Falco S
FASEB JOURNAL 2006;20(7):970-2

Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population
Rubattu S, Di Angelantonio E, Nitsch D, Gigante B, Zanda B, Stanzione R, et al

Atrial natriuretic peptide gene Polymorphisms and risk of ischemic stroke in humans
Rubattu S, Stanzione R, Di Angelantonio E, Zanda B, Evangelista A, Tarasi D, et al
STROKE 2004;35(4):814-8

Placenta growth factor is not required for exercise-induced angiogenesis
Gigante B, Tarsitano M, Cimini V, De Falco S, Persico Mg
Angiogenesis 2004;7(3):277-84

Role of genetic factors in the etiopathogenesis of cerebrovascular accidents: From an animal model to the human disease
Rubattu S, Stanzione R, Gigante B, Volpe M

Contribution of genetic factors to renal lesions in the stroke-prone spontaneously hypertensive rat
Gigante B, Rubattu S, Stanzione R, Lombardi A, Baldi A, Baldi F, et al
HYPERTENSION 2003;42(4):702-6

Functional cross-talk between angiotensin II and epidermal growth factor receptors in NIH3T3 fibroblasts
De Paolis P, Porcellini A, Savoia C, Lombardi A, Gigante B, Frati G, et al

Determinants and clinical significance of natriuretic peptides in hypertrophic cardiomyopathy
Briguori C, Betocchi S, Manganelli F, Gigante B, Losi Ma, Ciampi Q, et al
EUROPEAN HEART JOURNAL 2001;22(15):1328-36

Genetic susceptibility to cerebrovascular accidents
Rubattu T, Stanzione R, Gigante B, Bagalino A, Musumeci B, Volpe M

Non-random chromosomal distribution of SSLPs: systematic assessment using a novel genetic linkage map between two closely related rat strains
Gigante B, Rubattu S, Zee Ryl, Volpe M, Lindpaintner K

Analysis of the genetic basis of the endothelium-dependent impaired vasorelaxation in the stroke-prone spontaneously hypertensive rat: a candidate gene approach
Rubattu S, Giliberti R, Russo R, Gigante B, Ganten U, Volpe M

Defective suppression of the aldosterone biosynthesis during stroke permissive diet in the stroke-prone phenotype of the spontaneously hypertensive rat
Enea I, De Paolis P, Porcellini A, Piras O, Savoia C, Russo R, et al

Role of angiotensin II AT(1) and AT(2) subtype receptors in the regulation of atrial natriuretic peptide expression in salt-restricted rats
Gigante B, Piras O, Savoia C, De Paolis P, Rubattu S, Panina G, et al

Altered structure, regulation, and function of the gene encoding the atrial natriuretic peptide in the stroke-prone spontaneously hypertensive rat
Rubattu S, Lee-kirsch Ma, Depaolis P, Giliberti R, Gigante B, Lombardi A, et al
CIRCULATION RESEARCH 1999;85(10):900-5

Modulation of the AT(2) subtype receptor gene activation and expression by the AT(1) receptor in endothelial cells
De Paolis P, Porcellini A, Gigante B, Giliberti R, Lombardi A, Savoia C, et al
JOURNAL OF HYPERTENSION 1999;17(12):1873-7

Role of the angiotensin II AT(2)-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats
Gigante B, Piras O, De Paolis P, Porcellini A, Natale A, Volpe M
JOURNAL OF HYPERTENSION 1998;16(12):2039-43

Intrarenal determinants of sodium retention in mild heart failure - Effects of angiotensin-converting enzyme inhibition
Volpe M, Magri P, Rao Mae, Cangianiello S, Denicola L, Mele Af, et al
HYPERTENSION 1997;30(2):168-76

Opposite feedback control of renin and aldosterone biosynthesis in the adrenal cortex by angiotensin II AT(1)-subtype receptors
Gigante B, Rubattu S, Russo R, Porcellini A, Enea I, Depaolis P, et al
HYPERTENSION 1997;30(3):563-8

Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats
Volpe M, Gigante B, Enea I, Porcellini A, Russo R, Lee Ma, et al
CIRCULATION RESEARCH 1997;81(5):857-64

Regulation of 11 beta-hydroxylase cytochrome P450 expression by cholesterol in spontaneously hypertensive rats
Rubattu S, Russo R, Gigante B, Porcellini A, Finizia L, Trimarco B, et al
JOURNAL OF HYPERTENSION 1995;13(11):1253-8

Volpe M, Rubattu S, Gigante B, Ganten D, Porcellini A, Russo R, et al

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