Brinton Seashore-Ludlow
Senior Forskningsspecialist
E-postadress: brinton.seashore-ludlow@ki.se
Telefon: +46852487873
Besöksadress: Tomtebodavägen 23B, SciLifeLab, 17165 Stockholm
Postadress: K7 Onkologi-Patologi, K7 Forskning Kallioniemi SeashoreLudlow, 171 77 Stockholm
Om mig
- I currently hold two positions at the Karolinska Institute (KI). I am a team leader in the larger group of Olli Kallioniemi, and group leader of the biology team at Chemical Biology Consortium Sweden [1] (CBCS), a national infrastructure at SciLifeLab [2].2013-2015: *PostDoc*
- Broad Institute of Harvard and MIT2007-2012 *PhD*
- KTH Royal Institute of Technology, Stockholm, Sweden2005-2007 *MSc*
- California Institute of Technology, Pasadena, CA, USA2001-2005 *BA*
- Macalester College, St. Paul, MN, USA[1] https://www.scilifelab.se/facilities/cbcs/[2] https://www.scilifelab.se/
Forskningsbeskrivning
- .... Our ultimate goal is to promote the move away from one-size-fits-all therapies to improve patient outcome through treatment stratification and tailoring. Despite advances in precision medicine diagnostics, there are still major opportunities to improve individualized patient care throughout the entire health care value chain, spanning from preclinical studies in drug discovery through to the design of precision diagnostics. Research in my team focuses on challenges central to these fields, developing technologies and disease models that enable direct measurement of patient response to treatment ex vivo and investigation of the molecular determinants of drug response. Such methods and model systems are critical to improve the study of disease biology, identify and validate new drug targets, correctly prioritize drug candidates for clinical trials, uncover potential biomarkers for future patient stratification and have even recently been used successfully as diagnostics to match patients to effective treatments..... Our translational research group and surrounding team of clinicians and experts has two major themes as described below united by the main goal of investigating drug response and biomarkers in primary patient cells and other near-patient models of disease.
Undervisning
- I co-organize the Overview Course in Cancer Drug Discovery. [1][1] https://kiwas.ki.se/katalog/katalog/kurs/9373
- jsessionid=e5e6391eaf4fb87efa1707889446
Artiklar
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Article: NPJ PRECISION ONCOLOGY. 2024;8(1):38
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Article: SCIENTIFIC REPORTS. 2024;14(1):4000
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Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
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Article: SLAS TECHNOLOGY. 2023;28(6):423-432
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Article: NPJ PRECISION ONCOLOGY. 2023;7(1):111
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Article: NUCLEIC ACIDS RESEARCH. 2023;51(W1):W57-W61
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Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940
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Article: MICROMACHINES. 2022;13(11):1823
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Article: CELL DEATH & DISEASE. 2022;13(8):714
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Article: CELL REPORTS METHODS. 2022;2(7):100256
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Article: CANCER RESEARCH. 2021;81(22):5733-5744
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Article: CANCERS. 2021;13(14):3604
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Article: AMERICAN JOURNAL OF HEMATOLOGY. 2021;96(5):580-588
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Article: CLINICAL CANCER RESEARCH. 2020;26(18):4995-5006
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Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(6):928-943
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Article: SLAS DISCOVERY. 2020;25(2):118-126
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Article: CELL DEATH AND DIFFERENTIATION. 2019;26(12):2577-2593
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Article: CELL REPORTS. 2019;28(9):2331-2344.e8
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Article: ACS OMEGA. 2019;4(7):11642-11656
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Article: METHODS IN MOLECULAR BIOLOGY. 2019;1888:233-254
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Article: BIOCHEMISTRY. 2018;57(48):6715-6725
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Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(141)
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(2):136-142
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Article: ACS CHEMICAL BIOLOGY. 2018;13(4):942-950
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Article: MOLECULAR SYSTEMS BIOLOGY. 2018;14(3):e7858
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Article: CELL CHEMICAL BIOLOGY. 2018;25(2):224-229.e2
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Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;494(3-4):477-483
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Article: NATURE CHEMICAL BIOLOGY. 2017;13(10):1102-1108
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Article: NATURE. 2017;547(7664):453-457
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6231-E6239
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Article: JOURNAL OF BIOMOLECULAR SCREENING. 2016;21(10):1019-1033
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Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
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Article: CLINICAL CANCER RESEARCH. 2016;22(15):3903-3914
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(14):6848-6859
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Article: NATURE CHEMICAL BIOLOGY. 2016;12(2):109-116
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Article: CANCER DISCOVERY. 2015;5(11):1210-1223
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Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2015;137(16):5563-5568
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Article: ACS CHEMICAL BIOLOGY. 2014;9(10):2247-2254
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Article: CELL. 2014;158(5):1199-1209
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Article: ORGANIC LETTERS. 2012;14(24):6334-6337
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Article: ORGANIC LETTERS. 2012;14(15):3858-3861
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Article: CHEMISTRY-A EUROPEAN JOURNAL. 2012;18(23):7219-7223
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Article: ADVANCED SYNTHESIS & CATALYSIS. 2012;354(1):205-216
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Article: ORGANIC LETTERS. 2010;12(22):5274-5277
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Article: ORGANIC LETTERS. 2010;12(17):3732-3735
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Article: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2010;2010(20):3927-3933
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Article: TETRAHEDRON. 2010;66(26):4668-4686
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Alla övriga publikationer
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Review: INTERNATIONAL IMMUNOPHARMACOLOGY. 2020;83:106446