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Anthony Wright

Professor

Besöksadress : KFC/Gene Regulation Group (GRG); Novum plan 6, Hiss F; Hälsovägen 7-9, 141 57 Huddinge
Postadress : Institutionen för laboratoriemedicin (LABMED), H5, Kliniskt forskningscentrum, Kliniskt forskningscentrum, Gene Regulation group (GRG); Novum, plan 6, hiss F; Hälsovägen 7-9, 141 57 Huddinge
Leveransadress : KFC, MCG, Novum plan 5, Lab 514; Karolinska Universitetssjukhuset Huddinge; Vårdarvägen 1, 141 57 Huddinge

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Publikationer

Gene expression in the brain of a migratory songbird during breeding and migration
Boss J, Liedvogel M, Lundberg M, Olsson P, Reischke N, Naurin S, et al
Movement ecology 2016;4():4-

AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial-mesenchymal transition in triple-negative breast cancer
Qiao Y, Shiue Cn, Zhu J, Zhuang T, Jonsson P, Wright Ap, et al
Oncotarget 2015;6(10):7804-14

Myc-induced anchorage of the rDNA IGS region to nucleolar matrix modulates growth-stimulated changes in higher-order rDNA architecture
Shiue Cn, Nematollahi-mahani A, Wright Ap
Nucleic acids research 2014;42(9):5505-17

Characterisation of a transcriptome to find sequence differences between two differentially migrating subspecies of the willow warbler Phylloscopus trochilus
Lundberg M, Boss J, Canbäck B, Liedvogel M, Larson Kw, Grahn M, et al
BMC genomics 2013;14():330-

Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome
Xue-franzén Y, Henriksson J, Bürglin Tr, Wright Ap
BMC genomics 2013;14():479-

Origins of Myc proteins--using intrinsic protein disorder to trace distant relatives
Mahani A, Henriksson J, Wright Ap
PloS one 2013;8(9):e75057-

Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins
Nilsson J, Grahn M, Wright Aph
GENOME BIOLOGY 2011;12(7):R65-

Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
Nugent Rl, Johnsson A, Fleharty B, Gogol M, Xue-franzen Y, Seidel C, et al
BMC GENOMICS 2010;:59-

Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles
Xue-franzen Y, Johnsson A, Brodin D, Henriksson J, Burglin Tr, Wright Aph
BMC GENOMICS 2010;:200-

Nucleolar organization, growth control and cancer
Shiue Cn, Arabi A, Wright Aph
EPIGENETICS 2010;5(3):-

Nucleolar organization, growth control and cancer
Shiue Cn, Arabi A, Wright Ap
Epigenetics 2010;5(3):200-5

The role of specific HAT-HDAC interactions in transcriptional elongation
Johnsson Ae, Wright Aph
CELL CYCLE 2010;9(3):467-71

WD40 Domain Divergence Is Important for Functional Differences between the Fission Yeast Tup11 and Tup12 Co-Repressor Proteins
Ferreira Me, Berndt Kd, Nilsson J, Wright Aph
PLOS ONE 2010;5(6):e11009-

Activator-binding domains of the SWI/SNF chromatin remodeling complex characterized in vitro are required for its recruitment to promoters in vivo
Ferreira Me, Prochasson P, Berndt Kd, Workman Jl, Wright Aph
FEBS JOURNAL 2009;276(9):2557-65

c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells
Shiue Cn, Berkson Rg, Wright Aph
ONCOGENE 2009;28(16):1833-42

HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress
Johnsson A, Durand-dubief M, Xue-franzen Y, Ronnerblad M, Ekwall K, Wright A
EMBO REPORTS 2009;10(9):1009-14

Individual Subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes
Fagerstrom-billai F, Durand-dubief M, Ekwall K, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 2007;27(3):1069-82

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing
Durand-dubief M, Sinha I, Fagerstroem-billai F, Bonilla C, Wright A, Grunstein M, et al
EMBO JOURNAL 2007;26(10):2477-88

Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts
Beskow A, Wright Aph
YEAST 2006;23(13):929-35

Genomewide identification of pheromone-targeted transcription in fission yeast
Xue-franzen Yt, Kjaerulff S, Holmberg C, Wright A, Nielsen O
BMC GENOMICS 2006;:303-

Stress-specific role of fission yeast Gcn5 histone acetyltransferase in programming a subset of stress response genes
Johnsson A, Xue-franzen Y, Lundin M, Wright Aph
EUKARYOTIC CELL 2006;5(8):1337-46

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
Arabi A, Wu Sq, Ridderstrale K, Bierhoff H, Shiue C, Fatyol K, et al
NATURE CELL BIOLOGY 2005;7(3):303-10

Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast
Fagerstrom-billai F, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 2005;25(2):716-27

Mechanism of transcription factor recruitment by acidic activators
Ferreira Me, Hermann S, Prochasson P, Workman Jl, Berndt Kd, Wright Aph
JOURNAL OF BIOLOGICAL CHEMISTRY 2005;280(23):21779-84

A DNA microarray for fission yeast: minimal changes in global gene expression after temperature shift
Xue Yt, Haas Sa, Brino L, Gusnanto A, Reimers M, Talibi D, et al
YEAST 2004;21(1):25-39

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels
Arabi A, Rustum C, Hallberg E, Wright Aph
JOURNAL OF CELL SCIENCE 2003;116(9):1707-17

Activation functions 1 and 2 of nuclear receptors: Molecular strategies for transcriptional activation
Warnmark A, Treuter E, Wright Aph, Gustafsson Ja
MOLECULAR ENDOCRINOLOGY 2003;17(10):1901-9

A DNA microarray for genome-wide gene expression analysis in fission yeast.
Xue Yt, Haas S, Brino L, Gusnanto A, Riemers M, Talibi D, et al
YEAST 2003;:S333-S333

Characterisation of HAT/HDAC interactions in fission yeast gene expression networks.
Johnsson A, Xue Yt, Gomez E, Forsberg S, Lundin M, Wright A
YEAST 2003;:S123-S123

Characterisation of the Ssn6-Tup1 corepressor in Schizosaccharomyces pombe
Fagerstrom-billai F, Wright A
YEAST 2003;:S117-S117

Genome-scale design of PCR primers and long oligomers for DNA microarrays
Haas Sa, Hild M, Wright Aph, Hain T, Talibi D, Vingron M
NUCLEIC ACIDS RESEARCH 2003;31(19):5576-81

Dicer is required for chromosome segregation and gene silencing in fission yeast cells
Provost P, Silverstein Ra, Dishart D, Walfridsson J, Djupedal I, Kniola B, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002;99(26):16648-53

Recruitment of Gen5-containing complexes during c-Myc-dependent gene activation - Structure and function aspects
Flinn Em, Wallberg Ae, Hermann S, Grant Pa, Workman Jl, Wright Aph
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(26):23399-406

Chromatin-remodeling complexes involved in gene activation by the glucocorticoid receptor
Wallberg Ae, Wright A, Gustafsson Ja
VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 60 2001;:75-122

How transcriptional activators bind target proteins
Hermann S, Berndt Kd, Wright Ap
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(43):40127-32

The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties
Warnmark A, Wikstrom A, Wright Aph, Gustafsson Ja, Hard T
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(49):45939-44

Architectural principles for the structure and function of the glucocorticoid receptor tau 1 core activation domain
Warnmark A, Gustafsson Ja, Wright Aph
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(20):15014-8

Comparison of nucleosome remodeling by the yeast transcription factor Pho4 and the glucocorticoid receptor
Bergh Ft, Flinn Em, Svaren J, Wright Ap, Horz W
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(12):9035-42

Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis - Gln-642 plays an important role in steroid recognition and binding
Lind U, Greenidge P, Gillner M, Koehler Kf, Wright A, Carlstedt-duke J
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(25):19041-9

Recruitment of chromatin remodelling factors during gene activation via the glucocorticoid receptor N-terminal domain
Wallberg Ae, Flinn Em, Gustafsson Ja, Wright Aph
BIOCHEMICAL SOCIETY TRANSACTIONS 2000;:410-4

Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau 1 activation domain
Wallberg Ae, Neely Ke, Hassan Ah, Gustafsson Ja, Workman Jl, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 2000;20(6):2004-13

Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
Neely Ke, Hassan Ah, Wallberg Ae, Steger Dj, Cairns Br, Wright Aph, et al
MOLECULAR CELL 1999;4(4):649-55

Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors - Implications for the recruitment of trap and P160 coactivator complexes
Treuter E, Johansson L, Thomsen Js, Warnmark A, Leers J, Pelto-huikko M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 1999;274(10):6667-77

Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domain
Wallberg Ae, Neely Ke, Gustafsson Ja, Workman Jl, Wright Aph, Grant Pa
MOLECULAR AND CELLULAR BIOLOGY 1999;19(9):5952-9

Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae
Pedrajas Jr, Kosmidou E, Miranda-vizuete A, Gustafsson Ja, Wright Aph, Spyrou G
JOURNAL OF BIOLOGICAL CHEMISTRY 1999;274(10):6366-73

Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids
Lind U, Greenidge P, Gustafsson Ja, Wright Aph, Carlstedt-duke J
JOURNAL OF BIOLOGICAL CHEMISTRY 1999;274(26):18515-23

myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome
Flinn Em, Busch Cmc, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 1998;18(10):5961-9

Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors
Almlof T, Wallberg Ae, Gustafsson Ja, Wright Aph
BIOCHEMISTRY 1998;37(26):9586-94

Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein
Wakui H, Wright Aph, Gustafsson Ja, Zilliacus J
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(13):8153-6

Involvement of the transcription factor IID protein complex in gene activation by the N-terminal transactivation domain of the glucocorticoid receptor in vitro
Ford J, Mcewan Ij, Wright Aph, Gustafsson Ja
MOLECULAR ENDOCRINOLOGY 1997;11(10):1467-75

Mechanism of gene expression by the glucocorticoid receptor: Role of protein-protein interactions
Mcewan Ij, Wright Aph, Gustafsson Ja
BIOESSAYS 1997;19(2):153-60

Role of hydrophobic amino acid clusters in the transactivation activity of the human glucocorticoid receptor
Almlof T, Gustafsson Ja, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 1997;17(2):934-45

Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor
Henriksson A, Almlof T, Ford J, Mcewan Ij, Gustafsson Ja, Wright Aph
MOLECULAR AND CELLULAR BIOLOGY 1997;17(6):3065-73

Functional interaction of the c-Myc transactivation domain with the TATA binding protein: Evidence for an induced fit model of transactivation domain folding
Mcewan Ij, Dahlmanwright K, Ford J, Wright Aph
BIOCHEMISTRY 1996;35(29):9584-93

Identification of single amino acid substitutions of Cys-736 that affect the steroid-binding affinity and specificity of the glucocorticoid receptor using phenotypic screening in yeast
Lind U, Carlstedtduke J, Gustafsson Ja, Wright Aph
MOLECULAR ENDOCRINOLOGY 1996;10(11):1358-70

Mechanisms of transcription activation by nuclear receptors: Studies on the human glucocorticoid receptor tau(1), transactivation domain
Mcewan Ij, Dahlmanwright K, Amlof T, Ford J, Wright Aph, Gustafsson Ja
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 1995;333(1-2):15-22

MODULATION OF DNA-BINDING SPECIFICITY WITHIN THE NUCLEAR RECEPTOR FAMILY BY SUBSTITUTIONS AT A SINGLE AMINO-ACID POSITION
Zilliacus J, Wright Aph, Carlstedtduke J, Nilsson L, Gustafsson Ja
PROTEINS-STRUCTURE FUNCTION AND GENETICS 1995;21(1):57-67

ROLE OF ACIDIC AND PHOSPHORYLATED RESIDUES IN GENE ACTIVATION BY THE GLUCOCORTICOID RECEPTOR
Almlof T, Wright Aph, Gustafsson Ja
JOURNAL OF BIOLOGICAL CHEMISTRY 1995;270(29):17535-40

STRUCTURAL CHARACTERIZATION OF A MINIMAL FUNCTIONAL TRANSACTIVATION DOMAIN FROM THE HUMAN GLUCOCORTICOID RECEPTOR
Dahlmanwright K, Baumann H, Mcewan Ij, Almlof T, Wright Aph, Gustafsson Ja, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1995;92(5):1699-703

STRUCTURAL DETERMINANTS OF DNA-BINDING SPECIFICITY BY STEROID-RECEPTORS
Zilliacus J, Wright Aph, Carlstedtduke J, Gustafsson Ja
MOLECULAR ENDOCRINOLOGY 1995;9(4):389-400

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