Anton Gisterå

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Jag är legitimerad läkare och medicine doktor som bedriver forskning inom
aterosklerosimmunologi. För närvarande är jag biträdande lektor inom
experimentell kardiovaskulär forskning.
2004-2010, Läkarprogrammet, Uppsala Universitet
2010-2016, Medicine doktor, Karolinska Institutet

Forskningsbeskrivning

Undersöker hur det adaptiva immunsystemet är specifikt involverat i
åderförfettningsprocessen samt i andra relaterade kardiovaskulära
sjukdomstillstånd.

Undervisning

Undervisar på läkarprogrammet, biomedicinprogrammet, för masterstudenter
och doktorander. Medlem i styrgruppen för det kardiovaskulära
doktorandprogrammet.

Artiklar

Article: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2024;:1-11

Dysregulation of micro-RNA 143-3p as a Biomarker of Carotid Atherosclerosis and the Associated Immune Reactions During Disease Progression.

González-López P; Yu Y; Lin S; Escribano Ó; Gómez-Hernández A; Gisterå A
Article: CARDIOVASCULAR RESEARCH. 2023;119(11):2061-2073

Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events.

Edsfeldt A; Singh P; Matthes F; Tengryd C; Cavalera M; Bengtsson E; Dunér P; Volkov P; Karadimou G; Gisterå A; Orho-Melander M; Nilsson J; Sun J; Gonçalves I
Journal article: ATHEROSCLEROSIS. 2023;379:s23

PCSK6 ABLATION INCREASES ATHEROSCLEROTIC BURDEN, BUT PROVIDES PLAQUE STABILITY BY REGULATING TH17 AND SMOOTH MUSCLE CELL CONTENT

Matic L; Suur B; Karadimou G; Willems C; Bergman O; Lengquist M; Kronqvist M; Baumgartner R; Malin S; Gistera A; Hansson G; Malarstig A; Hedin U; Ketelhuth D
Journal article: ATHEROSCLEROSIS. 2023;379:s11

INDUCTION OF LIPID-LOWERING IMMUNE REACTIONS BY APOLIPOPROTEIN B-SPECIFIC T-HELPER CELLS IN HYPERCHOLESTEROLEMIC MICE

Lin S; Yu Y; Centa M; Malin S; Hansson G; Gistera A
Article: CARDIOVASCULAR RESEARCH. 2023;119(7):1524-1536

Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.

Forteza MJ; Berg M; Edsfeldt A; Sun J; Baumgartner R; Kareinen I; Casagrande FB; Hedin U; Zhang S; Vuckovic I; Dzeja PP; Polyzos KA; Gisterå A; Trauelsen M; Schwartz TW; Dib L; Herrmann J; Monaco C; Matic L; Gonçalves I; Ketelhuth DFJ
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1):64.03

PD1 blockade promotes IFN-γ production by progenitor exhausted PD1-expressing T cells in atherosclerotic plaques

Mulholland M; Yu Y; Lin S; Jakobsson G; Schiopu A; Bjorkbacka H; Lichtman AH; Gistera A; Engelbertsen D
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43

A Possible Role Of Apolipoprotein B In Degenerative Ascending Aortic Aneurysm Formation And Progression

Freiholtz D; Bergman O; Corbascio CO; Lang K; Olsson C; Franco-Cereceda A; Eriksson P; Gistera A; Bjorck HM
Article: JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY. 2023;76:18-26

Capsular inflammation after immediate breast reconstruction - Gene expression patterns and inflammatory cell infiltration in irradiated and non-irradiated breasts.

Frisell A; Bergman O; Khan A; Gisterå A; Fisher RM; Lagergren J; de Boniface J; Halle M
Article: CIRCULATION RESEARCH. 2022;130(12):1869-1887

Animal Models of Atherosclerosis-Supportive Notes and Tricks of the Trade.

Gisterå A; Ketelhuth DFJ; Malin SG; Hansson GK
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(9):5203

Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model.

Arora A; Tripodi GL; Kareinen I; Berg M; Forteza MJ; Gisterå A; Griepke S; Casagrande FB; Martins JO; Abdalla DSP; Cole J; Monaco C; Ketelhuth DFJ
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42:a217

PCSK6 Is A Key Regulator Of Immune Status In Mice And Its Ablation Increases Atherosclerotic Plaque Burden In A Bone Marrow Transplant Model

Suur BE; Karadimou G; Lengquist M; Kronqvist M; Gistera A; Malarstig A; Hedin U; Ketelhuth DF; Matic L
Article: PLATELETS. 2022;33(3):360-370

Platelets enhance CD4+ central memory T cell responses via platelet factor 4-dependent mitochondrial biogenesis and cell proliferation.

Tan S; Zhang J; Sun Y; Gisterå A; Sheng Z; Malmström RE; Hou M; Peng J; Ma C; Liao W; Li N
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:831039

Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice.

Kumawat AK; Zegeye MM; Paramel GV; Baumgartner R; Gisterå A; Amegavie O; Hellberg S; Jin H; Caravaca AS; Söderström LÅ; Gudmundsdotter L; Frejd FY; Ljungberg LU; Olofsson PS; Ketelhuth DFJ; Sirsjö A
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gisterå A; Malin SG; Tarnawski L; Matic L; Olofsson PS
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2685-2700

Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis.

Tan S; Li S; Min Y; Gisterå A; Moruzzi N; Zhang J; Sun Y; Andersson J; Malmström RE; Wang M; Berggren P-O; Schlisio S; Liao W; Ketelhuth DFJ; Ma C; Li N
Article: CARDIOVASCULAR RESEARCH. 2020;116(12):1948-1957

3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr-/- mice.

Berg M; Polyzos KA; Agardh H; Baumgartner R; Forteza MJ; Kareinen I; Gisterå A; Bottcher G; Hurt-Camejo E; Hansson GK; Ketelhuth DFJ
Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(3):321-334

Treatment with a Toll-like Receptor 7 ligand evokes protective immunity against atherosclerosis in hypercholesterolaemic mice.

Karadimou G; Gisterå A; Gallina AL; Caravaca AS; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson PS; Paulsson-Berne G
Article: INTERNATIONAL JOURNAL OF NANOMEDICINE. 2020;15:6137-6152

Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe.

Ahmed M; Tegnebratt T; Tran TA; Lu L; Damberg P; Gisterå A; Tarnawski L; Bone D; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1)

P1217Zirconium-89 labelled probe for molecular imaging of inflammation in experimental atherosclerosis

Ahmed M; Tegnebratt T; Tran T; Damberg P; Bone D; Lu L; Gistera A; Tarnawski L; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1)

P1942A trait of inflammation pathogenesis in human atherosclerosis: inflammasome driven interleukin-1 signaling in complex atherosclerotic plaques via hyperlipidemia trained innate immunity

Jiang X; Wang F; Wang J; Gistera A; Roy J; Berne GP; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z
Article: EUROPEAN HEART JOURNAL. 2019;40(30):2495-2503

Prevention of radiotherapy-induced arterial inflammation by interleukin-1 blockade.

Christersdottir T; Pirault J; Gisterå A; Bergman O; Gallina AL; Baumgartner R; Lundberg AM; Eriksson P; Yan Z-Q; Paulsson-Berne G; Hansson GK; Olofsson PS; Halle M
Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)

Quantification of Atherosclerosis in Mice

Centa M; Ketelhuth DFJ; Malin S; Gisterå A
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(148)

Quantification of Atherosclerosis in Mice.

Centa M; Ketelhuth DFJ; Malin S; Gisterå A
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(3):304-317

Inflammasome-Driven Interleukin-1α and Interleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity.

Jiang X; Wang F; Wang Y; Gisterå A; Roy J; Paulsson-Berne G; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z-Q
Article: CIRCULATION. 2018;138(22):2513-2526

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

Gisterå A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
Article: CIRCULATION. 2018;138(16):1693-1705

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.

Laguna-Fernandez A; Checa A; Carracedo M; Artiach G; Petri MH; Baumgartner R; Forteza MJ; Jiang X; Andonova T; Walker ME; Dalli J; Arnardottir H; Gisterå A; Thul S; Wheelock CE; Paulsson-Berne G; Ketelhuth DFJ; Hansson GK; Bäck M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.

Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gisterå A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: EUROPEAN HEART JOURNAL. 2018;39(27):2562-2573

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths.

Ruuth M; Nguyen SD; Vihervaara T; Hilvo M; Laajala TD; Kondadi PK; Gisterå A; Lähteenmäki H; Kittilä T; Huusko J; Uusitupa M; Schwab U; Savolainen MJ; Sinisalo J; Lokki M-L; Nieminen MS; Jula A; Perola M; Ylä-Herttula S; Rudel L; Öörni A; Baumann M; Baruch A; Laaksonen R; Ketelhuth DFJ; Aittokallio T; Jauhiainen M; Käkelä R; Borén J; Williams KJ; Kovanen PT; Öörni K
Article: CIRCULATION JOURNAL. 2017;81(12):1945-1952

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A.

Söderström LÅ; Jin H; Caravaca AS; Klement ML; Li Y; Gisterå A; Hedin U; Maegdefessel L; Hansson GK; Olofsson PS
Article: SCIENTIFIC REPORTS. 2017;7(1):15655

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population.

Mailer RKW; Gisterå A; Polyzos KA; Ketelhuth DFJ; Hansson GK
Article: CIRCULATION RESEARCH. 2017;120(11):1740-1753

Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver.

Mailer RKW; Gisterå A; Polyzos KA; Ketelhuth DFJ; Hansson GK
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(4):383-397

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis.

Gisterå A; Hermansson A; Strodthoff D; Klement ML; Hedin U; Fredrikson GN; Nilsson J; Hansson GK; Ketelhuth DFJ
Article: CARDIOVASCULAR RESEARCH. 2015;106(2):295-302

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.

Polyzos KA; Ovchinnikova O; Berg M; Baumgartner R; Agardh H; Pirault J; Gisterå A; Assinger A; Laguna-Fernandez A; Bäck M; Hansson GK; Ketelhuth DFJ
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(suppl_1)

Abstract 368: Inhibition of Ido-mediated Tryptophan Metabolism Aggravates Atherosclerosis in Hypercholesterolemic Mice

Polyzos KA; Ovchinnikova O; Berg M; Baumgartner R; Agardh H; Pirault J; Gisterå A; Assinger A; Laguna Fernandez A; Bäck M; Hansson GK; Ketelhuth DF
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1339:149-159

Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque.

Gisterå A; Ketelhuth DFJ
Article: CURRENT PHARMACEUTICAL DESIGN. 2013;19(33):5850-5858

T cell-based therapies for atherosclerosis.

Ketelhuth DFJ; Gisterå A; Johansson DK; Hansson GK
Article: SCIENCE TRANSLATIONAL MEDICINE. 2013;5(196):196ra100

Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway.

Gisterå A; Robertson A-KL; Andersson J; Ketelhuth DFJ; Ovchinnikova O; Nilsson SK; Lundberg AM; Li MO; Flavell RA; Hansson GK
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(3):1323-1334

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis.

Klingenberg R; Gerdes N; Badeau RM; Gisterå A; Strodthoff D; Ketelhuth DFJ; Lundberg AM; Rudling M; Nilsson SK; Olivecrona G; Zoller S; Lohmann C; Lüscher TF; Jauhiainen M; Sparwasser T; Hansson GK
Visa fler

Alla övriga publikationer

Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024

Virus-Specific T Cells in the Atheroma Crime Scene: Guilty Accomplices or Innocent Bystanders?

Gisterå A
Preprint: BIORXIV. 2023

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

Tan S; Sun Y; Sheng Z; Min Y; Gisterå A; Zhang J; Ketelhuth DFJ; Liao W; Andersson J; Hu H; Wang M; Hou M; Zhang M; Peng J; Ma C; Li N
Preprint: BIORXIV. 2022

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult

Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Björck HM; Francis R; Fagerberg L; Gisterå A; Zhang X; Metso J; Manfé V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2022;9:864602

The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease.

Smeets D; Gisterå A; Malin SG; Tsiantoulas D
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3832

Treating ApoE-/- mice with Toll-like receptor 7 ligand lead to expansion of marginal zone B cells, reduced plasma cholesterol and decreased atherosclerosis

Paulsson-Berne G; Karadimou G; Gistera A; Gallina A; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson P
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:1232

A trait of inflammation pathogenesis in human atherosclerosis: inflammasome driven interleukin-1 signaling in complex atherosclerotic plaques via hyperlipidemia trained innate immunity

Jiang X; Wang F; Wang J; Gistera A; Roy J; Berne GP; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39

In vivo Effects of Toll like Receptor 7 Ligand in Experimental Atherosclerosis

Karadimou G; Gistera A; Centa M; Hansson GK; Paulsson-Berne G
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:674

Zirconium-89 labelled probe for molecular imaging of inflammation in experimental atherosclerosis

Ahmed M; Tegnebratt T; Tran T; Damberg P; Bone D; Lu L; Gistera A; Tarnawski L; Hedin U; Eriksson P; Holmin S; Gustafsson B; Caidahl K
Review: CURRENT OPINION IN LIPIDOLOGY. 2018;29(5):375-380

Lipid-driven immunometabolic responses in atherosclerosis.

Gisterå A; Ketelhuth DFJ
Meeting abstract: ATHEROSCLEROSIS. 2017;263:E12

INSTABILITY OF LDL PARTICLES PREDICTS FUTURE CARDIOVASCULAR DEATHS

Ruuth M; Nguyen SD; Vihervaara T; Hilvo M; Laajala TD; Kondadi PK; Anton G; Huusko J; Uusitupa M; Schwab U; Lawrence R; Ketelhuth D; Laaksonen R; Baumann M; Aittokallio T; Jauhiainen M; Jan B; Williams KJ; Kovanen P; Oorni K
Review: NATURE REVIEWS NEPHROLOGY. 2017;13(6):368-380

The immunology of atherosclerosis.

Gisterå A; Hansson GK
Thesis / dissertation: 2015

T-cell specificity and regulation in atherosclerosis

Gisterå, Anton
Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):E88-E89

TRANSFORMING GROWTH FACTOR-BETA SIGNALING IN T CELLS PROMOTES STABILIZATION OF ATHEROSCLEROTIC PLAQUES THROUGH AN INTERLEUKIN-17 DEPENDENT PATHWAY

Gistera A; Robertson AK; Andersson J; Ketelhuth DFJ; Oychinnikova O; Nilsson SK; Lundberg AM; Li MO; Flavell RA; Hansson GK
Meeting abstract: ATHEROSCLEROSIS. 2014;235(2):E140

INHIBITION OF INDOLEAMINE 2,3-DIOXYGENASE-MEDIATED TRYPTOPHAN CATABOLISM ACCELERATES ATHEROSCLEROSIS IN HYPERCHOLESTEROLEMIC MICE

Polyzos K; Agardh H; Ovchinnikova O; Pirault J; Berg M; Gistera A; Assinger A; Laguna-Fernandez A; Back M; Hansson GK; Ketelhuth DFJ
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):61-62

TARGETED GENE DELETION IN THE TGF-BETA SIGNALING PATHWAY AFFECTS ATHEROSCLEROSIS AND TH17 CELL DIFFERENTIATION IN HYPERCHOLESTEROLEMIC MICE

Gistera A; Robertson AK; Andersson J; Ketelhuth DFJ; Lundberg AM; Li MO; Flavell RA; Hansson GK

Forskningsbidrag

Inflammation, ateroskleros och hjärtkärlsjukdom

Swedish Heart-Lung Foundation

1 January 2021 - 31 December 2023
Immune-Vascular Interactions in Atherosclerosis

Swedish Research Council

1 January 2021 - 31 December 2024
Nya läkemedel genom studier av LDL-autoimmunitet vid ateroskleros

Swedish Heart-Lung Foundation

1 January 2019 - 31 December 2021
Immune-Vascular Interactions in Atherosclerosis

Swedish Research Council

1 January 2017 - 31 December 2020

Anställningar

Biträdande Lektor, Medicin, Solna, Karolinska Institutet, 2021-2025

Examina och utbildning

Medicine Doktorsexamen, Institutionen för medicin, Solna, Karolinska Institutet, 2016

Om mig

Forskningsbeskrivning

Undervisning

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI