Anna Nilsson

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Forskningsbeskrivning

Vaccination är ett exempel på hur människan kan erhålla immunitet under lång tid. Barn som behandlas med cellgifter på grund av cancer förlorar ofta antikroppar de har fått vid tidigare vaccinationer, och ny vaccination kan inte alltid återställa skyddande nivåer av antikroppar mot sjukdomar som mässling och stelkramp. I vår forskning studerar vi hur olika immunmodulerande läkemedel påverkar antikroppsproducerande plasmaceller och deras stödjeceller i benmärgen in vitro och in vivo i olika studiemodeller.
Projektansvarig: Anna Nilsson MD PhD

Artiklar

Article: EJHAEM. 2023;4(1):115-124

Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T-cell acute lymphoblastic leukemia.

Enlund S; Sinha I; Amor AR; Fard SS; Tamm EP; Jiang Q; Lundin V; Nilsson A; Holm F
Article: JOURNAL OF VIROLOGY. 2022;96(22):e0131022-e01322

Four-Parameter FluoroSpot Assay Reveals That the Varicella Zoster Virus Elicits a Robust Memory T Cell IL-10 Response throughout Childhood.

Nilsson A; Höbinger A; Jahnmatz P; Tiselius E; Laestadius Å; Melén E; Björkander S; Saghafian-Hedengren S
Article: PEDIATRIC BLOOD & CANCER. 2022;69(10):e29773

COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients.

Sundberg E; Hoffman T; Nilsson A; Pahnke S; Enblad G; Kolstad L; Rönnberg B; Lundkvist Å; Torkki M; Zhou O; Anderson J; Harila-Saari A; Palle J
Article: PEDIATRIC BLOOD & CANCER. 2022;69(10):e29750

Low numbers of COVID-19 in Swedish pediatric oncology patients during the first pandemic year despite an open society.

Sundberg E; Georgantzi K; Langenskiöld C; Król L; Nilsson F; Vogt H; Palle J; Ek T; Nilsson A
Article: PEDIATRIC CRITICAL CARE MEDICINE. 2021;22(12):1050-1060

ICU Admission in Children With Acute Lymphoblastic Leukemia in Sweden: Prevalence, Outcome, and Risk Factors.

Ranta S; Broman LM; Abrahamsson J; Berner J; Fläring U; Hed Myrberg I; Kalzén H; Karlsson L; Mellgren K; Nilsson A; Norén-Nyström U; Palle J; von Schewelov K; Svahn JE; Törnudd L; Heyman M; Harila-Saari A
Article: JOURNAL FOR SPECIALISTS IN PEDIATRIC NURSING. 2021;26(4):e12337

Capillary blood sampling increases the risk of preanalytical errors in pediatric hospital care: Observational clinical study.

Hjelmgren H; Nilsson A; Myrberg IH; Andersson N; Ygge B-M; Nordlund B
Article: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 2021;43(2):e272-e275

Extracorporeal Membrane Oxygenation Support in Children With Hematologic Malignancies in Sweden.

Ranta S; Kalzén H; Nilsson A; von Schewelov K; Broman LM; Berner J; Fläring U; Norén-Nyström U; Svahn JE; Palle J; Törnudd L; Karlsson L; Mellgren K; Abrahamsson J; Harila-Saari A
Article: CHILDREN-BASEL. 2020;7(12):E296-296

Genetic Sequence Variants in TLR4, MBL or IL-1 Receptor Antagonist is not Associated to Increased Risk for Febrile Neutropenia in Children with ALL.

Wahlund M; Lindqvist Appell M; Hed Myrberg I; Berggren A; Nilsson A
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2020;39(12):1069-1074

Trends of Pediatric Bloodstream Infections in Stockholm, Sweden: A 20-year Retrospective Study.

Luthander J; Bennet R; Giske CG; Eriksson M; Nilsson A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(15):5305

The Feasibility of Host Transcriptome Profiling as a Diagnostic Tool for Microbial Etiology in Childhood Cancer Patients with Febrile Neutropenia.

Wahlund M; Sinha I; Broliden K; Saghafian-Hedengren S; Nilsson A; Berggren A
Article: INFECTIOUS DISEASES. 2020;52(6):419-422

Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child.

Nilsson A; Edner N; Albert J; Ternhag A
Article: ACTA PAEDIATRICA. 2020;109(6):1229-1235

Peripheral facial nerve palsy in children in a Borrelia high-endemic area, a retrospective follow-up study.

Arnason S; Hultcrantz M; Nilsson A; Laestadius Å
Article: VACCINE. 2020;38(25):4104-4110

Validation of the new Swedish vaccination register - Accuracy and completeness of register data.

Chrapkowska C; Galanis I; Kark M; Lepp T; Lindstrand A; Roth A; Nilsson A
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(7):e1150

Deficits in the IgG+ memory B-cell recovery after anthracycline treatment is confined to the spleen of rhesus macaques.

Lasaviciute G; Bricaud AL; Hellgren F; Ingelman-Sundberg HM; Eksborg S; Jonker M; Haanstra KG; Hed Myrberg I; Sverremark-Ekström E; Loré K; Saghafian-Hedengren S; Nilsson A
Article: JOURNAL OF PEDIATRICS. 2020;216:150-157.e1

The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.

Wahlund M; Nilsson A; Kahlin AZ; Broliden K; Myrberg IH; Appell ML; Berggren A
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2019;38(12):1208-1213

Clostridium difficile Infection in Children: Epidemiology and Trend in a Swedish Tertiary Care Hospital.

Malmqvist L; Ullberg M; Hed Myrberg I; Nilsson A
Article: ACTA PAEDIATRICA. 2019;108(10):1879-1886

Urinary PGE2 metabolite levels in hospitalised infants with infections compared to age-matched controls.

Hamrin J; Perez-Manzo M; Idborg H; Jakobsson P-J; Björk L; Eriksson M; Nilsson A; Herlenius E
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2019;38(9):929-933

Antimicrobial Use in a Swedish Pediatric Hospital: Results From Eight Point-prevalence Surveys Over a 15-Year Period (2003-2017).

Luthander J; Bennet R; Nilsson A; Eriksson M
Article: VACCINE. 2019;37(28):3685-3693

Altered proportions of circulating CXCR5+ helper T cells do not dampen influenza vaccine responses in children with rheumatic disease.

Laestadius Å; Ingelman-Sundberg HM; Myrberg IH; Verme A; Sundberg E; Schweiger B; Saghafian-Hedengren S; Nilsson A
Article: VACCINE. 2019;37(17):2348-2355

Homing defects of B cells in HIV-1 infected children impair vaccination responses.

Bekele Y; Lemma M; Bobosha K; Yibeltal D; Nasi A; Gebre M; Nilsson A; Aseffa A; Howe R; Chiodi F
Article: ACTA PAEDIATRICA. 2019;108(3):522-528

Retrospective study showed that blood sampling errors risked children's well-being and safety in a Swedish paediatric tertiary care.

Hjelmgren H; Nilsson A; Andersson-Papadogiannakis N; Ritzmo C; Ygge B-M; Nordlund B
Article: ACTA PAEDIATRICA. 2019;108(2):361-366

Early central line-associated blood stream infections in children with cancer pose a risk for premature catheter removal.

Moell J; Svenningsson A; Af Sandeberg M; Larsson M; Heyman M; Harila-Saari A; Nilsson A
Article: ACTA PAEDIATRICA. 2017;106(11):1825-1829

Changing diagnosis coding routines may confound the results of longitudinal childhood pneumonia studies.

Eriksson M; Nilsson A; Bennet R
Article: PEDIATRIC BLOOD & CANCER. 2017;64(10)

Hypertriglyceridemia during asparaginase treatment in children with acute lymphoblastic leukemia correlates with antithrombin activity in adolescents.

Persson L; Harila-Saari A; Hed Myrberg I; Heyman M; Nilsson A; Ranta S
Article: SCIENTIFIC REPORTS. 2017;7(1):8956

T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART.

Bekele Y; Yibeltal D; Bobosha K; Andargie TE; Lemma M; Gebre M; Mekonnen E; Habtewold A; Nilsson A; Aseffa A; Howe R; Chiodi F
Article: PEDIATRIC BLOOD & CANCER. 2017;64(7):e26397

Antibiotic use during infectious episodes in the first 6 months of anticancer treatment-A Swedish cohort study of children aged 7-16 years.

Af Sandeberg M; Johansson E; Wettergren L; Björk O; Hertting O; Nilsson A
Article: EUROPEAN JOURNAL OF PEDIATRICS. 2017;176(3):337-342

The impact of pneumococcal conjugate vaccine on community-acquired pneumonia hospitalizations in children with comorbidity.

Sterky E; Bennet R; Lindstrand A; Eriksson M; Nilsson A
Article: LAKARTIDNINGEN. 2017;114:D7IW

[The child immunisation programme--effective but insufficient. Experiences from the Astrid Lindgren pediatric hospital, 2008–2013].

Laestadius Å; Nilsson A; Bennet R; Bogdanovic G; Eriksson M
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1966

Hepatitis B Virus Vaccination in HIV-1-Infected Young Adults: A Tool to Reduce the Size of HIV-1 Reservoirs?

Bekele Y; Graham RL; Soeria-Atmadja S; Nasi A; Zazzi M; Vicenti I; Naver L; Nilsson A; Chiodi F
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1865

Epstein-Barr Virus, but Not Cytomegalovirus, Latency Accelerates the Decay of Childhood Measles and Rubella Vaccine Responses-A 10-Year Follow-up of a Swedish Birth Cohort.

Lasaviciute G; Björkander S; Carvalho-Queiroz C; Hed Myrberg I; Nussbaum B; Nilsson C; Bemark M; Nilsson A; Sverremark-Ekström E; Saghafian-Hedengren S
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2017;36(1):102-108

Assessment of Cytokine and Chemokine Signatures as Potential Biomarkers of Childhood Community-acquired Pneumonia Severity: A Nested Cohort Study in India.

Saghafian-Hedengren S; Mathew JL; Hagel E; Singhi S; Ray P; Ygberg S; Nilsson A
Article: ACTA PAEDIATRICA. 2016;105(8):979-982

A ten-year retrospective case series of glucocorticoid treatment of bacterial meningitis in children.

Ygberg S; Brauner A; Chambers BJ; Wiklund C; Nilsson A
Article: VACCINE. 2016;34(10):1304-1311

Diverse effects on vaccine-specific serum IgG titres and memory B cells upon methotrexate and anti-TNF-α therapy in children with rheumatic diseases: A cross-sectional study.

Ingelman-Sundberg HM; Laestadius Å; Chrapkowska C; Mördrup K; Magnusson B; Sundberg E; Nilsson A
Article: JOURNAL OF GLOBAL HEALTH. 2015;5(2):050418-232

Etiology of community acquired pneumonia among children in India: prospective, cohort study.

Mathew JL; Singhi S; Ray P; Hagel E; Saghafian-Hedengren S; Bansal A; Ygberg S; Sodhi KS; Kumar BVR; Nilsson A
Article: ACTA PAEDIATRICA. 2015;104(9):933-939

The aetiology of paediatric bloodstream infections changes after pneumococcal vaccination and group B streptococcus prophylaxis.

Luthander J; Bennet R; Giske CG; Nilsson A; Eriksson M
Article: MEDICINE. 2015;94(27):e1125

Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART.

Bekele Y; Amu S; Bobosha K; Lantto R; Nilsson A; Endale B; Gebre M; Aseffa A; Rethi B; Howe R; Chiodi F
Article: VACCINE. 2013;31(18):2231-2237

Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.

Cagigi A; Pensieroso S; Ruffin N; Sammicheli S; Thorstensson R; Pan-Hammarström Q; Hejdeman B; Nilsson A; Chiodi F
Article: ACTA PAEDIATRICA. 2013;102(2):182-186

Age and risk factors influence the microbial aetiology of bloodstream infection in children.

Luthander J; Bennet R; Giske CG; Nilsson A; Eriksson M
Article: VACCINE. 2013;31(4):711-717

Kinetics of antibody and memory B cell responses after MMR immunization in children and young adults.

Kakoulidou M; Ingelman-Sundberg H; Johansson E; Cagigi A; Farouk SE; Nilsson A; Johansen K
Article: JOURNAL OF INTERNAL MEDICINE. 2012;271(3):282-293

Soluble CD27 induces IgG production through activation of antigen-primed B cells.

Dang LVP; Nilsson A; Ingelman-Sundberg H; Cagigi A; Gelinck LBS; Titanji K; De Milito A; Grutzmeier S; Hedlund J; Kroon FP; Chiodi F
Article: FRONTIERS IN IMMUNOLOGY. 2011;2:90

The impact of inflammation and immune activation on B cell differentiation during HIV-1 infection.

Ruffin N; Thang PH; Rethi B; Nilsson A; Chiodi F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2010;225(1-2):34-42

Cytotoxic T-lymphocytes secrete soluble factors that induce caspase-mediated apoptosis in glioblastoma cell lines.

Cagigi A; Nilsson A; Levitsky V; Sabri F
Article: AIDS. 2010;24(13):2075-2080

The impact of active HIV-1 replication on the physiological age-related decline of immature-transitional B-cells in HIV-1 infected children.

Cagigi A; Palma P; Nilsson A; Di Cesare S; Pensieroso S; Kakoulidou M; Bernardi S; Rossi P; Chiodi F
Article: LANCET INFECTIOUS DISEASES. 2010;10(7):499-503

Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy.

Cagigi A; Nilsson A; Pensieroso S; Chiodi F
Article: IMMUNOLOGY. 2009;127(4):549-557

Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection.

Ehlin-Henriksson B; Liang W; Cagigi A; Mowafi F; Klein G; Nilsson A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(19):7939-7944

Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children.

Pensieroso S; Cagigi A; Palma P; Nilsson A; Capponi C; Freda E; Bernardi S; Thorstensson R; Chiodi F; Rossi P
Article: LAKARTIDNINGEN. 2009;106(9):580-582

[Chickenpox not always a harmless child disease. General vaccination in Sweden can prevent significant morbidity].

Grimheden P; Bennet R; Hjern A; Nilsson A; Eriksson M
Article: PLOS ONE. 2009;4(5):e5427

CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection.

Cagigi A; Du L; Dang LVP; Grutzmeier S; Atlas A; Chiodi F; Pan-Hammarström Q; Nilsson A
Article: BLOOD. 2008;112(12):4401-4410

Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.

Cagigi A; Mowafi F; Phuong Dang LV; Tenner-Racz K; Atlas A; Grutzmeier S; Racz P; Chiodi F; Nilsson A
Article: PEDIATRIC BLOOD & CANCER. 2008;50(4):812-817

Chemokine CXCL12 enhances proliferation in pre-B-ALL via STAT5 activation.

Mowafi F; Cagigi A; Matskova L; Björk O; Chiodi F; Nilsson A
Article: CANCER RESEARCH. 2007;67(11):5408-5417

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

De Milito A; Iessi E; Logozzi M; Lozupone F; Spada M; Marino ML; Federici C; Perdicchio M; Matarrese P; Lugini L; Nilsson A; Fais S
Article: BLOOD. 2006;108(5):1580-1587

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection.

Titanji K; De Milito A; Cagigi A; Thorstensson R; Grützmeier S; Atlas A; Hejdeman B; Kroon FP; Lopalco L; Nilsson A; Chiodi F
Article: IMMUNOLOGY. 2006;117(3):379-385

Epstein-Barr virus infection negatively impacts the CXCR4-dependent migration of tonsillar B cells.

Ehlin-Henriksson B; Mowafi F; Klein G; Nilsson A
Article: EXPERIMENTAL HEMATOLOGY. 2005;33(12):1500-1507

Expression of CD27-CD70 on early B cell progenitors in the bone marrow: implication for diagnosis and therapy of childhood ALL.

Nilsson A; de Milito A; Mowafi F; Winberg G; Björk O; Wolpert EZ; Chiodi F
Article: BLOOD. 2004;103(6):2180-2186

Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection.

De Milito A; Nilsson A; Titanji K; Thorstensson R; Reizenstein E; Narita M; Grutzmeier S; Sönnerborg A; Chiodi F
Article: JOURNAL OF MEDICAL VIROLOGY. 2004;72(3):345-351

Effects of potent antiretroviral therapy on the immune activation marker soluble CD27 in patients infected with HIV-1 subtypes A-D.

Atlas A; Thanh Ha TT; Lindström A; Nilsson A; Alaeus A; Chiodi F; De Milito A
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;132(2):297-303

Low frequency of plasma nerve-growth factor detection is associated with death of memory B lymphocytes in HIV-1 infection.

Titanji K; Nilsson A; Mörch C; Samuelsson A; Sönnerborg A; Grutzmeier S; Zazzi M; De Milito A
Article: PEDIATRICS. 2002;109(6):e91

Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens.

Nilsson A; De Milito A; Engström P; Nordin M; Narita M; Grillner L; Chiodi F; Björk O
Article: AIDS. 2001;15(9):1109-1113

Soluble CD23 in cerebrospinal fluid: a marker of AIDS-related non-Hodgkin's lymphoma in the brain.

Bossolasco S; Nilsson A; de Milito A; Lazzarin A; Linde A; Cinque P; Chiodi F
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2000;11(3):193-197

Wheezing following lower respiratory tract infections with respiratory syncytial virus and influenza A in infancy.

Eriksson M; Bennet R; Nilsson A
Article: ACTA PAEDIATRICA. 1996;85(12):1508-1510

Transient hypertriglyceridemia of infancy.

Nilsson A; Ortqvist E; Lagercrantz H; Nilsson-Ehle P; Henter JI
Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1996;28(2):121-123

Severe varicella pneumonia in adults in Stockholm County 1980-1989.

Nilsson A; Ortqvist A
Visa fler

Alla övriga publikationer

Review: FRONTIERS IN IMMUNOLOGY. 2021;12:582539

T Cell Subsets During Early Life and Their Implication in the Treatment of Childhood Acute Lymphoblastic Leukemia.

Saghafian-Hedengren S; Sverremark-Ekström E; Nilsson A
Editorial comment: JOURNAL OF INFECTIOUS DISEASES. 2020;222(2):176-179

Early Antiretroviral Therapy May Preserve Vaccine Responses in Human Immunodeficiency Virus-Infected Patients by Preventing Damage to Long-Lived Plasma Cells.

Nilsson A; Chiodi F
Editorial comment: ACTA PAEDIATRICA. 2018;107(12):2046-2047

What benefits do immunocompromised children get from the varicella zoster virus vaccination?

Nilsson A
Review: BLOOD REVIEWS. 2018;32(1):71-80

Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses.

Saghafian-Hedengren S; Söderström I; Sverremark-Ekström E; Nilsson A
Letter: HAEMATOLOGICA. 2015;100(4):e158-e161

Selective loss of vaccine-specific memory B cells in a rhesus macaque model of chemotherapy: influence of doxorubicin on immunological memory.

Ingelman-Sundberg HM; Saghafian-Hedengren S; Jahnmatz M; Eksborg S; Jonker M; Nilsson A
Review: ACTA PAEDIATRICA. 2012;101(2):120-127

The developing immune system - from foetus to toddler.

Ygberg S; Nilsson A
Editorial comment: PLOS PATHOGENS. 2011;7(2):e1001241

Measles outbreak in Africa--is there a link to the HIV-1 epidemic?

Nilsson A; Chiodi F
Published conference paper: VACCINE. 2008;26(24):3016-3025

B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design.

Cagigi A; Nilsson A; De Milito A; Chiodi F
Letter: EXPERIMENTAL HEMATOLOGY. 2006;34(5):574

In response to: CD27 expression in malignant and normal human B precursors: a confirmed phenomenon. Reply to Nilsson and colleagues.

Nilsson A
Meeting abstract: PEDIATRIC RESEARCH. 1999;45(5):756

Immunity to measles, mumps and rubella after acute lymphatic leukemia in childhood

Nilsson A; Nordin M; Chiodi F; Björk O

Anställningar

Universitetslektor/Överläkare, Kvinnors och barns hälsa, Karolinska Institutet, 2014-

Examina och utbildning

Docent, Pediatrik, Karolinska Institutet, 2009
MEDICINE DOKTORSEXAMEN, Institutionen för kvinnors och barns hälsa, Karolinska Institutet, 2004
Läkarexamen, Karolinska Institutet, 1991

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI