Anders Helldén

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2019;74(12):3565-3572

An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study.

Lindström J; Helldén A; Lycke J; Grahn A; Studahl M
Journal article: CLINICAL NEPHROLOGY. 2019;:220

Correction to: The importance of correct estimation of renal function for drug treatment in hospitalized elderly patients, especially women: A prospective observational study.

Helldén A
Article: CLINICAL NEPHROLOGY. 2019;91(4):254-264

The importance of correct estimation of renal function for drug treatment in hospitalized elderly patients, especially women: A prospective observational study .

Helldén A; Bergman U; Odar-Cederlöf I
Article: BMJ CASE REPORTS. 2015;2015:bcr2014207694

Ganciclovir concentrations in the cerebral extracellular space after valganciclovir treatment; a case study.

Peredo I; Helldén A; Wolmer-Solberg N; Pohanka A; Stragliotto G; Rahbar A; Ståhle L; Bellander B-M; Söderberg-Nauclér C
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2015;71(10):1223-1228

Lower CYP2C9 activity in Turkish patients with Behçet's disease compared to healthy subjects: a down-regulation due to inflammation?

Goktaş MT; Hatta F; Karaca O; Kalkisim S; Kilic L; Akdogan A; Babaoglu MO; Bozkurt A; Helldén A; Bertilsson L; Yasar U
Article: BMJ OPEN. 2015;5(7):e006775

Development of a computerised decisions support system for renal risk drugs targeting primary healthcare.

Helldén A; Al-Aieshy F; Bastholm-Rahmner P; Bergman U; Gustafsson LL; Höök H; Sjöviker S; Söderström A; Odar-Cederlöf I
Article: LAKARTIDNINGEN. 2014;111(43):1894-1897

[Electronic support in the medical record for drug dosage in renal failure].

Helldén A; Al-Aieshy F; Bastholm-Rahmner P; Bergman U; Gustafsson LL; Sjöviker S; Söderström A; Odar-Cederlöf I
Article: JOURNAL OF CLINICAL PHARMACOLOGY. 2014;54(7):785-791

Implications of serum creatinine measurements on GFR estimation and vancomycin dosing in children.

Neuman G; Nulman I; Adeli K; Koren G; Colantonio DA; Helldén A
Journal article: PHARMACOGENOMICS. 2013;14(14):1779-1791

Pregnancy and pharmacogenomics in the context of drug metabolism and response.

Helldén A; Madadi P
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2013;333:e650

Cotard's syndrome as an adverse effect of acyclovir treatment in renal failure

Lindén T; Helldén A
Article: THERAPEUTIC DRUG MONITORING. 2013;35(4):417-419

Differential diagnosis of central nervous system involvement in a patient treated with acyclovir.

von Euler M; Axelsson G; Helldén A
Article: BMJ OPEN. 2013;3(4):e002686

Renal function estimations and dose recommendations for dabigatran, gabapentin and valaciclovir: a data simulation study focused on the elderly.

Helldén A; Odar-Cederlöf I; Nilsson G; Sjöviker S; Söderström A; Euler MV; Ohlén G; Bergman U
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(9):1281-1286

The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans.

Helldén A; Panagiotidis G; Johansson P; Waters N; Waters S; Tedroff J; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(7):1033-1042

Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes.

Hatta FHM; Teh LK; Helldén A; Hellgren KE; Roh H-K; Salleh MZ; Aklillu E; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(8):791-795

Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9.

Helldén A; Bergman U; Engström Hellgren K; Masquelier M; Nilsson Remahl I; Odar-Cederlöf I; Ramsjö M; Bertilsson L
Article: DRUGS & AGING. 2009;26(7):595-606

Adverse drug reactions and impaired renal function in elderly patients admitted to the emergency department: a retrospective study.

Helldén A; Bergman U; von Euler M; Hentschke M; Odar-Cederlöf I; Ohlén G
Article: EUROPEAN JOURNAL OF INTERNAL MEDICINE. 2008;19(3):214-215

Pulmonary embolism associated with the use of anabolic steroids.

Liljeqvist S; Helldén A; Bergman U; Söderberg M
Article: LAKARTIDNINGEN. 2008;105(12-13):890-893

[Adverse drug effect as cause of hospital admission. Common drugs are the major part according to the cross-sectional study].

Odar-Cederlöf I; Oskarsson P; Ohlén G; Tesfa Y; Bergendal A; Helldén A; Bergman U
Article: LAKARTIDNINGEN. 2007;104(24-25):1916-1920

[Risk of CNS adverse effects of aciclovir and valaciclovir. Watch the renal function in treatment of herpes simplex and herpes zoster].

Helldén A; Bergman U; Dwyer R; Medin C; Molanaei H; Ståhle L; Thylén P; Odar-Cederlöf I
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2006;57(5):945-949

The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.

Helldén A; Lycke J; Vander T; Svensson J-O; Odar-Cederlöf I; Ståhle L
Journal article: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2005;76(12):1747

Aciclovir induced posterior leucoencephalopathy (vol 76, pg 1308, 2005)

Mahad DJ; Hellden A; Jarvis J
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2003;18(6):1135-1141

High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study.

Helldén A; Odar-Cederlöf I; Diener P; Barkholt L; Medin C; Svensson J-O; Säwe J; Ståhle L
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Preprint: MEDRXIV. 2023

Determination of glomerular filtration rate, a spin off after contrast-enhanced computed tomography among critically ill patients – proof of concept

Kågedal B; Helldén A; Dernroth DN; Andersen A; Ekman A; Haglund M; Kataria B; Oskarsson F; Tobieson L; Balkhed ÅÖ; Hanberger H
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180:245-246

Eight-Fold Increase In The Incidence Of Aciclovir-Induced Adverse Drug Reactions (AINS) In A SwedishTDM Database Since 2000; Analysis Of The Aciclovir Main Metabolite 9-Carboxymethoxymethylguanine (CMMG) Improves The Diagnosis Substantially

Hellden A
Conference publication: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2019;75:S35

A pharmacist-physician-based process to ensure quality assurance in standard order sets

Eriksson LR; Hellden A; Lovborg H
Conference publication: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2019;75:S54-S55

Simple measures with significant outcomes- how evaluation and education can alter medication order and reduce costs

Janefjord E; Hellden A; Bottiger Y
Conference publication: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2019;75:S72

The importance of correct estimate of renal function for drug treatment in hospitalized geriatric patients: a prospective observational study

Hellden A; Bergman U; Odar-Cederlof I
Conference publication: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2014;95:S65-S66

IMPLICATIONS OF SERUM CREATININE MEASUREMENTS ON GFR ESTIMATION AND VANCOMYCIN DOSING IN CHILDREN.

Neuman G; Nulman I; Adeli K; Koren G; Colantonio DA; Hellden A
Corrigendum: DRUGS & AGING. 2013;30(12):1043-1045

Erratum to: Adverse Drug Reactions and Impaired Renal Function in Elderly Patients Admitted to the Emergency Department (vol 26, pg 595, 2009)

Hellden A; Bergman U; von Euler M; Hentschke M; Odar-Cederlof I; Ohlen G
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2013;22:93-94

Low Renal Function in Hospitalized Geriatric Patients: Potentially Serious for Use of Renal Risk Drugs

Klarin I; Cederlof IO; Bergman U; Hellden A
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2012;21:86

Significant Differences between Methods to Estimate Renal Function May Have Major Inplications in Drug Dosing and Adverse Reactions in the Elderly: Concordant Results in a Cross-Comparison between Croatia and Sweden

Matanovic SM; Vlahovic-Palcevski V; Bergman U; Odar-Cederlof I; Hellden A
Review: LAKARTIDNINGEN. 2009;106(41):2607-2611

[Antithyroid drug-induced agranulocytosis. A rare but dreaded condition].

Lehtihet M; Zedenius J; Helldén A; Axelsson R; Calissendorff J
Letter: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2009;29(3):302-304

Acute clozapine intoxication.

Sparve E; Nordberg P; Forsberg S; Helldén A
Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2009;105:30

THE INCIDENCE OF ACICLOVIR-INDUCED NEUROPSYCHIATRIC SYMPTOMS IN STOCKHOLM

Hellden A; Odar-Cederlof I; Bergman U; Orvell C; Stahle L
Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2009;105:30

PHARMACOVIGILANCE AND PATIENT SAFETY - A PLEA FOR REGIONAL PHARMACOVIGILANCE CENTRES

Bergman U; Mejyr S; Odar-Cederlof I; Hellden A; Bradley T; Sjolin-Forsberg G
Conference publication: CLINICAL CHEMISTRY. 2009;55(6):A194

Cystatin C estimated Glomerular Filtration Rate (eGFR) in the Elderly.

Back R; Thylen P; Klarin I; Bergman U; Odar-Cederlof I; Hellden A
Editorial comment: BMJ-BRITISH MEDICAL JOURNAL. 2007;335(7633):1305

Death delusion.

Helldén A; Odar-Cederlöf I; Larsson K; Fehrman-Ekholm I; Lindén T
Conference publication: HAEMATOLOGICA. 2007;92:232

Aciclovir-induced neurotoxicity in hematological patients.: Measurement of the aciclovir main metabolite cmmg may differentiate between adverse drug reactions and herpes infections

Hellden A; Odar-Cederlof O
Conference publication: THERAPEUTIC DRUG MONITORING. 2007;29(4):550-551

Aciclovir-induced CNS adverse drug reactions.: Analysis of the pprincipal metabolite of aciclovir, 9-carboxymethoxymethyl-guanine (CMMG), in serum as a diagnostic tool to differentiate between herpes encephalitis and severe side effects of aciclovir or valaciclovir

Hellden A; Odar-Cederlof I; Stahle L
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2006;15:S100-S101

Elderly patients in stockholm are commonly prescribed drugs that require precautions in relation to reduced renal function

Odar-Cederlof I; Sjoviker S; Ronge S; Hellden A; Soderstrom A; Jacobsson L; Gustafsson LL; Andersen-Karlsson E; Korkmaz S; Fred L; Nilsson A; Bergman U
Letter: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2005;76(9):1308-1309

Aciclovir induced posterior leucoencephalopathy.

Mahad DJ; Helldén A; Jarvis J; Mitra D; Gholkar A; Chinnery PF
Meeting abstract: THERAPEUTIC DRUG MONITORING. 2005;27(2):221

Acyclovir-induced neurotoxicity increases the risk for thromboembolic events, cerebral hemorrhage and death

Helldén A; Cederlöf IO; Ståhle L
Conference publication: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 2004;31(11):A221

Renal function underestimated in elderly hospitalised patients with adverse drug reactions

Helldén A; Johansson M; Öhlén G; Bergman U
Letter: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2003;18(12):2680-2681

Aciclovir and valaciclovir neurotoxicity in patient's with renal failure -: Reply

Helldén A; Ståhle L
Conference publication: BONE MARROW TRANSPLANTATION. 2002;29:S192

Pre-emptive oral vs. IV ganciclovir therapy against cytomegalovirus disease after allogeneic hematopoietic stem cell transplantation (Hsct) in patients with solid tumor

Barkholt L; Lewensohn-Fuchs I; Hentschke P; Stahle L; Helldén A; Ringdén O
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Anställningar

Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2022-2025

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2010
Läkarexamen, Karolinska Institutet, 1990

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