Alexander Valdman

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Jag disputerade 2005 vid Karolinska Institutet på en avhandling om prostatacancer. Efter en postdoc period på Johns Hopkins i Baltimore, USA 2006-2007 återkom jag till Radiumhemmet på Karolinska Universitetssjukhuset där jag blev specialist i onkologi 2012 och sedermera docent i onkologi vid Karolinska Institutet.

Mitt forskningsområde är strålbehandling av bäckencancertumörer. Min forskning fokuserar på att studera kliniska effekter av olika strålslag som kan ge patienter en mer effektiv onkologisk behandling med mer skonsam biverkningsprofil.

Forskningsbeskrivning

Ansvarig huvudprövare (PI) för forskningsstudien PRORECT (NCT04525989) www.prorect.se

Artiklar

Article: JAMA NETWORK OPEN. 2023;6(9):e2332900

Biochemical Recurrence and Risk of Mortality Following Radiotherapy or Radical Prostatectomy.

Falagario UG; Abbadi A; Remmers S; Björnebo L; Bogdanovic D; Martini A; Valdman A; Carrieri G; Menon M; Akre O; Eklund M; Nordström T; Grönberg H; Lantz A; Wiklund P
Article: BRACHYTHERAPY. 2023;22(3):407-415

Validation of automated post-adjustments of HDR prostate brachytherapy treatment plans by quantitative measures and oncologist observer study.

Dohlmar F; Morén B; Sandborg M; Smedby Ö; Valdman A; Larsson T; Carlsson Tedgren Å
Journal article: INVESTIGATIVE UROLOGY. 2023;209(Supplement 4):e419

PD15-04 PREDICTION OF PROSTATE CANCER SPECIFIC MORTALITY IN MEN UNDERGOING RADIOTHERAPY WITH OR WITHOUT HORMONAL TREATMENT, RISK STRATIFICATION BASED ON CLINICAL CHARACTERISTICS AND PSA TREATMENT RESPONSE

Falagario U; Bogdanovic D; Björnebo L; Abbadi A; Valdman A; Eklund M; Nordström T; Aly M; Grönberg H; Wiklund P; Lantz A
Journal article: INVESTIGATIVE UROLOGY. 2023;209(Supplement 4):e214

MP17-06 VALIDATION OF EAU RISK GROUPS FOR BIOCHEMICAL RECURRENCE AFTER RADIOTHERAPY AND RADICAL PROSTATECTOMY FOR PREDICTION OF PROSTATE CANCER MORTALITY

Falagario U; Bogdanovic D; Björnebo L; Abbadi A; Valdman A; Eklund M; Nordström T; Aly M; Grönberg H; Lantz A; Wiklund P
Article: CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY. 2023;39:100562

Preoperative short-course radiation therapy with PROtons compared to photons in high-risk RECTal cancer (PRORECT): Initial dosimetric experience.

Pedone C; Sorcini B; Staff C; Färlin J; Fokstuen T; Frödin J-E; Nilsson PJ; Martling A; Valdman A
Journal article: EJSO. 2023;49(2):e132

Multidisciplinary, consensus-based target volume definition in locally recurrent rectal cancer

Piqeur F; Hupkens B; Nordkamp S; Witte M; Meijnen P; Ceha H; Berbee M; Dieters M; Heyman S; Valdman A; Nilsson M; Nederend J; Rutten H; Burger P; Peulen H
Journal article: EUROPEAN UROLOGY. 2023;83:s1613-s1614

Prediction of prostate cancer specific mortality in men undergoing radiotherapy with or without hormonal treatment, risk stratification based on clinical characteristics and PSA treatment response

Falagario UG; Bogdanovic D; Bjornebo L; Abbadi A; Valdman A; Eklund M; Nordstrom T; Aly M; Gronberg H; Wiklund P; Lantz A
Journal article: EUROPEAN UROLOGY. 2023;83:s379-s380

A0266 Validation of EAU Risk groups for biochemical recurrence after radiotherapy and radical prostatectomy for prediction of prostate cancer mortality

Falagario UG; Bogdanovic D; Björnebo L; Abbadi A; Valdman A; Eklund M; Nordström T; Aly M; Grönberg H; Lantz A; Wiklund P
Article: RADIOTHERAPY AND ONCOLOGY. 2022;177:214-221

Development of a consensus-based delineation guideline for locally recurrent rectal cancer.

Piqeur F; Hupkens BJP; Nordkamp S; Witte MG; Meijnen P; Ceha HM; Berbee M; Dieters M; Heyman S; Valdman A; Nilsson MP; Nederend J; Rutten HJT; Burger JWA; Marijnen CAM; Peulen HMU
Article: PHYSICS AND IMAGING IN RADIATION ONCOLOGY. 2022;22:67-72

Autosegmentation based on different-sized training datasets of consistently-curated volumes and impact on rectal contours in prostate cancer radiation therapy.

Elisabeth Olsson C; Suresh R; Niemelä J; Akram SU; Valdman A
Article: PHYSICS AND IMAGING IN RADIATION ONCOLOGY. 2019;11:88-91

Initial experience with introducing national guidelines for CT- and MRI-based delineation of organs at risk in radiotherapy.

Olsson C; Nyholm T; Wieslander E; Onjukka E; Gunnlaugsson A; Reizenstein J; Johnsson S; Kristensen I; Skönevik J; Karlsson M; Isacsson U; Flejmer A; Abel E; Nordström F; Nyström L; Bergfeldt K; Zackrisson B; Valdman A
Journal article: JOURNAL OF RADIATION ONCOLOGY. 2019;8(2):225-231

Salvage radiation therapy following radical prostatectomy in Stockholm County in 2008-2016

Falk J; Aly M; Berglund A; Nordstrom T; Valdman A
Article: MEDICAL PHYSICS. 2018;45(3):1210-1221

Quantitative evaluation of potential irradiation geometries for carbon-ion beam grid therapy.

Tsubouchi T; Henry T; Ureba A; Valdman A; Bassler N; Siegbahn A
Article: TECHNOLOGY IN CANCER RESEARCH & TREATMENT. 2017;16(6):749-757

Proton Grid Therapy: A Proof-of-Concept Study.

Henry T; Ureba A; Valdman A; Siegbahn A
Article: RADIOTHERAPY AND ONCOLOGY. 2016;119(2):344-350

A national approach for automated collection of standardized and population-based radiation therapy data in Sweden.

Nyholm T; Olsson C; Agrup M; Björk P; Björk-Eriksson T; Gagliardi G; Grinaker H; Gunnlaugsson A; Gustafsson A; Gustafsson M; Johansson B; Johnsson S; Karlsson M; Kristensen I; Nilsson P; Nyström L; Onjukka E; Reizenstein J; Skönevik J; Söderström K; Valdman A; Zackrisson B; Montelius A
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2010;44(6):371-377

Beta-tubulin III expression in prostate cancer.

Egevad L; Valdman A; Wiklund NP; Sève P; Dumontet C
Article: APMIS. 2010;118(5):360-365

Distribution of Foxp3-, CD4- and CD8-positive lymphocytic cells in benign and malignant prostate tissue.

Valdman A; Jaraj SJ; Compérat E; Charlotte F; Roupret M; Pisa P; Egevad L
Article: CELLULAR ONCOLOGY. 2010;32(1):39-44

Clinical significance of intratumoral CD8+ regulatory T cells in prostate carcinoma.

Compérat E; Egevad L; Camparo P; Roupret M; Vaessen C; Valdman A; Jonmarker S; Capron F; Cussenot O; Charlotte F
Article: CELLULAR ONCOLOGY. 2009;31(6):367-374

Expression of redox pathway enzymes in human prostatic tissue.

Valdman A; Häggarth L; Cheng L; Lopez-Beltran A; Montironi R; Ekman P; Egevad L
Article: CELLULAR ONCOLOGY. 2009;31(3):137-142

Endothelin-1 expression in prostate cancer and high grade prostatic intraepithelial neoplasia.

Rosenblatt R; Valdman A; Cheng L; Lopez-Beltran A; Montironi R; Ekman P; Egevad L
Article: APMIS. 2008;116(10):888-895

Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer.

Glaessgen A; Jonmarker S; Lindberg A; Nilsson B; Lewensohn R; Ekman P; Valdman A; Egevad L
Article: APMIS. 2008;116(6):491-498

Expression of PDX-1 in prostate cancer, prostatic intraepithelial neoplasia and benign prostatic tissue.

Jonmarker S; Glaessgen A; Culp WD; Pisa P; Lewensohn R; Ekman P; Valdman A; Egevad L
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2008;42(5):484-487

Atypical stromal hyperplasia of the prostate.

Egevad L; Carbin B-E; Castellanos E; Hellstrom M; Valdman A
Article: VIRCHOWS ARCHIV. 2006;449(3):297-301

Tissue shrinkage after fixation with formalin injection of prostatectomy specimens.

Jonmarker S; Valdman A; Lindberg A; Hellström M; Egevad L
Article: DIAGNOSTIC CYTOPATHOLOGY. 2006;34(5):317-322

Cytological features of prostatic intraepithelial neoplasia.

Valdman A; Jonmarker S; Ekman P; Egevad L
Article: EUROPEAN UROLOGY. 2005;48(5):852-857

Ezrin expression in prostate cancer and benign prostatic tissue.

Valdman A; Fang X; Pang S-T; Nilsson B; Ekman P; Egevad L
Article: PROSTATE. 2004;60(4):367-371

Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer.

Valdman A; Fang X; Pang S-T; Ekman P; Egevad L
Journal article: JOURNAL OF UROLOGY. 2004;171(4):110

PIM-1 expression in prostatic intraepithelial neoplasia and human prostate cancer

Valdman A; Fang XL; Pang ST; Ekman P; Egevad L
Article: UROLOGY. 2004;63(3):609-612

Expression of ezrin in prostatic intraepithelial neoplasia.

Pang S-T; Fang X; Valdman A; Norstedt G; Pousette A; Egevad L; Ekman P
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2003;22(5):1003-1007

Mutation analysis of the BRG1 gene in prostate cancer clinical samples.

Valdman A; Nordenskjöld A; Fang X; Naito A; Al-Shukri S; Larsson C; Ekman P; Li C
Journal article: EXPERIMENTAL ONCOLOGY. 2002;24(3):203-207

The effects of tumor activity on urinary concentration of matrix metalloproteinases 2 and 9 in bladder cancer

Daniltchenko D; Gerhards S; Jung K; Koenig F; Valdman A; Al-Shukri S; Loening SA
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Alla övriga publikationer

Conference publication: EUROPEAN UROLOGY. 2023;83:S379-S380

Validation of EAU Risk groups for biochemical recurrence after radiotherapy and radical prostatectomy for prediction of prostate cancer mortality

Falagario UG; Bogdanovic D; Bjornebo L; Abbadi A; Valdman A; Eklund M; Nordstrom T; Aly M; Gronberg H; Lantz A; Wiklund P
Conference publication: JOURNAL OF UROLOGY. 2023;209:E214-E215

VALIDATION OF EAU RISK GROUPS FOR BIOCHEMICAL RECURRENCE AFTER RADIOTHERAPY AND RADICAL PROSTATECTOMY FOR PREDICTION OF PROSTATE CANCER MORTALITY

Falagario U; Bogdanovic D; Bjornebo L; Abbadi A; Valdman A; Eklund M; Nordstrom T; Aly M; Gronberg H; Lantz A; Wiklund P
Conference publication: JOURNAL OF UROLOGY. 2023;209:E419

PREDICTION OF PROSTATE CANCER SPECIFIC MORTALITY IN MEN UNDERGOING RADIOTHERAPY WITH OR WITHOUT HORMONAL TREATMENT, RISK STRATIFICATION BASED ON CLINICAL CHARACTERISTICS AND PSA TREATMENT RESPONSE

Falagario U; Bogdanovic D; Bjornebo L; Abbadi A; Valdman A; Eklund M; Nordstrom T; Aly M; Gronberg H; Wiklund P; Lantz A
Conference publication: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2022;114(3):E249

Bladder Volumes Matter: Clinical Significance of Bladder Filling in Salvage Radiotherapy for Prostate Cancer

Grodeberg L; Jamtlien S; Koskela LR; Olsson CE; Valdman A
Conference publication: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2021;111(3S):E138

A Comparative Study Between AI-Generated, Real-Life Clinical as Well as Reference Rectal Volumes Defined in Accordance With the Swedish National STRONG Guidelines in Prostate Cancer Radiotherapy.

Suresh R; Niemelä J; Akram S; Valdman A; Olsson CE
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2021;161:S770-S772

Volumes and doses by various ways to define rectum in radiotherapy: clinical, standardized, and AI

Olsson C; Suresh R; Akram S; Niemela J; Valdman A
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2021;161:S1147-S1148

Differences between various rectal volumes and implications for patient-reported rectal toxicity

Pettersson N; Olsson C; Dang T; Olsson I; Valdman A
Review: ACTA ONCOLOGICA. 2020;59(10):1157-1163

A Nordic-Baltic perspective on indications for proton therapy with strategies for identification of proper patients.

Brandal P; Bergfeldt K; Aggerholm-Pedersen N; Bäckström G; Kerna I; Gubanski M; Björnlinger K; Evensen ME; Kuddu M; Pettersson E; Brydøy M; Hellebust TP; Dale E; Valdman A; Weber L; Høyer M
Conference publication: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2019;105(1):E620

Initial Experience with Introducing National Swedish Guidelines for CT- and MRI-based Delineation of Organs at Risk in Radiotherapy: The STRONG Project

Olsson C; Nyholm T; Wieslander E; Zackrisson B; Valdman A
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2019;133:S824-S825

Postoperative radiation therapy following radical prostatectomy in Stockholm County in 2008-2016

Falk J; Aly M; Nordstrom T; Valdman A
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2018;127:S1202-S1203

dosimetric evaluation of carbon-ion beam grid therapy of brain tumors

Tsubouchi T; Valdman A; Siegbahn A
Published paper: ACTA ONCOLOGICA. 2017;56(11):1437-1443

Development of an interlaced-crossfiring geometry for proton grid therapy.

Henry T; Bassler N; Ureba A; Tsubouchi T; Valdman A; Siegbahn A
Review: BRITISH JOURNAL OF RADIOLOGY. 2017;90(1078):20170073

Microbeam radiation therapy - grid therapy and beyond: a clinical perspective.

Schültke E; Balosso J; Breslin T; Cavaletti G; Djonov V; Esteve F; Grotzer M; Hildebrandt G; Valdman A; Laissue J
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2017;123:S959

Evaluation of proton grid therapy in challenging clinical cases

Henry T; Valdman A; Siegbahn A
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2017;123:S953

Proton grid therapy (PGT): a parameter study

Henry T; Valdman A; Siegbahn A
Conference publication: MEDICAL PHYSICS. 2017;44(6):3241

Nationwide Collection of Structured RT Data in Sweden

Nyholm T; Olsson C; Skonevik J; Gunnlaugsson A; Valdman A; Johnsson S; Zackrisson B
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2016;119:S260

The development of proton-beam grid therapy (PBGT)

Henry T; Valdman A; Siegbahn A
Conference publication: MODERN PATHOLOGY. 2009;22:171A

Prostate Atrophy, but Not Prostate Carcinoma, Is Characterised by a Relative Infiltration of Tregs

Gurel B; Valdman A; Cappelli L; Tsilidis K; Hicks J; De Marzo AM; Drake CG; Meeker AK
Conference publication: LABORATORY INVESTIGATION. 2009;89:171A

Prostate Atrophy, but Not Prostate Carcinoma, Is Characterised by a Relative Infiltration of Tregs

Gurel B; Valdman A; Cappelh I; Tahda K; Hicks I; De Marza AM; Draka CG; Mecker IA
Conference publication: EUROPEAN UROLOGY OPEN SCIENCE. 2008;7(3):252

Clinical signification of intratumoural CD8+CD25+ regulatory T (Treg) cells in prostate carcinoma

Comperat EM; Egevald L; Roupret M; Vaessen C; Valdman A; Jonmarker S; Richard F; Capron F; Charlotte F
Review: TUMOR BIOLOGY. 2008;29(5):311-322

Current status of prognostic immunohistochemical markers for urothelial bladder cancer.

Rosenblatt R; Jonmarker S; Lewensohn R; Egevad L; Sherif A; Kälkner KM; Nilsson S; Valdman A; Ullén A
Conference publication: MODERN PATHOLOGY. 2008;21:157A

Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer

Gloessgen A; Jonmarker S; Nilsson B; Lewensohn R; Ekman P; Valdman A; Egevad L
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2008;88:S315-S316

CLINICAL OUTCOME IN PATIENTS WITH PROSTATE CANCER TREATED WITH HIGH DOSE-RATE 192-IRIDIUM BRACHYTHERAPY AS MONOTHERAPY

Ryberg M; Castellanos E; Hjelm-Eriksson M; Cohn-Cedermark G; Valdman A; Ullen A; Nilsson J; Lundell M; Lundell G; Nilsson S; Kalkner KM
Conference publication: MODERN PATHOLOGY. 2008;21:186A

Distribution of FOXP3, CD4 and CD8 positive lymphocytic cells in benign and malignant prostatic tissues

Valdman A; Jonmarker S; Rosenblatt R; Comperat E; Charlotte F; Roupert M; Pisa P; Egevad L
Conference publication: LABORATORY INVESTIGATION. 2008;88:186A

Distribution of FOXP3, CD4 and CD8 positive lymphocytic cells in benign and malignant prostatic tissues

Valdman A; Jonmaker S; Rosenblatt R; Comperat E; Charlotte F; Roupert M; Pisa P; Egevad L
Conference publication: RADIOTHERAPY AND ONCOLOGY. 2008;88:S185

COMBINED EXTERNAL RADIOTHERAPY AND HIGH DOSE RATE BRACHYTHERAPY BOOST OF RELAPSING UROEPITHELIAL CANCER IN THE REMAINING URETER

Kalkner KM; Bengtsson E; Valdman A; Ullen A; Sward J; Brehmer M
Conference publication: PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. 2003;:49-54

The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis of urinary bladder cancer

Daniltchenko DI; Koenig F; Schnorr D; Valdman A; Al-Shukri S; Loening SA
Conference publication: JOURNAL OF UROLOGY. 2003;169(4):121

Characterization of significantly overexpressed genes identified by high throughput CDNA microarrays as new biomarkers in prostate cancer

Li CD; Lapointe J; Egevad L; Fang XL; Valdman A; Brooks J; Botstein D; Ekman PE; Pollack JR; Brown PO
Conference publication: JOURNAL OF UROLOGY. 2003;169(4):385

The T/T genotype of SNP33978 in the BRG1 gene is associated with early onset of highly malignant prostate cancer

Valdman A; Nordenskjöldd A; Fang XL; Naito A; Salman AS; Larsson C; Ekman PE; Li CD
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Anställningar

Senior Forskningsspecialist, Onkologi-Patologi, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Onkologi, Karolinska Institutet, 2021
MEDICINE DOKTORSEXAMEN, Institutionen för molekylär medicin och kirurgi, Karolinska Institutet, 2005
LICENTIATEXAMEN, INST F KIRURGISK VETENSKAP (K3), Karolinska Institutet, 2003

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

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