Theocharis Panaretakis forskargrupp

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Gruppmedlemmar

Theocharis Panaretakis, PhD, docent, gruppledare
Dimitris Chioureas, MSc, doktorand
Alessandro Occhionero, MSc, FOU-praktikant
Julia Vardaki, MSc student
Pedro Fonseca, MSc student

Utvalda publikationer

Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.
Panaretakis T, Pokrovskaja K, Shoshan M, Grandér D
J. Biol. Chem. 2002 Nov;277(46):44317-26

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
Panaretakis T, Laane E, Pokrovskaja K, Björklund A, Moustakas A, Zhivotovsky B, et al
Mol. Biol. Cell 2005 Aug;16(8):3821-31

Calreticulin exposure dictates the immunogenicity of cancer cell death.
Obeid M, Tesniere A, Ghiringhelli F, Fimia G, Apetoh L, Perfettini J, et al
Nat. Med. 2007 Jan;13(1):54-61

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death.
Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, et al
Cell Death Differ. 2008 Sep;15(9):1499-509

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death.
Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund A, Chapman D, et al
EMBO J. 2009 Mar;28(5):578-90

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.
Laane E, Tamm K, Buentke E, Ito K, Kharaziha P, Khahariza P, et al
Cell Death Differ. 2009 Jul;16(7):1018-29

Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies.
Grandér D, Kharaziha P, Laane E, Pokrovskaja K, Panaretakis T
Autophagy 2009 Nov;5(8):1198-200

Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells.
Kharaziha P, Rodriguez P, Li Q, Rundqvist H, Björklund A, Augsten M, et al
Cell Death Dis 2012 Jan;3():e262

Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model.
Kharaziha P, De Raeve H, Fristedt C, Li Q, Gruber A, Johnsson P, et al
Cancer Res. 2012 Oct;72(20):5348-62

Tumor cell-derived exosomes: a message in a bottle.
Kharaziha P, Ceder S, Li Q, Panaretakis T
Biochim. Biophys. Acta 2012 Aug;1826(1):103-11

Fullständig lista över publikationer