Seminar: Francisco J. Alvarez
Spinal rewiring after nerve injury prevents normal motor control despite regeneration
Associate Professor Francisco J. Alvarez
Department of Physiology, Emory University School of Medicine, Atlanta, USA
Francisco Alvarez has for many years worked on the development and plasticity of synaptic circuits in functional networks, in particular the formation of spinal circuits capable of adult-like locomotion. Within these circuits his main interest is on the specification, synaptogenesis and maturation of the neurochemical and electrophysiological properties of inhibitory interneurons (like Renshaw cells and Ia inhibitory interneurons) that modulate and pattern the activity of motoneurons. This basic understanding then constitutes the knowledge foundation to analyze how these circuits are modified after nerve injury and during motoneuron neurodegenerative disease.
Host: Staffan Cullheim