Receptor Biology and Signaling
Our research aims to increase the understanding of basic pharmacology and underlying mechanisms of signal transduction and signaling specificity mediated by the Class Frizzled (FZD) receptors. In mammals 10 FZDs (FZD1-10) are known. The FZDs are - among other ligands - activated by 19 mammalian WNTs, a group of secreted lipoglycoproteins with an improtant role in embryonic development, stem cell regulation and human diseases, such as cancer. So far, it remains obscure, which WNTs activate which FZDs and how ligand binding specifies the downstream signaling events.
Our goal is to map WNT-FZD interaction profiles and to characterize basic pharmacological parameters of distinct WNT/FZD pairs. The ultimate goal, of course, is to find mechanisms that could be employed at therepeutic targets to improve current therapy in human disease as diverse as cancer, neurodegenerative diseases, bone disease, etc.
Using biochemical and anatomical as well as live-cell imaging techniques the dynamics of receptor localisation and association of intracellular signalling molecules are investigated in recombinant cell systems and glial cellular models as well as in vivo.
Marie Curie International Training Network "WntsApp" to be launched
The Schulte group is part of the Marie Curie ITN "WntsApp" to be launched after summer 2013. WntsApp will take an integrated, multidisciplinary and intersectorial approach to address key unresolved questions on how WNT signals are relayed from the membrane to the cytosol in stem cells and cancer. By fostering a symbiosis between high-tech GPCR pharmacology, advanced in vivo imaging and peptide chemistry on the one hand and efficient transfer of know-how between academic and private sector partners on the other, WntsApp offers a unique training platform with a strong potential for innovation.
Breaking News - 2012 Nobel Prize in Chemistry
G protein-coupled receptors: Robert Lefkowitz/Brian Kobilka
The Schulte group - described by researchmedia
Fore information on researchmedia check: www.researchmedia.eu
International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors
Pharmacol Rev December 2010 62:632-667; doi:10.1124/pr.110.002931