Bertrand Joseph: Life and Death Decisions at the Cellular level
We are interested in the molecular signaling which regulates the decision between life and death at the cellular level and how its deregulation is implicated in human diseases. Our investigations are performed in various models of human diseases ranging from cancers to neurodegenerative disorders. Our group has a well establish national and international network of colleagues and collaborators which give use access to additional technical know-how and scientific expertise.
Our activities can be divided into three main, overlapping branches:
- Role for killer caspases in the control of microglia pro-inflammatory phenotype (see e.g., Nature, 2011, Cell Death Diff, 2011).
- Influence of histone posttranslational modifications on cell life and death decisions (see e.g., Nature, 2013, Autophagy, 2013, Oncogene, 2011).
- Transcriptional and epigenetic regulation of microglia tumor promoting phenotype, especially in glioma.
Knowledge of the molecular mechanisms underlying the integration of the signaling pathways controlling cell survival and death decision may provide new principles for drug development and/or gene therapy-based treatment of human diseases.
- Miguel Angel Burguillos, postdoc
- Xianli Chen, PhD student
- Jens Füllgrabe, PhD student
- Edel Kavanagh, postdoc
- Johanna Rodhe, PhD student
- Maria Salli, MSc student
The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Nature. 2013 Jul 17.
Histone post-translational modifications regulate autophagy flux and outcome.
Autophagy. 2013 Aug 7;9(10).
Caspase signalling controls microglia activation and neurotoxicity.
Nature. 2011 Apr 21;472(7343):319-24.
The executioners sing a new song: killer caspases activate microglia.
Cell Death Differ. 2011 Nov;18(11):1679-91.
Oncogene. 2011 Aug 4;30(31):3391-403.