The Nobel Prize in Physiology or Medicine 2007
Mario R Capecchi, Sir Martin J Evans och Oliver Smithies are the 2007 Nobel Laureates in Physiology or Medicine.
They are jointly awarded the prize for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells".
Their discoveries have led to the creation of gene targeting in mice. Gene targeting is often used to inactivate single genes and create "knockout mice". The technology is now being applied to virtually all areas of biomedicine, from basic research to the development of new therapies.
Gene targeting allows scientists to establish the roles of individual genes in health and disease. To date, more than ten thousand mouse genes have been knocked out.
For more information please contact Professor Hans Jörnvall, secretary of the Nobel Committee, phone +46 8 524 877 02, E-mail: Hans.Jornvall@ki.se