Professor of Vascular Biology, especially Regulation of Angiogenesis at the Department of Microbiology and Tumor and Cell Biology since 2004.
Angiogenesis is the formation of new blood vessels from pre-existing vessels. This process is one of the most important fields of research into the treatment of conditions as diverse as primary and secondary cancer, obesity, cardiac disease, stroke, diabetes and chronic inflammation.
Yihai Cao's the research group has focused on the study of the mechanisms behind pathological angiogenesis, and on the development of novel therapeutic strategies based on angiogenesis and anti-angiogenesis for these common and serious diseases. The formation of new lymphatic vessels, lymphangiogenesis, represents a completely new field of research into lymphatic metastases.
Prominent expression of acidic fibroblast growth factor in motor and sensory neurons.
Neuron. 1991 Sep;7(3):349-64.
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
Cell. 1994 Oct 21;79(2):315-28.
Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function.
Science. 1996 Jul 26;273(5274):510-3.
Angiogenesis inhibited by drinking tea.
Nature. 1999 Apr 1;398(6726):381.
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.
Nature. 2001 Nov 29;414(6863):550-4.
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.
Cancer Cell. 2002 Feb;1(1):99-108.
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.
Nat Med. 2003 May;9(5):604-13. Epub 2003 Mar 31.
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.
Cancer Cell. 2004 Oct;6(4):333-45.
Genomic instability in laminopathy-based premature aging.
Nat Med. 2005 Jul;11(7):780-5. Epub 2005 Jun 26.
Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.
Nat Rev Cancer. 2005 Sep;5(9):735-43.