Publications 2008-2012

Integrative Physiology research group

Chibalin AV, Heiny JA, Benziane B, Prokofiev AV, Vasiliev AV, Kravtsova VV, Krivoi II.

Chronic Nicotine Modifies Skeletal Muscle Na,K-ATPase Activity through Its Interaction with the Nicotinic Acetylcholine Receptor and Phospholemman.

PLoS One. 2012;7(3):e33719.

Boon H, Kostovski E, Pirkmajer S, Song M, Lubarski I, Iversen PO, Hjeltnes N, Widegren U, Chibalin AV.

Influence of chronic and acute spinal cord injury on skeletal muscle Na+/K+-ATPase and phospholemman expression in humans.

Am J Physiol Endocrinol Metab. 2012 Jan 24.

Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR.

Acute exercise remodels promoter methylation in human skeletal muscle.

Cell Metab. 2012 Mar 7;15(3):405-11.

Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM.

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.

Am J Physiol Endocrinol Metab. 2012 Mar;302(6):E731-9.

Zierath JR.

Remembering our classics: then and now.

Diabetologia. 2012 Jan;55(1):1-2.

Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME.

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.

Metabolism. 2012 Feb;61(2):175-85.

Salehzadeh F, Rune A, Osler M, Al-Khalili L.

Testosterone or 17β-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes.

J Endocrinol. 2011 Aug;210(2):219-29.

Tom RZ, Sjögren RJ, Vieira E, Glund S, Iglesias-Gutiérrez E, Garcia-Roves PM, Myers MG Jr, Björnholm M.

Increased hepatic insulin sensitivity in mice lacking inhibitory leptin receptor signals.

Endocrinology. 2011 Jun;152(6):2237-46.

Galuska D, Pirkmajer S, Barrès R, Ekberg K, Wahren J, Chibalin AV.

C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.

PLoS One. 2011;6(12):e28294.

Benziane B, Widegren U, Pirkmajer S, Henriksson J, Stepto NK, Chibalin AV.

Effect of exercise and training on phospholemman phosphorylation in human skeletal muscle.

Am J Physiol Endocrinol Metab. 2011 Sep;301(3):E456-66.

Essén-Gustavsson B, Granlund A, Benziane B, Jensen-Waern M, Chibalin AV.

Muscle glycogen resynthesis, signalling and metabolic responses following acute exercise in exercise-trained pigs carrying the PRKAG3 mutation.

Exp Physiol. 2011 Sep;96(9):927-37.

Pirkmajer S, Chibalin AV.

Serum starvation: caveat emptor.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C272-9.

O'Gorman DJ, Krook A.

Exercise and the treatment of diabetes and obesity.

Med Clin North Am. 2011 Sep;95(5):953-69.

Shemyakin A, Salehzadeh F, Esteves Duque-Guimaraes D, Böhm F, Rullman E, Gustafsson T, Pernow J, Krook A.

Endothelin-1 reduces glucose uptake in human skeletal muscle in vivo and in vitro.

Diabetes. 2011 Aug;60(8):2061-7.

Long YC, Kostovski E, Boon H, Hjeltnes N, Krook A, Widegren U.

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.

J Appl Physiol. 2011 May;110(5):1204-10. Erratum in: J Appl Physiol. 2011 Aug;111(2):622.

Huang-Doran I, Bicknell LS, Finucane FM, Rocha N, Porter KM, Tung YC, Szekeres F, Krook A, Nolan JJ, O'Driscoll M, Bober M, O'Rahilly S, Jackson AP, Semple RK. Majewski Osteodysplastic Primordial Dwarfism Study Group.

Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes.

Diabetes. 2011 Mar;60(3):925-35.

Shemyakin A, Salehzadeh F, Böhm F, Al-Khalili L, Gonon A, Wagner H, Efendic S, Krook A, Pernow J.

Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro.

J Clin Endocrinol Metab. 2010 May;95(5):2359-66.

Barres R, Zierath JR.

DNA methylation in metabolic disorders.

Am J Clin Nutr. 2011 Apr;93(4):897S-900.

Czepluch FS, Barrès R, Caidahl K, Olieslagers S, Krook A, Rickenlund A, Zierath JR, Waltenberger J.

Strenuous physical exercise adversely affects monocyte chemotaxis.

Thromb Haemost. 2011 Jan;105(1):122-30.

Egan B, Dowling P, O'Connor PL, Henry M, Meleady P, Zierath JR, O'Gorman DJ.

2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training.

Proteomics. 2011 Apr;11(8):1413-28.

Fritz T, Caidahl K, Osler M, Ostenson CG, Zierath JR, Wändell P.

Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance.

Diabet Med. 2011 Nov;28(11):1362-72.

Kulkarni SS, Karlsson HK, Szekeres F, Chibalin AV, Krook A, Zierath JR.

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

J Biol Chem. 2011 Oct 7;286(40):34567-74.

Mashili FL, Austin RL, Deshmukh AS, Fritz T, Caidahl K, Bergdahl K, Zierath JR, Chibalin AV, Moller DE, Kharitonenkov A, Krook A.

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.

Diabetes Metab Res Rev. 2011 Mar;27(3):286-97.

Vind BF, Pehmøller C, Treebak JT, Birk JB, Hey-Mogensen M, Beck-Nielsen H, Zierath JR, Wojtaszewski JF, Højlund K.

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Diabetologia. 2011 Jan;54(1):157-67.

Yan J, Zierath JR, Barrès R.

Evidence for non-CpG methylation in mammals.

Exp Cell Res. 2011 Nov 1;317(18):2555-61.

Zierath JR, Barrès RE.

Nutritional status affects the epigenomic profile of peripheral blood cells.

Epigenomics. 2011 Jun;3(3):259-60.

Yang JN, Wang Y, Garcia-Roves PM, Björnholm M, Fredholm BB.

Adenosine A(3) receptors regulate heart rate, motor activity and body temperature.

2010 Jun;199(2):221-30.

Heiny JA, Kravtsova VV, Mandel F, Radzyukevich TL, Benziane B, Prokofiev AV, Pedersen SE, Chibalin AV, Krivoi II.

The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.

J Biol Chem. 2010 Sep 10;285(37):28614-26.

Cantó C, Jiang LQ, Deshmukh AS, Mataki C, Coste A, Lagouge M, Zierath JR, Auwerx J.

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cell Metab. 2010 Mar 3;11(3):213-9.

Deshmukh AS, Long YC, Barbosa TD, Karlsson HKR, Glund S, Zavadoski WJ, Gibbs EM, Koistinen HA, Wallberg-Henriksson H, Zierath JR.

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha 1-specific activity and glucose transport in human skeletal muscle.

Diabetologia 53:1142-1150, 2010.

Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ.

Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor. coactivator-1 alpha mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.

Journal of Physiology 588:1779-1790, 2010.

Jiang LQ, Garcia-Roves PM, Barbosa TD, Zierath JR.

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

American Journal of Physiology Endocrinology and Metabolism 298:E8-E16, 2010.

Shemyakin A, Salehzadeh F, Bohm F, Al-Khalili L, Gonon A, Wagner H, Efendic S, Krook A, Pernow J.

Regulation of Glucose Uptake by Endothelin-1 in Human Skeletal Muscle in Vivo and in Vitro.

Journal of Clinical Endocrinology and Metabolism 95:2359-2366, 2010.

Sogaard P, Szekeres F, Garcia-Roves PM, Larsson D, Chibalin AV, Zierath JR.

Spatial Insulin Signalling in Isolated Skeletal Muscle Preparations.

Journal of Cellular Biochemistry 109:943-949, 2010.

Barres R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR.

Non-CpG Methylation of the PGC-1 alpha Promoter through DNMT3B Controls Mitochondrial Density.

Cell Metab 10:189-198, 2009.

Ehrenborg E, Krook A.

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor delta.

Pharmacological Reviews 61:373-393, 2009.

Karlsson HKR, Chibalin AV, Koistinen HA, Yang J, Koumanov F, Wallberg-Henriksson H, Zierath JR, Holman GD.

Kinetics of GLUT4 Trafficking in Rat and Human Skeletal Muscle.

Diabetes 58:847-854, 2009.

Krook A, Zierath JR.

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA.

Diabetologia 52:1231-1239, 2009.

Salehzadeh F, Al-Khalili L, Kulkarni SS, Wang MH, Lonnqvist F, Krook A.

Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 beta hydroxysteroid dehydrogenase type 1 in human skeletal muscle.

Diabetes/Metabolism Research and Reviews 25:250-258, 2009.

Sultan A, Strodthoff D, Robertson AK, Paulsson-Berne G, Fauconnier J, Parini P, Ryden M, Thierry-Mieg N, Johansson ME, Chibalin AV, Zierath JR, Arner P, Hansson GK.

T Cell-Mediated Inflammation in Adipose Tissue Does Not Cause Insulin Resistance in Hyperlipidemic Mice.

Circulation Research 104:961-U97, 2009.

Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A.

SiRNA-mediated reduction of inhibitor of nuclear factor-kappa B kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.

Diabetes 57:2066-2073, 2008.

Benziane B, Burton TJ, Scanlan B, Galuska D, Canny BJ, Chibalin AV, Zierath JR, Stepto NK.

Divergent cell signaling after short-term intensified endurance training in human skeletal muscle.

American Journal of Physiology Endocrinology and Metabolism 295:E1427-E1438, 2008.

Bouzakri K, Austin R, Rune A, Lassman ME, Garcia-Roves PM, Berger JP, Krook A, Chibalin AV, Zhang BB, Zierath JR.

Malonyl coenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Diabetes 57:1508-1516, 2008.

Cabrera O, Jacques-Silva MC, Speier S, Yang SN, Kohler M, Fachado A, Vieira E, Zierath JR, Kibbey R, Berman DM, Kenyon NS, Ricordi C, Caicedo A, Berggren PO.

Glutamate is a positive autocrine signal for glucagon release.

Cell Metabolism 7:545-554, 2008.

Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schurmann A, Joost HG, Al-Hasani H.

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Nature Genetics 40:1354-1359, 2008.

Chibalin AV, Leng Y, Vieira E, Krook A, Bjornholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylen C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR.

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Cell 132:375-386, 2008.

Deshmukh AS, Hawley JA, Zierath JR.

Exercise-induced phospho-proteins in skeletal muscle.

International Journal of Obesity 32:S18-S23, 2008.

Deshmukh AS, Treebak JT, Long YC, Viollet B, Wojtaszewski JFP, Zierath JR.

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Molecular Endocrinology 22:1105-1112, 2008.

Garcia-Roves PM, Osler ME, Holmstrom MH, Zierath JR.

Gain-of-function R225Q Mutation in AMP-activated Protein Kinase gamma 3 Subunit Increases Mitochondrial Biogenesis in Glycolytic Skeletal Muscle.

Journal of Biological Chemistry 283:35724-35734, 2008.

Glund S, Krook A.

Role of interleukin-6 signalling in glucose and lipid metabolism.

Acta Physiol 192:37-48, 2008.

Krook A.

IL-6 and metabolism - new evidence and new questions.

Diabetologia 51:1097-1099, 2008.

Kuoppamaa H, Skrobuk P, Sihvo M, Hiukka A, Chibalin AV, Zierath JR, Koistinen HA.

Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.

Diabetes/Metabolism Research and Reviews 24:554-562, 2008.

Long YC, Zierath JR.

Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle.

American Journal of Physiology Endocrinology and Metabolism 295:E545-E552, 2008.

Lundholm L, Bryzgalova G, Gao H, Portwood N, Falt S, Berndt KD, Dicker A, Galuska D, Zierath IR, Gustafsson JA, Efendic S, Dahlman-Wright K, Khan A.

The estrogen receptor alpha-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.

Journal of Endocrinology 199:275-286, 2008.

O'Gorman DJ, Krook A.

Exercise and the treatment of diabetes and obesity.

Endocrinology and Metabolism Clinics of North America 37:887-903, 2008.

Osler ME, Zierath JR.

Minireview: Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle.

Endocrinology 149:935-941, 2008.

Vieira E, Nilsson EC, Nerstedt A, Ormestad M, Long YC, Garcia-Roves PM, Zierath JR, Mahlapuu M.

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

American Journal of Physiology Endocrinology and Metabolism 295:E1032-E1037, 2008.

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR.

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Cell. Feb 8;132(3):375-86, 2008.

Last modified by: Ylva Haraldsdotter 2012-07-04