Muscle Physiology research group
We investigate the mechanisms behind muscle adaptations and maladaptations in disease. We are also investigating the fundamental causes of muscle fatigue.
Our original research focus was to discover the cellular causes of fatigue in skeletal muscle. The accumulated findings of our group and other groups have firmly established that muscle fatigue is not caused by increased lactate or acidosis. Our studies of the basic mechanisms underlying muscle fatigue continue.
Numerous common disorders, such as diabetes and general inflammatory diseases, are associated with skeletal and cardiac muscle dysfunction. Therefore, a large proportion of our research is dedicated to uncovering the mechanisms that produce functional adaptations and maladaptations in skeletal and cardiac muscle. Diseases studied in this context include type 2-diabetes, rheumatoid arthritis, and mitochondrial myopathies.