Professor of Medical Chemistry at the Department of Medical Biochemistry and Biophysics since 1994.
Karl Tryggvason's research is directed towards what are called basal membranes (BMs), which form an important part of human connective tissue. Along with his research group, he has identified and developed diagnostics for five serious genetic diseases, all of which are due to mutations in the genes for proteins that build the body's basal membranes.
BMs are an important component of the kidney filter that is currently a major target of the group's research. The involvement of BMs in diabetes complications and tumour invasion and metastasis is another major research focus.