Kenneth R. Chien group
The central scientific interest of the Chien lab is to understand heart development at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human heart disease.
The human heart, composed of highly diverse cell types, must be assembled into discrete anatomic and functional structures at the earliest stages of fetal life. While the anatomy and physiology of the human cardiovascular system has been extensively studied, the normal development of human heart and dysregulation in disease are poorly understood at the molecular and cellular level.
Our research group plans to provide new insight into several areas of human cardiogenesis, ranging from molecular decoding of human heart development to developing completely novel technologies to control gene expression in the intact heart in vivo.
Such work is highly interdisciplinary, breaking new ground at the intersection of stem cell biology, developmental biology, biotechnology of modified RNA therapeutics, in vivo delivery, large animal model systems, and cardiovascular biology and medicine.
Keywords: Stem cells, Developmental Biology, Heart Disease, Heart Development, Genetics, Biotechnology