Lifestyle and risk of abdominal aortic aneurysm
My project aims to investigate how modifiable lifestyle related factors, such as adiposity, diet and physical activity, may affect the risk of developing an abdominal aortic aneurysm. To prospectively assess this risk, I utilize our two cohorts: the Swedish Mammography Cohort (SMC) and the Cohort of Swedish Men (COSM).
Abdominal aortic aneurysm is a pathological dilatation of the abdominal aorta and associated with high mortality if this dilatation keeps growing to eventually rupture. Since the development of the disease is usually asymptomatic and the best way to detect it is by ultrasound screening, it is important to identify people at risk of the disease, making surgery to prevent rupture possible. The findings of lifestyle related factors affecting the risk of disease may also act as future recommendations for patients with detected abdominal aortic aneurysm. Smoking is heavily associated with the disease but other lifestyle related exposures that possibly could affect inflammation and oxidative stress in the aortic wall, are scarcely investigated.
2011 Doctor's degree in Medicine (MD), Karolinska Institutet
Obesity and abdominal aortic aneurysm
Br J Surg. 2012. doi: 10.1002/bjs.8983