Human NK cells in health and disease
Natural killer (NK) cells are lymphocytes of the innate immune system. Our group has a long-term interest in exploring the molecular specificity and function of human NK cells in health and in different disease settings.
Much of our work is carried out in collaboration with other scientists at the Center. Focus is aimed at characterizing NK cells in peripheral blood and different tissues in healthy humans.
Another focus is aimed at characterizing NK cells in peripheral blood and different tissues during viral infections and cancer. We are also exploring human primary immunodeficiency syndromes in which NK cells are not functioning properly, in particular with respect to their cytotoxic function. Finally, we are also interested in using NK cells in settings of adoptive immunotherapy, with a primary focus on hematological malignancies.
Keywords: NK cells, innate immunity, virus, cancer, hematology, immunotherapy